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The map label for this gene is lpxK [H]

Identifier: 225686069

GI number: 225686069

Start: 201882

End: 202907

Strand: Direct

Name: lpxK [H]

Synonym: BMEA_B0216

Alternate gene names: 225686069

Gene position: 201882-202907 (Clockwise)

Preceding gene: 225686068

Following gene: 225686074

Centisome position: 17.03

GC content: 62.28

Gene sequence:

>1026_bases
ATGGCAAGCGAGGCGCCGCCTTTCTGGTGGGACGAACCTGATTGGCGCGCCCTTGCGCTGGCGCCAGCCGCCTGGATTTA
CGGAAGGGTTTCCGGTCGCCGCCTCATCAGGGCCGTGCCGCCCAGGGTTTCCCTGCCCGTTCTGTGCGTTGGCAATTTTA
CGGTTGGCGGCGCGGGCAAGACGCCCACGGCCATCGCTTTTGCCAGAGGGGCGATTGCGCGGGGCATGAAACCCGGCATC
GTTTCGCGTGGCTATGGTGGCAATTATAGCGGGCTGCATCTGGTCGATCCCGGCCATGACGGCGCGCGGCATGTGGGCGA
CGAACCTCTGCTTCTGGCGCGTCATGCTGCGGTGGCGCTCTCGCCGGACCGGGTAAAAGCAGCCGAATATCTCAAATCGC
TGGGCTGCGATTTCATCATTATGGATGACGGTTTCCAGAGCGCGCGGCTTCATGCCGATTTTTCGCTTCTGGTGGTGGAT
GCTTCGCGAGGCATAGGCAATGGCCGGGTGATACCGGCGGGGCCGCTGCGCGCACCCCTGACGGACCAGATGCGCAAAAC
CGACGCGCTGCTATGCATCGGCAAGGGAAATGGGGCTGATTTCGTGATCCGGCAGGCCGCGCGGGCTGGAAGGCCGATCT
ATCACGCTCAGTTGCGGCCCTCGTCGTCAGCCACGGTGGCGGGCAGGCGCTGGCTTGCCTTTGCGGGCATCGGCAACCCG
GACAAGTTTTACGAGAGCGTTCGCCAGGCGGGCGGTGAAGTGGTGGAAACGCATTCCTTTGCCGATCACTACAGCTTTGA
GCCTGACGATATTCGTGGCCTGGTGGATATGGCGCGGCGGCAGGGGCTTGGCCTCATCACCACGGCAAAAGATCATGTCC
GCCTTGCAACAATGCCCGGCGTTCCGCCGGAGTTCCTGTCGAAACTCGCGGTTCTCGATGTCGATCTGGAATTTGATCGC
ACCGATGCGCTTGGCCATATTCTTGATACGGTTGTCGAGCGGTTCAAAAGCCGCCTGCATGGGTGA

Upstream 100 bases:

>100_bases
CGCTTGCCGCACTTGAACCATTCATCCAGCCGCTGGTCTTGCAGGCGCAATTGCCGGGCAACCGGAACGAGCCTGCGTTC
AGTCTGGACGAGCACTGACC

Downstream 100 bases:

>100_bases
GAAGGCTGAAAGATCAGGCCTTTTTGCGGCTGCGCAGTTCCGGGTTCATCTCAAGTTCGCGCTCGAAGGAGATGAGGCCG
CTCGCATAGGGTTCCTGCCG

Product: tetraacyldisaccharide 4'-kinase

Products: NA

Alternate protein names: Lipid A 4'-kinase [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MASEAPPFWWDEPDWRALALAPAAWIYGRVSGRRLIRAVPPRVSLPVLCVGNFTVGGAGKTPTAIAFARGAIARGMKPGI
VSRGYGGNYSGLHLVDPGHDGARHVGDEPLLLARHAAVALSPDRVKAAEYLKSLGCDFIIMDDGFQSARLHADFSLLVVD
ASRGIGNGRVIPAGPLRAPLTDQMRKTDALLCIGKGNGADFVIRQAARAGRPIYHAQLRPSSSATVAGRRWLAFAGIGNP
DKFYESVRQAGGEVVETHSFADHYSFEPDDIRGLVDMARRQGLGLITTAKDHVRLATMPGVPPEFLSKLAVLDVDLEFDR
TDALGHILDTVVERFKSRLHG

Sequences:

>Translated_341_residues
MASEAPPFWWDEPDWRALALAPAAWIYGRVSGRRLIRAVPPRVSLPVLCVGNFTVGGAGKTPTAIAFARGAIARGMKPGI
VSRGYGGNYSGLHLVDPGHDGARHVGDEPLLLARHAAVALSPDRVKAAEYLKSLGCDFIIMDDGFQSARLHADFSLLVVD
ASRGIGNGRVIPAGPLRAPLTDQMRKTDALLCIGKGNGADFVIRQAARAGRPIYHAQLRPSSSATVAGRRWLAFAGIGNP
DKFYESVRQAGGEVVETHSFADHYSFEPDDIRGLVDMARRQGLGLITTAKDHVRLATMPGVPPEFLSKLAVLDVDLEFDR
TDALGHILDTVVERFKSRLHG
>Mature_340_residues
ASEAPPFWWDEPDWRALALAPAAWIYGRVSGRRLIRAVPPRVSLPVLCVGNFTVGGAGKTPTAIAFARGAIARGMKPGIV
SRGYGGNYSGLHLVDPGHDGARHVGDEPLLLARHAAVALSPDRVKAAEYLKSLGCDFIIMDDGFQSARLHADFSLLVVDA
SRGIGNGRVIPAGPLRAPLTDQMRKTDALLCIGKGNGADFVIRQAARAGRPIYHAQLRPSSSATVAGRRWLAFAGIGNPD
KFYESVRQAGGEVVETHSFADHYSFEPDDIRGLVDMARRQGLGLITTAKDHVRLATMPGVPPEFLSKLAVLDVDLEFDRT
DALGHILDTVVERFKSRLHG

Specific function: Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) [H]

COG id: COG1663

COG function: function code M; Tetraacyldisaccharide-1-P 4'-kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxK family [H]

Homologues:

Organism=Escherichia coli, GI1787144, Length=302, Percent_Identity=33.7748344370861, Blast_Score=133, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003758 [H]

Pfam domain/function: PF02606 LpxK [H]

EC number: =2.7.1.130 [H]

Molecular weight: Translated: 36724; Mature: 36593

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASEAPPFWWDEPDWRALALAPAAWIYGRVSGRRLIRAVPPRVSLPVLCVGNFTVGGAGK
CCCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCEEECCCCCCCCEEEEECEEECCCCC
TPTAIAFARGAIARGMKPGIVSRGYGGNYSGLHLVDPGHDGARHVGDEPLLLARHAAVAL
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCEEEEECCEEEE
SPDRVKAAEYLKSLGCDFIIMDDGFQSARLHADFSLLVVDASRGIGNGRVIPAGPLRAPL
CCHHHHHHHHHHHCCCCEEEECCCCCCEEEECCEEEEEEECCCCCCCCEEECCCCCCCCH
TDQMRKTDALLCIGKGNGADFVIRQAARAGRPIYHAQLRPSSSATVAGRRWLAFAGIGNP
HHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEEEEEECCCCH
DKFYESVRQAGGEVVETHSFADHYSFEPDDIRGLVDMARRQGLGLITTAKDHVRLATMPG
HHHHHHHHHCCCCEEEECCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
VPPEFLSKLAVLDVDLEFDRTDALGHILDTVVERFKSRLHG
CCHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
ASEAPPFWWDEPDWRALALAPAAWIYGRVSGRRLIRAVPPRVSLPVLCVGNFTVGGAGK
CCCCCCCCCCCCCCEEEEECHHHHHHHCCCCCCCEEECCCCCCCCEEEEECEEECCCCC
TPTAIAFARGAIARGMKPGIVSRGYGGNYSGLHLVDPGHDGARHVGDEPLLLARHAAVAL
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCEEEEECCEEEE
SPDRVKAAEYLKSLGCDFIIMDDGFQSARLHADFSLLVVDASRGIGNGRVIPAGPLRAPL
CCHHHHHHHHHHHCCCCEEEECCCCCCEEEECCEEEEEEECCCCCCCCEEECCCCCCCCH
TDQMRKTDALLCIGKGNGADFVIRQAARAGRPIYHAQLRPSSSATVAGRRWLAFAGIGNP
HHHHHCCCEEEEEECCCCCHHHHHHHHHCCCCEEEEEECCCCCCEECCCEEEEEECCCCH
DKFYESVRQAGGEVVETHSFADHYSFEPDDIRGLVDMARRQGLGLITTAKDHVRLATMPG
HHHHHHHHHCCCCEEEECCHHHCCCCCHHHHHHHHHHHHHCCCEEEEECCCCEEEEECCC
VPPEFLSKLAVLDVDLEFDRTDALGHILDTVVERFKSRLHG
CCHHHHHCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA