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The map label for this gene is fhuB

Identifier: 226224563

GI number: 226224563

Start: 2026624

End: 2027649

Strand: Reverse

Name: fhuB

Synonym: Lm4b_01977

Alternate gene names: 226224563

Gene position: 2027649-2026624 (Counterclockwise)

Preceding gene: 226224564

Following gene: 226224562

Centisome position: 69.61

GC content: 44.05

Gene sequence:

>1026_bases
ATGGATAAGTCAAAACAGATAAAAATGAATACAAGACCGACTGTTGCTAAATTCATACTTTCGGGTGGGATTTTGTTGCT
TCTCATTTTAGCGTTATTCGGGATTGCGGTTGGTGCAGCCGATATTAATTTAAGTACGGTTTGGGATGCACTTTTTCATT
ATAATAGTTCGGATACGCAGCACCAGATTATACGTAGTTTACGTGTTCCTCGGGTGGTTGCGGATATGGCGATAGGGGCT
GCTTTTGCGGTTGCTGGAGCGATTATGCAAGGAATCACTCGGAATCCACTTGCTGATTCAGGCTTGCTTGGGTTGAATGC
TGGATCGACGTTTATGGTAGCAGTTTGTTTTGCATTTATGCCTTGGCTTAGTTATAATTCGCTCATTTTATTTTCTTTTG
TTGGGGCGGCAATTGGGGCATTTTTAGTATTTGGCGTTAGTTCTCTTGCAGGGAGCGCAATGTCGCCAACGAGGCTAGTG
CTTGCTGGAGCGGCGGTTAGTTCATTGCTTACTGCGCTTAGTGAAGGACTCGCGATTTATTTTCAGTTAAGTCAGGATTT
GGCCTTTTGGTACGCGGGCGGTGTTGCTGGTGTGAAATGGAGTCAGCTTGCAGCGATTTGGCCTTGGTTACTTGGAGCGC
TTATTGCGGCGATTTTGCTAAGTAGATCGATTACCATTTTAAGCTTAGGCGATGATATTGCTGTTGGTTTAGGTGAAAAA
ACTACTTTTGTTAAAATTGCTTCGATGGTTGTGGTGTTGATTTTGGCGGGGCTTGCTGTGTCGGTTGTTGGTCCGGTTGG
GTTTATCGGCTTGATTGTACCGCATTTGGTACGATTTTTAGTTGGAGTAGATTATCGCTGGATTATCCCTTGCTCGGCGG
TTGTTGGAGCCTTTCTGACATTAGCGGCGGATATTGTGGCGAGAACAATCAATCCGCCATATGAAACGCCAATCAGTGTT
ATTTTTGCATTAATCGGGGTTCCTTTCTTCTTATATGTAGCACGTAAAGAAAGGAGGAACTTATAA

Upstream 100 bases:

>100_bases
GATTGCGCTTAGTGAATGATATTGATATAATTTTCTTTGCGATTGATAATTATTATCACTTAAAATGAGCGGATAATTTA
GATGGAAGGAACATGTGCAG

Downstream 100 bases:

>100_bases
TGTATATGACAACGGCAGAAAAACGAAAAAAATCGCGGCGAGTTTGGACGTTAATTATTTTAAGCGTGTTAATTTTTTGT
ACATTTACATATAGTGTCAA

Product: ferrichrome ABC transporter (permease)

Products: ADP; phosphate; ferric enterobactin [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MDKSKQIKMNTRPTVAKFILSGGILLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQHQIIRSLRVPRVVADMAIGA
AFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFMPWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLV
LAGAAVSSLLTALSEGLAIYFQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSRSITILSLGDDIAVGLGEK
TTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLTLAADIVARTINPPYETPISV
IFALIGVPFFLYVARKERRNL

Sequences:

>Translated_341_residues
MDKSKQIKMNTRPTVAKFILSGGILLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQHQIIRSLRVPRVVADMAIGA
AFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFMPWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLV
LAGAAVSSLLTALSEGLAIYFQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSRSITILSLGDDIAVGLGEK
TTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLTLAADIVARTINPPYETPISV
IFALIGVPFFLYVARKERRNL
>Mature_341_residues
MDKSKQIKMNTRPTVAKFILSGGILLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQHQIIRSLRVPRVVADMAIGA
AFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFMPWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLV
LAGAAVSSLLTALSEGLAIYFQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSRSITILSLGDDIAVGLGEK
TTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLTLAADIVARTINPPYETPISV
IFALIGVPFFLYVARKERRNL

Specific function: Part of the ABC transporter complex fhuBGCD involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786805, Length=305, Percent_Identity=36.3934426229508, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790740, Length=322, Percent_Identity=31.3664596273292, Blast_Score=143, Evalue=1e-35,
Organism=Escherichia coli, GI1790741, Length=293, Percent_Identity=34.1296928327645, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788004, Length=282, Percent_Identity=35.8156028368794, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1786347, Length=341, Percent_Identity=29.9120234604106, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1786804, Length=311, Percent_Identity=30.5466237942122, Blast_Score=107, Evalue=9e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 36029; Mature: 36029

Theoretical pI: Translated: 9.81; Mature: 9.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKSKQIKMNTRPTVAKFILSGGILLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQ
CCCCCCEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHH
HQIIRSLRVPRVVADMAIGAAFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHH
PWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLVLAGAAVSSLLTALSEGLAIY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
FQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSRSITILSLGDDIAVGLGEK
EEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCC
TTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
LAADIVARTINPPYETPISVIFALIGVPFFLYVARKERRNL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDKSKQIKMNTRPTVAKFILSGGILLLLILALFGIAVGAADINLSTVWDALFHYNSSDTQ
CCCCCCEECCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCHH
HQIIRSLRVPRVVADMAIGAAFAVAGAIMQGITRNPLADSGLLGLNAGSTFMVAVCFAFM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEECCCCHHHHHHHHHHHH
PWLSYNSLILFSFVGAAIGAFLVFGVSSLAGSAMSPTRLVLAGAAVSSLLTALSEGLAIY
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEE
FQLSQDLAFWYAGGVAGVKWSQLAAIWPWLLGALIAAILLSRSITILSLGDDIAVGLGEK
EEEHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEECCCCC
TTFVKIASMVVVLILAGLAVSVVGPVGFIGLIVPHLVRFLVGVDYRWIIPCSAVVGAFLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECHHHHHHHHHH
LAADIVARTINPPYETPISVIFALIGVPFFLYVARKERRNL
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; ferric enterobactin [Periplasm]; H2O [C]

Specific reaction: ATP + ferric enterobactin [Periplasm] + H2O = ADP + phosphate + ferric enterobactin [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377; 8388528 [H]