Click here to switch to the map view.

The map label for this gene is capA [H]

Identifier: 226223141

GI number: 226223141

Start: 546633

End: 548063

Strand: Reverse

Name: capA [H]

Synonym: Lm4b_00538

Alternate gene names: 226223141

Gene position: 548063-546633 (Counterclockwise)

Preceding gene: 226223142

Following gene: 226223138

Centisome position: 18.82

GC content: 38.02

Gene sequence:

>1431_bases
TTGAAGAGACGTACCTATGTTATTATTACTGGTTTAGTACTTATTTTTGTCGCTGGTGCTTTTTGGATTACAAATTCTAC
TAATCAATCTGACCAAAAAGCCACTCAAACCGAGCCACTAAAAAAAACAAGTCCAGCTAATGTTAAAACCATTTCATCAG
AAGCTAAGAAAACCTTGAATTCCCTAGCAAGTTCAGGAGCTGACAAAGCTTCTATTTCCGATTTAAATCAATTAATTAAA
GAACTAAAATCCTATCCAGTTGAAAAAAATGATTCTGGCGCCTATCTCCAAAATCTCACAGCCTGTTTAGAAGCTGTAAA
ATCGTATACGACCGGCAAAACAGATGAAAAAACGCTTGGGAAAGTATATCCTGCTTTTCTTGCAAGTGAACAAAAACTAT
CAGCCATCGAAAAAACAAATCAATATGATTGGTTTTATGCCGCAGCCGCAACCAATCAACAAGGTTTGAAAGAAAAAGGT
GTTGTCACTTTGACCATGGTTGGCGATAATTCATTTGGAACCTATCCTGAAACGCCCGAACACCTCAAATTCGATAACGT
ATTCCAAAAAAACAACGGCAATAATACCTATGTTTATAAAAACTGCCTTCCTTGGTTTAAATCTGATGACTACACTGTCA
TTAACGCTGAAAGTGCCTTTACGAATGCAACAAAAGCAGAAAATAAAAAATGGCGCATCAAAAGTGACCCTGCACACGTC
GCCTTTTTACCAGCGAGCGGTGTAGAAGCAGCAAATTTGGCCAATAACCATACAATGGATTACTTCCAAGTTGGTTACGA
TGACACATTAAAGGCTTTTAAAGAGAATAATATTCCTGTTTTCAATACCGACGCTCCACTTGAAACAACCATTAAAGGGA
TGAAAACTGTTCTACTAGGCTACGATTGCCGTATGAGTCAGCAATCCCCTGCTTATCTTGAAAGAATTGTAAAAGACGTG
AAGAAATACAAAAAAGAAAATACTCTCGTTATCGTTAATATGCACTGGGGCGTCGAATATCGCGAAACACCAACGGATTA
TCAAACCCAATTTGGTCATGCGATTTTAGATGCTGGTGCTGATATAATTATGGGCTCTCACCCTCATCGCCTAGAAAGCG
TTGAAAAATATAAAGATAAATACATCGTTTATAGCATGGGCGACTTTGCTTTTGGAGCTGATCCTACGCTACTTTCCCGT
ATGACATCGATGTTCCAACTGCGCTTTACGAAGGAAGATAATAAAATCGTTCTAAAAGATATTTCTATCGTTCCAACTTA
TGAAAATTCAGATGGTAGTACGACAGAAAACAATTATCAACCGCTCCCTGTGTTTGGTGATGATGCTAAAAAAATCGTCG
ATGAACTTAACCGTATTAGTAAACCTATCGAGGGCGGCGTAACAGAATACACTTACTTCGATCCATTTTGA

Upstream 100 bases:

>100_bases
AAACAATTTATTTTGGGCTTTTGTTTTACTAAATATAGACTTGTGTTTCTTCCTTACAATTACTATACTTAGAAAAAAAG
GAACTACGGAGGATATCTAG

Downstream 100 bases:

>100_bases
TAATAAAAAGCGTAGATATCTTCTAACAAAGATATCTACGCTTTTTTTATCTAGCTATTAAAGTATCGCAAATTGCATGA
GCCATAATATAAGAAGAAAC

Product: encapsulation protein CapA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIK
ELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKG
VVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHV
AFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDV
KKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSR
MTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF

Sequences:

>Translated_476_residues
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIK
ELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKG
VVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHV
AFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDV
KKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSR
MTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
>Mature_476_residues
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLNSLASSGADKASISDLNQLIK
ELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLGKVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKG
VVTLTMVGDNSFGTYPETPEHLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHV
AFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLGYDCRMSQQSPAYLERIVKDV
KKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGADIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSR
MTSMFQLRFTKEDNKIVLKDISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF

Specific function: Essential for the synthesis of the polyglutamate capsule of B.anthracis which is one of the principal virulence factors during anthrax infection. May form a polyglutamyl synthetase complex together with proteins CapB and CapC [H]

COG id: COG2843

COG function: function code M; Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation)

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CapA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019079 [H]

Pfam domain/function: PF09587 PGA_cap [H]

EC number: NA

Molecular weight: Translated: 53410; Mature: 53410

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLN
CCCEEEEHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHH
SLASSGADKASISDLNQLIKELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
KVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPE
HHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
HLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHV
CCCCCHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCHHHCCCHHCCCCCEEEECCCCEE
AFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLG
EEEECCCCCHHHCCCCCCCEEEECCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCC
YDCRMSQQSPAYLERIVKDVKKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCHHHHHHHHHHHCCC
DIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKD
CEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEEECCCCEEEEEE
ISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
EEEEEEEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCC
>Mature Secondary Structure
MKRRTYVIITGLVLIFVAGAFWITNSTNQSDQKATQTEPLKKTSPANVKTISSEAKKTLN
CCCEEEEHHHHHHHHHHHHHHEEECCCCCCHHHHHHCCCCCCCCCCCEEHHHHHHHHHHH
SLASSGADKASISDLNQLIKELKSYPVEKNDSGAYLQNLTACLEAVKSYTTGKTDEKTLG
HHHHCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHH
KVYPAFLASEQKLSAIEKTNQYDWFYAAAATNQQGLKEKGVVTLTMVGDNSFGTYPETPE
HHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCEEEEEEECCCCCCCCCCCC
HLKFDNVFQKNNGNNTYVYKNCLPWFKSDDYTVINAESAFTNATKAENKKWRIKSDPAHV
CCCCCHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCHHHCCCHHCCCCCEEEECCCCEE
AFLPASGVEAANLANNHTMDYFQVGYDDTLKAFKENNIPVFNTDAPLETTIKGMKTVLLG
EEEECCCCCHHHCCCCCCCEEEECCHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHCC
YDCRMSQQSPAYLERIVKDVKKYKKENTLVIVNMHWGVEYRETPTDYQTQFGHAILDAGA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEEECCEEECCCCCCHHHHHHHHHHHCCC
DIIMGSHPHRLESVEKYKDKYIVYSMGDFAFGADPTLLSRMTSMFQLRFTKEDNKIVLKD
CEEECCCCHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHEEEEECCCCEEEEEE
ISIVPTYENSDGSTTENNYQPLPVFGDDAKKIVDELNRISKPIEGGVTEYTYFDPF
EEEEEEEECCCCCCCCCCCCCCCEECCHHHHHHHHHHHHCCCCCCCCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2536679; 10475962; 12004073 [H]