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The map label for this gene is yiaY [H]

Identifier: 225861975

GI number: 225861975

Start: 2020996

End: 2022147

Strand: Reverse

Name: yiaY [H]

Synonym: SPT_2170

Alternate gene names: 225861975

Gene position: 2022147-2020996 (Counterclockwise)

Preceding gene: 225861976

Following gene: 225861974

Centisome position: 95.74

GC content: 41.23

Gene sequence:

>1152_bases
ATGGCTACATTTTATGTTCCGGCAGTCAACCTTATTGGTAAAGGTGTTGTAAATGAAGTGGGTCCTTATATCAAGGAACT
TGGCTATAAAAAGGCACTTTTGGTGACAGATAAGTACATCGAAGGCAGTGACATTTTACCTAAGGTTTTAAAACCACTGG
ATACAGAAGGAATCGAATATGTCATCTTTAGCGATGTAGAGCCAAACCCTACTTGTAAGAATGTCACAGATGGGGTAGCT
GCTTTGCAAGAACATGGATGTGATTTTATCATCAGTCTTGGTGGGGGTTCTCCACAGGATGCAGCTAGTTGTATTTCTAT
CATGGCTACAAATGGTGGAAAACCACAGGATTATGAAGGGCTTCATAAGTCTGCTAAAAAAGGCTTGCCAGTTGTGGCTA
TCAATACAACGGCAGGAACTTCTGCAGAAATCACTATTAACTATGTGATTACTGATGAAGAACGCAAGGTTAAGATGGTA
ATGGTTGACAAGAATAGCCTTGCTCTTATCTCTGTTAATGACCCGGAACTCATGCTTTCCAAACCTAAAGGCCTGACTGC
TGCTACTGGTATGGATGCTCTGACTCACGCTGTTGAAGCTTTGGTAACACCTGGTGCTTATGATGTAACCAAGAAACTGT
CTATTGGTGCTATTGAGCTTATCAAGGAATATCTTCCTCGTGCTGTAGAAAATGGATACGATATTGAAGCGCGTGAAGGT
ATGGTCAATGCCATCTTCCTTGGTGGTATGAGCTTTAATAATGCTGGTCTTGGTTATGTTCACTCAATGGCTCACCAACT
CGGTGCAGTATATAATTTGCCACATGGTGTTTGCTGTGCCATGTTGCTACCAGTTATAGAACGTGAAAATGCTAAACGTG
TACCAGAAGCTTTCCGCAATGTTGCCAAAGCCTTGGGCCTTCATGTGGAAGGTAAATCAGATCAAGAGTGTGCCGATTAT
GCGATTGCTGAGATTGAGAAGCTTTCTGAGACAGTAGGTATTCCTAAGAAATTGACTGAACTTGGTATTGAAGAAAAAGA
TTTCGACTTTGAATACCTTTCTAAGAATGCCTTGATTGATGCCTGCGCACCAGGAAATCCATTTATGCCAACCTTAGAAG
AAACGATTGCCTTTTATAAAGAGTTATTTTAG

Upstream 100 bases:

>100_bases
AAAAAGATTTGTTAAACAATTCACAAATAATTGAAAACGAATACAAAAACTAATATAATGATGTTAAATAGATAGCGCGG
AGGCGCAGGAGGAAAATTAT

Downstream 100 bases:

>100_bases
CAAGAGATTAGACGACAATAGGACAATTCACCTCTAATTATTGACATTTCAGGAAAAATCGCAGTAAAAACGGCACAGCC
TTCTTTAAATGTGCTATAAT

Product: NAD-dependent methanol dehydrogenase (medh)

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVA
ALQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
MVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGYDIEAREG
MVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADY
AIAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF

Sequences:

>Translated_383_residues
MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVA
ALQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMV
MVDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGYDIEAREG
MVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADY
AIAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF
>Mature_382_residues
ATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKVLKPLDTEGIEYVIFSDVEPNPTCKNVTDGVAA
LQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEGLHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMVM
VDKNSLALISVNDPELMLSKPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGYDIEAREGM
VNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRNVAKALGLHVEGKSDQECADYA
IAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALIDACAPGNPFMPTLEETIAFYKELF

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=378, Percent_Identity=25.3968253968254, Blast_Score=97, Evalue=2e-20,
Organism=Escherichia coli, GI48994951, Length=379, Percent_Identity=48.0211081794195, Blast_Score=358, Evalue=1e-100,
Organism=Escherichia coli, GI1789163, Length=375, Percent_Identity=41.6, Blast_Score=289, Evalue=2e-79,
Organism=Escherichia coli, GI87082107, Length=377, Percent_Identity=35.5437665782493, Blast_Score=214, Evalue=1e-56,
Organism=Escherichia coli, GI1787493, Length=379, Percent_Identity=32.7176781002639, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789386, Length=358, Percent_Identity=24.3016759776536, Blast_Score=91, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17537053, Length=381, Percent_Identity=26.246719160105, Blast_Score=115, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6321181, Length=380, Percent_Identity=42.3684210526316, Blast_Score=310, Evalue=4e-85,
Organism=Drosophila melanogaster, GI24657991, Length=375, Percent_Identity=24.8, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 41237; Mature: 41106

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKVLKPLDTEGIEY
CCEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEE
VIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEG
EEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHH
LHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMVMVDKNSLALISVNDPELMLS
HHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCCEEEE
KPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGYDIEAREG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCC
MVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRN
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
VAKALGLHVEGKSDQECADYAIAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALID
HHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHCCCCEEE
ACAPGNPFMPTLEETIAFYKELF
ECCCCCCCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
ATFYVPAVNLIGKGVVNEVGPYIKELGYKKALLVTDKYIEGSDILPKVLKPLDTEGIEY
CEEEECHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCCCCCEEE
VIFSDVEPNPTCKNVTDGVAALQEHGCDFIISLGGGSPQDAASCISIMATNGGKPQDYEG
EEEECCCCCCCCCCHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHCCCCCCCCCHHH
LHKSAKKGLPVVAINTTAGTSAEITINYVITDEERKVKMVMVDKNSLALISVNDPELMLS
HHHHHHCCCCEEEEECCCCCCEEEEEEEEEECCCCEEEEEEEECCCEEEEEECCCCEEEE
KPKGLTAATGMDALTHAVEALVTPGAYDVTKKLSIGAIELIKEYLPRAVENGYDIEAREG
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHCC
MVNAIFLGGMSFNNAGLGYVHSMAHQLGAVYNLPHGVCCAMLLPVIERENAKRVPEAFRN
CEEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
VAKALGLHVEGKSDQECADYAIAEIEKLSETVGIPKKLTELGIEEKDFDFEYLSKNALID
HHHHHCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCHHHHCCCCEEE
ACAPGNPFMPTLEETIAFYKELF
ECCCCCCCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8041620; 9278503; 7768815 [H]