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The map label for this gene is hepT [H]

Identifier: 222527256

GI number: 222527256

Start: 4988502

End: 4989587

Strand: Reverse

Name: hepT [H]

Synonym: Chy400_4040

Alternate gene names: 222527256

Gene position: 4989587-4988502 (Counterclockwise)

Preceding gene: 222527259

Following gene: 222527255

Centisome position: 94.7

GC content: 58.84

Gene sequence:

>1086_bases
ATGGCCGGCTACCAGTTACCATTCAATCCGTCAGGTTCATTCACGGTACCAGAGGCTCGTACATCGCTGCCATCGAGTCA
TCGCCTTGTTGGTGAACTGCCACCCCAGACTGCTGGTGGGCTAGCCGGTATCTTCCACCGGGCCGACATTCTGGCCGATC
TCGGTGCTATCGAGCAACGTCTGCTGGAATGTACGCAGTCCCGTGTTGCGGTTATCAGTGCCGCCGGTATGCATACGGTG
CGCTCCGGTGGTAAGCGACTGCGTGCTGCCCTGGCTGTGCTGGCCGCACGCCTCGGGCACTATCAGCTTGAACGGGTGAT
CCATCCGGCAGCGGCGGCTGAACTGATTCACGCTGCCTCACTTGTGCATGACGATCTGGTTGACCAGGCTAATCGTCGGC
GTGGGCAGATCACGGTGCATGCGCGTTGGGACAACGACGTGGCACTGATGGTAGGCGATTACTTTTTTGCTCTTGCCGCC
GCCGAGATGGCCCGTAGCCCTGATCCACGGATTATTACCTTCTATGCCGAGGCTGTCCAGACGATCTGTGAGGGTGAACT
CAGTCCGGTCACGGTTGCCGAGCCTTTTGATAAAGCCTTGCGCCAGTATCTCTACAAAACCGGGGCCAAGACGGCAGTGC
TCTTCGAGGCCGCCTGCAAGGCCGGTATGGTTGCCGGTGGCGGCAGCGATGAAGAGATTGCTGCGCTGGGGAGCTACGGG
TACGATCTGGGTATGGCCTTCCAGATCATCGATGATGTCCTCGATTTTATCGGTGATGAGCGCACCCTTGGGAAGCCTGC
CGGGAACGATTTACGTCAGGGTACGATTACGTTGCCGCTTATCTATGCCACTGCTGCATCACCGAGTCAGGTCTTACGCG
ATGTGCTTTTGCACACTCCACCATCCGATACGTTGGTGGCCGAGGTGATCCGTGAAGTGATCAATGCTGGTGGGGTGGCT
GCGGCCCAGACCGAGGCGGCTCGCTATATCGACCAGGCGGTAAGTCACCTTGAGCGGTTCCCATCCAGCCCGGCTCGCCA
GGCGTTGATCGACATTGCCCACTTTGTGCTTGAGCGCTCGGTGTAG

Upstream 100 bases:

>100_bases
GAATATCTCACCATGTATCTGGCGTTAGTCACCACAATCGCCGGATCGTCGTCGCCTCCGGCGCCAGACCGGCTCGGCGA
TCCTAGGAAGGAACAGCCGC

Downstream 100 bases:

>100_bases
TACACGGGGACAGTGTTCACCACAGAGGCACGGAGTACACAGAGGGTGATGGTGTTGCTACGGGAGAAAAATGATCCTCT
CTGGGCAAGAGGTGGTCATC

Product: polyprenyl synthetase

Products: NA

Alternate protein names: HEPPP synthase subunit 2 [H]

Number of amino acids: Translated: 361; Mature: 360

Protein sequence:

>361_residues
MAGYQLPFNPSGSFTVPEARTSLPSSHRLVGELPPQTAGGLAGIFHRADILADLGAIEQRLLECTQSRVAVISAAGMHTV
RSGGKRLRAALAVLAARLGHYQLERVIHPAAAAELIHAASLVHDDLVDQANRRRGQITVHARWDNDVALMVGDYFFALAA
AEMARSPDPRIITFYAEAVQTICEGELSPVTVAEPFDKALRQYLYKTGAKTAVLFEAACKAGMVAGGGSDEEIAALGSYG
YDLGMAFQIIDDVLDFIGDERTLGKPAGNDLRQGTITLPLIYATAASPSQVLRDVLLHTPPSDTLVAEVIREVINAGGVA
AAQTEAARYIDQAVSHLERFPSSPARQALIDIAHFVLERSV

Sequences:

>Translated_361_residues
MAGYQLPFNPSGSFTVPEARTSLPSSHRLVGELPPQTAGGLAGIFHRADILADLGAIEQRLLECTQSRVAVISAAGMHTV
RSGGKRLRAALAVLAARLGHYQLERVIHPAAAAELIHAASLVHDDLVDQANRRRGQITVHARWDNDVALMVGDYFFALAA
AEMARSPDPRIITFYAEAVQTICEGELSPVTVAEPFDKALRQYLYKTGAKTAVLFEAACKAGMVAGGGSDEEIAALGSYG
YDLGMAFQIIDDVLDFIGDERTLGKPAGNDLRQGTITLPLIYATAASPSQVLRDVLLHTPPSDTLVAEVIREVINAGGVA
AAQTEAARYIDQAVSHLERFPSSPARQALIDIAHFVLERSV
>Mature_360_residues
AGYQLPFNPSGSFTVPEARTSLPSSHRLVGELPPQTAGGLAGIFHRADILADLGAIEQRLLECTQSRVAVISAAGMHTVR
SGGKRLRAALAVLAARLGHYQLERVIHPAAAAELIHAASLVHDDLVDQANRRRGQITVHARWDNDVALMVGDYFFALAAA
EMARSPDPRIITFYAEAVQTICEGELSPVTVAEPFDKALRQYLYKTGAKTAVLFEAACKAGMVAGGGSDEEIAALGSYGY
DLGMAFQIIDDVLDFIGDERTLGKPAGNDLRQGTITLPLIYATAASPSQVLRDVLLHTPPSDTLVAEVIREVINAGGVAA
AQTEAARYIDQAVSHLERFPSSPARQALIDIAHFVLERSV

Specific function: Supplies heptaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinone menaquinone-7 (MQ-7) [H]

COG id: COG0142

COG function: function code H; Geranylgeranyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FPP/GGPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI50659086, Length=285, Percent_Identity=32.9824561403509, Blast_Score=141, Evalue=9e-34,
Organism=Escherichia coli, GI1789578, Length=312, Percent_Identity=36.2179487179487, Blast_Score=179, Evalue=3e-46,
Organism=Escherichia coli, GI1786623, Length=213, Percent_Identity=34.2723004694836, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17505681, Length=248, Percent_Identity=36.2903225806452, Blast_Score=145, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6319475, Length=295, Percent_Identity=27.7966101694915, Blast_Score=123, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24651612, Length=287, Percent_Identity=29.9651567944251, Blast_Score=138, Evalue=5e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014119
- InterPro:   IPR000092
- InterPro:   IPR017446
- InterPro:   IPR008949 [H]

Pfam domain/function: PF00348 polyprenyl_synt [H]

EC number: =2.5.1.30 [H]

Molecular weight: Translated: 38571; Mature: 38440

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00723 POLYPRENYL_SYNTHET_1 ; PS00444 POLYPRENYL_SYNTHET_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGYQLPFNPSGSFTVPEARTSLPSSHRLVGELPPQTAGGLAGIFHRADILADLGAIEQR
CCCCCCCCCCCCCEECCHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLECTQSRVAVISAAGMHTVRSGGKRLRAALAVLAARLGHYQLERVIHPAAAAELIHAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVHDDLVDQANRRRGQITVHARWDNDVALMVGDYFFALAAAEMARSPDPRIITFYAEAVQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
TICEGELSPVTVAEPFDKALRQYLYKTGAKTAVLFEAACKAGMVAGGGSDEEIAALGSYG
HHHCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
YDLGMAFQIIDDVLDFIGDERTLGKPAGNDLRQGTITLPLIYATAASPSQVLRDVLLHTP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCC
PSDTLVAEVIREVINAGGVAAAQTEAARYIDQAVSHLERFPSSPARQALIDIAHFVLERS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
V
C
>Mature Secondary Structure 
AGYQLPFNPSGSFTVPEARTSLPSSHRLVGELPPQTAGGLAGIFHRADILADLGAIEQR
CCCCCCCCCCCCEECCHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
LLECTQSRVAVISAAGMHTVRSGGKRLRAALAVLAARLGHYQLERVIHPAAAAELIHAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVHDDLVDQANRRRGQITVHARWDNDVALMVGDYFFALAAAEMARSPDPRIITFYAEAVQ
HHHHHHHHHHHCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHH
TICEGELSPVTVAEPFDKALRQYLYKTGAKTAVLFEAACKAGMVAGGGSDEEIAALGSYG
HHHCCCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHCCC
YDLGMAFQIIDDVLDFIGDERTLGKPAGNDLRQGTITLPLIYATAASPSQVLRDVLLHTP
CHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEEECCCCHHHHHHHHHHCCC
PSDTLVAEVIREVINAGGVAAAQTEAARYIDQAVSHLERFPSSPARQALIDIAHFVLERS
CCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
V
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7629164 [H]