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The map label for this gene is ydgF [H]

Identifier: 226223404

GI number: 226223404

Start: 811156

End: 812532

Strand: Direct

Name: ydgF [H]

Synonym: Lm4b_00802

Alternate gene names: 226223404

Gene position: 811156-812532 (Clockwise)

Preceding gene: 226223403

Following gene: 226223405

Centisome position: 27.85

GC content: 37.76

Gene sequence:

>1377_bases
ATGGAAGAGCAAAAAGAAGAATTGCAAAGAGGGCTGAAAAATAGACACATTCAGTTAATCGCGATTGGCGGAGCAATTGG
TACAGGGCTTTTTCTAGGAGCAGGGAAGTCAATTCATTTAGCCGGACCTTCTATCATGTTAGTTTACTTAATTATTGGGG
CTATTTTATTCTTTGTTATGAGAGCTTTGGGTGAATTATTAATACATAATCCAACAACAGGATCTTTTACAGAATTCGCA
GAGCAATTTATTGGACCATGGGCTGGCTTTATTACTGGTTGGACATATTGGTTCTGCTGGATTGTGACAGGTATTGCAGA
AATTACAGCAGTTGGCATGTACGTAAAATTTTGGGTGCCAGACTTACCGCAATGGATTCCAGCACTTGCATGTGTTTTGA
TACTTCTATTGTTTAACTTAGCAACTGTTAAAGCTTTTGGTGAAATCGAATTTTGGTTTGCGATTATTAAAGTGGTTGTT
ATTATTGCCTTAATTGTTATTGGATTTGTACTCGTATTTATTGGTTACAAACATGGCACAAGTACAGCTTCATTTTCTAA
TTTAGTAGATTATGGTGGCTTTTTCCCGAATGGAATTGCCGGGTTCTTGCTAGCATTCCAAATGGCGACATTTTCTTTTG
TTGGAATTGAGCTTGTTGGGGTTACTGCAGGAGAAGCGGATGATCCAGAGCGCACACTTCCAAAAGCCATTAATAATATT
CCGATTCGGATTTTAATCTTTTATATTGGTGCGCTACTCGTATTAATGTCGATTTATCCGTGGAGCAATATTGATCCAAA
CACAAGCCCATTCGTAAGCGTCTTTACGATGATTGGGATTCCTGCAGCTGCCGGTATTATTAACTTTGTGGTGTTAACGG
CTGCTATGTCTTCTTGTAATAGTGGGATTTTCAGTACAAGCCGGATGCTTTATACTCTTTCTGCAGAAGGAAAAGCACCG
AAAAAAATGCATCATTTGAGCTCTAATGGTGTTCCAGCAACAGCGTTAATCACATCTACAGCATGTTTACTTATTGGTGT
GTTTTTAAATTATTTCTTACCAGAACAAGTATTTATTTTAGTAACAAGTATCGCGACGATTTGCTTTATCTGGGTTTGGG
GCGTTATTTTAGTGGCGCATTTACGTTTTCGTCATAAACATCCAGAAATCGCAGAAAAAAGTAAATTCAAAATGCCATTA
TCTCCTTTAATGAACTGGGTTAGCTTAATTTTCTTCGGAGGATTACTAGTTATCCTCGGTTTTGCAGCAGATACAAGAAT
CGCACTTTTCGTCACACCAGTATGGTTCTTGATTTTAGGTATCGCTTATCAAGTTTTAAAAGCTTCCAACCGAAAGACAA
AAATTCGCCATAATTAA

Upstream 100 bases:

>100_bases
CCTTTATAAATTGGTAAAGTAGAGAAGTAGATTGATCGATAAAGTGCTGAATTAACTCGGCACTTTATTCTTTTTAATTA
CTCGAAAGGGATGAATTTGG

Downstream 100 bases:

>100_bases
TAACTGAGCAAGCATTCGCTAAATGGAGCTATTTTAGGGAATGCTTGCTTTTTTTCGGCATGAAAATGCTCCGCGAAATT
CTTTACAAATGAAAAAAATC

Product: amino acid transporter

Products: D-glycine [Cytoplasm]; D-alanine [Cytoplasm]; Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 458

Protein sequence:

>458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYFLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAEKSKFKMPL
SPLMNWVSLIFFGGLLVILGFAADTRIALFVTPVWFLILGIAYQVLKASNRKTKIRHN

Sequences:

>Translated_458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYFLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAEKSKFKMPL
SPLMNWVSLIFFGGLLVILGFAADTRIALFVTPVWFLILGIAYQVLKASNRKTKIRHN
>Mature_458_residues
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVMRALGELLIHNPTTGSFTEFA
EQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVPDLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVV
IIALIVIGFVLVFIGYKHGTSTASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCNSGIFSTSRMLYTLSAEGKAP
KKMHHLSSNGVPATALITSTACLLIGVFLNYFLPEQVFILVTSIATICFIWVWGVILVAHLRFRHKHPEIAEKSKFKMPL
SPLMNWVSLIFFGGLLVILGFAADTRIALFVTPVWFLILGIAYQVLKASNRKTKIRHN

Specific function: Probable amino-acid or metabolite transport protein [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=341, Percent_Identity=26.099706744868, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI115648063, Length=461, Percent_Identity=27.3318872017354, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI115648022, Length=461, Percent_Identity=27.3318872017354, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI4507047, Length=425, Percent_Identity=22.5882352941176, Blast_Score=74, Evalue=4e-13,
Organism=Homo sapiens, GI181337167, Length=345, Percent_Identity=21.1594202898551, Blast_Score=69, Evalue=7e-12,
Organism=Homo sapiens, GI71999149, Length=340, Percent_Identity=24.4117647058824, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI258614005, Length=383, Percent_Identity=22.4543080939948, Blast_Score=66, Evalue=8e-11,
Organism=Homo sapiens, GI258614003, Length=383, Percent_Identity=22.4543080939948, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=54.1666666666667, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI48994972, Length=456, Percent_Identity=48.0263157894737, Blast_Score=420, Evalue=1e-119,
Organism=Escherichia coli, GI1786302, Length=453, Percent_Identity=44.1501103752759, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786789, Length=446, Percent_Identity=44.8430493273543, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI1786602, Length=451, Percent_Identity=44.7893569844789, Blast_Score=394, Evalue=1e-111,
Organism=Escherichia coli, GI87081915, Length=409, Percent_Identity=42.5427872860636, Blast_Score=350, Evalue=1e-97,
Organism=Escherichia coli, GI87081708, Length=461, Percent_Identity=34.2733188720174, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1789017, Length=433, Percent_Identity=35.5658198614319, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788480, Length=477, Percent_Identity=34.8008385744235, Blast_Score=275, Evalue=4e-75,
Organism=Escherichia coli, GI87082023, Length=285, Percent_Identity=25.6140350877193, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081869, Length=325, Percent_Identity=21.5384615384615, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI2367353, Length=400, Percent_Identity=21.5, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17531343, Length=436, Percent_Identity=21.7889908256881, Blast_Score=66, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=449, Percent_Identity=33.4075723830735, Blast_Score=225, Evalue=1e-59,
Organism=Saccharomyces cerevisiae, GI6324061, Length=442, Percent_Identity=33.0316742081448, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6324924, Length=494, Percent_Identity=31.1740890688259, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=445, Percent_Identity=31.2359550561798, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6324059, Length=443, Percent_Identity=30.2483069977427, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324990, Length=422, Percent_Identity=31.7535545023697, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6324553, Length=398, Percent_Identity=30.1507537688442, Blast_Score=167, Evalue=4e-42,
Organism=Saccharomyces cerevisiae, GI6319608, Length=482, Percent_Identity=26.9709543568465, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6321629, Length=433, Percent_Identity=27.0207852193995, Blast_Score=163, Evalue=6e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=400, Percent_Identity=27.75, Blast_Score=162, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320717, Length=403, Percent_Identity=24.5657568238213, Blast_Score=160, Evalue=3e-40,
Organism=Saccharomyces cerevisiae, GI6321053, Length=392, Percent_Identity=29.0816326530612, Blast_Score=160, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6319824, Length=401, Percent_Identity=25.6857855361596, Blast_Score=159, Evalue=6e-40,
Organism=Saccharomyces cerevisiae, GI6322967, Length=403, Percent_Identity=30.0248138957816, Blast_Score=158, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6319542, Length=403, Percent_Identity=27.0471464019851, Blast_Score=155, Evalue=9e-39,
Organism=Saccharomyces cerevisiae, GI6319543, Length=397, Percent_Identity=27.9596977329975, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=408, Percent_Identity=28.921568627451, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320364, Length=501, Percent_Identity=24.5508982035928, Blast_Score=117, Evalue=6e-27,
Organism=Drosophila melanogaster, GI24668806, Length=429, Percent_Identity=22.3776223776224, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI21356285, Length=429, Percent_Identity=22.3776223776224, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24668802, Length=429, Percent_Identity=22.3776223776224, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI221512776, Length=340, Percent_Identity=21.4705882352941, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24666159, Length=340, Percent_Identity=21.4705882352941, Blast_Score=71, Evalue=2e-12,
Organism=Drosophila melanogaster, GI161077963, Length=360, Percent_Identity=22.5, Blast_Score=69, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24667468, Length=340, Percent_Identity=22.3529411764706, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281366235, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI116007820, Length=360, Percent_Identity=24.1666666666667, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50322; Mature: 50322

Theoretical pI: Translated: 9.10; Mature: 9.10

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVM
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
RALGELLIHNPTTGSFTEFAEQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVP
HHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVVIIALIVIGFVLVFIGYKHGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
STASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHCCC
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIFSTSRMLYTLSAEGKAPKKMHHLSSNGVPATALITSTACLLIGVFLNYFLPEQVFIL
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATICFIWVWGVILVAHLRFRHKHPEIAEKSKFKMPLSPLMNWVSLIFFGGLLVILG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FAADTRIALFVTPVWFLILGIAYQVLKASNRKTKIRHN
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEEQKEELQRGLKNRHIQLIAIGGAIGTGLFLGAGKSIHLAGPSIMLVYLIIGAILFFVM
CCCHHHHHHHHHHHCCEEEEEECCHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHH
RALGELLIHNPTTGSFTEFAEQFIGPWAGFITGWTYWFCWIVTGIAEITAVGMYVKFWVP
HHHHHHHCCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
DLPQWIPALACVLILLLFNLATVKAFGEIEFWFAIIKVVVIIALIVIGFVLVFIGYKHGT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
STASFSNLVDYGGFFPNGIAGFLLAFQMATFSFVGIELVGVTAGEADDPERTLPKAINNI
CCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHHHHHHCCC
PIRILIFYIGALLVLMSIYPWSNIDPNTSPFVSVFTMIGIPAAAGIINFVVLTAAMSSCN
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGIFSTSRMLYTLSAEGKAPKKMHHLSSNGVPATALITSTACLLIGVFLNYFLPEQVFIL
CCCCCCCCEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VTSIATICFIWVWGVILVAHLRFRHKHPEIAEKSKFKMPLSPLMNWVSLIFFGGLLVILG
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHH
FAADTRIALFVTPVWFLILGIAYQVLKASNRKTKIRHN
HCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-glycine [Periplasm]; D-alanine [Periplasm]; Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-glycine [Periplasm] = Proton [Cytoplasm] + D-glycine [Cytoplasm] Proton [Periplasm] + D-alanine [Periplasm] = Proton [Cytoplasm] + D-alanine [Cytoplasm] Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cyto

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]