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The map label for this gene is purL

Identifier: 226224373

GI number: 226224373

Start: 1829742

End: 1830425

Strand: Reverse

Name: purL

Synonym: Lm4b_01784

Alternate gene names: 226224373

Gene position: 1830425-1829742 (Counterclockwise)

Preceding gene: 226224374

Following gene: 226224372

Centisome position: 62.84

GC content: 41.37

Gene sequence:

>684_bases
ATGAAATTTGCTGTCATTCAGTTCCCAGGTTCTAATTGTGATCTTGATATGCTACATGCGATTCGCGATTCTCTTGGCGA
GGAGGCGGAATATGTATGGCATGCGGAAACAAGTCTTGCAGGTTTTGATGCGGTTTTACTTCCAGGTGGATTTTCTTACG
GAGATTACTTGCGAACTGGTGCGATTGCAAAATTTTCAAGTATTATGCCAGAAGTTTTGCGCTTTGCTGAAATGGGAAAA
CCAGTGCTTGGTGTGTGTAACGGATTCCAAATTTTAACTGAAATTGGTTTACTGCCAGGTGCTTTAATTAGAAACAATAA
TTTGCATTTTATTTGTAAGACGGTGCCGCTTCGTGTGGCGAATGCAAGTACGATGTTTACCGGGCTTTATAAAGAAGGCG
AAATTATCCAAGTTCCAGTTGCTCACGGGGAAGGTAATTATTACTGTGACGATGAAACACTTTTAAAATTAAAAGATAAT
AACCAAATTGTGTTTACATATGATAGCGTGAATCCGAATGGTAGCCGTGCGGATATTGCGGGGATCGTAAATGAGCGCGG
TAATGTGCTTGGAATGATGCCACACCCAGAACGCGCGGTAGAAGAAATTATTGGCGGTACAGATGGTTTAAGACTTTTCG
AGTCCGTTGTAAAAGCTTGGAAGGAGGAACAAGTAAATGCCTAA

Upstream 100 bases:

>100_bases
AGATCGAGATATTCATGAAGTATTGAATGAAATGTGCGACAAACTGCTAACAAATCCGGTGATGGAAGATTACCGATATG
AAATAGAGGAGGCTTAAACG

Downstream 100 bases:

>100_bases
CATGGAGCCAACGACAAAGGAAATTAAAGAACAAAAGATTTATCAAGAAATGGGCTTAACTGATAGTGAATATGAGCTTG
TTTGTTCGATTCTTGGACGC

Product: phosphoribosylformylglycinamidine synthase I

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase I; FGAM synthase I [H]

Number of amino acids: Translated: 227; Mature: 227

Protein sequence:

>227_residues
MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTGAIAKFSSIMPEVLRFAEMGK
PVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVANASTMFTGLYKEGEIIQVPVAHGEGNYYCDDETLLKLKDN
NQIVFTYDSVNPNGSRADIAGIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA

Sequences:

>Translated_227_residues
MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTGAIAKFSSIMPEVLRFAEMGK
PVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVANASTMFTGLYKEGEIIQVPVAHGEGNYYCDDETLLKLKDN
NQIVFTYDSVNPNGSRADIAGIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA
>Mature_227_residues
MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTGAIAKFSSIMPEVLRFAEMGK
PVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVANASTMFTGLYKEGEIIQVPVAHGEGNYYCDDETLLKLKDN
NQIVFTYDSVNPNGSRADIAGIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA

Specific function: Unknown

COG id: COG0047

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, glutamine amidotransferase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=251, Percent_Identity=28.6852589641434, Blast_Score=77, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6321498, Length=182, Percent_Identity=32.4175824175824, Blast_Score=63, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24582111, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24582109, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI17137292, Length=230, Percent_Identity=26.9565217391304, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR010075 [H]

Pfam domain/function: PF00117 GATase [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 24871; Mature: 24871

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00442 GATASE_TYPE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTG
CCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHH
AIAKFSSIMPEVLRFAEMGKPVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVA
HHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCCCCEEECCCEEEEEEECCEEEC
NASTMFTGLYKEGEIIQVPVAHGEGNYYCDDETLLKLKDNNQIVFTYDSVNPNGSRADIA
CCHHHEEEECCCCCEEEEEEEECCCCEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHH
GIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA
HHHCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKFAVIQFPGSNCDLDMLHAIRDSLGEEAEYVWHAETSLAGFDAVLLPGGFSYGDYLRTG
CCEEEEEECCCCCCHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEECCCCCHHHHHHHH
AIAKFSSIMPEVLRFAEMGKPVLGVCNGFQILTEIGLLPGALIRNNNLHFICKTVPLRVA
HHHHHHHHHHHHHHHHHHCCCHHHHHCHHHHHHHHHCCCCCEEECCCEEEEEEECCEEEC
NASTMFTGLYKEGEIIQVPVAHGEGNYYCDDETLLKLKDNNQIVFTYDSVNPNGSRADIA
CCHHHEEEECCCCCEEEEEEEECCCCEEECCCEEEEEECCCEEEEEECCCCCCCCCHHHH
GIVNERGNVLGMMPHPERAVEEIIGGTDGLRLFESVVKAWKEEQVNA
HHHCCCCCEEEECCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]