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The map label for this gene is hisD

Identifier: 226223196

GI number: 226223196

Start: 607767

End: 609050

Strand: Reverse

Name: hisD

Synonym: Lm4b_00593

Alternate gene names: 226223196

Gene position: 609050-607767 (Counterclockwise)

Preceding gene: 226223197

Following gene: 226223195

Centisome position: 20.91

GC content: 43.54

Gene sequence:

>1284_bases
ATGAAAATTTTAACCGGAACAGTAAATGAGCTATTAAACGAGCTCAAAATAGAAACTGATACGAACACTTCCATCCAGGT
GGAAACCGAAGTAAAAACGATTATCGAAAAAGTCAAAACAGCTGGCGACCAAGCCCTATTTGACTTCACATCCAAGTTTG
ACGGCGTAGGGCTCACCGAACTCCGCGTTCCAGCCGCTGACATCCAAGCTGCAAGCGCAAAAATCGAACCTGCCTTCTTA
GACGCGCTCCAACAAGCAAAAGTAAATATCGAAAGTTTCCACAGCAAGCAAAAACAACATGCTTTCCTTGATAGTGAAAA
AGACGGCGTCATTCGAGGGCAATTAATTCGTCCACTAGAAACCGTCGGCGTTTACGTTCCCGGTGGCACAGCAGCCTATC
CTTCATCGGTTTTAATGAATGTGTTGCCAGCCAAAATTGCCGGAGTAAAGCGAATCGTAATGATTACCCCTCCCGGTGAA
AACGGTATTAATCCTTACGTTCTAGCCTCAGCTCAACTAGCTGGTGTGGACGAAATTTACCAAGTTGGCGGTGCACACGG
AATCGCCGCTCTAGCTCACGGAACAGAATCTATCCCTAAAGTAGATAAAATCGTCGGTCCTGGAAATATCTATGTCGCCA
CTGCCAAACGTGAAGTATTCGGCTTAGTTGATATTGACATGATAGCCGGTCCATCCGAAATCGTCGTGCTCGCAGATGAA
AACGCCAATCCTGCTTTTATCGCAGCCGACTTACTCTCCCAAGCAGAGCACGATATTTTAGCCCGTGCTATCTTAATCAC
AACTAGTAAAAAAATCGCCGAGGAAACACAAAATGAAATTGACAAACAGCTAGAAAATCTACCGCGAAAAGCGATTGCTC
AGAAATCTATCGAAACACGAGGAAAAATCATTATCGCAGCAACCACACAAGAAATGTTCGATATCATGAACGAAATCGCC
CCAGAACACTTAGAAGTACAACTTGAAAATCCGATGAACTATCTCTATCAAATTAAAAACGCTGGCTCCATTTTCTTAGG
GAGTTATGCATCGGAACCTCTTGGCGACTATTTTGCTGGCCCAAATCACGTCTTACCTACAAGTGGTACCGCAAAATTCT
TCTCTCCTCTTGGTGTTGAAGATTTTACCAAACGTTCCGCCTTTATTTCTTATACAAAAGAAGCACTCGCAAAGGAAAAA
GATGCTATCGTTTTACTTGCTAAAAAAGAAGGTCTAGACGCCCATGCCAAAGCCATTCAAATTCGTTTTGAGGAGGAAAA
CTAA

Upstream 100 bases:

>100_bases
CCCGTCTGATTGTCAATAAAGCTTCCTTAAAACAGAACAAAACGCAAATTTTCCAATTAATCGACCAATTAGAACAAGTG
ATAAAGGAGGAGCGCGCTGA

Downstream 100 bases:

>100_bases
ATGAGAACAGCGACTAAAACACGCATTACTGCTGAAACTTCTATTGAGCTTTCCATTAACCTAGATTCCCAAGCAGAATC
AATTATTTCTACTGGAGTCG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MKILTGTVNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQAASAKIEPAFL
DALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGE
NGINPYVLASAQLAGVDEIYQVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVDIDMIAGPSEIVVLADE
NANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIAATTQEMFDIMNEIA
PEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEK
DAIVLLAKKEGLDAHAKAIQIRFEEEN

Sequences:

>Translated_427_residues
MKILTGTVNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQAASAKIEPAFL
DALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGE
NGINPYVLASAQLAGVDEIYQVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVDIDMIAGPSEIVVLADE
NANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIAATTQEMFDIMNEIA
PEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEK
DAIVLLAKKEGLDAHAKAIQIRFEEEN
>Mature_427_residues
MKILTGTVNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTELRVPAADIQAASAKIEPAFL
DALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLETVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGE
NGINPYVLASAQLAGVDEIYQVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVDIDMIAGPSEIVVLADE
NANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETRGKIIIAATTQEMFDIMNEIA
PEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAGPNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEK
DAIVLLAKKEGLDAHAKAIQIRFEEEN

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=395, Percent_Identity=42.5316455696203, Blast_Score=310, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6319819, Length=402, Percent_Identity=40.547263681592, Blast_Score=284, Evalue=2e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_LISMF (Q722Y3)

Other databases:

- EMBL:   AE017262
- RefSeq:   YP_013201.1
- ProteinModelPortal:   Q722Y3
- SMR:   Q722Y3
- STRING:   Q722Y3
- GeneID:   2798888
- GenomeReviews:   AE017262_GR
- KEGG:   lmf:LMOf2365_0596
- TIGR:   LMOf2365_0596
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   LDAHKNA
- ProtClustDB:   PRK00877
- BioCyc:   LMON265669:LMOF2365_0596-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46147; Mature: 46147

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 322-322 ACT_SITE 323-323 BINDING 232-232 BINDING 254-254 BINDING 257-257 BINDING 323-323 BINDING 356-356 BINDING 410-410 BINDING 415-415

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILTGTVNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTE
CCEECHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
LRVPAADIQAASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLE
EECCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHH
TVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDEIY
HCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCHHCCHHHHH
QVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVDIDMIAGPSEIVVLADE
HHCCCCHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCEEEEEEEHEECCCCEEEEEECC
NANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETR
CCCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
GKIIIAATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAG
CCEEEEECHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCEEEECCCCCCCHHHCCC
PNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQ
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEE
IRFEEEN
EEEECCC
>Mature Secondary Structure
MKILTGTVNELLNELKIETDTNTSIQVETEVKTIIEKVKTAGDQALFDFTSKFDGVGLTE
CCEECHHHHHHHHHHEEECCCCCEEEEEHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEE
LRVPAADIQAASAKIEPAFLDALQQAKVNIESFHSKQKQHAFLDSEKDGVIRGQLIRPLE
EECCHHHHHHHCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCHHHHHCCHH
TVGVYVPGGTAAYPSSVLMNVLPAKIAGVKRIVMITPPGENGINPYVLASAQLAGVDEIY
HCEEECCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEECCHHCCHHHHH
QVGGAHGIAALAHGTESIPKVDKIVGPGNIYVATAKREVFGLVDIDMIAGPSEIVVLADE
HHCCCCHHHHHHCCCCCCCCHHHCCCCCCEEEEEECCCEEEEEEEHEECCCCEEEEEECC
NANPAFIAADLLSQAEHDILARAILITTSKKIAEETQNEIDKQLENLPRKAIAQKSIETR
CCCCHHHHHHHHHHHHHHHHHHHHHEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
GKIIIAATTQEMFDIMNEIAPEHLEVQLENPMNYLYQIKNAGSIFLGSYASEPLGDYFAG
CCEEEEECHHHHHHHHHHHCCCCEEEEECCCCCCCEEECCCCCEEEECCCCCCCHHHCCC
PNHVLPTSGTAKFFSPLGVEDFTKRSAFISYTKEALAKEKDAIVLLAKKEGLDAHAKAIQ
CCCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCEEEE
IRFEEEN
EEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA