Click here to switch to the map view.

The map label for this gene is yycG [H]

Identifier: 226222924

GI number: 226222924

Start: 319580

End: 321412

Strand: Direct

Name: yycG [H]

Synonym: Lm4b_00316

Alternate gene names: 226222924

Gene position: 319580-321412 (Clockwise)

Preceding gene: 226222923

Following gene: 226222925

Centisome position: 10.97

GC content: 39.5

Gene sequence:

>1833_bases
ATGCATAAAATGAGATTTTTTCAGTCCGTACAATTTAAGTTAGTTATTATGTATTTGCTACTAATTATCGTTGCAATGCA
AGTAATCGGCGCGTATTTTGTACGTGAGCTGGAAGGGCAACTGGAGAAAAATTTTCAAGATTCTATTACGAATAGTATTA
CGCTTTTAGATTATAACGCTAGAGAAGAAATTATTAAAAATAGCGACAACTCCGTCAAGTTACAAAATGATATTAGAGAA
CTCTTAGTCGATTATTCTCGCGCAAGTAGCAATTTAATCGAAGTAAGAATTGTAGATGACAAAGGAAAAATTCTCGGCAC
ATCTAATTTAAATAACCAAGGAATTGTTGGACAAAAAAGCAACGATCCACTTGTAAAACGAACATTATCACTTGGAACGA
CTTCTGAGGACAAAATCTATAAAGACGAATCGAATAAAAATAACCGCGTTTGGGTGAACGTATCCTCCATCAAAAATAAA
GGCCAAGTGATAGGGGCTATTTATCTTGTCGCCGATATCGAAAGTGTCTATAAACAAGTTGATGATATTACAAACATTTT
CATCACAGGGACTTTGATTGCGATGATTATTACAGCCGTCCTTGGAATTCTATTATCAAGAACCATTACTAAACCAATTA
TCGAAATGAAACGTCAAGCTTATGCGATGGCTCGCGGCAACTATAGCCGCAAAGTTAAAGTATACGGTGTCGATGAAATT
GGTGAACTGGCTGATTCTTTTAATACACTAACAAAACGAGTCCAAGAAGCCCAAGCAATGACTGAAGGGGAGCGGCGCAA
GTTATCCTCTGTACTCGCATATATGACTGATGGCGTAATTGCAACAGACCGCCGCGGGAAAGTAATTCTCATTAATACGC
CAGCAGAAAAAATGCTTCGCGTGAAACATGAAAGTGCGAATGGGCGCTCGATTATTGATGTTTTAGACATCGGAGACACG
TACCAATTTGAAGATTTAATGGAAGTAGATGGGTCACTAACAATGGACCGTAGTACTCTCGACAAACCATACGTGCTTCG
TGCCAATTTCTCGGTCATTCAAAGGGAAACAGGCTTTAATAATGGGGTTATCGCGGTACTTCACGATATTACCGATCAAG
AAAAAGTCGACCAAGAACGTCGCGATTTCGTATCCAATGTATCACATGAACTAAGAACCCCACTTACCAGTATGCATAGC
TATTTAGAAGCATTAAGCGACGGCGCGTGGGAAGATAAAGAAATCGCTCCACGTTTCCTTGAAGTAACGCAAAATGAGAC
CGAACGAATGATTCGTCTCGTTAACGATCTCCTCAAACTTTCCAGAATGGATGGCGGCAGAGAACAACTCGAAAAAAGCT
TCGTGAACTTTACGGATTTCTTTAACCATATTATTGACCGTTTTGAAATGATGAAAAAAGAAACAATCATGTTCAAACGC
CATATTCCAAGAGAGCCAGTCATCATCGAAATTGATGAAGATAAAGTAATGCAAGTGCTTGATAATATTATTTCTAACGC
CAATAAATATTCACCGGATGGTGGCCGCATTTCCTTCTATCTGAAAAAATTTGAAGATGAAATTGAAGTAAGCATTGCCG
ATGAAGGTTTAGGCGTACCAGACGAGGATTTAGCAAATGTGTTCGACCGATTCTTCCGTGTAGACAAAGCACGCTCGCGA
GAAATGGGAGGAACAGGGTTAGGACTCGCTATTGCTCGAGAAGTTATCGAAGCACATGGTGGTCGAATTTGGGCCGAACG
TAATAAAACCAAAGGAACCATAATTAAATTTACCCTGCCATACAGTGACTTACCGGAGGATGATTGGGAATGA

Upstream 100 bases:

>100_bases
AAATAAATCGACCCAATTAACAGGAAAAACAATACGTCTACACCATAACATATGGTATACTAATTTAAATATATTACCCC
GAATAGGAGTAGAAAGACTT

Downstream 100 bases:

>100_bases
TGAAAAAAACAGGATTTCGCTCATTTATACTAACCATTTTAGTCGTACTCAGTATTGTCCTAAGCTACTTTATTTGGAAG
GGACAACCTGATTACGAAGC

Product: two-component sensor histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 610; Mature: 610

Protein sequence:

>610_residues
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNAREEIIKNSDNSVKLQNDIRE
LLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKSNDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNK
GQVIGAIYLVADIESVYKQVDDITNIFITGTLIAMIITAVLGILLSRTITKPIIEMKRQAYAMARGNYSRKVKVYGVDEI
GELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLRVKHESANGRSIIDVLDIGDT
YQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFNNGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHS
YLEALSDGAWEDKEIAPRFLEVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKR
HIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVPDEDLANVFDRFFRVDKARSR
EMGGTGLGLAIAREVIEAHGGRIWAERNKTKGTIIKFTLPYSDLPEDDWE

Sequences:

>Translated_610_residues
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNAREEIIKNSDNSVKLQNDIRE
LLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKSNDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNK
GQVIGAIYLVADIESVYKQVDDITNIFITGTLIAMIITAVLGILLSRTITKPIIEMKRQAYAMARGNYSRKVKVYGVDEI
GELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLRVKHESANGRSIIDVLDIGDT
YQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFNNGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHS
YLEALSDGAWEDKEIAPRFLEVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKR
HIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVPDEDLANVFDRFFRVDKARSR
EMGGTGLGLAIAREVIEAHGGRIWAERNKTKGTIIKFTLPYSDLPEDDWE
>Mature_610_residues
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNAREEIIKNSDNSVKLQNDIRE
LLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKSNDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNK
GQVIGAIYLVADIESVYKQVDDITNIFITGTLIAMIITAVLGILLSRTITKPIIEMKRQAYAMARGNYSRKVKVYGVDEI
GELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLRVKHESANGRSIIDVLDIGDT
YQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFNNGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHS
YLEALSDGAWEDKEIAPRFLEVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKR
HIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVPDEDLANVFDRFFRVDKARSR
EMGGTGLGLAIAREVIEAHGGRIWAERNKTKGTIIKFTLPYSDLPEDDWE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH and ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=365, Percent_Identity=27.1232876712329, Blast_Score=145, Evalue=8e-36,
Organism=Escherichia coli, GI1788393, Length=228, Percent_Identity=33.3333333333333, Blast_Score=135, Evalue=8e-33,
Organism=Escherichia coli, GI1790346, Length=247, Percent_Identity=33.1983805668016, Blast_Score=110, Evalue=2e-25,
Organism=Escherichia coli, GI1786783, Length=240, Percent_Identity=29.5833333333333, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=27.5862068965517, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1786912, Length=231, Percent_Identity=29.8701298701299, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI1788713, Length=233, Percent_Identity=27.0386266094421, Blast_Score=94, Evalue=4e-20,
Organism=Escherichia coli, GI48994928, Length=291, Percent_Identity=24.7422680412371, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1788549, Length=377, Percent_Identity=24.4031830238727, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1789149, Length=231, Percent_Identity=25.5411255411255, Blast_Score=86, Evalue=8e-18,
Organism=Escherichia coli, GI1790861, Length=215, Percent_Identity=25.5813953488372, Blast_Score=85, Evalue=2e-17,
Organism=Escherichia coli, GI1790551, Length=245, Percent_Identity=28.1632653061224, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=26.1603375527426, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1787894, Length=229, Percent_Identity=25.3275109170306, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1790436, Length=223, Percent_Identity=26.457399103139, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=26.7782426778243, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=241, Percent_Identity=27.8008298755187, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1789403, Length=206, Percent_Identity=27.6699029126214, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1787374, Length=229, Percent_Identity=25.764192139738, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR001610
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 69519; Mature: 69519

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
REEIIKNSDNSVKLQNDIRELLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKS
HHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCC
NDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNKGQVIGAIYLVADIESVYKQV
CCHHHHHHHHCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHH
DDITNIFITGTLIAMIITAVLGILLSRTITKPIIEMKRQAYAMARGNYSRKVKVYGVDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
GELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCHHHHHH
VKHESANGRSIIDVLDIGDTYQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFN
HHCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEECHHHCCCCEEEECCHHHHHHCCCCC
NGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHSYLEALSDGAWEDKEIAPRFL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHH
EVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVP
CCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEHEECCCCCEEEEECCCCCCCC
DEDLANVFDRFFRVDKARSREMGGTGLGLAIAREVIEAHGGRIWAERNKTKGTIIKFTLP
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECC
YSDLPEDDWE
CCCCCCCCCC
>Mature Secondary Structure
MHKMRFFQSVQFKLVIMYLLLIIVAMQVIGAYFVRELEGQLEKNFQDSITNSITLLDYNA
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCH
REEIIKNSDNSVKLQNDIRELLVDYSRASSNLIEVRIVDDKGKILGTSNLNNQGIVGQKS
HHHHHCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEEEECCCCCEEECCCCCCCCCCCCCC
NDPLVKRTLSLGTTSEDKIYKDESNKNNRVWVNVSSIKNKGQVIGAIYLVADIESVYKQV
CCHHHHHHHHCCCCCCCCEECCCCCCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHHHHH
DDITNIFITGTLIAMIITAVLGILLSRTITKPIIEMKRQAYAMARGNYSRKVKVYGVDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECHHH
GELADSFNTLTKRVQEAQAMTEGERRKLSSVLAYMTDGVIATDRRGKVILINTPAEKMLR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCEEEEECCHHHHHH
VKHESANGRSIIDVLDIGDTYQFEDLMEVDGSLTMDRSTLDKPYVLRANFSVIQRETGFN
HHCCCCCCCEEEEEEECCCCCCHHHHHHCCCCCEECHHHCCCCEEEECCHHHHHHCCCCC
NGVIAVLHDITDQEKVDQERRDFVSNVSHELRTPLTSMHSYLEALSDGAWEDKEIAPRFL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCHHHHHHHH
EVTQNETERMIRLVNDLLKLSRMDGGREQLEKSFVNFTDFFNHIIDRFEMMKKETIMFKR
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
HIPREPVIIEIDEDKVMQVLDNIISNANKYSPDGGRISFYLKKFEDEIEVSIADEGLGVP
CCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCEEEEHEECCCCCEEEEECCCCCCCC
DEDLANVFDRFFRVDKARSREMGGTGLGLAIAREVIEAHGGRIWAERNKTKGTIIKFTLP
CHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCEEEEEECC
YSDLPEDDWE
CCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9829949; 10878122; 11758928 [H]