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The map label for this gene is cah [H]

Identifier: 226223428

GI number: 226223428

Start: 838453

End: 839154

Strand: Direct

Name: cah [H]

Synonym: Lm4b_00826

Alternate gene names: 226223428

Gene position: 838453-839154 (Clockwise)

Preceding gene: 226223427

Following gene: 226223429

Centisome position: 28.79

GC content: 38.6

Gene sequence:

>702_bases
ATGACTAAGGAGAAAGTGTTATGGGGTTACGATGAAAAGACTGGGCCAGAAATGTGGGGGCATATCTGCTCTGACTTTGA
AATCGCACATACTGGAAAGGCACAATCGCCAGTAGATATTGAACAAGCTGACGTTGTGAAATTAAAACCATCAACAATGA
AATTTTACTATAAAGAAACAGACTATACGATTAGAAGAATTGAACAATCGGTGCATGTTTTTCCGCATGACAAAGAACAA
GGGTTACGCTTTAACGGCGAGTATTATCCGCTTGTATCATTCCATGCACATATTCCGGCGGAGCATTTGCTTGACGGTTA
TATATATCCGATTGAATGGCATTTTGTTCATGAAAAACCAGACGGCACAACGCTTGTAATGAGTGCTTGGATGGAAATTG
ATAATACAAATAATGTCGAATTCAAAGATTTACCAACCTATTTCCCAGAAGTGTTCGCTGATTTTGAAACAGAACGGGAA
ATTACTTTAGACGTGAATGAATTTATGCCAGAAGAACGTGTTTTCTATACGTACCAAGGTTCACGGACGACACCACCAAC
CGTGGAAGGCGTAACTTGGATCGTGTTAAAAAATGCGAAGACACTTGGCCAAGAAGATTTCACTGAATTTGAAAAAGCAA
TTGGTAATACAAGTCGACCAGTGCAAGATTTAAATGGTCGTGAAATTACTTTTTATAATTAA

Upstream 100 bases:

>100_bases
CCAAAGTCAAAACACGAACATTAAGCATATAACTTGTGGAATAGATCAGCTATCCGCTAAAATAATGTTACGCAATTTTT
TTCGAAAAGGAGAAATGGTT

Downstream 100 bases:

>100_bases
AAAACTAGAAAGCCTCGCTCGAATCTTGTATAGTATAGACATAGATTCTGAGTGGAGGCTTCTTTTTATGTATGAAAAAG
CGAGACAGATGATGATCAAA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVDIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQ
GLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETERE
ITLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN

Sequences:

>Translated_233_residues
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVDIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQ
GLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETERE
ITLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
>Mature_232_residues
TKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVDIEQADVVKLKPSTMKFYYKETDYTIRRIEQSVHVFPHDKEQG
LRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKPDGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREI
TLDVNEFMPEERVFYTYQGSRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI258679498, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI192447434, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI192447432, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI192447430, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4502517, Length=259, Percent_Identity=28.1853281853282, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI4557395, Length=259, Percent_Identity=29.3436293436293, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI38348436, Length=267, Percent_Identity=26.2172284644195, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4885101, Length=262, Percent_Identity=27.0992366412214, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI4885099, Length=263, Percent_Identity=23.9543726235741, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=251, Percent_Identity=27.8884462151394, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645604, Length=256, Percent_Identity=26.5625, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 27251; Mature: 27120

Theoretical pI: Translated: 4.57; Mature: 4.57

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVDIEQADVVKLKPSTMKFYYKET
CCCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCEEEEEEECC
DYTIRRIEQSVHVFPHDKEQGLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKP
CHHHHHHHHHHEECCCCCCCCCEECCEEEEEEEEECCCCHHHHHCCEEEEEEEEEEEECC
DGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREITLDVNEFMPEERVFYTYQG
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECC
SRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEEC
>Mature Secondary Structure 
TKEKVLWGYDEKTGPEMWGHICSDFEIAHTGKAQSPVDIEQADVVKLKPSTMKFYYKET
CCCCEEECCCCCCCHHHHHHHHCCCEEEECCCCCCCCCCCCCCEEEECCCEEEEEEECC
DYTIRRIEQSVHVFPHDKEQGLRFNGEYYPLVSFHAHIPAEHLLDGYIYPIEWHFVHEKP
CHHHHHHHHHHEECCCCCCCCCEECCEEEEEEEEECCCCHHHHHCCEEEEEEEEEEEECC
DGTTLVMSAWMEIDNTNNVEFKDLPTYFPEVFADFETEREITLDVNEFMPEERVFYTYQG
CCCEEEEEEEEEECCCCCEEECCCCHHHHHHHHCCCCCCEEEEEHHHCCCCCEEEEEECC
SRTTPPTVEGVTWIVLKNAKTLGQEDFTEFEKAIGNTSRPVQDLNGREITFYN
CCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9108244; 7721686; 9761692 [H]