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The map label for this gene is purQ

Identifier: 226224372

GI number: 226224372

Start: 1827530

End: 1829749

Strand: Reverse

Name: purQ

Synonym: Lm4b_01783

Alternate gene names: 226224372

Gene position: 1829749-1827530 (Counterclockwise)

Preceding gene: 226224373

Following gene: 226224371

Centisome position: 62.82

GC content: 42.7

Gene sequence:

>2220_bases
ATGCCTAACATGGAGCCAACGACAAAGGAAATTAAAGAACAAAAGATTTATCAAGAAATGGGCTTAACTGATAGTGAATA
TGAGCTTGTTTGTTCGATTCTTGGACGCGAGCCTAATTATACAGAAACTGGGCTTTTCTCTGTTATGTGGTCGGAACATT
GTAGCTATAAAAATTCTAAACCAGTACTTCGGAAATTTCCTACAGAAGGCAAACAAGTATTACAAGGACCTGGTGAAGGC
GCTGGGATTGTCGATATTGGCGATGGTTTAGGTGTTGCTTTTAAAGTGGAGAGTCATAATCATCCATCCTACGTGGAGCC
GTATCAAGGGGCTGCGACTGGGGTCGGCGGGATTATCCGTGATGTGTTCTCGATGGGAGCTAGACCGATTGCAATGCTTA
ACTCGCTTCGTTTTGGTGAGTTAGATACACCCCATGCGAAATACTTAGTTAGTGAAGTCGTTGCGGGAATCGCAGGATAC
GGTAACTCCATTGGGATTCCAACGGTTGGTGGCGAAATCCAATTTGATCCTTGTTATACAAAAAATCCGCTAGTTAATGC
AATGTGTGTTGGTTTAATCGAGGCGAAAGATATTCAAAAAGGGCAAGCAAAAGGAATTGGTAATCCGGTGATGTATGTTG
GCGCTAAAACTGGTCGTGACGGGATTCATGGTGCTACTTTTGCTTCTGTAGAGTTTAGTGAAGAAGGCGAACAACAACGC
TCTGCTGTACAGGTTGGCGATCCTTTTATGGAGAAATTGTTGCTTGAAGCTTGTTTAGATGTGATTCGTGATCATTCGGA
TATTTTAGTGGGAATTCAAGATATGGGGGCTGCAGGTCTCGTTAGTTCAAGTTCTGAAATGGCCTCAAAAGCGGGCGCTG
GGCTAGAATTAATTATGGATGATGTGCCGCAACGAGAACTAAATATGACGCCTTATGAAATGTTGCTTTCTGAATCGCAA
GAACGGATGCTTCTATGTGTGAAAAAAGGGCATGTGGAAGAAATCCAAGCGTTATTTGAACGTTATGGTTTAGAGGCTGT
TGTGATTGGTCAAGTAACAGATGATAAAATGTACAAAATTATTCATCATGGTGAAGTAGTTGCGAATGTTCCTGTAGATG
CGCTTGCAGAAGATGCGCCAGTTTATCATAAACCTTCCAAAGAGCCAGCTCGTTATCAAGCTTTCCAAGAAGAGGAATCG
TTTGTGCCAGTTATGGAAGATGTGGTCGGTGTTTGGAAGGAACTGCTTGCTCAGCCAACGATTGCTAGTAAGCGCCATAT
TTATGAGCAATATGATTATCAAGTTCGGACGGATACAGCTGTTGTACCTGGTTCAGATGCGGCGATTGTTCGTGTGCGTG
GGACCGAGAAGGCAATTGCCATGACAACTGATTGTAACTCACGCTATTTGTATCTTGATCCAGAAGTAGGCGGAGCGATA
GCGGTTGCGGAAGCGGCGCGCAATATCGTTTGTTCTGGCGGGAAACCACTAGCGATTACAGATGGACTGAACTTTGGAAA
TCCTGAAAAACCAGAAATTTTTTGGGAAATTGAAAAAGCGGCTGATGGTATTAGTGCGGCTTGTTTAGAACTTGATACGC
CTGTTATCTCTGGTAATGTATCGCTTTATAATGAAACAGATGGTACCGGAATTTATCCAACGCCAGTCATTGGAATGGTT
GGTTTAGTAGAAGATTTGGCACATATTACGACACAAGATTTTAAAAATAGTGGCGATGTGATTTTCTTAATTGGTGAAAC
AAAAGCTGAATATAGTGGTTCGGAATTGCAAAAATTGCAACAAGGGAAAATTAGCGGACGTGCGCCGGAATTAGATTTAA
CGACAGAGAAAAAATACCAACAATTACTTCTAACGGCGATTCAGGAAGGTCTAGTTGCTTCTAGTCACGATTTGGCAGAA
GGTGGATTTGGTGTTGCCCTTGCGGAAGCGACTTTTAAAGCAGGGCTTGGTGCGGATGTAGAAGTACCGTTTGAGTTGAA
TCAACTATTCAGTGAATCGCAATCACGTTTCTTAGTATCGGTAAAACCGGAAAACGAAGCAGCTTTTGCGCAATTAATGG
AACTGGAAAAAGTATACCGCCTTGGTGTAGTAACCGAGGATGATACGATTCGTGTGAAACATAAGGAAGATCAAGTTACA
GCGAAAACAACGGAATTACGATCCATTTGGGAAGGGGCTATTCCATGCTTGCTGAAGTAA

Upstream 100 bases:

>100_bases
ATGCCACACCCAGAACGCGCGGTAGAAGAAATTATTGGCGGTACAGATGGTTTAAGACTTTTCGAGTCCGTTGTAAAAGC
TTGGAAGGAGGAACAAGTAA

Downstream 100 bases:

>100_bases
AAGGACTTAACGAAGAATGTGGTATTTTTGGTATTTGGGATCATCCTAATGCAGCGGAAATCACCTATTATGGGTTGCAT
AGTTTACAACATCGCGGTCA

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II [H]

Number of amino acids: Translated: 739; Mature: 738

Protein sequence:

>739_residues
MPNMEPTTKEIKEQKIYQEMGLTDSEYELVCSILGREPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTEGKQVLQGPGEG
AGIVDIGDGLGVAFKVESHNHPSYVEPYQGAATGVGGIIRDVFSMGARPIAMLNSLRFGELDTPHAKYLVSEVVAGIAGY
GNSIGIPTVGGEIQFDPCYTKNPLVNAMCVGLIEAKDIQKGQAKGIGNPVMYVGAKTGRDGIHGATFASVEFSEEGEQQR
SAVQVGDPFMEKLLLEACLDVIRDHSDILVGIQDMGAAGLVSSSSEMASKAGAGLELIMDDVPQRELNMTPYEMLLSESQ
ERMLLCVKKGHVEEIQALFERYGLEAVVIGQVTDDKMYKIIHHGEVVANVPVDALAEDAPVYHKPSKEPARYQAFQEEES
FVPVMEDVVGVWKELLAQPTIASKRHIYEQYDYQVRTDTAVVPGSDAAIVRVRGTEKAIAMTTDCNSRYLYLDPEVGGAI
AVAEAARNIVCSGGKPLAITDGLNFGNPEKPEIFWEIEKAADGISAACLELDTPVISGNVSLYNETDGTGIYPTPVIGMV
GLVEDLAHITTQDFKNSGDVIFLIGETKAEYSGSELQKLQQGKISGRAPELDLTTEKKYQQLLLTAIQEGLVASSHDLAE
GGFGVALAEATFKAGLGADVEVPFELNQLFSESQSRFLVSVKPENEAAFAQLMELEKVYRLGVVTEDDTIRVKHKEDQVT
AKTTELRSIWEGAIPCLLK

Sequences:

>Translated_739_residues
MPNMEPTTKEIKEQKIYQEMGLTDSEYELVCSILGREPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTEGKQVLQGPGEG
AGIVDIGDGLGVAFKVESHNHPSYVEPYQGAATGVGGIIRDVFSMGARPIAMLNSLRFGELDTPHAKYLVSEVVAGIAGY
GNSIGIPTVGGEIQFDPCYTKNPLVNAMCVGLIEAKDIQKGQAKGIGNPVMYVGAKTGRDGIHGATFASVEFSEEGEQQR
SAVQVGDPFMEKLLLEACLDVIRDHSDILVGIQDMGAAGLVSSSSEMASKAGAGLELIMDDVPQRELNMTPYEMLLSESQ
ERMLLCVKKGHVEEIQALFERYGLEAVVIGQVTDDKMYKIIHHGEVVANVPVDALAEDAPVYHKPSKEPARYQAFQEEES
FVPVMEDVVGVWKELLAQPTIASKRHIYEQYDYQVRTDTAVVPGSDAAIVRVRGTEKAIAMTTDCNSRYLYLDPEVGGAI
AVAEAARNIVCSGGKPLAITDGLNFGNPEKPEIFWEIEKAADGISAACLELDTPVISGNVSLYNETDGTGIYPTPVIGMV
GLVEDLAHITTQDFKNSGDVIFLIGETKAEYSGSELQKLQQGKISGRAPELDLTTEKKYQQLLLTAIQEGLVASSHDLAE
GGFGVALAEATFKAGLGADVEVPFELNQLFSESQSRFLVSVKPENEAAFAQLMELEKVYRLGVVTEDDTIRVKHKEDQVT
AKTTELRSIWEGAIPCLLK
>Mature_738_residues
PNMEPTTKEIKEQKIYQEMGLTDSEYELVCSILGREPNYTETGLFSVMWSEHCSYKNSKPVLRKFPTEGKQVLQGPGEGA
GIVDIGDGLGVAFKVESHNHPSYVEPYQGAATGVGGIIRDVFSMGARPIAMLNSLRFGELDTPHAKYLVSEVVAGIAGYG
NSIGIPTVGGEIQFDPCYTKNPLVNAMCVGLIEAKDIQKGQAKGIGNPVMYVGAKTGRDGIHGATFASVEFSEEGEQQRS
AVQVGDPFMEKLLLEACLDVIRDHSDILVGIQDMGAAGLVSSSSEMASKAGAGLELIMDDVPQRELNMTPYEMLLSESQE
RMLLCVKKGHVEEIQALFERYGLEAVVIGQVTDDKMYKIIHHGEVVANVPVDALAEDAPVYHKPSKEPARYQAFQEEESF
VPVMEDVVGVWKELLAQPTIASKRHIYEQYDYQVRTDTAVVPGSDAAIVRVRGTEKAIAMTTDCNSRYLYLDPEVGGAIA
VAEAARNIVCSGGKPLAITDGLNFGNPEKPEIFWEIEKAADGISAACLELDTPVISGNVSLYNETDGTGIYPTPVIGMVG
LVEDLAHITTQDFKNSGDVIFLIGETKAEYSGSELQKLQQGKISGRAPELDLTTEKKYQQLLLTAIQEGLVASSHDLAEG
GFGVALAEATFKAGLGADVEVPFELNQLFSESQSRFLVSVKPENEAAFAQLMELEKVYRLGVVTEDDTIRVKHKEDQVTA
KTTELRSIWEGAIPCLLK

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family [H]

Homologues:

Organism=Escherichia coli, GI48994899, Length=799, Percent_Identity=24.4055068836045, Blast_Score=124, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17553022, Length=687, Percent_Identity=22.2707423580786, Blast_Score=96, Evalue=6e-20,
Organism=Saccharomyces cerevisiae, GI6321498, Length=678, Percent_Identity=23.3038348082596, Blast_Score=94, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =6.3.5.3 [H]

Molecular weight: Translated: 80221; Mature: 80090

Theoretical pI: Translated: 4.44; Mature: 4.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNMEPTTKEIKEQKIYQEMGLTDSEYELVCSILGREPNYTETGLFSVMWSEHCSYKNSK
CCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PVLRKFPTEGKQVLQGPGEGAGIVDIGDGLGVAFKVESHNHPSYVEPYQGAATGVGGIIR
CHHHHCCCCCHHHHCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
DVFSMGARPIAMLNSLRFGELDTPHAKYLVSEVVAGIAGYGNSIGIPTVGGEIQFDPCYT
HHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
KNPLVNAMCVGLIEAKDIQKGQAKGIGNPVMYVGAKTGRDGIHGATFASVEFSEEGEQQR
CCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHH
SAVQVGDPFMEKLLLEACLDVIRDHSDILVGIQDMGAAGLVSSSSEMASKAGAGLELIMD
HHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCHHHHHHCCCCCEEHHH
DVPQRELNMTPYEMLLSESQERMLLCVKKGHVEEIQALFERYGLEAVVIGQVTDDKMYKI
CCCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHH
IHHGEVVANVPVDALAEDAPVYHKPSKEPARYQAFQEEESFVPVMEDVVGVWKELLAQPT
HHCCCEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
IASKRHIYEQYDYQVRTDTAVVPGSDAAIVRVRGTEKAIAMTTDCNSRYLYLDPEVGGAI
HHHHHHHHHHCCCEEECCEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEE
AVAEAARNIVCSGGKPLAITDGLNFGNPEKPEIFWEIEKAADGISAACLELDTPVISGNV
HHHHHHHHEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHCCCCCEEECCE
SLYNETDGTGIYPTPVIGMVGLVEDLAHITTQDFKNSGDVIFLIGETKAEYSGSELQKLQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
QGKISGRAPELDLTTEKKYQQLLLTAIQEGLVASSHDLAEGGFGVALAEATFKAGLGADV
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCE
EVPFELNQLFSESQSRFLVSVKPENEAAFAQLMELEKVYRLGVVTEDDTIRVKHKEDQVT
ECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCEECCCCEEEEEECCCCHH
AKTTELRSIWEGAIPCLLK
HHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PNMEPTTKEIKEQKIYQEMGLTDSEYELVCSILGREPNYTETGLFSVMWSEHCSYKNSK
CCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCC
PVLRKFPTEGKQVLQGPGEGAGIVDIGDGLGVAFKVESHNHPSYVEPYQGAATGVGGIIR
CHHHHCCCCCHHHHCCCCCCCCEEECCCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHH
DVFSMGARPIAMLNSLRFGELDTPHAKYLVSEVVAGIAGYGNSIGIPTVGGEIQFDPCYT
HHHHCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCC
KNPLVNAMCVGLIEAKDIQKGQAKGIGNPVMYVGAKTGRDGIHGATFASVEFSEEGEQQR
CCCHHHHHHHHHHHHHHCCCCHHCCCCCCEEEEECCCCCCCCCCCEEEEEEECHHHHHHH
SAVQVGDPFMEKLLLEACLDVIRDHSDILVGIQDMGAAGLVSSSSEMASKAGAGLELIMD
HHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEHHHCCCCCCCCCCHHHHHHCCCCCEEHHH
DVPQRELNMTPYEMLLSESQERMLLCVKKGHVEEIQALFERYGLEAVVIGQVTDDKMYKI
CCCCCCCCCCHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCCHHHHH
IHHGEVVANVPVDALAEDAPVYHKPSKEPARYQAFQEEESFVPVMEDVVGVWKELLAQPT
HHCCCEEECCCHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCC
IASKRHIYEQYDYQVRTDTAVVPGSDAAIVRVRGTEKAIAMTTDCNSRYLYLDPEVGGAI
HHHHHHHHHHCCCEEECCEEEECCCCEEEEEEECCCCEEEEEECCCCEEEEECCCCCCEE
AVAEAARNIVCSGGKPLAITDGLNFGNPEKPEIFWEIEKAADGISAACLELDTPVISGNV
HHHHHHHHEEECCCCCEEEECCCCCCCCCCCCEEEEEHHHCCCHHHHHHCCCCCEEECCE
SLYNETDGTGIYPTPVIGMVGLVEDLAHITTQDFKNSGDVIFLIGETKAEYSGSELQKLQ
EEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCHHHHHHH
QGKISGRAPELDLTTEKKYQQLLLTAIQEGLVASSHDLAEGGFGVALAEATFKAGLGADV
HCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEEHHHHHHCCCCCCE
EVPFELNQLFSESQSRFLVSVKPENEAAFAQLMELEKVYRLGVVTEDDTIRVKHKEDQVT
ECCHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCEECCCCEEEEEECCCCHH
AKTTELRSIWEGAIPCLLK
HHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]