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The map label for this gene is hisB

Identifier: 226223195

GI number: 226223195

Start: 607182

End: 607766

Strand: Reverse

Name: hisB

Synonym: Lm4b_00592

Alternate gene names: 226223195

Gene position: 607766-607182 (Counterclockwise)

Preceding gene: 226223196

Following gene: 226223194

Centisome position: 20.87

GC content: 40.68

Gene sequence:

>585_bases
ATGAGAACAGCGACTAAAACACGCATTACTGCTGAAACTTCTATTGAGCTTTCCATTAACCTAGATTCCCAAGCAGAATC
AATTATTTCTACTGGAGTCGGATTTTTGGATCACATGCTCACCCTTTTCGCCAAACACAGCCGAATAACTTTAAATGTAA
AAGCAGATGGTGATACATATATCGATGCGCATCACACCGTAGAAGACATCGGCATCACACTCGGGCTTTGTTTAAAAGAA
GCACTTGCTGATAAAGCAAGCATTAATCGTTACGGCTCCGCTTATGTACCGATGGACGAATCACTTGGCTTTTGCGCACT
AGATTTAAGTGGTCGTTCTTATTTAGTTTTTGACGCCGAATTAACAAACCCTAAACTCGGTGATTTTGACACAGAACTAG
TGGAAGAATTTTTCCAAGCAGTTGCCTTTAACACGGAAATGAACCTTCATCTCCGCGTTCTTTATGGCAAAAACACGCAT
CATAAAATCGAAGCACTTTTTAAAGCATTCGGTCGTGCTCTTCGTGAAGCAATCACGATTAACCCAGAAATCAAAGGTGT
AAATTCAACTAAAGGGGTCCTGTAA

Upstream 100 bases:

>100_bases
ACTCGCAAAGGAAAAAGATGCTATCGTTTTACTTGCTAAAAAAGAAGGTCTAGACGCCCATGCCAAAGCCATTCAAATTC
GTTTTGAGGAGGAAAACTAA

Downstream 100 bases:

>100_bases
ATGATTGTTATTATTGACTACGATACAGGAAATACGAAAAGCATCAGTAAAGCCCTTGATTTTATCGGGTTACAAAACAA
AATTTCTAGTGATAAAACAG

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MRTATKTRITAETSIELSINLDSQAESIISTGVGFLDHMLTLFAKHSRITLNVKADGDTYIDAHHTVEDIGITLGLCLKE
ALADKASINRYGSAYVPMDESLGFCALDLSGRSYLVFDAELTNPKLGDFDTELVEEFFQAVAFNTEMNLHLRVLYGKNTH
HKIEALFKAFGRALREAITINPEIKGVNSTKGVL

Sequences:

>Translated_194_residues
MRTATKTRITAETSIELSINLDSQAESIISTGVGFLDHMLTLFAKHSRITLNVKADGDTYIDAHHTVEDIGITLGLCLKE
ALADKASINRYGSAYVPMDESLGFCALDLSGRSYLVFDAELTNPKLGDFDTELVEEFFQAVAFNTEMNLHLRVLYGKNTH
HKIEALFKAFGRALREAITINPEIKGVNSTKGVL
>Mature_194_residues
MRTATKTRITAETSIELSINLDSQAESIISTGVGFLDHMLTLFAKHSRITLNVKADGDTYIDAHHTVEDIGITLGLCLKE
ALADKASINRYGSAYVPMDESLGFCALDLSGRSYLVFDAELTNPKLGDFDTELVEEFFQAVAFNTEMNLHLRVLYGKNTH
HKIEALFKAFGRALREAITINPEIKGVNSTKGVL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=193, Percent_Identity=48.7046632124352, Blast_Score=181, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324776, Length=211, Percent_Identity=40.2843601895735, Blast_Score=152, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD [H]

EC number: =4.2.1.19 [H]

Molecular weight: Translated: 21383; Mature: 21383

Theoretical pI: Translated: 5.56; Mature: 5.56

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTATKTRITAETSIELSINLDSQAESIISTGVGFLDHMLTLFAKHSRITLNVKADGDTY
CCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
IDAHHTVEDIGITLGLCLKEALADKASINRYGSAYVPMDESLGFCALDLSGRSYLVFDAE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCEEEEEEEE
LTNPKLGDFDTELVEEFFQAVAFNTEMNLHLRVLYGKNTHHKIEALFKAFGRALREAITI
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEC
NPEIKGVNSTKGVL
CCCCCCCCCCCCCC
>Mature Secondary Structure
MRTATKTRITAETSIELSINLDSQAESIISTGVGFLDHMLTLFAKHSRITLNVKADGDTY
CCCCCCEEEEEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEE
IDAHHTVEDIGITLGLCLKEALADKASINRYGSAYVPMDESLGFCALDLSGRSYLVFDAE
EECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCEEEEEECCCEEEEEEEE
LTNPKLGDFDTELVEEFFQAVAFNTEMNLHLRVLYGKNTHHKIEALFKAFGRALREAITI
CCCCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHEEC
NPEIKGVNSTKGVL
CCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]