Click here to switch to the map view.

The map label for this gene is hisG [H]

Identifier: 225686044

GI number: 225686044

Start: 173668

End: 174363

Strand: Direct

Name: hisG [H]

Synonym: BMEA_B0189

Alternate gene names: 225686044

Gene position: 173668-174363 (Clockwise)

Preceding gene: 225686043

Following gene: 225686052

Centisome position: 14.65

GC content: 60.34

Gene sequence:

>696_bases
ATGAGCGTCACATTGGCATTGCCGTCCAAGGGGCGGCTGAAGGAAAAGACGCTCGCCGTGCTGGAAAAGGCCGGTTACAA
GGTGGTTTTGCCGGATGACGACCGCAATTATCGTGCGCGCGTCGAAGGCGAGGACGATCTTGATATCCTCTTCCTCTCCG
CTTCGGAAATTGCGCGCAAACTCGGTTATGGCAGCGTCGATCTGGGGGTGACGGGCGAAGACCTCGTGCGCGAAACGCTG
GCACATGCCGATGAGCGTGTCGCTATCGAGGCACAGCTTGGTTTCGGCCATGCCGATGTGGTCGTGGCGGTGCCGGAAGT
ATGGCGCGACGTGACCACAATGGCCGATCTTGACGATGTGGCGGCGGATTTTCGCCAGCGCCATGGCCGCCGCCTGCGCA
TCGCCACCAAATATTGGCGGCTGACGCAGCAGTTCTTTTCGCAGAAACACGGCATTCAGGTTTACCGTATCGTGGAAAGC
CTTGGCGCGACCGAGGGTGCCCCGGCGGCAGGTTCTGCCGACATGATCGTGGATATCACCTCAACCGGCTCCACCTTGCG
TGCAAACCGTCTCAAGGTTCTGGAAGACGGCATTATCCTGCGCTCGCAGGCCTGTCTCGTTTCGGCCCGCCGCAGCCATA
CCAGCCGCCGCGTAGAAGAGATCGCGGCACGCATTCGCGCGGGACTGGAAATATAA

Upstream 100 bases:

>100_bases
ATGATCGGCTTCTGACCATGCTTGGCGCTTGCGAAGCCATTCCCGGCGTCGGTTTCTCCATCTGGCTTGACCGGCTTCAG
GCGCTGGCGGGAGAAAAGCA

Downstream 100 bases:

>100_bases
GGCCAGTTTTTCAATCAAAAAAAGCCGGGTTGATCGCCCGGCTTTTTTGTTGGCTTTCAAGTGGCCGACGGTTCAGCTTT
TGCTGCCGATGAGGCCATAG

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase [H]

Number of amino acids: Translated: 231; Mature: 230

Protein sequence:

>231_residues
MSVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARKLGYGSVDLGVTGEDLVRETL
AHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVES
LGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI

Sequences:

>Translated_231_residues
MSVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARKLGYGSVDLGVTGEDLVRETL
AHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVES
LGATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
>Mature_230_residues
SVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARKLGYGSVDLGVTGEDLVRETLA
HADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDVAADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESL
GATEGAPAAGSADMIVDITSTGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6320896, Length=231, Percent_Identity=27.7056277056277, Blast_Score=74, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 25468; Mature: 25337

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARK
CEEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCCEEEEECHHHHHHH
LGYGSVDLGVTGEDLVRETLAHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDV
HCCCCEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHH
AADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDIT
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEE
STGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
CCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SVTLALPSKGRLKEKTLAVLEKAGYKVVLPDDDRNYRARVEGEDDLDILFLSASEIARK
EEEEECCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEEECCCCCCEEEEECHHHHHHH
LGYGSVDLGVTGEDLVRETLAHADERVAIEAQLGFGHADVVVAVPEVWRDVTTMADLDDV
HCCCCEECCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCEEEECHHHHHHHHHHHHHHHH
AADFRQRHGRRLRIATKYWRLTQQFFSQKHGIQVYRIVESLGATEGAPAAGSADMIVDIT
HHHHHHHCCCEEEEHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEE
STGSTLRANRLKVLEDGIILRSQACLVSARRSHTSRRVEEIAARIRAGLEI
CCCCCHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA