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The map label for this gene is pdxA

Identifier: 225852203

GI number: 225852203

Start: 689196

End: 690227

Strand: Reverse

Name: pdxA

Synonym: BMEA_A0719

Alternate gene names: 225852203

Gene position: 690227-689196 (Counterclockwise)

Preceding gene: 225852204

Following gene: 225852202

Centisome position: 32.47

GC content: 60.37

Gene sequence:

>1032_bases
ATGCGCGCAAAGCCACTTCCTCCGCTCGCCGTCAGTATTGGCGACCCTTCGGGTATCGGGGCGGATGTTGCCCTTGCCGC
GTGGTTGAAGCGTTGCGAACTCTCCCTGCCGCCCTTCTTTCTGATTGCCGATCCGAAACAGCTTGCCGCACGGGCGCGCC
ATCTGGGCCTTGCCGTTGATTTTGCTATTCTTTCCGATCCTCGGGAAGCAGAAGCAGCCTTTGGTGAAAGGCTGCCCCTT
CTGGCGCTGAAACACAGCCATACGGAAAGCCCCGGTAAACCGCTAACGGAAAATGCCGCCGGGGTTATCGAGGCAATCGA
GCGTGCTGTCGAACTGACGCTCAAAGGCGAAGCCGCCGCAGTCGTCACCTGCCCCATTGCCAAGAAACCCCTCTATGAAG
CGGGCTTCCAGCATCCCGGCCATACGGAATTTCTGGCCGAGCTCGCAGGCCACCATCTCGGCAAGCCAGTCACACCGGTT
ATGATGCTTGCCGGGCCGCAGCTACGCGCCGTGCCGGTGACTATCCATATTCCGCTATCAGAGGTGCCAGCTCGGCTTAC
CACGACGGAAATCGTCGCGGTTTCGCGCATCACAGCAAACGAATTGCGAGAGCGGTTCGGCATTGCATCGCCACGCCTTG
CCATTTCCGGCCTCAACCCCCATGCGGGCGAAGGCGGCGCCTTGGGCAAGGAAGATGATGCCATCATTCTTCCCGCGATC
GAGCAACTGATACGCGAGGGGATTGATGCGCGCGGCCCCCTGCCTGCCGATACGATGTTTCACGCGCCCGCGCGCGCCAC
ATATGATGCGGCCATCTGCATGTATCACGATCAGGCGCTCATTCCCGCCAAGGCGCTTGCATTCGATGAAACCGTGAATG
TGACGCTGGGGCTGCCCTTCATTCGCACTTCGCCCGATCACGGAACAGCATTTGATATTGCCGGAAAAGGCATTGCCCGC
CCGGATAGTCTGGTGGCAGCCATGCGCCTTGCGCAACAGCTTGCTGAAAACGCGGCGAGCCGCAACGCATGA

Upstream 100 bases:

>100_bases
GAACTGCGCGAAAAGGCCACCATCGTCAATCGTTGACGGCGCCGAAGATAGGGCGCCATTCGCGCCCTTTCGCCTCGGCA
GCTTCCGGATCAGTGTTCAC

Downstream 100 bases:

>100_bases
GCATCGACAGCCTTCCCCCGCTTCGTGAGGTGATCGAACGGCATGATCTCATGCCGAAAAAATCTCTCGGCCAGAATTTT
CTGTTCGATCTCAACCTGAC

Product: 4-hydroxythreonine-4-phosphate dehydrogenase

Products: NA

Alternate protein names: 4-(phosphohydroxy)-L-threonine dehydrogenase

Number of amino acids: Translated: 343; Mature: 343

Protein sequence:

>343_residues
MRAKPLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPL
LALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPV
MMLAGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAI
EQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIAR
PDSLVAAMRLAQQLAENAASRNA

Sequences:

>Translated_343_residues
MRAKPLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPL
LALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPV
MMLAGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAI
EQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIAR
PDSLVAAMRLAQQLAENAASRNA
>Mature_343_residues
MRAKPLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVDFAILSDPREAEAAFGERLPL
LALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAAVVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPV
MMLAGPQLRAVPVTIHIPLSEVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAI
EQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPFIRTSPDHGTAFDIAGKGIAR
PDSLVAAMRLAQQLAENAASRNA

Specific function: Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)

COG id: COG1995

COG function: function code H; Pyridoxal phosphate biosynthesis protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pdxA family

Homologues:

Organism=Escherichia coli, GI1786237, Length=329, Percent_Identity=38.6018237082067, Blast_Score=204, Evalue=8e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXA_BRUME (P65680)

Other databases:

- EMBL:   AE008917
- PIR:   AD3410
- RefSeq:   NP_540183.1
- ProteinModelPortal:   P65680
- SMR:   P65680
- GeneID:   1196977
- GenomeReviews:   AE008917_GR
- KEGG:   bme:BMEI1266
- HOGENOM:   HBG451136
- OMA:   LETAYQM
- PhylomeDB:   P65680
- ProtClustDB:   PRK05312
- BioCyc:   BMEL224914:BMEI1266-MONOMER
- BRENDA:   1.1.1.262
- GO:   GO:0005737
- HAMAP:   MF_00536
- InterPro:   IPR005255
- TIGRFAMs:   TIGR00557

Pfam domain/function: PF04166 PdxA

EC number: =1.1.1.262

Molecular weight: Translated: 36193; Mature: 36193

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: BINDING 141-141 BINDING 142-142 BINDING 284-284 BINDING 293-293 BINDING 302-302

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAKPLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVD
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCEEEE
FAILSDPREAEAAFGERLPLLALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAA
EEECCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEE
VVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPVMMLAGPQLRAVPVTIHIPLS
EEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCEEEEEEEEEECHH
EVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAI
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHH
EQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPF
HHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCEEEEEECCCE
IRTSPDHGTAFDIAGKGIARPDSLVAAMRLAQQLAENAASRNA
EEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRAKPLPPLAVSIGDPSGIGADVALAAWLKRCELSLPPFFLIADPKQLAARARHLGLAVD
CCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHHCEEEE
FAILSDPREAEAAFGERLPLLALKHSHTESPGKPLTENAAGVIEAIERAVELTLKGEAAA
EEECCCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHEEEECCCCEE
VVTCPIAKKPLYEAGFQHPGHTEFLAELAGHHLGKPVTPVMMLAGPQLRAVPVTIHIPLS
EEECCCCCCCHHHHCCCCCCHHHHHHHHHHHHCCCCCCHHHEECCCCEEEEEEEEEECHH
EVPARLTTTEIVAVSRITANELRERFGIASPRLAISGLNPHAGEGGALGKEDDAIILPAI
HCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEHHHH
EQLIREGIDARGPLPADTMFHAPARATYDAAICMYHDQALIPAKALAFDETVNVTLGLPF
HHHHHHCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCCCCHHHHCCCCEEEEEECCCE
IRTSPDHGTAFDIAGKGIARPDSLVAAMRLAQQLAENAASRNA
EEECCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11756688