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The map label for this gene is sirC [H]

Identifier: 226223742

GI number: 226223742

Start: 1155990

End: 1156469

Strand: Direct

Name: sirC [H]

Synonym: Lm4b_01146

Alternate gene names: 226223742

Gene position: 1155990-1156469 (Clockwise)

Preceding gene: 226223738

Following gene: 226223743

Centisome position: 39.69

GC content: 39.58

Gene sequence:

>480_bases
ATGAAATATCCGATAATGCTTGATATTACAGGGAAACGGGTTGTCATAATTGGCGGTGGGAAGGTGGCGCTTCGTAAAGT
AAAGGGGCTGCTTCACACCGGAGCTGATATTTTAATTGTCGGGTTAGACGTTTTGCCAGAGATTAAAGAGCTTCAAGTGC
AGGTGAAAGAAGAAGCATACCGGGCAGAACATCTAATTGGTGCTTTTCTGATATTTATTTGTACGAATAACCCAGAAGTA
AATCAAATGGTACTGAAAGATCGCTTGCCAGAACAACTAGTGAATGATACGACTGAACAAAAGAATTCCGATTTTTTCAA
TATGGCAACTGTATCAAAAAATGAGTTGCTAGTTGGTATTTCAACAGGAGGCGGGAATCCTGGATACGCCAAGAAAGTAA
AACGGGAAGTACGCCAGTTAGTAGAAAATTTAGAAACAGAAGAAATCGGAAGGCGTAATAAAAATGATAAAACCTGCTAA

Upstream 100 bases:

>100_bases
ATTAAACATTTATTTTACCTCCTTTTGAATTATTTTAACTATACCCGAAAAATGTTTCAATTATGTGTTAAAATGAAGAA
AAATGTGCGGGGGCTTGATG

Downstream 100 bases:

>100_bases
TTTTAGTAGGTTTTTTATTCTATTATATTGCTCTCTTTTAGGTTGCAAAATTTTACTATAGATTTTGGAATGTAAACGCT
CTATCATTGAAGTATACTGA

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 159; Mature: 159

Protein sequence:

>159_residues
MKYPIMLDITGKRVVIIGGGKVALRKVKGLLHTGADILIVGLDVLPEIKELQVQVKEEAYRAEHLIGAFLIFICTNNPEV
NQMVLKDRLPEQLVNDTTEQKNSDFFNMATVSKNELLVGISTGGGNPGYAKKVKREVRQLVENLETEEIGRRNKNDKTC

Sequences:

>Translated_159_residues
MKYPIMLDITGKRVVIIGGGKVALRKVKGLLHTGADILIVGLDVLPEIKELQVQVKEEAYRAEHLIGAFLIFICTNNPEV
NQMVLKDRLPEQLVNDTTEQKNSDFFNMATVSKNELLVGISTGGGNPGYAKKVKREVRQLVENLETEEIGRRNKNDKTC
>Mature_159_residues
MKYPIMLDITGKRVVIIGGGKVALRKVKGLLHTGADILIVGLDVLPEIKELQVQVKEEAYRAEHLIGAFLIFICTNNPEV
NQMVLKDRLPEQLVNDTTEQKNSDFFNMATVSKNELLVGISTGGGNPGYAKKVKREVRQLVENLETEEIGRRNKNDKTC

Specific function: Catalyzes the dehydrogenation of precorrin-2 to form sirohydrochlorin used as precursor in both siroheme biosynthesis and in the anaerobic branch of adenosylcobalamin biosynthesis (Probable) [H]

COG id: COG1648

COG function: function code H; Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR006367 [H]

Pfam domain/function: NA

EC number: =1.3.1.76 [H]

Molecular weight: Translated: 17732; Mature: 17732

Theoretical pI: Translated: 8.70; Mature: 8.70

Prosite motif: PS50972 PTERIN_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKYPIMLDITGKRVVIIGGGKVALRKVKGLLHTGADILIVGLDVLPEIKELQVQVKEEAY
CCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCHHCCCHHHHHHHHHHHHH
RAEHLIGAFLIFICTNNPEVNQMVLKDRLPEQLVNDTTEQKNSDFFNMATVSKNELLVGI
HHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHCCHHHHCCCCEEEEEEECCCEEEEEE
STGGGNPGYAKKVKREVRQLVENLETEEIGRRNKNDKTC
ECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC
>Mature Secondary Structure
MKYPIMLDITGKRVVIIGGGKVALRKVKGLLHTGADILIVGLDVLPEIKELQVQVKEEAY
CCCCEEEEECCCEEEEEECCHHHHHHHHHHHHCCCCEEEECCHHCCCHHHHHHHHHHHHH
RAEHLIGAFLIFICTNNPEVNQMVLKDRLPEQLVNDTTEQKNSDFFNMATVSKNELLVGI
HHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHCCHHHHCCCCEEEEEEECCCEEEEEE
STGGGNPGYAKKVKREVRQLVENLETEEIGRRNKNDKTC
ECCCCCCHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 10217486 [H]