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The map label for this gene is malL [H]

Identifier: 226222886

GI number: 226222886

Start: 270957

End: 272654

Strand: Direct

Name: malL [H]

Synonym: Lm4b_00278

Alternate gene names: 226222886

Gene position: 270957-272654 (Clockwise)

Preceding gene: 226222885

Following gene: 226222887

Centisome position: 9.3

GC content: 37.04

Gene sequence:

>1698_bases
GTGGAAATAACAGAAACGAAAGAATGGTGGAAAGAATCGGTAGTGTACCAAATCTATCCGCGTAGTTTTCAAGATTCAAA
TGGGGATGGTATTGGAGATATTAGAGGAATTATAGAACGACTTCCTTATTTGAAAGATTTAGGTATTAATGTGATTTGGC
TTTGTCCTGTCTATAAATCACCTATGGATGATGGTGGTTATGACATTTCTGATTACTATGAGATTGATCCAATGTTTGGA
ACGATGAGTGATATGGATGAATTAATTGAGAAGGCAGAAAAATTAGGAATAAAAATATTGATGGATTTGGTGGTAAACCA
TACATCTGATGAACATGAATGGTTTGAAAAAGCAATAGCTGACCCAAAAAGTAAATATCGAGATTATTATATTTTCCGAG
AGGGTGTAAATGGAAACCCGCCTAATAATTGGCGTTCTTATTTTGGAGGATCTGCGTGGGAAGCCGTACCAGGTGAGGAA
AACATGTTTTACCTACATGCTTTTTCTAAAAAACAGCCAGATTTAAACTGGGAAAACATTGTAGTGCGTAATGAATGTAT
CCAAATGATTAACTGGTGGCTTGAAAAAGGTTTAGGTGGCTTTAGAATTGATGCCATTTTAAATTTGAAGAAAAGAATTG
AGTACGGTACTTTCCCAGCGGACGGGGAAGATGGCTTGGTTTTCATCGGTCATTGGATTTTAAATCAGCCGGGAATTGAA
GAGTGGCTCAAGGAGATTGACGAACGGACATTTAAAAAACATAATGCATTTACTGTGGCTGAGGCGGATGTGCCTGAAGA
AAGACTTTCTGAATTTATAGGTGAAAATGGTCATTTCCGTATGGTGTTTGATTTTAGCTATACAGATATTGATACTCCTG
AAACAGGCGAATGGTTCAAGAATTCAGAATGGACAGTAAAAGAATTAAAAGAGAAAATAATTACCAATGAACTGGTGACA
CAGCGAAATGGTTGGGGGGCAAAATACTTAGAAAATCATGATCAACCGCGTTCGATAAATAAGTATTTACCTCAAGAATA
CCAAGATGATCGTAGCAAAAAAATGCTAGGCACGTTATTTATGATGTTGCACGGTACGCCGTTCATTTATCAAGGACAAG
AGATTGGTATGAGTAATACTCGGATGGAAAGTATAGATGATTATAACGATATTGCGACGCACGATCAATACCATCGCGCA
ATTCTCTCTGGAATGAGTCCGGAAGAAGCGCTTGAAGGAATGTATCGGCGTAGTAGGGATAATTCAAGAACACCGATGCA
ATGGAATAATCAAAAGAACGCTGGTTTTTCCGACTCAGATGAAATTTGGTTGAAAGCAAACCCTAATTACCTTGATATTA
ACGTAGAGCAGGAACAAATCGATGATAATTCCGTATTGAATTTTTATAAGAAATTAATCCATTTAAGAAGTGATTCTAGT
AAATATAAAGAAGTGGCTGTTTATGGAGAATTACTGCCAGTAGAATCAAGTGATGAAGTTATTGCTTACAAACGTAAAAC
AGATGACGCTGAGCTCTTAATCATCGTGAATTTTTCTGATTCTGAAAATCAATTATGCATTGAAGGTACTTATGAACAGG
TACTTGCTAATGTAGCGTTGCCAGAAATGGTAGAAAATGTCCTTGAAATACCTGCATATACAGGTGCCGTCTTCTCAAGG
GTTTTGGAGGTAGACTGA

Upstream 100 bases:

>100_bases
TGATTGCGGTACCAATTACAATACTGTTTATTTATTTGCAAAAATATTATGTTGAAGGCATTACAAGTGGTGCTGTTAAA
GGATAGGAGATAGATTAATA

Downstream 100 bases:

>100_bases
TTGCAAATTAAAAATAAAGCTATGTTAATTACTTATTCTGATAGTTTAGGGAAAAATATGGAAGAATTATCCAAGGTGAT
GGAAACTTATTTTGAAGATG

Product: exo-alpha-1,4-glucosidase

Products: NA

Alternate protein names: Dextrin 6-alpha-D-glucanohydrolase; Oligosaccharide alpha-1,6-glucosidase; Sucrase-isomaltase; Isomaltase [H]

Number of amino acids: Translated: 565; Mature: 565

Protein sequence:

>565_residues
MEITETKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLKDLGINVIWLCPVYKSPMDDGGYDISDYYEIDPMFG
TMSDMDELIEKAEKLGIKILMDLVVNHTSDEHEWFEKAIADPKSKYRDYYIFREGVNGNPPNNWRSYFGGSAWEAVPGEE
NMFYLHAFSKKQPDLNWENIVVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGTFPADGEDGLVFIGHWILNQPGIE
EWLKEIDERTFKKHNAFTVAEADVPEERLSEFIGENGHFRMVFDFSYTDIDTPETGEWFKNSEWTVKELKEKIITNELVT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLGTLFMMLHGTPFIYQGQEIGMSNTRMESIDDYNDIATHDQYHRA
ILSGMSPEEALEGMYRRSRDNSRTPMQWNNQKNAGFSDSDEIWLKANPNYLDINVEQEQIDDNSVLNFYKKLIHLRSDSS
KYKEVAVYGELLPVESSDEVIAYKRKTDDAELLIIVNFSDSENQLCIEGTYEQVLANVALPEMVENVLEIPAYTGAVFSR
VLEVD

Sequences:

>Translated_565_residues
MEITETKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLKDLGINVIWLCPVYKSPMDDGGYDISDYYEIDPMFG
TMSDMDELIEKAEKLGIKILMDLVVNHTSDEHEWFEKAIADPKSKYRDYYIFREGVNGNPPNNWRSYFGGSAWEAVPGEE
NMFYLHAFSKKQPDLNWENIVVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGTFPADGEDGLVFIGHWILNQPGIE
EWLKEIDERTFKKHNAFTVAEADVPEERLSEFIGENGHFRMVFDFSYTDIDTPETGEWFKNSEWTVKELKEKIITNELVT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLGTLFMMLHGTPFIYQGQEIGMSNTRMESIDDYNDIATHDQYHRA
ILSGMSPEEALEGMYRRSRDNSRTPMQWNNQKNAGFSDSDEIWLKANPNYLDINVEQEQIDDNSVLNFYKKLIHLRSDSS
KYKEVAVYGELLPVESSDEVIAYKRKTDDAELLIIVNFSDSENQLCIEGTYEQVLANVALPEMVENVLEIPAYTGAVFSR
VLEVD
>Mature_565_residues
MEITETKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLKDLGINVIWLCPVYKSPMDDGGYDISDYYEIDPMFG
TMSDMDELIEKAEKLGIKILMDLVVNHTSDEHEWFEKAIADPKSKYRDYYIFREGVNGNPPNNWRSYFGGSAWEAVPGEE
NMFYLHAFSKKQPDLNWENIVVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGTFPADGEDGLVFIGHWILNQPGIE
EWLKEIDERTFKKHNAFTVAEADVPEERLSEFIGENGHFRMVFDFSYTDIDTPETGEWFKNSEWTVKELKEKIITNELVT
QRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLGTLFMMLHGTPFIYQGQEIGMSNTRMESIDDYNDIATHDQYHRA
ILSGMSPEEALEGMYRRSRDNSRTPMQWNNQKNAGFSDSDEIWLKANPNYLDINVEQEQIDDNSVLNFYKKLIHLRSDSS
KYKEVAVYGELLPVESSDEVIAYKRKTDDAELLIIVNFSDSENQLCIEGTYEQVLANVALPEMVENVLEIPAYTGAVFSR
VLEVD

Specific function: Unknown

COG id: COG0366

COG function: function code G; Glycosidases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyl hydrolase 13 family [H]

Homologues:

Organism=Homo sapiens, GI187423904, Length=203, Percent_Identity=43.3497536945813, Blast_Score=186, Evalue=4e-47,
Organism=Homo sapiens, GI61744475, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744477, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI65506891, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744481, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744479, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI61744483, Length=135, Percent_Identity=31.8518518518519, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790687, Length=523, Percent_Identity=38.8145315487572, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1786604, Length=132, Percent_Identity=36.3636363636364, Blast_Score=92, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI32565753, Length=536, Percent_Identity=23.6940298507463, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI25147709, Length=212, Percent_Identity=31.6037735849057, Blast_Score=93, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6321731, Length=546, Percent_Identity=37.3626373626374, Blast_Score=322, Evalue=8e-89,
Organism=Saccharomyces cerevisiae, GI6319776, Length=544, Percent_Identity=37.3161764705882, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6322245, Length=572, Percent_Identity=35.3146853146853, Blast_Score=316, Evalue=6e-87,
Organism=Saccharomyces cerevisiae, GI6321726, Length=596, Percent_Identity=35.9060402684564, Blast_Score=309, Evalue=8e-85,
Organism=Saccharomyces cerevisiae, GI6322241, Length=588, Percent_Identity=36.0544217687075, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6322021, Length=588, Percent_Identity=36.0544217687075, Blast_Score=300, Evalue=4e-82,
Organism=Saccharomyces cerevisiae, GI6324416, Length=593, Percent_Identity=36.0876897133221, Blast_Score=298, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24583745, Length=555, Percent_Identity=35.6756756756757, Blast_Score=298, Evalue=6e-81,
Organism=Drosophila melanogaster, GI24583747, Length=548, Percent_Identity=35.036496350365, Blast_Score=295, Evalue=8e-80,
Organism=Drosophila melanogaster, GI24583749, Length=548, Percent_Identity=35.036496350365, Blast_Score=294, Evalue=9e-80,
Organism=Drosophila melanogaster, GI24586593, Length=537, Percent_Identity=36.8715083798883, Blast_Score=290, Evalue=1e-78,
Organism=Drosophila melanogaster, GI24586599, Length=538, Percent_Identity=34.2007434944238, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24586587, Length=573, Percent_Identity=34.0314136125654, Blast_Score=280, Evalue=3e-75,
Organism=Drosophila melanogaster, GI221330053, Length=545, Percent_Identity=33.9449541284404, Blast_Score=278, Evalue=7e-75,
Organism=Drosophila melanogaster, GI45549022, Length=557, Percent_Identity=33.3931777378815, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24586591, Length=573, Percent_Identity=32.6352530541012, Blast_Score=266, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24586589, Length=552, Percent_Identity=33.1521739130435, Blast_Score=265, Evalue=9e-71,
Organism=Drosophila melanogaster, GI24586597, Length=537, Percent_Identity=32.9608938547486, Blast_Score=261, Evalue=1e-69,
Organism=Drosophila melanogaster, GI281360393, Length=482, Percent_Identity=34.0248962655602, Blast_Score=208, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013780
- InterPro:   IPR006047
- InterPro:   IPR006589
- InterPro:   IPR017853
- InterPro:   IPR013781 [H]

Pfam domain/function: PF00128 Alpha-amylase [H]

EC number: =3.2.1.10 [H]

Molecular weight: Translated: 65729; Mature: 65729

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEITETKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLKDLGINVIWLCPVYKS
CCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCC
PMDDGGYDISDYYEIDPMFGTMSDMDELIEKAEKLGIKILMDLVVNHTSDEHEWFEKAIA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DPKSKYRDYYIFREGVNGNPPNNWRSYFGGSAWEAVPGEENMFYLHAFSKKQPDLNWENI
CHHHHHCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHE
VVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGTFPADGEDGLVFIGHWILNQPGIE
EEHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCCCHH
EWLKEIDERTFKKHNAFTVAEADVPEERLSEFIGENGHFRMVFDFSYTDIDTPETGEWFK
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCC
NSEWTVKELKEKIITNELVTQRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLGTLF
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
MMLHGTPFIYQGQEIGMSNTRMESIDDYNDIATHDQYHRAILSGMSPEEALEGMYRRSRD
HHHCCCCEEECCCCCCCCCCHHHHCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCC
NSRTPMQWNNQKNAGFSDSDEIWLKANPNYLDINVEQEQIDDNSVLNFYKKLIHLRSDSS
CCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECHHHHCCCHHHHHHHHHHHHHCCCCH
KYKEVAVYGELLPVESSDEVIAYKRKTDDAELLIIVNFSDSENQLCIEGTYEQVLANVAL
HHHHEEEEHEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHH
PEMVENVLEIPAYTGAVFSRVLEVD
HHHHHHHHHCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEITETKEWWKESVVYQIYPRSFQDSNGDGIGDIRGIIERLPYLKDLGINVIWLCPVYKS
CCCCCHHHHHHHCCEEEECCCCCCCCCCCCCHHHHHHHHHCCHHHHCCCCEEEEECCCCC
PMDDGGYDISDYYEIDPMFGTMSDMDELIEKAEKLGIKILMDLVVNHTSDEHEWFEKAIA
CCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHC
DPKSKYRDYYIFREGVNGNPPNNWRSYFGGSAWEAVPGEENMFYLHAFSKKQPDLNWENI
CHHHHHCCEEEEECCCCCCCCCHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCHHHE
VVRNECIQMINWWLEKGLGGFRIDAILNLKKRIEYGTFPADGEDGLVFIGHWILNQPGIE
EEHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCEEEEEEHHCCCCCHH
EWLKEIDERTFKKHNAFTVAEADVPEERLSEFIGENGHFRMVFDFSYTDIDTPETGEWFK
HHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCC
NSEWTVKELKEKIITNELVTQRNGWGAKYLENHDQPRSINKYLPQEYQDDRSKKMLGTLF
CCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCHHHHHCCHHHHHHHHHHHHHHHH
MMLHGTPFIYQGQEIGMSNTRMESIDDYNDIATHDQYHRAILSGMSPEEALEGMYRRSRD
HHHCCCCEEECCCCCCCCCCHHHHCCCHHHHHCCHHHHHHHHCCCCHHHHHHHHHHHCCC
NSRTPMQWNNQKNAGFSDSDEIWLKANPNYLDINVEQEQIDDNSVLNFYKKLIHLRSDSS
CCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECHHHHCCCHHHHHHHHHHHHHCCCCH
KYKEVAVYGELLPVESSDEVIAYKRKTDDAELLIIVNFSDSENQLCIEGTYEQVLANVAL
HHHHEEEEHEEECCCCCCCEEEEEECCCCCEEEEEEEECCCCCCEEEECCHHHHHHHHHH
PEMVENVLEIPAYTGAVFSRVLEVD
HHHHHHHHHCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1761534 [H]