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The map label for this gene is gcvT [H]

Identifier: 222526989

GI number: 222526989

Start: 4687247

End: 4688350

Strand: Direct

Name: gcvT [H]

Synonym: Chy400_3767

Alternate gene names: 222526989

Gene position: 4687247-4688350 (Clockwise)

Preceding gene: 222526988

Following gene: 222526990

Centisome position: 88.96

GC content: 58.79

Gene sequence:

>1104_bases
ATGCTGAAACGAACTCCTCTTTACAATGCGCACCTGGCAATGGGCGCGCGCATGGTCGAATTTGGCGGCTGGGAGATGCC
AGTGCAGTATCGCGGCATCATCGAAGAGCACCACGCTGTGCGCAACCGGGCCGGTCTGTTCGACATCAGTCATATGGGGC
GGTTTATGGTGCGTGGTGCGCATGCCGAGGCGTTTCTCCAGCAGATGGTTACCTGTGACGTGCGGGCCATCCCGCTCGGC
CACGCCAGCTACGGTCTGCTCTGTCGGCCTGATGGTGGGATTGTGGACGACGTGTTCCTGTACCATCTCCCCGACGAGTT
TATGGTGGTGGTGAATGCGGCCAACCGGCAAAAAGACTGGGACTGGCTCCAGCAGCATACGGCTGGATTTGAGGTGGAGA
TTGAAGATCGTTCCGAGCGTTGGGCGATGCTGGCGCTCCAGGGGCCACAGGCTGAACAACTGCTGGCTGGGGCAGAGAGT
TCAACAACCGCTGACATTGGCTCGTTGCCGTTTCACGGGGTGGCCATGACGACGATCTTCGGGCAAAATGCACTGATTGC
CCGCACCGGCTACACCGGCGAAGACGGGTTTGAAATCTTTTTTGAGGCTGTCCACGCCGAACAGTTCTGGCACGGTTTGC
TCGCGCTCGGCGGCAATGCGGTGCAGGCTTGTGGCCTGGGGGCACGTGATAGCCTGCGCTTTGAGGCGTGTCTGGCGTTG
TACGGTCATGAAATTGACGAGACGACGAATCCTTACGAAGCCCGTTTGGGATGGGTGGTCAAACTGGATAAGGGCGACTT
TATCGGTCGGGAAGCGTTGCAGGCGATCAAGCAGAATGGGGTAAGCCGACGACTGGTTGGTTTCGAGATGGTTGGAAAGG
GAATCGCCCGCGCCGGCTATCCGGTACATCGGCCAGACGGCGAGCCGGTCGGGTTTGTTACCAGTGGTATGCCATCACCG
ACCCTCGGTCGTCCACTGGGAATGGCGTATGTGCCAACCGATCTCAGTAGCGAAGGTAGTGAATTTGATGTCATCGTGCG
CGAGCGTCCGGTACGTGCGCGCGTGGTAAAGATGCCTTTCTATAAGCCGCGCTACAAGCGCTAG

Upstream 100 bases:

>100_bases
CGATGACGAGCTGGCTCGCCACGCGATTGCCTGTCGTGAAATGTTGCGCCGTGTGCGCGCCGGATTGGAAGAAGGCCATT
CATAGCTGATGGGAATGGGT

Downstream 100 bases:

>100_bases
AGGAGTTCGACATGGCTTACAACACTCCATCCGATCTACGGTACAGCAAAACCCACGAGTGGGTACGACAGGAGGGTGAT
GAGGTCGTGATTGGGATTAC

Product: glycine cleavage system T protein

Products: NA

Alternate protein names: Glycine cleavage system T protein [H]

Number of amino acids: Translated: 367; Mature: 367

Protein sequence:

>367_residues
MLKRTPLYNAHLAMGARMVEFGGWEMPVQYRGIIEEHHAVRNRAGLFDISHMGRFMVRGAHAEAFLQQMVTCDVRAIPLG
HASYGLLCRPDGGIVDDVFLYHLPDEFMVVVNAANRQKDWDWLQQHTAGFEVEIEDRSERWAMLALQGPQAEQLLAGAES
STTADIGSLPFHGVAMTTIFGQNALIARTGYTGEDGFEIFFEAVHAEQFWHGLLALGGNAVQACGLGARDSLRFEACLAL
YGHEIDETTNPYEARLGWVVKLDKGDFIGREALQAIKQNGVSRRLVGFEMVGKGIARAGYPVHRPDGEPVGFVTSGMPSP
TLGRPLGMAYVPTDLSSEGSEFDVIVRERPVRARVVKMPFYKPRYKR

Sequences:

>Translated_367_residues
MLKRTPLYNAHLAMGARMVEFGGWEMPVQYRGIIEEHHAVRNRAGLFDISHMGRFMVRGAHAEAFLQQMVTCDVRAIPLG
HASYGLLCRPDGGIVDDVFLYHLPDEFMVVVNAANRQKDWDWLQQHTAGFEVEIEDRSERWAMLALQGPQAEQLLAGAES
STTADIGSLPFHGVAMTTIFGQNALIARTGYTGEDGFEIFFEAVHAEQFWHGLLALGGNAVQACGLGARDSLRFEACLAL
YGHEIDETTNPYEARLGWVVKLDKGDFIGREALQAIKQNGVSRRLVGFEMVGKGIARAGYPVHRPDGEPVGFVTSGMPSP
TLGRPLGMAYVPTDLSSEGSEFDVIVRERPVRARVVKMPFYKPRYKR
>Mature_367_residues
MLKRTPLYNAHLAMGARMVEFGGWEMPVQYRGIIEEHHAVRNRAGLFDISHMGRFMVRGAHAEAFLQQMVTCDVRAIPLG
HASYGLLCRPDGGIVDDVFLYHLPDEFMVVVNAANRQKDWDWLQQHTAGFEVEIEDRSERWAMLALQGPQAEQLLAGAES
STTADIGSLPFHGVAMTTIFGQNALIARTGYTGEDGFEIFFEAVHAEQFWHGLLALGGNAVQACGLGARDSLRFEACLAL
YGHEIDETTNPYEARLGWVVKLDKGDFIGREALQAIKQNGVSRRLVGFEMVGKGIARAGYPVHRPDGEPVGFVTSGMPSP
TLGRPLGMAYVPTDLSSEGSEFDVIVRERPVRARVVKMPFYKPRYKR

Specific function: The glycine cleavage system catalyzes the degradation of glycine [H]

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family [H]

Homologues:

Organism=Homo sapiens, GI44662838, Length=376, Percent_Identity=36.436170212766, Blast_Score=209, Evalue=3e-54,
Organism=Homo sapiens, GI257796258, Length=351, Percent_Identity=36.1823361823362, Blast_Score=196, Evalue=4e-50,
Organism=Homo sapiens, GI257796254, Length=370, Percent_Identity=34.5945945945946, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI257796256, Length=319, Percent_Identity=34.1692789968652, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI24797151, Length=365, Percent_Identity=26.8493150684932, Blast_Score=132, Evalue=6e-31,
Organism=Homo sapiens, GI194306651, Length=373, Percent_Identity=26.0053619302949, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI197927446, Length=288, Percent_Identity=25, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI21361378, Length=288, Percent_Identity=25, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI1789272, Length=371, Percent_Identity=40.7008086253369, Blast_Score=254, Evalue=6e-69,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=36.0742705570292, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71994045, Length=343, Percent_Identity=26.530612244898, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI71994052, Length=343, Percent_Identity=26.530612244898, Blast_Score=118, Evalue=6e-27,
Organism=Caenorhabditis elegans, GI32563613, Length=348, Percent_Identity=25.5747126436782, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6320222, Length=392, Percent_Identity=37.2448979591837, Blast_Score=221, Evalue=1e-58,
Organism=Drosophila melanogaster, GI20129441, Length=378, Percent_Identity=37.3015873015873, Blast_Score=228, Evalue=4e-60,
Organism=Drosophila melanogaster, GI28571104, Length=332, Percent_Identity=24.6987951807229, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI20130091, Length=321, Percent_Identity=22.7414330218069, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903 [H]

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C [H]

EC number: =2.1.2.10 [H]

Molecular weight: Translated: 40709; Mature: 40709

Theoretical pI: Translated: 6.45; Mature: 6.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKRTPLYNAHLAMGARMVEFGGWEMPVQYRGIIEEHHAVRNRAGLFDISHMGRFMVRGA
CCCCCCCCCHHHHHCCEEEECCCEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHEECC
HAEAFLQQMVTCDVRAIPLGHASYGLLCRPDGGIVDDVFLYHLPDEFMVVVNAANRQKDW
HHHHHHHHHHHCCEEEEECCCCCCCEEECCCCCCCCCEEEEECCCCEEEEEECCCCCCHH
DWLQQHTAGFEVEIEDRSERWAMLALQGPQAEQLLAGAESSTTADIGSLPFHGVAMTTIF
HHHHHHCCCCEEEECCCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
GQNALIARTGYTGEDGFEIFFEAVHAEQFWHGLLALGGNAVQACGLGARDSLRFEACLAL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
YGHEIDETTNPYEARLGWVVKLDKGDFIGREALQAIKQNGVSRRLVGFEMVGKGIARAGY
HCCCCCCCCCCHHEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PVHRPDGEPVGFVTSGMPSPTLGRPLGMAYVPTDLSSEGSEFDVIVRERPVRARVVKMPF
CCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEECCC
YKPRYKR
CCCCCCC
>Mature Secondary Structure
MLKRTPLYNAHLAMGARMVEFGGWEMPVQYRGIIEEHHAVRNRAGLFDISHMGRFMVRGA
CCCCCCCCCHHHHHCCEEEECCCEECCHHHHHHHHHHHHHHHCCCEEEHHHHHHHHEECC
HAEAFLQQMVTCDVRAIPLGHASYGLLCRPDGGIVDDVFLYHLPDEFMVVVNAANRQKDW
HHHHHHHHHHHCCEEEEECCCCCCCEEECCCCCCCCCEEEEECCCCEEEEEECCCCCCHH
DWLQQHTAGFEVEIEDRSERWAMLALQGPQAEQLLAGAESSTTADIGSLPFHGVAMTTIF
HHHHHHCCCCEEEECCCCCEEEEEEECCCCHHHHHHCCCCCCCCCCCCCCCCCEEEEEEE
GQNALIARTGYTGEDGFEIFFEAVHAEQFWHGLLALGGNAVQACGLGARDSLRFEACLAL
CCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHH
YGHEIDETTNPYEARLGWVVKLDKGDFIGREALQAIKQNGVSRRLVGFEMVGKGIARAGY
HCCCCCCCCCCHHEEEEEEEEECCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCC
PVHRPDGEPVGFVTSGMPSPTLGRPLGMAYVPTDLSSEGSEFDVIVRERPVRARVVKMPF
CCCCCCCCCCEEEECCCCCCCCCCCCCEEEECCCCCCCCCCEEEEEECCCCEEEEEECCC
YKPRYKR
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA