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The map label for this gene is hisG

Identifier: 226223197

GI number: 226223197

Start: 609047

End: 609688

Strand: Reverse

Name: hisG

Synonym: Lm4b_00594

Alternate gene names: 226223197

Gene position: 609688-609047 (Counterclockwise)

Preceding gene: 226223198

Following gene: 226223196

Centisome position: 20.93

GC content: 40.03

Gene sequence:

>642_bases
ATGAAAGCTCTAAAAATTGCTCTAACGAAAGGTCGACTGGAGAAAGACGCAGTGGCACTTTTGGAAAAAGCTGGGATTGA
CTGTTCTTCTATGACAGATAAAAAGCGTAAACTAATTTTTCATAGTAGCACTCAACCAATCTCTTTTATTTTAGTAAAAG
CGGTCGATGTCATGACTTACGTAAAGCACGGGGTTGCGGATATTGGCATCGTTGGTAAAGACGTTTTAATGGAAGCATCT
AAATCCCATTATGAAATGCTCGACCTTGAAATCGGCAAATGCCAGTTTTGCCTTGCTTCTACACCTGACTTTGACCCGAG
CAGTTATCGACGAAAAATCATCGCAACCAAGTATCCAACTGTTGCTTCCAAATTTTTCCGTGAAAAAGGCGAAGATGTAG
AAATTATCAAAATCGAAGGATCCGTCGAGATTGCTCCAGTGCTTGGTCTTGCTGATGCCATCATCGATATCGTCGAAACT
GGCTCCACTTTAAAAGAAAACGGCTTACTTATTTATGAAAAAATGTATCCAATCTCCGCCCGTCTGATTGTCAATAAAGC
TTCCTTAAAACAGAACAAAACGCAAATTTTCCAATTAATCGACCAATTAGAACAAGTGATAAAGGAGGAGCGCGCTGAAT
GA

Upstream 100 bases:

>100_bases
CATCAAACGCCATCTCTTTTGCAAAAAAATGGCATATTCCCGAAGTCGTTCACGTCTCGAGCCAAGGCATCCAAACTATT
TTCCAAAGGGAGGTGGACTG

Downstream 100 bases:

>100_bases
AAATTTTAACCGGAACAGTAAATGAGCTATTAAACGAGCTCAAAATAGAAACTGATACGAACACTTCCATCCAGGTGGAA
ACCGAAGTAAAAACGATTAT

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 213; Mature: 213

Protein sequence:

>213_residues
MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTYVKHGVADIGIVGKDVLMEAS
KSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPTVASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVET
GSTLKENGLLIYEKMYPISARLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE

Sequences:

>Translated_213_residues
MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTYVKHGVADIGIVGKDVLMEAS
KSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPTVASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVET
GSTLKENGLLIYEKMYPISARLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE
>Mature_213_residues
MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTYVKHGVADIGIVGKDVLMEAS
KSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPTVASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVET
GSTLKENGLLIYEKMYPISARLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=219, Percent_Identity=35.1598173515982, Blast_Score=113, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6320896, Length=211, Percent_Identity=30.8056872037915, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23724; Mature: 23724

Theoretical pI: Translated: 8.04; Mature: 8.04

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTY
CCCEEEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHH
VKHGVADIGIVGKDVLMEASKSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPT
HHHCCHHHCCCCHHHHHHHHHCHHEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCH
VASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVETGSTLKENGLLIYEKMYPISA
HHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCEE
RLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKALKIALTKGRLEKDAVALLEKAGIDCSSMTDKKRKLIFHSSTQPISFILVKAVDVMTY
CCCEEEEEECCCCHHHHHHHHHHHCCCHHHCCCHHHEEEEECCCCCHHHHHHHHHHHHHH
VKHGVADIGIVGKDVLMEASKSHYEMLDLEIGKCQFCLASTPDFDPSSYRRKIIATKYPT
HHHCCHHHCCCCHHHHHHHHHCHHEEEEEECCCEEEEECCCCCCCHHHHHHHHHCCCCCH
VASKFFREKGEDVEIIKIEGSVEIAPVLGLADAIIDIVETGSTLKENGLLIYEKMYPISA
HHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCCHHHCCEEEEEECCCCEE
RLIVNKASLKQNKTQIFQLIDQLEQVIKEERAE
EEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]