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The map label for this gene is trxA

Identifier: 226223833

GI number: 226223833

Start: 1240208

End: 1240519

Strand: Direct

Name: trxA

Synonym: Lm4b_01238

Alternate gene names: 226223833

Gene position: 1240208-1240519 (Clockwise)

Preceding gene: 226223832

Following gene: 226223834

Centisome position: 42.58

GC content: 39.74

Gene sequence:

>312_bases
ATGGTAAAAGAAATTACAGATGCAACATTTGAACAAGAAACTAGCGAAGGCTTAGTATTAACAGATTTCTGGGCAACATG
GTGTGGTCCTTGCCGCATGGTGGCTCCAGTTTTAGAAGAAATACAAGAAGAACGCGGCGAAGCACTTAAAATCGTCAAAA
TGGACGTAGATGAAAACCCAGAAACACCAGGAAGTTTTGGTGTGATGAGTATTCCAACACTTCTTATCAAAAAAGACGGC
GAAGTAGTAGAAACAATTATCGGCTACCGTCCAAAAGAAGAACTGGATGAAGTCATCAACAAATACGTTTAA

Upstream 100 bases:

>100_bases
CGATTGTTGAGTTCAAGTAAACAACTGAGCAAAAACATGGCTCCAAATAGGTCTAGGTGCTATACTGTGTGTACGAAAGT
CATAAGGAGTGAATTAAATC

Downstream 100 bases:

>100_bases
AATTATGCTAAAATGAAAGAAGCTTAGAACAAACATTCTAAGCTTCTTTTTAAATGTGTAACTGGAGTTGATAAAATGTC
TTCTGAACATATCCAAAATA

Product: thioredoxin

Products: NA

Alternate protein names: Trx

Number of amino acids: Translated: 103; Mature: 103

Protein sequence:

>103_residues
MVKEITDATFEQETSEGLVLTDFWATWCGPCRMVAPVLEEIQEERGEALKIVKMDVDENPETPGSFGVMSIPTLLIKKDG
EVVETIIGYRPKEELDEVINKYV

Sequences:

>Translated_103_residues
MVKEITDATFEQETSEGLVLTDFWATWCGPCRMVAPVLEEIQEERGEALKIVKMDVDENPETPGSFGVMSIPTLLIKKDG
EVVETIIGYRPKEELDEVINKYV
>Mature_103_residues
MVKEITDATFEQETSEGLVLTDFWATWCGPCRMVAPVLEEIQEERGEALKIVKMDVDENPETPGSFGVMSIPTLLIKKDG
EVVETIIGYRPKEELDEVINKYV

Specific function: Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain

Homologues:

Organism=Homo sapiens, GI21361403, Length=90, Percent_Identity=31.1111111111111, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI87082331, Length=99, Percent_Identity=42.4242424242424, Blast_Score=99, Evalue=4e-23,
Organism=Escherichia coli, GI1788936, Length=85, Percent_Identity=41.1764705882353, Blast_Score=84, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI212646193, Length=81, Percent_Identity=35.8024691358025, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI71980562, Length=84, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=91, Percent_Identity=32.967032967033, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321648, Length=94, Percent_Identity=38.2978723404255, Blast_Score=73, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323072, Length=78, Percent_Identity=41.025641025641, Blast_Score=72, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319925, Length=73, Percent_Identity=39.7260273972603, Blast_Score=67, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24639826, Length=73, Percent_Identity=38.3561643835616, Blast_Score=72, Evalue=8e-14,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=34, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17648013, Length=87, Percent_Identity=37.9310344827586, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24583090, Length=87, Percent_Identity=37.9310344827586, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24664269, Length=86, Percent_Identity=34.8837209302326, Blast_Score=65, Evalue=1e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THIO_LISIN (P0A4L4)

Other databases:

- EMBL:   AL596167
- PIR:   AC1582
- RefSeq:   NP_470533.1
- ProteinModelPortal:   P0A4L4
- SMR:   P0A4L4
- GeneID:   1129754
- GenomeReviews:   AL592022_GR
- KEGG:   lin:lin1196
- GenoList:   LIN1196
- HOGENOM:   HBG493509
- OMA:   TLMLFKG
- ProtClustDB:   CLSK564305
- BioCyc:   LINN272626:LIN1196-MONOMER
- GO:   GO:0006810
- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335
- Gene3D:   G3DSA:3.40.30.10
- PANTHER:   PTHR10438
- PIRSF:   PIRSF000077
- PRINTS:   PR00421
- TIGRFAMs:   TIGR01068

Pfam domain/function: PF00085 Thioredoxin; SSF52833 Thiordxn-like_fd

EC number: NA

Molecular weight: Translated: 11620; Mature: 11620

Theoretical pI: Translated: 3.99; Mature: 3.99

Prosite motif: PS00194 THIOREDOXIN_1; PS51352 THIOREDOXIN_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVKEITDATFEQETSEGLVLTDFWATWCGPCRMVAPVLEEIQEERGEALKIVKMDVDENP
CCCCCCCHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
ETPGSFGVMSIPTLLIKKDGEVVETIIGYRPKEELDEVINKYV
CCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MVKEITDATFEQETSEGLVLTDFWATWCGPCRMVAPVLEEIQEERGEALKIVKMDVDENP
CCCCCCCHHHHHCCCCCEEEEHHHHHHCCHHHHHHHHHHHHHHHCCCEEEEEEECCCCCC
ETPGSFGVMSIPTLLIKKDGEVVETIIGYRPKEELDEVINKYV
CCCCCCCHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669