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The map label for this gene is msrA [H]

Identifier: 226224463

GI number: 226224463

Start: 1921022

End: 1921555

Strand: Reverse

Name: msrA [H]

Synonym: Lm4b_01876

Alternate gene names: 226224463

Gene position: 1921555-1921022 (Counterclockwise)

Preceding gene: 226224464

Following gene: 226224462

Centisome position: 65.97

GC content: 39.51

Gene sequence:

>534_bases
ATGACAAAAGAATCACTTGAAAAAGCAACATTTGCTGGAGGATGCTTTTGGTGTATGGTAAAACCTTTTGACACGCAACC
AGGAATTGAAAAAGTTATTTCAGGTTATACGGGTGGTCATACGGTTAATCCAACCTATAAAGAAGTTTGCAGCGGGACAA
CAGGACATACAGAAGCAATCCAAATCACATTTGATCCGGCAGTTTTTCCATATGAGAAATTAGTCGAAGTATATTGGCAA
CAAACTGATCCGACTGATGCGGCAGGCCAATTTGTTGACCGTGGTGATTCGTATCGACCAGTTATTTTTTACCACAATGA
AGAGCAAAAAGAAATTGCTGAAAAATCAAAAGCAGCCCTTGATGCGAGTGGTAGATTTAAAAAGCCGATTGTCACAGAAA
TTGCCAAAGCAGAAACATTTTATCCTGCTGAAGAATATCATCAAGATTTTTACAAGAAAGAAAAAGCGCACTATGAGGGA
TATCAAGTTGCTTCAGGTCGTGCTGCATTCATAGATGCCAACTGGAAAGGGTGA

Upstream 100 bases:

>100_bases
GTGCTGATACACTAAATTTGAAGAAAGATGACATTTCGTTTACACTTTTAGTACCAGTTAAGTAATTTGGCTGGCTGAAT
CCTAGTTAGGGGGCATTTTT

Downstream 100 bases:

>100_bases
AATCAAATGGATGAAAGTAAAAAGAACGAGCGCCTTCAACAACTAACAGATATACAATATAATGTGACCCAAAAAGCGGG
TACCGAACGCCCATTTCAAA

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 177; Mature: 176

Protein sequence:

>177_residues
MTKESLEKATFAGGCFWCMVKPFDTQPGIEKVISGYTGGHTVNPTYKEVCSGTTGHTEAIQITFDPAVFPYEKLVEVYWQ
QTDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAALDASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEG
YQVASGRAAFIDANWKG

Sequences:

>Translated_177_residues
MTKESLEKATFAGGCFWCMVKPFDTQPGIEKVISGYTGGHTVNPTYKEVCSGTTGHTEAIQITFDPAVFPYEKLVEVYWQ
QTDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAALDASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEG
YQVASGRAAFIDANWKG
>Mature_176_residues
TKESLEKATFAGGCFWCMVKPFDTQPGIEKVISGYTGGHTVNPTYKEVCSGTTGHTEAIQITFDPAVFPYEKLVEVYWQQ
TDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAALDASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEGY
QVASGRAAFIDANWKG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=159, Percent_Identity=38.3647798742138, Blast_Score=114, Evalue=6e-26,
Organism=Homo sapiens, GI208609995, Length=159, Percent_Identity=38.3647798742138, Blast_Score=113, Evalue=7e-26,
Organism=Homo sapiens, GI208609993, Length=115, Percent_Identity=33.9130434782609, Blast_Score=71, Evalue=4e-13,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=43.8709677419355, Blast_Score=129, Evalue=9e-32,
Organism=Caenorhabditis elegans, GI17533973, Length=151, Percent_Identity=36.4238410596026, Blast_Score=87, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6320881, Length=158, Percent_Identity=29.1139240506329, Blast_Score=72, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=35.9154929577465, Blast_Score=95, Evalue=2e-20,
Organism=Drosophila melanogaster, GI45553131, Length=137, Percent_Identity=35.036496350365, Blast_Score=90, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24664631, Length=142, Percent_Identity=35.2112676056338, Blast_Score=89, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 19947; Mature: 19816

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKESLEKATFAGGCFWCMVKPFDTQPGIEKVISGYTGGHTVNPTYKEVCSGTTGHTEAI
CCHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEE
QITFDPAVFPYEKLVEVYWQQTDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAAL
EEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHC
DASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEGYQVASGRAAFIDANWKG
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCC
>Mature Secondary Structure 
TKESLEKATFAGGCFWCMVKPFDTQPGIEKVISGYTGGHTVNPTYKEVCSGTTGHTEAI
CHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEE
QITFDPAVFPYEKLVEVYWQQTDPTDAAGQFVDRGDSYRPVIFYHNEEQKEIAEKSKAAL
EEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHHC
DASGRFKKPIVTEIAKAETFYPAEEYHQDFYKKEKAHYEGYQVASGRAAFIDANWKG
CCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]