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The map label for this gene is ksgA [H]

Identifier: 225852202

GI number: 225852202

Start: 688369

End: 689199

Strand: Reverse

Name: ksgA [H]

Synonym: BMEA_A0718

Alternate gene names: 225852202

Gene position: 689199-688369 (Counterclockwise)

Preceding gene: 225852203

Following gene: 225852197

Centisome position: 32.42

GC content: 59.57

Gene sequence:

>831_bases
ATGAGCATCGACAGCCTTCCCCCGCTTCGTGAGGTGATCGAACGGCATGATCTCATGCCGAAAAAATCTCTCGGCCAGAA
TTTTCTGTTCGATCTCAACCTGACATCGAAAATCGCAAGGCAGGCAGGCGATCTGCGCGACCAACCGGTGATCGAGGTCG
GCCCCGGCCCCGGCGGCCTCACGCGCGCACTTCTCGCGCAGGGCGCATATGTCACCGCCATAGAACGGGATGATCGCTGT
CTTGAAGCCCTGGCAGAAATTGCGGCGCATTACCCCGGCAGGCTCAGGATCATTGCCGGCGATGCGCTGGAACAGGATTT
CACCGCACTTTTCCCGGAAGGGCCGAAGCCGCGCATCGTTGCCAACCTGCCTTATAATGTCGGCACGCAATTGCTGCTGA
ACTGGCTGCTGGTCGAGCCATGGCCGCCATTTTATTCATCCATGACGCTCATGTTCCAGCGCGAAGTCGCCGAACGCATC
GTGGCAAAGCCGGATAGCGACCATTATGGCCGGCTGGGTGTGCTTGCCGGATGGCGCACACAGGCCAAAATCGCCTTTGA
TGTGCCGCCGCAGGCTTTCACTCCGCCACCAAAGGTGATGTCGTCCGTGGTCCATATCGTACCACGCGAAACGCCACTGC
CCTGTCGCGCGGAAGCGCTTGGCCAGATTACGCAAGCAGCCTTTGGCCAACGCCGCAAGATGCTGCGCCAAAGCCTGAAA
TCCATCGGCGGCGCCGCACTTCTGGAAAAAACGGGCATCGACGGCACCCGCCGTGCCGAGACACTAAGCGTCGAGGAGTT
TGTCGCTCTCGCTAATGCATGTCTCCCATAA

Upstream 100 bases:

>100_bases
CATTTGATATTGCCGGAAAAGGCATTGCCCGCCCGGATAGTCTGGTGGCAGCCATGCGCCTTGCGCAACAGCTTGCTGAA
AACGCGGCGAGCCGCAACGC

Downstream 100 bases:

>100_bases
GTGGGAACCGGTTTTGGGAAACATGCAAAAAGCGGTTCGTGAAGCCGCTTCAACCCCAAATACCGCTCTATTGGCCGTTA
TGTGCCGGTTTATCCGCCGA

Product: dimethyladenosine transferase

Products: NA

Alternate protein names: 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase; 16S rRNA dimethyladenosine transferase; 16S rRNA dimethylase; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase [H]

Number of amino acids: Translated: 276; Mature: 275

Protein sequence:

>276_residues
MSIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGLTRALLAQGAYVTAIERDDRC
LEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIVANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERI
VAKPDSDHYGRLGVLAGWRTQAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLK
SIGGAALLEKTGIDGTRRAETLSVEEFVALANACLP

Sequences:

>Translated_276_residues
MSIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGLTRALLAQGAYVTAIERDDRC
LEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIVANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERI
VAKPDSDHYGRLGVLAGWRTQAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLK
SIGGAALLEKTGIDGTRRAETLSVEEFVALANACLP
>Mature_275_residues
SIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGLTRALLAQGAYVTAIERDDRCL
EALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIVANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERIV
AKPDSDHYGRLGVLAGWRTQAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLKS
IGGAALLEKTGIDGTRRAETLSVEEFVALANACLP

Specific function: Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits [H]

COG id: COG0030

COG function: function code J; Dimethyladenosine transferase (rRNA methylation)

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily [H]

Homologues:

Organism=Homo sapiens, GI156415992, Length=292, Percent_Identity=37.3287671232877, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI7657198, Length=236, Percent_Identity=33.0508474576271, Blast_Score=110, Evalue=2e-24,
Organism=Escherichia coli, GI1786236, Length=257, Percent_Identity=36.9649805447471, Blast_Score=150, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI25141369, Length=295, Percent_Identity=32.5423728813559, Blast_Score=142, Evalue=1e-34,
Organism=Caenorhabditis elegans, GI25146882, Length=213, Percent_Identity=30.0469483568075, Blast_Score=93, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324989, Length=230, Percent_Identity=28.695652173913, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357273, Length=296, Percent_Identity=32.4324324324324, Blast_Score=127, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21358017, Length=241, Percent_Identity=29.4605809128631, Blast_Score=103, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023165
- InterPro:   IPR020596
- InterPro:   IPR001737
- InterPro:   IPR020598
- InterPro:   IPR011530 [H]

Pfam domain/function: PF00398 RrnaAD [H]

EC number: =2.1.1.182 [H]

Molecular weight: Translated: 30307; Mature: 30175

Theoretical pI: Translated: 8.07; Mature: 8.07

Prosite motif: PS01131 RRNA_A_DIMETH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGL
CCCCCCCHHHHHHHHHCCCCCHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEECCCCCHH
TRALLAQGAYVTAIERDDRCLEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIV
HHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCEE
ANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERIVAKPDSDHYGRLGVLAGWRT
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
QAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLK
CCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SIGGAALLEKTGIDGTRRAETLSVEEFVALANACLP
HHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SIDSLPPLREVIERHDLMPKKSLGQNFLFDLNLTSKIARQAGDLRDQPVIEVGPGPGGL
CCCCCCHHHHHHHHHCCCCCHHCCCCEEEECCHHHHHHHHHCCCCCCCEEEECCCCCHH
TRALLAQGAYVTAIERDDRCLEALAEIAAHYPGRLRIIAGDALEQDFTALFPEGPKPRIV
HHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHCCCCCCCCEE
ANLPYNVGTQLLLNWLLVEPWPPFYSSMTLMFQREVAERIVAKPDSDHYGRLGVLAGWRT
EECCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCC
QAKIAFDVPPQAFTPPPKVMSSVVHIVPRETPLPCRAEALGQITQAAFGQRRKMLRQSLK
CCEEEEECCCCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
SIGGAALLEKTGIDGTRRAETLSVEEFVALANACLP
HHCCHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA