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The map label for this gene is aroE [H]

Identifier: 225685901

GI number: 225685901

Start: 31558

End: 32343

Strand: Direct

Name: aroE [H]

Synonym: BMEA_B0036

Alternate gene names: 225685901

Gene position: 31558-32343 (Clockwise)

Preceding gene: 225685900

Following gene: 225685902

Centisome position: 2.66

GC content: 61.7

Gene sequence:

>786_bases
ATGACGGTTACTGGCCATACAAGGGTGTTCGCCATTATCGCGGACCCGGTTCATCATGTCCGCACGCCGCAGGCCCTGAA
CGCCTTATTTGCTGCGCGTGGCTATGACGGCATCGTCGTGCCCGCTGCCGTTCCCGCCAGCGGGCTGAAATATGCAGCGG
CTGCCCTGCGTGCCTTCGGCAATTGGGGCGGTTTCATTGTCACCGTGCCGCACAAGACGGAAATGCCCGCCTTTTGCGAC
CGGCTGACGCCGCGCGCGCAAGCAGCCGGGGCGGTGAATGTGATCCGCCGCGAGGCCGATGGGAGCCTGACGGGCGAATT
GCTGGATGGTGTCGGTTTTGTGCGCGGGCTTGCCAATGCGGGCCATGATGTGAAGGGCAGGAGCGTTTATCTTGCCGGTG
CAGGCGGTGCGGCTTCGGCCATTGCCTTTGCCCTTGCAGAGGCGGGCGTTGTCCGCTTGACGGTCGTGAACCGTTCCAGC
GAAAAGGCCGGGCAGCTTGTTGCGCGGCTGAAGGAACATTTCCCGGCGGGCATGTTCGTATCGCAGGGTACGCCTGCCGG
TCATGACATCATCGTCAACGGCACGTCGCTTGGCCTGAAAGAAGGCGATGCACTGCCGGTGGACCCGCAATATCTCCGGC
CTGAAATGCTGGTGGCAGAGGTTATCATGTCGCCGGAAGTGACGCCGCTTTTGCAGATCGCGAAAGATAGCGGCTGCTCT
ATCCATCCCGGCAAGGCCATGCTGGATGGCCAGTTGGCCGAGATGTTCGATTTCTTCACGCGATAA

Upstream 100 bases:

>100_bases
ATCGGTTCCAGTTGGAGCCGATCTATCTCTCTGTTTTTAAATATGTCTTTATCCCAAAAGCGGTTTCCGTTTTTGGGAGA
CATGCCCCAGGAGCGATGCA

Downstream 100 bases:

>100_bases
TTGCATCTGGCGGCTCATACAGCCCGCCGAATGAAGCCACATATGCGTCATGTATACATCCGTATATGTCTTATACCACA
ATGCACCAGCATATCAGCCT

Product: Shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTVTGHTRVFAIIADPVHHVRTPQALNALFAARGYDGIVVPAAVPASGLKYAAAALRAFGNWGGFIVTVPHKTEMPAFCD
RLTPRAQAAGAVNVIRREADGSLTGELLDGVGFVRGLANAGHDVKGRSVYLAGAGGAASAIAFALAEAGVVRLTVVNRSS
EKAGQLVARLKEHFPAGMFVSQGTPAGHDIIVNGTSLGLKEGDALPVDPQYLRPEMLVAEVIMSPEVTPLLQIAKDSGCS
IHPGKAMLDGQLAEMFDFFTR

Sequences:

>Translated_261_residues
MTVTGHTRVFAIIADPVHHVRTPQALNALFAARGYDGIVVPAAVPASGLKYAAAALRAFGNWGGFIVTVPHKTEMPAFCD
RLTPRAQAAGAVNVIRREADGSLTGELLDGVGFVRGLANAGHDVKGRSVYLAGAGGAASAIAFALAEAGVVRLTVVNRSS
EKAGQLVARLKEHFPAGMFVSQGTPAGHDIIVNGTSLGLKEGDALPVDPQYLRPEMLVAEVIMSPEVTPLLQIAKDSGCS
IHPGKAMLDGQLAEMFDFFTR
>Mature_260_residues
TVTGHTRVFAIIADPVHHVRTPQALNALFAARGYDGIVVPAAVPASGLKYAAAALRAFGNWGGFIVTVPHKTEMPAFCDR
LTPRAQAAGAVNVIRREADGSLTGELLDGVGFVRGLANAGHDVKGRSVYLAGAGGAASAIAFALAEAGVVRLTVVNRSSE
KAGQLVARLKEHFPAGMFVSQGTPAGHDIIVNGTSLGLKEGDALPVDPQYLRPEMLVAEVIMSPEVTPLLQIAKDSGCSI
HPGKAMLDGQLAEMFDFFTR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=273, Percent_Identity=32.2344322344322, Blast_Score=124, Evalue=8e-30,
Organism=Escherichia coli, GI1789675, Length=258, Percent_Identity=30.2325581395349, Blast_Score=83, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320332, Length=272, Percent_Identity=25.7352941176471, Blast_Score=67, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 27248; Mature: 27116

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVTGHTRVFAIIADPVHHVRTPQALNALFAARGYDGIVVPAAVPASGLKYAAAALRAFG
CCCCCCEEEEEEEECCHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
NWGGFIVTVPHKTEMPAFCDRLTPRAQAAGAVNVIRREADGSLTGELLDGVGFVRGLANA
CCCCEEEECCCCCCCCHHHHHCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GHDVKGRSVYLAGAGGAASAIAFALAEAGVVRLTVVNRSSEKAGQLVARLKEHFPAGMFV
CCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
SQGTPAGHDIIVNGTSLGLKEGDALPVDPQYLRPEMLVAEVIMSPEVTPLLQIAKDSGCS
ECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCCE
IHPGKAMLDGQLAEMFDFFTR
ECCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TVTGHTRVFAIIADPVHHVRTPQALNALFAARGYDGIVVPAAVPASGLKYAAAALRAFG
CCCCCEEEEEEEECCHHHHCCHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHHHHHC
NWGGFIVTVPHKTEMPAFCDRLTPRAQAAGAVNVIRREADGSLTGELLDGVGFVRGLANA
CCCCEEEECCCCCCCCHHHHHCCCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHC
GHDVKGRSVYLAGAGGAASAIAFALAEAGVVRLTVVNRSSEKAGQLVARLKEHFPAGMFV
CCCCCCCEEEEEECCCHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHHCCCCEEE
SQGTPAGHDIIVNGTSLGLKEGDALPVDPQYLRPEMLVAEVIMSPEVTPLLQIAKDSGCS
ECCCCCCCEEEEECCCCCCCCCCCCCCCHHHHCHHHHHHHHHHCCCCHHHHHHHHCCCCE
IHPGKAMLDGQLAEMFDFFTR
ECCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11679669 [H]