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The map label for this gene is yycF [H]

Identifier: 226222923

GI number: 226222923

Start: 318682

End: 319395

Strand: Direct

Name: yycF [H]

Synonym: Lm4b_00315

Alternate gene names: 226222923

Gene position: 318682-319395 (Clockwise)

Preceding gene: 226222922

Following gene: 226222924

Centisome position: 10.94

GC content: 39.36

Gene sequence:

>714_bases
ATGGCAGAAAAGAAAATTCTTGTAGTAGATGACGAAAAACCGATTGCGGATATAGTTAAGTTTAATCTAAATAAAGAAGG
CTTTGATGTATATTGCGCCTATGATGGCGATGAAGCGTTAGAACTTGTAGAAGAAGTTCAGCCAGATTTAATTTTACTGG
ATATTATGCTTCCAGGTCGTGATGGTATTGAGGTATGTCGTGAAGTACGTAAAAAATATGATATGCCAATAATTATGGTA
ACAGCGAAAGATTCAGAGATTGACAAAGTTATCGGACTAGAACTTGGTGCAGATGACTACGTAACGAAACCATTTAGTAA
TCGCGAGTTAATTGCTCGAGTGAAAGCCAATTTGCGCCGTCACAGCCAAGTCAGCTCAAATGCAGCCGAGGAAGAAGAAA
ACAGCGAACTAGAAATTGGTTCTTTGATTATTCATCCGGATGCATATGTGGCTTCTAAACGTGGAGAAACAATCGAACTA
ACACATCGTGAATTCGAATTACTACATTATTTAGCAAAACATATGGGACAAGTCATGACACGTGAACATTTACTTCAAAC
CGTTTGGGGCTATGACTACTTCGGCGATGTTCGTACGGTGGATGTTACCGTTCGTCGTTTACGTGAGAAAATTGAAGATA
ACCCAAGTCACCCAGCATGGTTAGTAACTAGACGCGGAGTTGGCTATTATTTACGCAATCCAGAACAAGAATAA

Upstream 100 bases:

>100_bases
CCAGAATTTAAAATGTTTAGTGAGATTTTTACGCATTAAATAAAAAGTATCTGTCCCGGTTAAAGCCGGCGAAATCCAGG
AATGAGAGGACTGTAAAAAA

Downstream 100 bases:

>100_bases
ATAACAAGAAGTGGTCGCCGAAGTGAAAAAAATTCGGTGACCACTTTTTTTGGGTATTTTCGCTTACTTAGTTACTATTT
TTATAAATAAATCGACCCAA

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 237; Mature: 236

Protein sequence:

>237_residues
MAEKKILVVDDEKPIADIVKFNLNKEGFDVYCAYDGDEALELVEEVQPDLILLDIMLPGRDGIEVCREVRKKYDMPIIMV
TAKDSEIDKVIGLELGADDYVTKPFSNRELIARVKANLRRHSQVSSNAAEEEENSELEIGSLIIHPDAYVASKRGETIEL
THREFELLHYLAKHMGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPAWLVTRRGVGYYLRNPEQE

Sequences:

>Translated_237_residues
MAEKKILVVDDEKPIADIVKFNLNKEGFDVYCAYDGDEALELVEEVQPDLILLDIMLPGRDGIEVCREVRKKYDMPIIMV
TAKDSEIDKVIGLELGADDYVTKPFSNRELIARVKANLRRHSQVSSNAAEEEENSELEIGSLIIHPDAYVASKRGETIEL
THREFELLHYLAKHMGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPAWLVTRRGVGYYLRNPEQE
>Mature_236_residues
AEKKILVVDDEKPIADIVKFNLNKEGFDVYCAYDGDEALELVEEVQPDLILLDIMLPGRDGIEVCREVRKKYDMPIIMVT
AKDSEIDKVIGLELGADDYVTKPFSNRELIARVKANLRRHSQVSSNAAEEEENSELEIGSLIIHPDAYVASKRGETIELT
HREFELLHYLAKHMGQVMTREHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPAWLVTRRGVGYYLRNPEQE

Specific function: Member of the two-component regulatory system YycG/YycF involved in the regulation of the ftsAZ operon, the yocH, ykvT, cwlO, lytE, ydjM, yjeA, yoeB genes and the tagAB and tagDEF operons. Probably phosphorylates YycF. Binds to the ftsAZ P1 promoter seque

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=43.5344827586207, Blast_Score=178, Evalue=3e-46,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=43.2314410480349, Blast_Score=172, Evalue=1e-44,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=37.6106194690265, Blast_Score=164, Evalue=3e-42,
Organism=Escherichia coli, GI1788394, Length=226, Percent_Identity=40.7079646017699, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI87082012, Length=225, Percent_Identity=38.6666666666667, Blast_Score=155, Evalue=2e-39,
Organism=Escherichia coli, GI1786784, Length=234, Percent_Identity=37.6068376068376, Blast_Score=148, Evalue=3e-37,
Organism=Escherichia coli, GI1790863, Length=237, Percent_Identity=35.0210970464135, Blast_Score=147, Evalue=9e-37,
Organism=Escherichia coli, GI145693140, Length=228, Percent_Identity=37.280701754386, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1790860, Length=239, Percent_Identity=35.5648535564854, Blast_Score=137, Evalue=5e-34,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.3612334801762, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=34.8017621145374, Blast_Score=131, Evalue=4e-32,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=33.7719298245614, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=32.618025751073, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1787375, Length=227, Percent_Identity=31.7180616740088, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788550, Length=122, Percent_Identity=36.8852459016393, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1790299, Length=116, Percent_Identity=31.8965517241379, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787487, Length=133, Percent_Identity=27.8195488721804, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27286; Mature: 27155

Theoretical pI: Translated: 4.70; Mature: 4.70

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEKKILVVDDEKPIADIVKFNLNKEGFDVYCAYDGDEALELVEEVQPDLILLDIMLPGR
CCCCEEEEEECCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEECCC
DGIEVCREVRKKYDMPIIMVTAKDSEIDKVIGLELGADDYVTKPFSNRELIARVKANLRR
CHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HSQVSSNAAEEEENSELEIGSLIIHPDAYVASKRGETIELTHREFELLHYLAKHMGQVMT
HHHHHCCCCCCCCCCCEEEEEEEECCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
REHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPAWLVTRRGVGYYLRNPEQE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCC
>Mature Secondary Structure 
AEKKILVVDDEKPIADIVKFNLNKEGFDVYCAYDGDEALELVEEVQPDLILLDIMLPGR
CCCEEEEEECCCCHHHHHHHCCCCCCCEEEEEECCHHHHHHHHHCCCCEEEEEEEECCC
DGIEVCREVRKKYDMPIIMVTAKDSEIDKVIGLELGADDYVTKPFSNRELIARVKANLRR
CHHHHHHHHHHHCCCCEEEEEECCCCHHHHEEEEECCCCCCCCCCCCHHHHHHHHHHHHH
HSQVSSNAAEEEENSELEIGSLIIHPDAYVASKRGETIELTHREFELLHYLAKHMGQVMT
HHHHHCCCCCCCCCCCEEEEEEEECCCHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
REHLLQTVWGYDYFGDVRTVDVTVRRLREKIEDNPSHPAWLVTRRGVGYYLRNPEQE
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7584024; 9384377; 9829949; 10878122 [H]