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The map label for this gene is uvrC

Identifier: 226223834

GI number: 226223834

Start: 1240595

End: 1242406

Strand: Direct

Name: uvrC

Synonym: Lm4b_01239

Alternate gene names: 226223834

Gene position: 1240595-1242406 (Clockwise)

Preceding gene: 226223833

Following gene: 226223835

Centisome position: 42.59

GC content: 39.29

Gene sequence:

>1812_bases
ATGTCTTCTGAACATATCCAAAATAAACTAGCGCTTCTGCCGGACCAACCTGGTTGTTATTTGATGAAAGATAGACAAGG
AACCATTATTTATGTTGGGAAAGCAAAAATTTTAAAAAATCGTGTTCGATCCTATTTTTCAGGAACACACGATAGTAAAA
CGCAACGCTTAGTTCAAGAAATTGTGGACTTTGAATATATCGTAACATCATCCAACGTAGAAGCCTTGCTACTAGAAATC
AATTTGATCAAAAAACATGATCCTCGTTTTAATATTCGCCTAAAAGATGATAAAACTTATCCGTTTATTAAAATCACGAA
CGAACGACATCCACGCCTAATTATTACCCGTCAAGTAAAAAAAGACAAAGGGAAATATTTTGGTCCATATCCAAATGTGT
ATGCTGCTAATGAAGTAAAACGTATTTTAGATCGACTGTATCCATTACGTAAATGCAGTACGCTACCAAATAAAGTGTGT
TTGTACTATCACCTCGGACAATGCCTTGCCCCGTGTGTATTTGACGTGGAAGCAAGTAAGTATAAAGAAATGCAAGACGA
GATAGTCGCATTCCTAAATGGCGGCTATAAAACTGTCAAAAATGATTTAATGAAGAAAATGCAAGAAGCAGCTGAAAATA
TGGAATTCGAAAAAGCGGGTGAATTCCGCGACCAAATCAACGCAATCGAAACAACAATGGAAAAACAAAAAATGACGATG
AACGATTTCGTTGACCGTGATGTCTTTGGTTATGCCATTGATAAAGGCTGGATGTGCGTCCAAGTATTCTTCATTCGTCA
AGGGAAACTGATTGAGCGCGATGTCTCCCAGTTTCCATTTTATAATGATGCAGATGAAGATTTCCTCACATTTATTGGTC
AATTTTACCAAAAAGCCAATCATATTCCGCCTAAAGAAATTTATTTACCAGATGATGTCGATAGCGAAGCCGTTCAAGCG
GTCGTTCCTGACACAAAAATCATCGTACCACAACGCGGAAATAAGAAAGATCTCGTAAAACTTGCATACAAAAATGCGAA
AATTGCCTTAAACGAAAAATTTATGCTACTTGAACGTAATGAAGAACGCACAGTCGGAGCAGTTGAACGGCTTGGAGAAG
CAATGGGAATCCCAACACCGTCACGCGTCGAAGCTTTCGATAACTCGAATATTCACGGTACAGACCCAGTTTCCGCGATG
GTCACATTCCTCGATGGCAAACCAAGTAAAAATGATTACCGTAAATACAAAATCAAAACCGTAGAAGGACCTGATGATTA
CGCAACAATGCGCGAAGTTATTCGACGTCGTTACTGGAGAGTACTTAAAGAAGAACTACCAATGCCGGATTTAATCTTAA
TTGATGGTGGTAAAGGGCAAATTGATAGTGCCAAAGATGTCCTAACGAATGAGCTAGGCTTAGATATTCCAGTAGCAGGA
CTTGCAAAAGACGACAAACACCGTACTAGCCAACTATTATTCGGTGACCCACTTGAAATAGTCCCACTCGAACGAAACAG
CCAAGAATTCTACCTATTACAACGAATGCAAGATGAAGTCCACCGTTTCGCTATTACATTCCACCGCCAACTACGCAGCA
AAACAGGCTTCCAATCCATTCTTGACGGCATCCCAGGAGTAGGACCCGGTCGCAAGAAAAAATTACTTAAACACTTCGGC
TCCATGAAAAAATTAAAAGAAGCATCGGTAGAAGAAATTAAAGAAGCCGGTGTCCCTTTGAATGTTGCAGAAGAAGTGCA
TAAACACATCACAGCATTCAATGAAAAAGCAAAAAATACCGAGCAAAAATGA

Upstream 100 bases:

>100_bases
TGAAGTCATCAACAAATACGTTTAAAATTATGCTAAAATGAAAGAAGCTTAGAACAAACATTCTAAGCTTCTTTTTAAAT
GTGTAACTGGAGTTGATAAA

Downstream 100 bases:

>100_bases
TTTTAAACACGATTTTAAACGCCAATAACTTTGATGTTATTGGCGTTTTATTGCATAAAAATTGTTACTAACATGTCAGA
TTAAATAGCTTTTACATATA

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C [H]

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEI
NLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVC
LYYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTM
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQA
VVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAM
VTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAG
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFG
SMKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNTEQK

Sequences:

>Translated_603_residues
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEI
NLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVC
LYYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTM
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQA
VVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAM
VTFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAG
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFG
SMKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNTEQK
>Mature_602_residues
SSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQEIVDFEYIVTSSNVEALLLEIN
LIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVKKDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCL
YYHLGQCLAPCVFDVEASKYKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTMN
DFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKANHIPPKEIYLPDDVDSEAVQAV
VPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERNEERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMV
TFLDGKPSKNDYRKYKIKTVEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAGL
AKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSILDGIPGVGPGRKKKLLKHFGS
MKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNTEQK

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision [H]

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI87081999, Length=603, Percent_Identity=38.6401326699834, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305 [H]

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N [H]

EC number: NA

Molecular weight: Translated: 69375; Mature: 69244

Theoretical pI: Translated: 9.01; Mature: 9.01

Prosite motif: PS50151 UVR ; PS50164 UVRC_1 ; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQE
CCCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
IVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVK
HHCCEEEEECCCCEEEEEEEEHHHCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHH
KDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASK
HCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHH
YKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKAN
HHHHCCCHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
HIPPKEIYLPDDVDSEAVQAVVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERN
CCCCCEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEECCEEEEEECC
EERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKT
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEE
VEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSI
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LDGIPGVGPGRKKKLLKHFGSMKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EQK
CCC
>Mature Secondary Structure 
SSEHIQNKLALLPDQPGCYLMKDRQGTIIYVGKAKILKNRVRSYFSGTHDSKTQRLVQE
CCHHHHHHHHCCCCCCCEEEEECCCCCEEEECCHHHHHHHHHHHHCCCCCHHHHHHHHH
IVDFEYIVTSSNVEALLLEINLIKKHDPRFNIRLKDDKTYPFIKITNERHPRLIITRQVK
HHCCEEEEECCCCEEEEEEEEHHHCCCCCEEEEEECCCCCCEEEECCCCCCEEEEEEHHH
KDKGKYFGPYPNVYAANEVKRILDRLYPLRKCSTLPNKVCLYYHLGQCLAPCVFDVEASK
HCCCCCCCCCCCCEEHHHHHHHHHHHCCHHHHCCCCCCEEHHHHHHHHHHHHHCCCCHHH
YKEMQDEIVAFLNGGYKTVKNDLMKKMQEAAENMEFEKAGEFRDQINAIETTMEKQKMTM
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
NDFVDRDVFGYAIDKGWMCVQVFFIRQGKLIERDVSQFPFYNDADEDFLTFIGQFYQKAN
HHHHCCCHHHHHHCCCCEEEEEEHHHCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHC
HIPPKEIYLPDDVDSEAVQAVVPDTKIIVPQRGNKKDLVKLAYKNAKIALNEKFMLLERN
CCCCCEEECCCCCCHHHHHHHCCCCEEEECCCCCHHHHHHHHHCCCEEEECCEEEEEECC
EERTVGAVERLGEAMGIPTPSRVEAFDNSNIHGTDPVSAMVTFLDGKPSKNDYRKYKIKT
CCHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEE
VEGPDDYATMREVIRRRYWRVLKEELPMPDLILIDGGKGQIDSAKDVLTNELGLDIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCHHHHHHHHCCCCCCCCC
LAKDDKHRTSQLLFGDPLEIVPLERNSQEFYLLQRMQDEVHRFAITFHRQLRSKTGFQSI
CCCCCHHHHHHCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHH
LDGIPGVGPGRKKKLLKHFGSMKKLKEASVEEIKEAGVPLNVAEEVHKHITAFNEKAKNT
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCC
EQK
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]