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The map label for this gene is fur

Identifier: 226224561

GI number: 226224561

Start: 2024908

End: 2025360

Strand: Reverse

Name: fur

Synonym: Lm4b_01975

Alternate gene names: 226224561

Gene position: 2025360-2024908 (Counterclockwise)

Preceding gene: 226224562

Following gene: 226224560

Centisome position: 69.54

GC content: 38.19

Gene sequence:

>453_bases
ATGGAAGGTCGTATTGGACGCATTAAAGCACAACTTCATGATGCTAGTTATAAATTAACCCCACAGCGAGAAGCTACTGT
TCGCGTTTTACTGGAAAATGAAAAAGATCATTTAAGTGCCGAGGAAGTTTTCTTGCGTGTGAAAGATATTGCACCTGACA
CTGGCCTTGCAACCGTTTATAGAACGTTGGAACTTTTAACCGAATTACGCGTGGTTGATAAAATTAATTTTGGTGACGGT
GTTTCTCGGTATGACTTGAGACAAGAAGGCGCCAAACATTTCCATCATCATTTAGTATGTTTAGAGTGTGGTTCTGTAGA
AGAAATTCAAGAAGATTTATTAGAAGATGTGGAGAAAATCGTCGAATCGAAGTGGAATTTTCTTGTTAAAGACCATCGAC
TGACTTTCCAAGGGATTTGCGCAGATTGCAGACAAAAATCTAAAAAAGAATAA

Upstream 100 bases:

>100_bases
GCATTTTATTTATAATTATTATAAACTGTATTTATTGTTAAATGATAATAATGATAATTTAGAAAGACAACTTGTTGTAG
CAACCAAGGGAGGAACCATA

Downstream 100 bases:

>100_bases
TACAAGAGTTTGGGATAATTTATCTCAAACTTTTTTTATGATTAAAAAAGATGGACTGAATTGCGCGAAAAGTATTATAA
GTCTTTTTCTATTAATTAAA

Product: transcriptional regulator (Fur family)

Products: NA

Alternate protein names: Ferric uptake regulator [H]

Number of amino acids: Translated: 150; Mature: 150

Protein sequence:

>150_residues
MEGRIGRIKAQLHDASYKLTPQREATVRVLLENEKDHLSAEEVFLRVKDIAPDTGLATVYRTLELLTELRVVDKINFGDG
VSRYDLRQEGAKHFHHHLVCLECGSVEEIQEDLLEDVEKIVESKWNFLVKDHRLTFQGICADCRQKSKKE

Sequences:

>Translated_150_residues
MEGRIGRIKAQLHDASYKLTPQREATVRVLLENEKDHLSAEEVFLRVKDIAPDTGLATVYRTLELLTELRVVDKINFGDG
VSRYDLRQEGAKHFHHHLVCLECGSVEEIQEDLLEDVEKIVESKWNFLVKDHRLTFQGICADCRQKSKKE
>Mature_150_residues
MEGRIGRIKAQLHDASYKLTPQREATVRVLLENEKDHLSAEEVFLRVKDIAPDTGLATVYRTLELLTELRVVDKINFGDG
VSRYDLRQEGAKHFHHHLVCLECGSVEEIQEDLLEDVEKIVESKWNFLVKDHRLTFQGICADCRQKSKKE

Specific function: Iron uptake repressor. Acts on the transcription of ferri-siderophore uptake genes [H]

COG id: COG0735

COG function: function code P; Fe2+/Zn2+ uptake regulation proteins

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Fur family [H]

Homologues:

Organism=Escherichia coli, GI1786899, Length=136, Percent_Identity=36.7647058823529, Blast_Score=87, Evalue=5e-19,

Paralogues:

None

Copy number: 3432 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002481 [H]

Pfam domain/function: PF01475 FUR [H]

EC number: NA

Molecular weight: Translated: 17329; Mature: 17329

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGRIGRIKAQLHDASYKLTPQREATVRVLLENEKDHLSAEEVFLRVKDIAPDTGLATVY
CCCCHHHHHHHEECCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHH
RTLELLTELRVVDKINFGDGVSRYDLRQEGAKHFHHHLVCLECGSVEEIQEDLLEDVEKI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHH
VESKWNFLVKDHRLTFQGICADCRQKSKKE
HHHHHCEEHHCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEGRIGRIKAQLHDASYKLTPQREATVRVLLENEKDHLSAEEVFLRVKDIAPDTGLATVY
CCCCHHHHHHHEECCCEEECCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCHHHHHH
RTLELLTELRVVDKINFGDGVSRYDLRQEGAKHFHHHLVCLECGSVEEIQEDLLEDVEKI
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHH
VESKWNFLVKDHRLTFQGICADCRQKSKKE
HHHHHCEEHHCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377; 9701813 [H]