Definition Brucella melitensis ATCC 23457 chromosome chromosome II, complete sequence.
Accession NC_012442
Length 1,185,518

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The map label for this gene is emrB [H]

Identifier: 225685978

GI number: 225685978

Start: 114330

End: 115907

Strand: Reverse

Name: emrB [H]

Synonym: BMEA_B0119

Alternate gene names: 225685978

Gene position: 115907-114330 (Counterclockwise)

Preceding gene: 225685979

Following gene: 225685977

Centisome position: 9.78

GC content: 58.11

Gene sequence:

>1578_bases
ATGGCCGCAGACACCACCATAGGCACTGTCGGCGGAAAAAATCCGGCAGATGATCGCATTGATCCCAAAAAGACCATCGG
CTTTATGGCCATGGTCTTCGGCATGTTCATGGCGATCCTCGACATCCAGATTGTCTCGGCCTCGCTCTCCGAAATTCAGG
CGGGCCTTGGCGCCAGCACCGATGAAATTTCCTGGGTGCAGATCTCCTACCTGATCGCGGAAGTCATCATGATTCCGCTT
TCGGGTTTTTTGGGACGGCTTCTCTCGACGCGCGTGCTGTTTACCATTTCGGCGACGGGCTTCACCCTTGCCAGCATGCT
CTGCGCGACGGCCACCAATATCGAGCAGATGATAGTTTACCGCGCCATTCAGGGCTTCATCGGCGGCGGTATGATCCCCA
GCGTCTTCGCGGCCGCCTTCACCATCTTTCCCCCCTCCAAGCGATCCATCGTCTCACCGATGATCGGTCTTGTGGCAACG
CTCGCGCCCACCATCGGCGGCTATCTCAGCCATGCCTTTTCCTGGCACTGGCTGTTCCTCGTCAATGTCGGCCCCGGCAT
TCTGGTGACCATTGCCGCATGGAACCTCATCGATTTCGATGAAGGCGACCTTTCCCTTCTCGACAAGTTCGACTGGTGGG
GGCTTTTCGGCATGGCGGCCTTCCTTGGCTCCCTTGAATATGTGCTGGAGGAAGGGCCACGCAACGACTGGCTCCAGGAC
CACACGATCTTCATCATGTCGATCATCCTGACCGTCGGGGCCATCGTGTTCTTCTACCGCGTCTTCACAGCCGAACAGCC
GATCGTGGATTTCCGCGCATTCAGGAACATGAATTTCGCCTTCGGCTCGCTCTTTTCCTTTGTGATGGGCGTCGGCCTTT
ACGGACTCACCTATCTCTATCCGCTCTATCTCAGCATGATCCGCGGTTATGACGCGCTGATGATCGGCGAAGCGCTGTTC
GTCAGCGGCCTTGCCATGTTCTTCACCGCACCGGTTGCGGGCTTCCTGTCAAACCGGATGGACCCGCGCCTCATGATGAT
GATCGGCTTCGTCGGCTTTGCCATCGGCACATGGCTCGTTACCGGGCTTACCGCCGACTGGGATTTCAATGAGCTTTTGA
TGCCGCAAATCCTGCGCGGCTGCTCGCTGATGCTGTGCATGGTGCCGATCAACAATCTGGCGCTCGGTACATTGCCGCCC
TCGCTGATGAAGAACGCCTCCGGCCTTTTCAACCTCACCCGCAATCTGGGCGGCGCGGTCGGCCTGGCCGTCATCAATAC
GATCCTGACACGCCGCGGCGACATGCATTATGCGCGCCTGGCCGAACATGTGCGCAACGGCAATGCCGAAGCTGAAAACA
TGATTGCAAACCTGACAGCCAAGTATAATGCCGCCGGAATGGATGGGGCCTCGATAGCCATAGCCAAGCTTTCCGGCATG
GTGCGCCAGCAGGCGACGCTTCTGTCTTTCATCGACGTCTTCTTCATTCTGACGATGATGTTCTGCTCGCTTGCCATCTG
CGCGATGCTTCTGCGCAAGCCCTCACCGGCAGCAGGCGGTGGCGGCGGCGGGCATTAA

Upstream 100 bases:

>100_bases
CAAACTGACTGGAACAGCAAAACATTCAGAACCGAATGGCGAAGCCTGAAAGCCTGAACGGGCCGGGCATTGCCGTTTTC
TCTTCCCGGAGCGCGTCAAT

Downstream 100 bases:

>100_bases
AACATACCTCCCAAAAGCGGGGCCCGGTTTTGGGAATAAGATGCGCGCGATTCGCAACCGAAGTGTTTCATCCGAAAGCA
GAAAGGTTCACTGCCTTTCG

Product: drug resistance transporter, EmrB/QacA subfamily protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MAADTTIGTVGGKNPADDRIDPKKTIGFMAMVFGMFMAILDIQIVSASLSEIQAGLGASTDEISWVQISYLIAEVIMIPL
SGFLGRLLSTRVLFTISATGFTLASMLCATATNIEQMIVYRAIQGFIGGGMIPSVFAAAFTIFPPSKRSIVSPMIGLVAT
LAPTIGGYLSHAFSWHWLFLVNVGPGILVTIAAWNLIDFDEGDLSLLDKFDWWGLFGMAAFLGSLEYVLEEGPRNDWLQD
HTIFIMSIILTVGAIVFFYRVFTAEQPIVDFRAFRNMNFAFGSLFSFVMGVGLYGLTYLYPLYLSMIRGYDALMIGEALF
VSGLAMFFTAPVAGFLSNRMDPRLMMMIGFVGFAIGTWLVTGLTADWDFNELLMPQILRGCSLMLCMVPINNLALGTLPP
SLMKNASGLFNLTRNLGGAVGLAVINTILTRRGDMHYARLAEHVRNGNAEAENMIANLTAKYNAAGMDGASIAIAKLSGM
VRQQATLLSFIDVFFILTMMFCSLAICAMLLRKPSPAAGGGGGGH

Sequences:

>Translated_525_residues
MAADTTIGTVGGKNPADDRIDPKKTIGFMAMVFGMFMAILDIQIVSASLSEIQAGLGASTDEISWVQISYLIAEVIMIPL
SGFLGRLLSTRVLFTISATGFTLASMLCATATNIEQMIVYRAIQGFIGGGMIPSVFAAAFTIFPPSKRSIVSPMIGLVAT
LAPTIGGYLSHAFSWHWLFLVNVGPGILVTIAAWNLIDFDEGDLSLLDKFDWWGLFGMAAFLGSLEYVLEEGPRNDWLQD
HTIFIMSIILTVGAIVFFYRVFTAEQPIVDFRAFRNMNFAFGSLFSFVMGVGLYGLTYLYPLYLSMIRGYDALMIGEALF
VSGLAMFFTAPVAGFLSNRMDPRLMMMIGFVGFAIGTWLVTGLTADWDFNELLMPQILRGCSLMLCMVPINNLALGTLPP
SLMKNASGLFNLTRNLGGAVGLAVINTILTRRGDMHYARLAEHVRNGNAEAENMIANLTAKYNAAGMDGASIAIAKLSGM
VRQQATLLSFIDVFFILTMMFCSLAICAMLLRKPSPAAGGGGGGH
>Mature_524_residues
AADTTIGTVGGKNPADDRIDPKKTIGFMAMVFGMFMAILDIQIVSASLSEIQAGLGASTDEISWVQISYLIAEVIMIPLS
GFLGRLLSTRVLFTISATGFTLASMLCATATNIEQMIVYRAIQGFIGGGMIPSVFAAAFTIFPPSKRSIVSPMIGLVATL
APTIGGYLSHAFSWHWLFLVNVGPGILVTIAAWNLIDFDEGDLSLLDKFDWWGLFGMAAFLGSLEYVLEEGPRNDWLQDH
TIFIMSIILTVGAIVFFYRVFTAEQPIVDFRAFRNMNFAFGSLFSFVMGVGLYGLTYLYPLYLSMIRGYDALMIGEALFV
SGLAMFFTAPVAGFLSNRMDPRLMMMIGFVGFAIGTWLVTGLTADWDFNELLMPQILRGCSLMLCMVPINNLALGTLPPS
LMKNASGLFNLTRNLGGAVGLAVINTILTRRGDMHYARLAEHVRNGNAEAENMIANLTAKYNAAGMDGASIAIAKLSGMV
RQQATLLSFIDVFFILTMMFCSLAICAMLLRKPSPAAGGGGGGH

Specific function: Translocase that confers resistance to substances of high hydrophobicity [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1789042, Length=463, Percent_Identity=28.7257019438445, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1788710, Length=505, Percent_Identity=28.7128712871287, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI87081983, Length=430, Percent_Identity=26.046511627907, Blast_Score=110, Evalue=3e-25,
Organism=Escherichia coli, GI1790195, Length=419, Percent_Identity=26.7303102625298, Blast_Score=109, Evalue=4e-25,
Organism=Escherichia coli, GI1788392, Length=413, Percent_Identity=24.2130750605327, Blast_Score=92, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 56795; Mature: 56664

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
6.1 %Met     (Translated Protein)
7.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
5.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAADTTIGTVGGKNPADDRIDPKKTIGFMAMVFGMFMAILDIQIVSASLSEIQAGLGAST
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEISWVQISYLIAEVIMIPLSGFLGRLLSTRVLFTISATGFTLASMLCATATNIEQMIVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHH
RAIQGFIGGGMIPSVFAAAFTIFPPSKRSIVSPMIGLVATLAPTIGGYLSHAFSWHWLFL
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
VNVGPGILVTIAAWNLIDFDEGDLSLLDKFDWWGLFGMAAFLGSLEYVLEEGPRNDWLQD
EECCCCCEEEEEHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
HTIFIMSIILTVGAIVFFYRVFTAEQPIVDFRAFRNMNFAFGSLFSFVMGVGLYGLTYLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
PLYLSMIRGYDALMIGEALFVSGLAMFFTAPVAGFLSNRMDPRLMMMIGFVGFAIGTWLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TGLTADWDFNELLMPQILRGCSLMLCMVPINNLALGTLPPSLMKNASGLFNLTRNLGGAV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHCCHHHHHHHHHHCHHH
GLAVINTILTRRGDMHYARLAEHVRNGNAEAENMIANLTAKYNAAGMDGASIAIAKLSGM
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VRQQATLLSFIDVFFILTMMFCSLAICAMLLRKPSPAAGGGGGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AADTTIGTVGGKNPADDRIDPKKTIGFMAMVFGMFMAILDIQIVSASLSEIQAGLGAST
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DEISWVQISYLIAEVIMIPLSGFLGRLLSTRVLFTISATGFTLASMLCATATNIEQMIVY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHHH
RAIQGFIGGGMIPSVFAAAFTIFPPSKRSIVSPMIGLVATLAPTIGGYLSHAFSWHWLFL
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEE
VNVGPGILVTIAAWNLIDFDEGDLSLLDKFDWWGLFGMAAFLGSLEYVLEEGPRNDWLQD
EECCCCCEEEEEHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHH
HTIFIMSIILTVGAIVFFYRVFTAEQPIVDFRAFRNMNFAFGSLFSFVMGVGLYGLTYLY
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHH
PLYLSMIRGYDALMIGEALFVSGLAMFFTAPVAGFLSNRMDPRLMMMIGFVGFAIGTWLV
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
TGLTADWDFNELLMPQILRGCSLMLCMVPINNLALGTLPPSLMKNASGLFNLTRNLGGAV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHCCHHHHHHHHHHCHHH
GLAVINTILTRRGDMHYARLAEHVRNGNAEAENMIANLTAKYNAAGMDGASIAIAKLSGM
HHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHH
VRQQATLLSFIDVFFILTMMFCSLAICAMLLRKPSPAAGGGGGGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]