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The map label for this gene is dxs [C]

Identifier: 225861946

GI number: 225861946

Start: 1988843

End: 1989775

Strand: Reverse

Name: dxs [C]

Synonym: SPT_2139

Alternate gene names: 225861946

Gene position: 1989775-1988843 (Counterclockwise)

Preceding gene: 225861947

Following gene: 225861945

Centisome position: 94.21

GC content: 35.37

Gene sequence:

>933_bases
ATGATGAGAAGTACGAAAGAATTACGGCATGTATATAGAGACTTCCTTTTAGAGGCTAATCAAAGTTCTTCTGATATAGT
AGTCTTAGAAGCCGATTTGTCAAGTTCGATGGCTACTCATAATCTTGAAAAGGACTTTGGAGACCGTTATGTGAATGTTG
GGATTATGGAAGCAGAAATGGTCGGCCTTGCAGCAGGCTTGTCTATTCAGGGGTTTAGACCTTATCTTCATACATTTGGT
CCTTTTTCTTCACGAAGGGTATTTGATCAATTATTTATTTCTCTTGGATACGCACAATTGGATGCCACTGTGATTGGATC
AGATGCAGGAGTAACTGCAGAAATGAATGGTGGGACACATATGCCATTTGAAGAAATTGGATTGTTACGTTTAATTCCTA
AATCGATCATTTTTGAAGCAACTGATGATATCCAATTTCGTGAAATATTGAACCAGACATTAGACTTAAAAGGACTAAAA
TATATTCGAACAATTAGAAAAGCTCCAGTTCCTGTGTATCAAGGTGGAGAAGATTTTTCTAAAGGCTACATTGAGTTAAG
ACATGGTGAAGATCTTGTAATCGTTGCTTCTGGTATAATGGTTGCTCCAAGTATTCGAGTTGCAGATGAACTGTCTAAAT
TAGGTTATTCAGTAGGTGTGATAGATTTATTTAGAATCAAACCGATACCAGAACAGATAAAAACAATGTTAAGTGGAAAA
ACTATATTTACTGTAGAAAACCACAATCAGATAGGTGGAATTGGCAGTTCTTTATGTGAATTATTCTCTGATGATGGAAT
AACAAAAATTCATCGGATGGGTGTTCAAGAAAGATTTGGTCAAGTAGGGAAAATGGATTATCTTCTTAATGAGTATGGTT
TGAGTGAATCGAATATAAAAGAGAAGGTTCTAGAAATTTATAATGCAAGATAG

Upstream 100 bases:

>100_bases
AAGAAATGAAATCCAATCATCATCTTCGCCCTACTGTAGAGGAGAAACAAATGTTAACTTCAGTTGTAGAAAGATTAAGT
CAGGAATTGGAGGAAACAGA

Downstream 100 bases:

>100_bases
ATGTTAAATACACTTATCTGAAAGAATTTCTGTAAAAATTACATTACGTTATTTAAAAAAAGCGGATTAAAAAGCATATT
CTGGTCATCAGAAAGTGCAC

Product: transketolase, C- subunit

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEKDFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFG
PFSSRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVGVIDLFRIKPIPEQIKTMLSGK
TIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR

Sequences:

>Translated_310_residues
MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEKDFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFG
PFSSRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVGVIDLFRIKPIPEQIKTMLSGK
TIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR
>Mature_310_residues
MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEKDFGDRYVNVGIMEAEMVGLAAGLSIQGFRPYLHTFG
PFSSRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTHMPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLK
YIRTIRKAPVPVYQGGEDFSKGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVGVIDLFRIKPIPEQIKTMLSGK
TIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQERFGQVGKMDYLLNEYGLSESNIKEKVLEIYNAR

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI225637461, Length=287, Percent_Identity=32.7526132404181, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI225637459, Length=287, Percent_Identity=32.7526132404181, Blast_Score=139, Evalue=2e-33,
Organism=Homo sapiens, GI225637463, Length=287, Percent_Identity=32.7526132404181, Blast_Score=139, Evalue=3e-33,
Organism=Homo sapiens, GI133778974, Length=290, Percent_Identity=28.2758620689655, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI205277463, Length=303, Percent_Identity=27.3927392739274, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI4507521, Length=303, Percent_Identity=27.3927392739274, Blast_Score=116, Evalue=3e-26,
Organism=Escherichia coli, GI1786622, Length=300, Percent_Identity=24.3333333333333, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI17539652, Length=298, Percent_Identity=27.8523489932886, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24645119, Length=305, Percent_Identity=25.5737704918033, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45551847, Length=305, Percent_Identity=25.5737704918033, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI45550715, Length=305, Percent_Identity=25.5737704918033, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24666278, Length=305, Percent_Identity=22.6229508196721, Blast_Score=91, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 34525; Mature: 34525

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEKDFGDRYVNVGIMEAEM
CCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEHHHH
VGLAAGLSIQGFRPYLHTFGPFSSRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTH
HHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCHHHCCEEEEECCCCEEEECCCCCC
MPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLKYIRTIRKAPVPVYQGGEDFS
CCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
KGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVGVIDLFRIKPIPEQIKTMLSGK
CCEEEEECCCCEEEEECCEEECCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCC
TIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQERFGQVGKMDYLLNEYGLSESNIK
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHCCCCHHHHHHHHHCCCCCHHH
EKVLEIYNAR
HHHHHHHCCC
>Mature Secondary Structure
MMRSTKELRHVYRDFLLEANQSSSDIVVLEADLSSSMATHNLEKDFGDRYVNVGIMEAEM
CCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCEEEEEEEHHHH
VGLAAGLSIQGFRPYLHTFGPFSSRRVFDQLFISLGYAQLDATVIGSDAGVTAEMNGGTH
HHHHCCCCCCCCCHHHHHCCCCHHHHHHHHHHHHHCHHHCCEEEEECCCCEEEECCCCCC
MPFEEIGLLRLIPKSIIFEATDDIQFREILNQTLDLKGLKYIRTIRKAPVPVYQGGEDFS
CCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCCCCCC
KGYIELRHGEDLVIVASGIMVAPSIRVADELSKLGYSVGVIDLFRIKPIPEQIKTMLSGK
CCEEEEECCCCEEEEECCEEECCCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHCCC
TIFTVENHNQIGGIGSSLCELFSDDGITKIHRMGVQERFGQVGKMDYLLNEYGLSESNIK
EEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHCHHHHHCCCCHHHHHHHHHCCCCCHHH
EKVLEIYNAR
HHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]