Click here to switch to the map view.

The map label for this gene is ttcA

Identifier: 225852344

GI number: 225852344

Start: 830734

End: 831615

Strand: Direct

Name: ttcA

Synonym: BMEA_A0870

Alternate gene names: 225852344

Gene position: 830734-831615 (Clockwise)

Preceding gene: 225852343

Following gene: 225852345

Centisome position: 39.08

GC content: 55.33

Gene sequence:

>882_bases
ATGAACGCTTTCGATGCTGATATCACGGAACATGCTGACAGCAGTGGTTGTCATCCTTTGTTTCGCGATGTGCCTGCCAC
AGTGGAATTCAACAAGCTGCGCAAGCGCCTTCTGCGCCTGACACGGCAGGCCATTGAAGATTTCGCCATGGTAAAGCCGG
GTGATCGCTGGATGGTCTGCCTGTCGGGCGGCAAGGATTCCTATGGCCTTCTCGCCTTGCTGCTCGACCTGAAATGGCGC
GGCCTTCTGCCGGTTGAACTTCTGGCTGTCAATCTCGATCAGGGCCAGCCCAACTTCCCAAAGCATATTCTGCCGGATTT
CCTCACGCGCTATGGCATCGAGCACCGCATCGAATATCAGGACACCTATTCGATCGTTACCGACAAGCTGCCGGAAACGA
GCACCTATTGTTCGCTTTGTTCGCGCCTGCGCCGTGGCAATCTTTATCGCATAGCGCGCGAGGAGGGCTGCTCTGCCATT
GTTCTGGGCCATCACCGTGAAGATATTCTCGAAACCTTCTTCATGAATCTCTTCCATGGCGGCCGCCTTGCGGCCATGCC
GCCAAAACTTCTGAACGACGAAGGCGATCTTATGGTTTTCCGCCCGCTTGCCTATGCTGCGGAAGATGATCTGGAAAAAT
TCGCCAACGCAATGCAGTTTCCGATCATTCCGTGCGACCTTTGCGGCAGTCAGGACGGCCTTCAGCGCAACGCCATGAAA
GCCATGCTGATCGATATTGAAAAGCGTATGCCGGGACGGAAGGACACGATGATCCGCGCCCTGACCAATGTGCGGCCGAG
CCATCTTCTGGATCGCAAACTGTTCGATTTTGCGGGCCTGATGGCCAATGGCGAGAAGGGTAGTGACGATGCGCTTTGGT
GA

Upstream 100 bases:

>100_bases
GATAAGATGCGCGTCAAAAAATAGTTGGAGCGCCGATCTGATTCATTCAGATTAAAACGCGCTCCAAACCTGCAATATCC
TCAATTGTTCGGGAAGCACC

Downstream 100 bases:

>100_bases
TGGACAACTCGATTGGCTGGCGGATCTTCTGGCAGAAGCGGCAGCCAAAGAAATAATGCCGCGTTTCCGCCATCTGGAAG
TGGGTGACATCCGGCAGAAG

Product: PP-loop domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 293; Mature: 293

Protein sequence:

>293_residues
MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWR
GLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAI
VLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMK
AMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW

Sequences:

>Translated_293_residues
MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWR
GLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAI
VLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMK
AMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
>Mature_293_residues
MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVCLSGGKDSYGLLALLLDLKWR
GLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQDTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAI
VLGHHREDILETFFMNLFHGGRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMK
AMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=256, Percent_Identity=55.46875, Blast_Score=304, Evalue=4e-84,
Organism=Caenorhabditis elegans, GI193211090, Length=233, Percent_Identity=31.3304721030043, Blast_Score=113, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540090, Length=218, Percent_Identity=27.9816513761468, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_BRUA1 (B2S568)

Other databases:

- EMBL:   CP000887
- RefSeq:   YP_001934789.1
- ProteinModelPortal:   B2S568
- GeneID:   6327954
- GenomeReviews:   CP000887_GR
- KEGG:   bmc:BAbS19_I07940
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- ProtClustDB:   PRK10696
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 33260; Mature: 33260

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVC
CCCCCCCHHHCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LSGGKDSYGLLALLLDLKWRGLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQ
EECCCCCHHHHHHHHHHCCCCCCCEEHEEEECCCCCCCCCHHHHHHHHHHCCCHHEECHH
DTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHREDILETFFMNLFHG
HHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCEEEECCCHHHHHHHHHHHHHCC
GRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMK
CEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHH
AMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNAFDADITEHADSSGCHPLFRDVPATVEFNKLRKRLLRLTRQAIEDFAMVKPGDRWMVC
CCCCCCCHHHCCCCCCCCHHHHCCCCCEEHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEE
LSGGKDSYGLLALLLDLKWRGLLPVELLAVNLDQGQPNFPKHILPDFLTRYGIEHRIEYQ
EECCCCCHHHHHHHHHHCCCCCCCEEHEEEECCCCCCCCCHHHHHHHHHHCCCHHEECHH
DTYSIVTDKLPETSTYCSLCSRLRRGNLYRIAREEGCSAIVLGHHREDILETFFMNLFHG
HHHHHHHHCCCCHHHHHHHHHHHHCCCEEEEHHHCCCCEEEECCCHHHHHHHHHHHHHCC
GRLAAMPPKLLNDEGDLMVFRPLAYAAEDDLEKFANAMQFPIIPCDLCGSQDGLQRNAMK
CEEECCCHHHHCCCCCEEEEECHHHHHHHHHHHHHHHHCCCCEEHHHCCCCCCHHHHHHH
AMLIDIEKRMPGRKDTMIRALTNVRPSHLLDRKLFDFAGLMANGEKGSDDALW
HHHHHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA