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The map label for this gene is hisZ

Identifier: 226223198

GI number: 226223198

Start: 609688

End: 610866

Strand: Reverse

Name: hisZ

Synonym: Lm4b_00595

Alternate gene names: 226223198

Gene position: 610866-609688 (Counterclockwise)

Preceding gene: 226223200

Following gene: 226223197

Centisome position: 20.97

GC content: 38.85

Gene sequence:

>1179_bases
ATGAACTTAAATAAGAACTTACCAACCGGAACACGTGATAAACTCTTTCGTGAAGCACAAGCTGCATACAAAATTGAGCA
ACAAGTGAATCATTATTTTGAAAAACGTGGATTTAAACGTATTGAAACACCTGTTATCGAGTTTGAAGATGTCTTTTCTT
CTGAACATCAAGCCGATGCGAAGTTATACCGTTTCTTTGACGAAAAAGGACGTTTGACAGTTCTACGTCCGGACATGACC
CTTCCAATTGGTCGAGTTGTGAGTACAACTGGTGTGATGCTCCCTCTAAAACTTTCTTATAGCGGAAAAATTTTTCGTGC
CAATGAAGATTTTGGTGGCGAACAAAACGAACAAACGCAAGCTGGAATTGAAATCATTGGCTATCCTTCGATTAAAGCAG
AGATTGAATGTATTTTAAGTGGAATCGGGGTTTTAAATGCTCTAGAAATTCCGAATTTTCAAATTGAACTCGGACATGCA
GCAATTTATCGTCGTGTTATACAACTTTTAAATCTCTCCGAAACAGCTGAAATTGATTTTCGCCAACTAATTCAAAATAA
AAGCTTAACTGGTATTAAACGATTTGTTGCCAATAATCCAAGTACACTTGACGATTTTATTTTAGCCATACCAAGATTAT
TTGGCCCAGCGACAGCTATTTTAAACCAAGCAAAAAGTTTAACGACTGACAAAGGAATTTTAACGGCACTGCGTGAAATG
GAAACCATTGTGGAAGCTGTTTCTTACACAGCAGATATTAGTGTCGATTTAGGACTCGTACAAGATTTTCATTATTATAC
AGGTATAATTTTTAGAGGATACGCTGACCTTGCTGCTGATAATTTTTTAAGCGGCGGCCGTTACGATCACCTACTAGAAC
AATTCACCAGCTCTTCCTCCCCAGCAGTTGGTTTGGCTCTTAATCTCGACTCCCTCACAACTCTACAAAACCGCGCTGGC
ATCATCAAAAAACAAACGCCAACAACTCTTTTGATCCACTACGACCTTGAAGCACTCCCACAAGCAGAAAAATTCATGCA
AGAAACACCAAATAGTGAATTAAGTTTTTTTGAAACAGCATCAAACGCCATCTCTTTTGCAAAAAAATGGCATATTCCCG
AAGTCGTTCACGTCTCGAGCCAAGGCATCCAAACTATTTTCCAAAGGGAGGTGGACTGA

Upstream 100 bases:

>100_bases
AATTATACCATAAGCAACTATTTTTCTATTCATTATTTACAAAAACACTTTAACGTGCTAACATGCTAATAAACTAAAAT
ATCGTAAAGGAGCTAACCAG

Downstream 100 bases:

>100_bases
TGAAAGCTCTAAAAATTGCTCTAACGAAAGGTCGACTGGAGAAAGACGCAGTGGCACTTTTGGAAAAAGCTGGGATTGAC
TGTTCTTCTATGACAGATAA

Product: ATP phosphoribosyltransferase regulatory subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMT
LPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHA
AIYRRVIQLLNLSETAEIDFRQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREM
ETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSSPAVGLALNLDSLTTLQNRAG
IIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETASNAISFAKKWHIPEVVHVSSQGIQTIFQREVD

Sequences:

>Translated_392_residues
MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMT
LPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHA
AIYRRVIQLLNLSETAEIDFRQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREM
ETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSSPAVGLALNLDSLTTLQNRAG
IIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETASNAISFAKKWHIPEVVHVSSQGIQTIFQREVD
>Mature_392_residues
MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADAKLYRFFDEKGRLTVLRPDMT
LPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQAGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHA
AIYRRVIQLLNLSETAEIDFRQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREM
ETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSSPAVGLALNLDSLTTLQNRAG
IIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETASNAISFAKKWHIPEVVHVSSQGIQTIFQREVD

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

Organism=Homo sapiens, GI6996014, Length=357, Percent_Identity=22.96918767507, Blast_Score=82, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6325290, Length=357, Percent_Identity=23.8095238095238, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI24643061, Length=357, Percent_Identity=23.8095238095238, Blast_Score=81, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR004517
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: NA

Molecular weight: Translated: 43903; Mature: 43903

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCHHHHH
KLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQ
HHHHHHCCCCCEEEECCCCCCCHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCHHH
AGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHAAIYRRVIQLLNLSETAEIDF
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHH
RQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREM
HHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
ETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSS
HHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
PAVGLALNLDSLTTLQNRAGIIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETA
CCEEEEEECHHHHHHHHHCCCEECCCCCEEEEEECHHHCCHHHHHHHHCCCCCHHHHHHH
SNAISFAKKWHIPEVVHVSSQGIQTIFQREVD
HHHHHHHHHCCCCCEEEECHHHHHHHHHHCCC
>Mature Secondary Structure
MNLNKNLPTGTRDKLFREAQAAYKIEQQVNHYFEKRGFKRIETPVIEFEDVFSSEHQADA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCHHHHHHHHCCCHHHHH
KLYRFFDEKGRLTVLRPDMTLPIGRVVSTTGVMLPLKLSYSGKIFRANEDFGGEQNEQTQ
HHHHHHCCCCCEEEECCCCCCCHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCHHH
AGIEIIGYPSIKAEIECILSGIGVLNALEIPNFQIELGHAAIYRRVIQLLNLSETAEIDF
CCEEEEECCCHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCCHHH
RQLIQNKSLTGIKRFVANNPSTLDDFILAIPRLFGPATAILNQAKSLTTDKGILTALREM
HHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCHHHHHHHHHHHCCCCHHHHHHHHHH
ETIVEAVSYTADISVDLGLVQDFHYYTGIIFRGYADLAADNFLSGGRYDHLLEQFTSSSS
HHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHCCCC
PAVGLALNLDSLTTLQNRAGIIKKQTPTTLLIHYDLEALPQAEKFMQETPNSELSFFETA
CCEEEEEECHHHHHHHHHCCCEECCCCCEEEEEECHHHCCHHHHHHHHCCCCCHHHHHHH
SNAISFAKKWHIPEVVHVSSQGIQTIFQREVD
HHHHHHHHHCCCCCEEEECHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]