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The map label for this gene is phoR [H]

Identifier: 222527024

GI number: 222527024

Start: 4733816

End: 4735324

Strand: Direct

Name: phoR [H]

Synonym: Chy400_3803

Alternate gene names: 222527024

Gene position: 4733816-4735324 (Clockwise)

Preceding gene: 222527023

Following gene: 222527026

Centisome position: 89.84

GC content: 59.58

Gene sequence:

>1509_bases
GTGTTTAGGGGACTACGCTGGCAATTTACCCTGTTCTACGCCTGTGCTGCCGTAGCTATCATCGCATTGATCGGCGGCGG
CACCTACGTGAGCGTTGCCGGCTACTTCGAGCGCATCACCGATCTGGCCCTCCAGCACAAGATGGTACACGAATTTCATG
CGCTCAATGCCCCATTGCCACCAGAACTGGCCCACGCCGACGCCGACTGGTCACTTTTGCGGTCGGCCAACACCACGAAC
CGCAACCGGCGACTGTCCGCAGATGAGGCGGCGCAGATTGCCTTGAGCGTGCGTGGTGGCGAGATCAGAGAGGTCAAATT
AGATGACTCATACTACGAAGTCAAACTGCGTGACGGCAGCGAGATCGAGATTGATGCATACAGCGGCAAGATCATCGAAA
TCAAGCTCAAAGGCGAGGCGACGACGACCATCCCTACCAGTCCAGCTCTGCCATCCGCGTATGATGCCGAGCTGGCATCA
ATCTTTGTTCTGCCCCTCGATGAGCAGGGTCGGATTCTATTCAACCCCAATCCGGCAGCACTACCGATGCCGGCCCATCA
AGAAGCGTTAGCCGCTGCGTTACGTAACGGCTCTGACATCCGCACCATCGAGACCACCACCGGCCAGCGCGTCCGTCTGC
TCACCTATCGCCTCACCCGACCTGACGGCCCGGCAGCCCTGCAATTGGGGCGTCTCCTGACCGATCAGGAACAGGTATTG
CGACAGTTGGTATCAGGACTCATCGGCCTGGGTTTGTTCGGCGCCGTGATTATCGGCTTTGCCGGCTGGTGGCTGGCCGG
ACGATCACTCCGCCCGGCAGAAGAAGCCTGGGTGCGCCAGACGCGCTTTATTGCCAGTGCCAGCCATGAATTGCGGGCGC
CCCTCACCCTGATTCGGGCCAGTGCCGAAGTTGCACTGCGCCACGCCGACGATCCAGATCAACGCGAACTCCTGTCTGAC
GTGCTGAGTGAAAGCGATCACATGCGGCGTCTGGTCGATGATCTGCTGACCCTCTCACGTCTCGACAGCGGTGCCCTGGT
CTTACAGCGCCAACCGGTATCGCTCCCATCATTCCTCGCCGATCTCCACCGGCAGGTACGGCGCCTGGGAGAGGAAAAGG
GCATCGCAATTCAGCTTGCGCCAATCACCGGCACTGTACTCGCCGATCCGGATCGCTTACGGCAGGTGTTATTAATCCTG
ATCGACAACGCCCTGCGCTATACCCCATCTGGAGGCGTTATTACCATCGCCACCGAACCGGCAGGAAAACAGATTCGTCT
GAGTGTCAGCGACAACGGCTGCGGAATTGCCCCGGAACACCTCCCTCACCTCTTCGAGCGCTTCTATCGGGTTGATGTGG
CACGGAATCGGAGTGATGGGCATGCCGGCCTTGGGCTGGCAATAGCCAAAGGACTGGTTGAAGCACACAGCGGCGCCATC
GGTATTGAGAGCGAGGTCAATCGCGGCACGCGGGTCTGGTTTACGTTACCGGTGGCGGCAACCGGGTGA

Upstream 100 bases:

>100_bases
GATGTCTACATCTCATACCTGCGCCGCAAGCTCAATGCGTCGGGCGAGACCGACCCGATCAACACCATTCGAGGGATCGG
TTACCGATTGGAGGCTGAAC

Downstream 100 bases:

>100_bases
TGTGGCATGACGAACATCGCCAGGGGTATCGTAACCCGCTTTATACCAATCACCCCGACACCGCATCTGATCACGGATGC
GCACACCAATGTTCTTGCAC

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 502; Mature: 502

Protein sequence:

>502_residues
MFRGLRWQFTLFYACAAVAIIALIGGGTYVSVAGYFERITDLALQHKMVHEFHALNAPLPPELAHADADWSLLRSANTTN
RNRRLSADEAAQIALSVRGGEIREVKLDDSYYEVKLRDGSEIEIDAYSGKIIEIKLKGEATTTIPTSPALPSAYDAELAS
IFVLPLDEQGRILFNPNPAALPMPAHQEALAAALRNGSDIRTIETTTGQRVRLLTYRLTRPDGPAALQLGRLLTDQEQVL
RQLVSGLIGLGLFGAVIIGFAGWWLAGRSLRPAEEAWVRQTRFIASASHELRAPLTLIRASAEVALRHADDPDQRELLSD
VLSESDHMRRLVDDLLTLSRLDSGALVLQRQPVSLPSFLADLHRQVRRLGEEKGIAIQLAPITGTVLADPDRLRQVLLIL
IDNALRYTPSGGVITIATEPAGKQIRLSVSDNGCGIAPEHLPHLFERFYRVDVARNRSDGHAGLGLAIAKGLVEAHSGAI
GIESEVNRGTRVWFTLPVAATG

Sequences:

>Translated_502_residues
MFRGLRWQFTLFYACAAVAIIALIGGGTYVSVAGYFERITDLALQHKMVHEFHALNAPLPPELAHADADWSLLRSANTTN
RNRRLSADEAAQIALSVRGGEIREVKLDDSYYEVKLRDGSEIEIDAYSGKIIEIKLKGEATTTIPTSPALPSAYDAELAS
IFVLPLDEQGRILFNPNPAALPMPAHQEALAAALRNGSDIRTIETTTGQRVRLLTYRLTRPDGPAALQLGRLLTDQEQVL
RQLVSGLIGLGLFGAVIIGFAGWWLAGRSLRPAEEAWVRQTRFIASASHELRAPLTLIRASAEVALRHADDPDQRELLSD
VLSESDHMRRLVDDLLTLSRLDSGALVLQRQPVSLPSFLADLHRQVRRLGEEKGIAIQLAPITGTVLADPDRLRQVLLIL
IDNALRYTPSGGVITIATEPAGKQIRLSVSDNGCGIAPEHLPHLFERFYRVDVARNRSDGHAGLGLAIAKGLVEAHSGAI
GIESEVNRGTRVWFTLPVAATG
>Mature_502_residues
MFRGLRWQFTLFYACAAVAIIALIGGGTYVSVAGYFERITDLALQHKMVHEFHALNAPLPPELAHADADWSLLRSANTTN
RNRRLSADEAAQIALSVRGGEIREVKLDDSYYEVKLRDGSEIEIDAYSGKIIEIKLKGEATTTIPTSPALPSAYDAELAS
IFVLPLDEQGRILFNPNPAALPMPAHQEALAAALRNGSDIRTIETTTGQRVRLLTYRLTRPDGPAALQLGRLLTDQEQVL
RQLVSGLIGLGLFGAVIIGFAGWWLAGRSLRPAEEAWVRQTRFIASASHELRAPLTLIRASAEVALRHADDPDQRELLSD
VLSESDHMRRLVDDLLTLSRLDSGALVLQRQPVSLPSFLADLHRQVRRLGEEKGIAIQLAPITGTVLADPDRLRQVLLIL
IDNALRYTPSGGVITIATEPAGKQIRLSVSDNGCGIAPEHLPHLFERFYRVDVARNRSDGHAGLGLAIAKGLVEAHSGAI
GIESEVNRGTRVWFTLPVAATG

Specific function: Member of the two-component regulatory system phoP/phoR involved in the alkaline phosphatase genes regulation. PhoR may function as a membrane-associated protein kinase that phosphorylates phoP in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=36, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786600, Length=216, Percent_Identity=38.4259259259259, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1788393, Length=199, Percent_Identity=40.2010050251256, Blast_Score=135, Evalue=9e-33,
Organism=Escherichia coli, GI1789149, Length=229, Percent_Identity=30.5676855895196, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI48994928, Length=225, Percent_Identity=30.2222222222222, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=32.2274881516588, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1788713, Length=234, Percent_Identity=29.0598290598291, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI1790346, Length=222, Percent_Identity=28.8288288288288, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=34.1584158415842, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1790436, Length=220, Percent_Identity=30.9090909090909, Blast_Score=92, Evalue=8e-20,
Organism=Escherichia coli, GI1788549, Length=227, Percent_Identity=30.8370044052863, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081816, Length=236, Percent_Identity=31.3559322033898, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1787894, Length=219, Percent_Identity=30.1369863013699, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI145693157, Length=230, Percent_Identity=27.8260869565217, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=28.4403669724771, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI1789808, Length=226, Percent_Identity=29.2035398230088, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI1788279, Length=238, Percent_Identity=27.3109243697479, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=236, Percent_Identity=30.9322033898305, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI87082128, Length=242, Percent_Identity=25.2066115702479, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR000014
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 54773; Mature: 54773

Theoretical pI: Translated: 6.71; Mature: 6.71

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFRGLRWQFTLFYACAAVAIIALIGGGTYVSVAGYFERITDLALQHKMVHEFHALNAPLP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PELAHADADWSLLRSANTTNRNRRLSADEAAQIALSVRGGEIREVKLDDSYYEVKLRDGS
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCC
EIEIDAYSGKIIEIKLKGEATTTIPTSPALPSAYDAELASIFVLPLDEQGRILFNPNPAA
EEEEEECCCEEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCC
LPMPAHQEALAAALRNGSDIRTIETTTGQRVRLLTYRLTRPDGPAALQLGRLLTDQEQVL
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHCCCHHHHH
RQLVSGLIGLGLFGAVIIGFAGWWLAGRSLRPAEEAWVRQTRFIASASHELRAPLTLIRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHH
SAEVALRHADDPDQRELLSDVLSESDHMRRLVDDLLTLSRLDSGALVLQRQPVSLPSFLA
HHHHEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
DLHRQVRRLGEEKGIAIQLAPITGTVLADPDRLRQVLLILIDNALRYTPSGGVITIATEP
HHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECC
AGKQIRLSVSDNGCGIAPEHLPHLFERFYRVDVARNRSDGHAGLGLAIAKGLVEAHSGAI
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GIESEVNRGTRVWFTLPVAATG
CCHHHCCCCCEEEEEEEEEECC
>Mature Secondary Structure
MFRGLRWQFTLFYACAAVAIIALIGGGTYVSVAGYFERITDLALQHKMVHEFHALNAPLP
CCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
PELAHADADWSLLRSANTTNRNRRLSADEAAQIALSVRGGEIREVKLDDSYYEVKLRDGS
HHHHCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCEEEEEEECCCEEEEEECCCC
EIEIDAYSGKIIEIKLKGEATTTIPTSPALPSAYDAELASIFVLPLDEQGRILFNPNPAA
EEEEEECCCEEEEEEECCCEEEECCCCCCCCCCCCCCEEEEEEEEECCCCCEEECCCCCC
LPMPAHQEALAAALRNGSDIRTIETTTGQRVRLLTYRLTRPDGPAALQLGRLLTDQEQVL
CCCCCHHHHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCHHHHHHHHHCCCHHHHH
RQLVSGLIGLGLFGAVIIGFAGWWLAGRSLRPAEEAWVRQTRFIASASHELRAPLTLIRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHHHCCHHHHHH
SAEVALRHADDPDQRELLSDVLSESDHMRRLVDDLLTLSRLDSGALVLQRQPVSLPSFLA
HHHHEEECCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHH
DLHRQVRRLGEEKGIAIQLAPITGTVLADPDRLRQVLLILIDNALRYTPSGGVITIATEP
HHHHHHHHHCCCCCEEEEEECCCCEEECCHHHHHHHHHHHHHHHHEECCCCCEEEEEECC
AGKQIRLSVSDNGCGIAPEHLPHLFERFYRVDVARNRSDGHAGLGLAIAKGLVEAHSGAI
CCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCC
GIESEVNRGTRVWFTLPVAATG
CCHHHCCCCCEEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3142862; 9387221; 9384377 [H]