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The map label for this gene is ifcA [H]

Identifier: 226222982

GI number: 226222982

Start: 383947

End: 385467

Strand: Direct

Name: ifcA [H]

Synonym: Lm4b_00374

Alternate gene names: 226222982

Gene position: 383947-385467 (Clockwise)

Preceding gene: 226222980

Following gene: 226222983

Centisome position: 13.18

GC content: 39.25

Gene sequence:

>1521_bases
ATGAAAAAAAGGTTAGCTACAACTTTCATCATGCTACTATCGCTTGCATTAATTATCGCAGGTTGTGGCAGCAATAACAC
AAGCAAAAGTGACACGGAGAAAACAAAAGAAAAAGAAAAAACAGAAGTTACATCGGGAGCGTCAAAAACTAGCTACACAG
ATCCATCCGAATTAAAAGATAAATATGATATCGTTATTGTTGGTGCAGGTGGTGCAGGAATGTCCGCAGCACTAGAAGCA
AAAGCGAAAGGCATGAACCCAGTAATCCTTGAAAAAATGCCACTAGCAGGCGGAAACACAATGAAAGCCTCTTCTGGTAT
GAACGCCTCTGAAACTAAATTCCAAAAAGAAGAAGGAATTAATGATAGCAACGACAAATTTTACGAAGAAACATTAAAAG
GTGGTCACGGAACAAACGATAAAGCAATGCTTCGTTTTTTCGTAGACAATTCCGCCAGCGCCATTGACTGGTTGGATTCC
ATGGACATTAAATTAAACAACTTAACTATCACAGGCGGAATGAGCGAAAAACGTACGCACCGTCCTGAAGATGGCTCGGC
TGTTGGTAAATACTTAGTAGACGGTTTACTAAAAAATGTTCAAGAACAAAAAATCCCAGTTTTCGTTAACGCAGACGTAA
AAGAAATTACACAAAAAGACGGAAAAGTAACTGGCGTGAAAGTAAAATTAAACAATAAAGACGAAAAAACAATTAGTTCG
GATGCAGTAGTTGTCACAACTGGTGGCTACGGAGCTAATAAAGATATGATTGAAAAAGAACGTCCAGACTTAAAAGGATA
TGTAACAACGAACCAAGAAGGAAGTACTGGCGACGGTATTAAAATGATCGAAAAACTTGGTGGAACAACAGTAGACATGG
ATCAAATCCAAGTTCACCCAACTGTTCAACAAGATAAATCTTACCTTATCGGTGAAGCCGTTCGTGGTGAAGGTGCGATT
TTAGTTTCTCAAGAAGGTAAACGTTTCGGAAACGAATTAGACACACGCGATAACGTAACAGCTTCTATCAACAAATTACC
AGAAAAATCCGCGTACCTAGTATTTGATTCAGGCGTGAAAGACCGCGTCAAAGCTATCGCGCAATATGAAGAAATGGGCT
TTGTGGAAGAAGGTAAAACAATTGATGAATTAGCCGGCAAAATCAATGTACCAAAAGAAGAGCTAACTAAAACATTAGAT
ACTTGGAATGCAAGTGTGAAAAACAAAAAAGACGAAGCATTCGGCAGAACAACCGCAATGGATAATGATTTATCTAAAGC
ACCATATTACGCAATCAAAATCGGACCAGGAATTCATTACACAATGGGTGGCGTAAAAATCAATACAAATACAGAAGTTT
TAGACAAAGACGGTAAACCAATCACAGGCCTATTTGCTGCGGGAGAAGTAACTGGTGGCTTGCACGGGGAAAACCGTATT
GGCGGAAACTCTGTCGCTGAAATCATTATTTTCGGACGTCAAGCTGGCGACAAATCAGCAGAATTTGTAAAAGCACAATA
A

Upstream 100 bases:

>100_bases
TGATGACCTGTAAAGATATCTCAATTAGTGATATAATATGTTAATATAATCACAAACTATTGGTCTAGGGGAAAATTTTC
AAAAAAGTGGAGGTACGAAA

Downstream 100 bases:

>100_bases
GAACCCATACACCATAGTGATGTGATTAATAGAAAATAAAAACTTGTTAGGACGCCTTAAACAGACGTTTTAGCAAGTTT
TTTATTGGCTAAATAGCGCG

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: Fe(3+)-induced flavocytochrome C3; Ifc3; Iron(III)-induced flavocytochrome C3 [H]

Number of amino acids: Translated: 506; Mature: 506

Protein sequence:

>506_residues
MKKRLATTFIMLLSLALIIAGCGSNNTSKSDTEKTKEKEKTEVTSGASKTSYTDPSELKDKYDIVIVGAGGAGMSAALEA
KAKGMNPVILEKMPLAGGNTMKASSGMNASETKFQKEEGINDSNDKFYEETLKGGHGTNDKAMLRFFVDNSASAIDWLDS
MDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEQKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTISS
DAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQDKSYLIGEAVRGEGAI
LVSQEGKRFGNELDTRDNVTASINKLPEKSAYLVFDSGVKDRVKAIAQYEEMGFVEEGKTIDELAGKINVPKEELTKTLD
TWNASVKNKKDEAFGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGENRI
GGNSVAEIIIFGRQAGDKSAEFVKAQ

Sequences:

>Translated_506_residues
MKKRLATTFIMLLSLALIIAGCGSNNTSKSDTEKTKEKEKTEVTSGASKTSYTDPSELKDKYDIVIVGAGGAGMSAALEA
KAKGMNPVILEKMPLAGGNTMKASSGMNASETKFQKEEGINDSNDKFYEETLKGGHGTNDKAMLRFFVDNSASAIDWLDS
MDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEQKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTISS
DAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQDKSYLIGEAVRGEGAI
LVSQEGKRFGNELDTRDNVTASINKLPEKSAYLVFDSGVKDRVKAIAQYEEMGFVEEGKTIDELAGKINVPKEELTKTLD
TWNASVKNKKDEAFGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGENRI
GGNSVAEIIIFGRQAGDKSAEFVKAQ
>Mature_506_residues
MKKRLATTFIMLLSLALIIAGCGSNNTSKSDTEKTKEKEKTEVTSGASKTSYTDPSELKDKYDIVIVGAGGAGMSAALEA
KAKGMNPVILEKMPLAGGNTMKASSGMNASETKFQKEEGINDSNDKFYEETLKGGHGTNDKAMLRFFVDNSASAIDWLDS
MDIKLNNLTITGGMSEKRTHRPEDGSAVGKYLVDGLLKNVQEQKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTISS
DAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHPTVQQDKSYLIGEAVRGEGAI
LVSQEGKRFGNELDTRDNVTASINKLPEKSAYLVFDSGVKDRVKAIAQYEEMGFVEEGKTIDELAGKINVPKEELTKTLD
TWNASVKNKKDEAFGRTTAMDNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGENRI
GGNSVAEIIIFGRQAGDKSAEFVKAQ

Specific function: Catalyzes unidirectional fumarate reduction using artificial electron donors such as methyl viologen. The physiological reductant is unknown [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 cytochrome c domain [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=438, Percent_Identity=24.4292237442922, Blast_Score=103, Evalue=5e-22,
Organism=Escherichia coli, GI1788928, Length=459, Percent_Identity=28.1045751633987, Blast_Score=129, Evalue=5e-31,
Organism=Escherichia coli, GI1790597, Length=400, Percent_Identity=28.25, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1786942, Length=475, Percent_Identity=25.8947368421053, Blast_Score=89, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI71986328, Length=464, Percent_Identity=34.4827586206897, Blast_Score=255, Evalue=4e-68,
Organism=Caenorhabditis elegans, GI17505833, Length=438, Percent_Identity=25.5707762557078, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17550100, Length=436, Percent_Identity=25, Blast_Score=93, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6320788, Length=463, Percent_Identity=36.7170626349892, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6322511, Length=487, Percent_Identity=34.9075975359343, Blast_Score=239, Evalue=6e-64,
Organism=Saccharomyces cerevisiae, GI6322701, Length=475, Percent_Identity=25.6842105263158, Blast_Score=99, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6322416, Length=477, Percent_Identity=25.5765199161426, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI17137288, Length=501, Percent_Identity=26.1477045908184, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24655642, Length=501, Percent_Identity=26.1477045908184, Blast_Score=109, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24655647, Length=501, Percent_Identity=26.1477045908184, Blast_Score=109, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR013027
- InterPro:   IPR010960
- InterPro:   IPR011031 [H]

Pfam domain/function: PF00890 FAD_binding_2 [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 54499; Mature: 54499

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRLATTFIMLLSLALIIAGCGSNNTSKSDTEKTKEKEKTEVTSGASKTSYTDPSELKD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCC
KYDIVIVGAGGAGMSAALEAKAKGMNPVILEKMPLAGGNTMKASSGMNASETKFQKEEGI
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCC
NDSNDKFYEETLKGGHGTNDKAMLRFFVDNSASAIDWLDSMDIKLNNLTITGGMSEKRTH
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHCCCCEEEEEEEEECCCCHHHCC
RPEDGSAVGKYLVDGLLKNVQEQKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTISS
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEEECCCCCCEECC
DAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHP
CEEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCCEEECC
TVQQDKSYLIGEAVRGEGAILVSQEGKRFGNELDTRDNVTASINKLPEKSAYLVFDSGVK
CHHCCCCEEEHHEECCCCEEEECCCCHHCCCCCCCCCCCHHHHHCCCCCCEEEEEECCHH
DRVKAIAQYEEMGFVEEGKTIDELAGKINVPKEELTKTLDTWNASVKNKKDEAFGRTTAM
HHHHHHHHHHHCCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHCCCCHHHCCCHHCC
DNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGENRI
CCCCCCCCEEEEEECCCEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCCCC
GGNSVAEIIIFGRQAGDKSAEFVKAQ
CCCCEEEEEEEECCCCCCCCCCEECC
>Mature Secondary Structure
MKKRLATTFIMLLSLALIIAGCGSNNTSKSDTEKTKEKEKTEVTSGASKTSYTDPSELKD
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHCC
KYDIVIVGAGGAGMSAALEAKAKGMNPVILEKMPLAGGNTMKASSGMNASETKFQKEEGI
CCCEEEEECCCCCCHHHHHHHHCCCCCEEEEECCCCCCCCEECCCCCCHHHHHHHHHHCC
NDSNDKFYEETLKGGHGTNDKAMLRFFVDNSASAIDWLDSMDIKLNNLTITGGMSEKRTH
CCCCHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHCCCCEEEEEEEEECCCCHHHCC
RPEDGSAVGKYLVDGLLKNVQEQKIPVFVNADVKEITQKDGKVTGVKVKLNNKDEKTISS
CCCCCHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHCCCCEEEEEEEECCCCCCEECC
DAVVVTTGGYGANKDMIEKERPDLKGYVTTNQEGSTGDGIKMIEKLGGTTVDMDQIQVHP
CEEEEEECCCCCCCCHHHHCCCCCCEEEEECCCCCCCHHHHHHHHHCCCEEECCCEEECC
TVQQDKSYLIGEAVRGEGAILVSQEGKRFGNELDTRDNVTASINKLPEKSAYLVFDSGVK
CHHCCCCEEEHHEECCCCEEEECCCCHHCCCCCCCCCCCHHHHHCCCCCCEEEEEECCHH
DRVKAIAQYEEMGFVEEGKTIDELAGKINVPKEELTKTLDTWNASVKNKKDEAFGRTTAM
HHHHHHHHHHHCCCHHCCCCHHHHHCCCCCCHHHHHHHHHHHCCHHCCCCHHHCCCHHCC
DNDLSKAPYYAIKIGPGIHYTMGGVKINTNTEVLDKDGKPITGLFAAGEVTGGLHGENRI
CCCCCCCCEEEEEECCCEEEEECCEEECCCCCEECCCCCCEEEEEECCCCCCCCCCCCCC
GGNSVAEIIIFGRQAGDKSAEFVKAQ
CCCCEEEEEEEECCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10455032; 10581549 [H]