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The map label for this gene is bceR [H]

Identifier: 226224348

GI number: 226224348

Start: 1800832

End: 1801509

Strand: Reverse

Name: bceR [H]

Synonym: Lm4b_01759

Alternate gene names: 226224348

Gene position: 1801509-1800832 (Counterclockwise)

Preceding gene: 226224349

Following gene: 226224347

Centisome position: 61.85

GC content: 32.15

Gene sequence:

>678_bases
ATGGTAAAGGTATATATCGTAGAAGATGATGAAGTAATTCGTGATACAATCCGAAAACATTTAAGTAAATGGGGATTTGA
GATTGGTGTAGTAGAGGATTTTAACAATATTTTACAAGAGTTTTTAGCTTTCGAACCTCAATTAGTTATTTTAGATGTTA
ATCTTCCTTTCTTTGATGGCTTTTATTGGTGTAATCAAATTCGAGAAGTTTCGAATGTACCCATTATCTTTTTATCATCA
CGTAATTCGCGAATGGACCAAATAATGGGCATGAATATGGGTGCAGACTATTATATTGAAAAACCAGTTGATCTGGATGT
TTTAATGGCGCGGATAAATGCTCTATTAAGGCGGACATATTCTTACGCAGATTTAGAAGAAGCCAATGTGATGGAGCATA
ATAATGTTTTCCTACACATTGATACGAACACACTTACACATTTAGAAGATAAAATTGAGCTAACGAAAAATGAATTTTTG
ATTTTATATGAATTAATGAAACAAAAAGGTAGCATTGTAAGTCGTGATGAAATTATGCGCGCACTTTGGGAAGATGAAAG
TTTTGTTGATGATAATACATTGACAGTTAATGTTGTTCGTATTCGTAAAAAACTAGCAGAAATTGGTTTGAGCGAATTTA
TCAAAACGAAAAAAGGCCAAGGATATATGATTGAATGA

Upstream 100 bases:

>100_bases
ATTCTTTTACCAAAATTGTGATGGCCAATAAAAAGTAATTGGCTTTTGTGGTTATTTCAGCTAAAATGAGAAGAGAGTTC
CACCGAGGGAGGCACTAGAA

Downstream 100 bases:

>100_bases
CGAAAAAACAGGAAGATAGCGCTAAAAAACGCGAACTTCCTGTTTTTCGTAAATGGAGGAGGAGTCTAAATGAAAATTTT
AGTATTCGGTGGTACTCGTT

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MVKVYIVEDDEVIRDTIRKHLSKWGFEIGVVEDFNNILQEFLAFEPQLVILDVNLPFFDGFYWCNQIREVSNVPIIFLSS
RNSRMDQIMGMNMGADYYIEKPVDLDVLMARINALLRRTYSYADLEEANVMEHNNVFLHIDTNTLTHLEDKIELTKNEFL
ILYELMKQKGSIVSRDEIMRALWEDESFVDDNTLTVNVVRIRKKLAEIGLSEFIKTKKGQGYMIE

Sequences:

>Translated_225_residues
MVKVYIVEDDEVIRDTIRKHLSKWGFEIGVVEDFNNILQEFLAFEPQLVILDVNLPFFDGFYWCNQIREVSNVPIIFLSS
RNSRMDQIMGMNMGADYYIEKPVDLDVLMARINALLRRTYSYADLEEANVMEHNNVFLHIDTNTLTHLEDKIELTKNEFL
ILYELMKQKGSIVSRDEIMRALWEDESFVDDNTLTVNVVRIRKKLAEIGLSEFIKTKKGQGYMIE
>Mature_225_residues
MVKVYIVEDDEVIRDTIRKHLSKWGFEIGVVEDFNNILQEFLAFEPQLVILDVNLPFFDGFYWCNQIREVSNVPIIFLSS
RNSRMDQIMGMNMGADYYIEKPVDLDVLMARINALLRRTYSYADLEEANVMEHNNVFLHIDTNTLTHLEDKIELTKNEFL
ILYELMKQKGSIVSRDEIMRALWEDESFVDDNTLTVNVVRIRKKLAEIGLSEFIKTKKGQGYMIE

Specific function: Member of the two-component regulatory system BceS/BceR involved in the regulation of bacitracin resistance. When activated by BceS, binds to the upstream region of the bceAB promoter and up-regulates the expression of these two genes [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=32.1428571428571, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI1786599, Length=223, Percent_Identity=29.1479820627803, Blast_Score=112, Evalue=1e-26,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=31.6964285714286, Blast_Score=108, Evalue=2e-25,
Organism=Escherichia coli, GI87082012, Length=221, Percent_Identity=28.9592760180996, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=29.2035398230088, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1790863, Length=225, Percent_Identity=31.1111111111111, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1787375, Length=225, Percent_Identity=28.8888888888889, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1786911, Length=223, Percent_Identity=28.6995515695067, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=25.8928571428571, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1787229, Length=229, Percent_Identity=29.2576419213974, Blast_Score=100, Evalue=9e-23,
Organism=Escherichia coli, GI1790552, Length=224, Percent_Identity=29.9107142857143, Blast_Score=94, Evalue=6e-21,
Organism=Escherichia coli, GI1786784, Length=225, Percent_Identity=27.1111111111111, Blast_Score=91, Evalue=5e-20,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=27.3913043478261, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=28.0172413793103, Blast_Score=82, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26415; Mature: 26415

Theoretical pI: Translated: 4.53; Mature: 4.53

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKVYIVEDDEVIRDTIRKHLSKWGFEIGVVEDFNNILQEFLAFEPQLVILDVNLPFFDG
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
FYWCNQIREVSNVPIIFLSSRNSRMDQIMGMNMGADYYIEKPVDLDVLMARINALLRRTY
HHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHC
SYADLEEANVMEHNNVFLHIDTNTLTHLEDKIELTKNEFLILYELMKQKGSIVSRDEIMR
CCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHH
ALWEDESFVDDNTLTVNVVRIRKKLAEIGLSEFIKTKKGQGYMIE
HHHCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHCCCCCEECC
>Mature Secondary Structure
MVKVYIVEDDEVIRDTIRKHLSKWGFEIGVVEDFNNILQEFLAFEPQLVILDVNLPFFDG
CEEEEEECCCHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
FYWCNQIREVSNVPIIFLSSRNSRMDQIMGMNMGADYYIEKPVDLDVLMARINALLRRTY
HHHHHHHHHHCCCCEEEEECCCCHHHHHHCCCCCCCEEEECCCCHHHHHHHHHHHHHHHC
SYADLEEANVMEHNNVFLHIDTNTLTHLEDKIELTKNEFLILYELMKQKGSIVSRDEIMR
CCCCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHH
ALWEDESFVDDNTLTVNVVRIRKKLAEIGLSEFIKTKKGQGYMIE
HHHCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]