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The map label for this gene is ndk

Identifier: 226224533

GI number: 226224533

Start: 1992380

End: 1992823

Strand: Reverse

Name: ndk

Synonym: Lm4b_01946

Alternate gene names: 226224533

Gene position: 1992823-1992380 (Counterclockwise)

Preceding gene: 226224534

Following gene: 226224532

Centisome position: 68.42

GC content: 39.64

Gene sequence:

>444_bases
ATGGAACAAACTTATGTAATGGTTAAGCCGGATGGTGTAGAACGAGGACTTATTGGTGAAATTGTCACAAGAATAGAGAA
AAAAGGCTTAAAAATAGTTGCTGGAAAATTAATGCAAATTGACCGCGAACTAGCAGAAAAACATTACGCGGAACATATTG
GAAAATCTTTTTTCGAGGATTTAATTGGATTTATTACTTCTGGACCAGTGTTTGCGATGGTGTTAGAAGGAGACGATGCG
ATTGCAACAGCACGCCGAATGATGGGGAAAACAAATCCGTTAGAAGCTGACCCCGGAACAATTCGCGCTGATTATGCGGT
ACATACAAATCGAAATGTGATTCATGGATCGGATAGCCCAGAAAGTGCGAAACGGGAAATTCAGTTGTTTTTTGCACCGC
AGGAAATTTTAAGTTATCAAAAGGCAATCGACACTTGGATTTAA

Upstream 100 bases:

>100_bases
AATACTGGATTCTTTGCCGCAAGTGCCTGAATTAAAACCATTAAAACAAATCGTTCGTGTTTTAGATAAAAGAAATTATT
AACGTGAGGGAGGATTCTTT

Downstream 100 bases:

>100_bases
CATAGTATAGAGTTTAGGGAAACCTAGGCTCTTTTTTTATAGAGAAATTACCATTTCATGCGGTTTTTTGGTAAGATGAA
AGAATGAAACGAAAGTATTG

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase

Number of amino acids: Translated: 147; Mature: 147

Protein sequence:

>147_residues
MEQTYVMVKPDGVERGLIGEIVTRIEKKGLKIVAGKLMQIDRELAEKHYAEHIGKSFFEDLIGFITSGPVFAMVLEGDDA
IATARRMMGKTNPLEADPGTIRADYAVHTNRNVIHGSDSPESAKREIQLFFAPQEILSYQKAIDTWI

Sequences:

>Translated_147_residues
MEQTYVMVKPDGVERGLIGEIVTRIEKKGLKIVAGKLMQIDRELAEKHYAEHIGKSFFEDLIGFITSGPVFAMVLEGDDA
IATARRMMGKTNPLEADPGTIRADYAVHTNRNVIHGSDSPESAKREIQLFFAPQEILSYQKAIDTWI
>Mature_147_residues
MEQTYVMVKPDGVERGLIGEIVTRIEKKGLKIVAGKLMQIDRELAEKHYAEHIGKSFFEDLIGFITSGPVFAMVLEGDDA
IATARRMMGKTNPLEADPGTIRADYAVHTNRNVIHGSDSPESAKREIQLFFAPQEILSYQKAIDTWI

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family

Homologues:

Organism=Homo sapiens, GI38045913, Length=147, Percent_Identity=46.9387755102041, Blast_Score=161, Evalue=2e-40,
Organism=Homo sapiens, GI4557797, Length=147, Percent_Identity=46.9387755102041, Blast_Score=160, Evalue=2e-40,
Organism=Homo sapiens, GI37693993, Length=146, Percent_Identity=49.3150684931507, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI66392227, Length=147, Percent_Identity=44.8979591836735, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI66392205, Length=147, Percent_Identity=44.8979591836735, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI4505409, Length=147, Percent_Identity=44.8979591836735, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI66392192, Length=147, Percent_Identity=44.8979591836735, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI66392203, Length=147, Percent_Identity=44.8979591836735, Blast_Score=158, Evalue=2e-39,
Organism=Homo sapiens, GI4826862, Length=138, Percent_Identity=47.1014492753623, Blast_Score=141, Evalue=3e-34,
Organism=Homo sapiens, GI7019465, Length=133, Percent_Identity=39.0977443609023, Blast_Score=93, Evalue=7e-20,
Organism=Homo sapiens, GI37574614, Length=133, Percent_Identity=39.0977443609023, Blast_Score=93, Evalue=8e-20,
Organism=Homo sapiens, GI5031951, Length=135, Percent_Identity=37.037037037037, Blast_Score=85, Evalue=2e-17,
Organism=Homo sapiens, GI4505413, Length=134, Percent_Identity=34.3283582089552, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI148839372, Length=139, Percent_Identity=30.9352517985612, Blast_Score=74, Evalue=6e-14,
Organism=Homo sapiens, GI30023828, Length=135, Percent_Identity=31.8518518518519, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1788866, Length=137, Percent_Identity=46.7153284671533, Blast_Score=131, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI17506807, Length=147, Percent_Identity=46.2585034013605, Blast_Score=146, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI71995094, Length=129, Percent_Identity=34.1085271317829, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322783, Length=146, Percent_Identity=50, Blast_Score=166, Evalue=9e-43,
Organism=Drosophila melanogaster, GI45549037, Length=146, Percent_Identity=48.6301369863014, Blast_Score=163, Evalue=3e-41,
Organism=Drosophila melanogaster, GI18860097, Length=134, Percent_Identity=36.5671641791045, Blast_Score=97, Evalue=5e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NDK_LISMC (C1KWM9)

Other databases:

- EMBL:   FM242711
- RefSeq:   YP_002758640.1
- ProteinModelPortal:   C1KWM9
- SMR:   C1KWM9
- GeneID:   7704380
- GenomeReviews:   FM242711_GR
- KEGG:   lmc:Lm4b_01946
- OMA:   ERPFFGA
- ProtClustDB:   PRK00668
- GO:   GO:0005737
- HAMAP:   MF_00451
- InterPro:   IPR001564
- InterPro:   IPR023005
- Gene3D:   G3DSA:3.30.70.141
- PANTHER:   PTHR11349
- PRINTS:   PR01243
- SMART:   SM00562

Pfam domain/function: PF00334 NDK; SSF54919 NDK

EC number: =2.7.4.6

Molecular weight: Translated: 16435; Mature: 16435

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00469 NDP_KINASES

Important sites: ACT_SITE 115-115 BINDING 9-9 BINDING 57-57 BINDING 85-85 BINDING 91-91 BINDING 102-102 BINDING 112-112

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTYVMVKPDGVERGLIGEIVTRIEKKGLKIVAGKLMQIDRELAEKHYAEHIGKSFFED
CCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGFITSGPVFAMVLEGDDAIATARRMMGKTNPLEADPGTIRADYAVHTNRNVIHGSDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEECCCCC
ESAKREIQLFFAPQEILSYQKAIDTWI
HHHHHHEEEEECHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEQTYVMVKPDGVERGLIGEIVTRIEKKGLKIVAGKLMQIDRELAEKHYAEHIGKSFFED
CCCCEEEECCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LIGFITSGPVFAMVLEGDDAIATARRMMGKTNPLEADPGTIRADYAVHTNRNVIHGSDSP
HHHHHCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCEEEEEEEECCCCEEECCCCC
ESAKREIQLFFAPQEILSYQKAIDTWI
HHHHHHEEEEECHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA