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The map label for this gene is accC [H]

Identifier: 222526904

GI number: 222526904

Start: 4593925

End: 4595292

Strand: Reverse

Name: accC [H]

Synonym: Chy400_3682

Alternate gene names: 222526904

Gene position: 4595292-4593925 (Counterclockwise)

Preceding gene: 222526905

Following gene: 222526903

Centisome position: 87.21

GC content: 58.63

Gene sequence:

>1368_bases
ATGATTCGCAAAGTATTAGTAGCCAACCGCGGTGAAATTGCTGTACGTATCATTCGGGCCTGTCAGGAGTTGGGCATTCG
CACGGTAGTCGCCTACAGCACTGCCGACCGCGACTCACTGGCCGTTCGTCTGGCCGATGAAGCGGTATGTATCGGCCCAC
CACCGGCAGCAAAGTCGTACCTCAACGCTCCGGCTCTCATCAGCGCTGCCCTCGTATCGGGATGTGATGCGATCCATCCC
GGCTACGGTTTTCTCTCAGAAAACCCCTACTTTGCCGAAATGTGCGCCGACTGCAAACTGACCTTCATCGGTCCGCCGCC
TGAACCGATCCGGCTGATGGGTGATAAGGCGATTGGACGTGAGACGATGCGCAAAGCCGGCGTCCCAACCGTCCCCGGCT
CTGATGGCGAAGTTCGCTCGCTCGAAGAGGCCATCGATGTCGCCCGCCAGATCGGGTATCCGGTACTGCTCAAGCCCTCT
GGCGGTGGTGGTGGTCGCGGCATGCGCGTCGCTTACGACGAAGCCGATCTCCAGCGCGCCTTCCCCACTGCGCGTGCCGA
AGCCGAGGCAGCGTTCGGGAACGGTGCGCTTCTACTGGAAAAATACCTCACCCGCGTGCGCCACGTCGAAATCCAGGTCC
TGGCCGACCAGTACGGTCATGCCATCCACCTCGGCGAACGCGACTGCTCGGCGCAACGTCGTCACCAGAAAATCGTTGAA
GAGGCGCCATCACCGGCAGTCACCCCCGAATTGCGCGAGCGGATGGGGGCCGATGCTGTGCGTGGGATCAAATCGATTGG
CTATGTGAATGCCGGCACGCTCGAATTCCTGCTCGATCAGGACGGCAACTACTACTTCATCGAAATGAACACCCGCATCC
AGGTTGAGCATCCCGTCACCGAACAGGTGACCGGAATCGACCTCGTGCGCTGGCAGCTACTCATCGCCAGCGGCGAGCGC
TTGACGCTGCGCCAGGAAGACATTAAAATAACCCGGCACGCAATCGAGTGCCGGATCAATGCCGAAGACCCGGAGCGTGA
CTTTTTACCGGCAAGTGGTGAAGTTGAGTTCTATTTGCCGCCCGGCGGCCCTGGAGTTCGAGTCGACTCCCACCTCTATT
CCGGGTACACACCACCCGGAACCTACGACTCATTGTTGGCGAAAATTATTACCTTTGGCGACACACGCGACGAAGCGCTC
AACCGGATGCGGCGAGCGCTCAACGAATGCGTGATTACTGGTATTAAAACAACCATCCCGTTCCAGTTGGCGCTGATCGA
CGATCCGGAATTCCGGGCAGGTCGCATTCATACCGGTTACGTGGCTGAATTACTGCGCCAATGGAAAGAAACACTCAATC
CGGTATAA

Upstream 100 bases:

>100_bases
CGGCTGAAGTTGCGGGACTTGTCTGTTTCCTGGCCTCTGATGCCGGCGCATATATCAGCGGTCAAACGCTGACTATCGAC
GGTGGAATGGTGATGTCCTG

Downstream 100 bases:

>100_bases
AACGGTGACGGGATGCGTATGGGGAGGGCAAGATTGGCAAGTCAGCGGCATCGGGTACGGATCGCAGCATTGCAGATCCT
CTTTGAAGTTGATGAAACCG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MIRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCIGPPPAAKSYLNAPALISAALVSGCDAIHP
GYGFLSENPYFAEMCADCKLTFIGPPPEPIRLMGDKAIGRETMRKAGVPTVPGSDGEVRSLEEAIDVARQIGYPVLLKPS
GGGGGRGMRVAYDEADLQRAFPTARAEAEAAFGNGALLLEKYLTRVRHVEIQVLADQYGHAIHLGERDCSAQRRHQKIVE
EAPSPAVTPELRERMGADAVRGIKSIGYVNAGTLEFLLDQDGNYYFIEMNTRIQVEHPVTEQVTGIDLVRWQLLIASGER
LTLRQEDIKITRHAIECRINAEDPERDFLPASGEVEFYLPPGGPGVRVDSHLYSGYTPPGTYDSLLAKIITFGDTRDEAL
NRMRRALNECVITGIKTTIPFQLALIDDPEFRAGRIHTGYVAELLRQWKETLNPV

Sequences:

>Translated_455_residues
MIRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCIGPPPAAKSYLNAPALISAALVSGCDAIHP
GYGFLSENPYFAEMCADCKLTFIGPPPEPIRLMGDKAIGRETMRKAGVPTVPGSDGEVRSLEEAIDVARQIGYPVLLKPS
GGGGGRGMRVAYDEADLQRAFPTARAEAEAAFGNGALLLEKYLTRVRHVEIQVLADQYGHAIHLGERDCSAQRRHQKIVE
EAPSPAVTPELRERMGADAVRGIKSIGYVNAGTLEFLLDQDGNYYFIEMNTRIQVEHPVTEQVTGIDLVRWQLLIASGER
LTLRQEDIKITRHAIECRINAEDPERDFLPASGEVEFYLPPGGPGVRVDSHLYSGYTPPGTYDSLLAKIITFGDTRDEAL
NRMRRALNECVITGIKTTIPFQLALIDDPEFRAGRIHTGYVAELLRQWKETLNPV
>Mature_455_residues
MIRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCIGPPPAAKSYLNAPALISAALVSGCDAIHP
GYGFLSENPYFAEMCADCKLTFIGPPPEPIRLMGDKAIGRETMRKAGVPTVPGSDGEVRSLEEAIDVARQIGYPVLLKPS
GGGGGRGMRVAYDEADLQRAFPTARAEAEAAFGNGALLLEKYLTRVRHVEIQVLADQYGHAIHLGERDCSAQRRHQKIVE
EAPSPAVTPELRERMGADAVRGIKSIGYVNAGTLEFLLDQDGNYYFIEMNTRIQVEHPVTEQVTGIDLVRWQLLIASGER
LTLRQEDIKITRHAIECRINAEDPERDFLPASGEVEFYLPPGGPGVRVDSHLYSGYTPPGTYDSLLAKIITFGDTRDEAL
NRMRRALNECVITGIKTTIPFQLALIDDPEFRAGRIHTGYVAELLRQWKETLNPV

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=447, Percent_Identity=47.8747203579418, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.0812641083521, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.0812641083521, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.0812641083521, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=447, Percent_Identity=47.8747203579418, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI106049295, Length=447, Percent_Identity=47.8747203579418, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI106049292, Length=447, Percent_Identity=47.8747203579418, Blast_Score=408, Evalue=1e-114,
Organism=Homo sapiens, GI38679960, Length=512, Percent_Identity=32.421875, Blast_Score=261, Evalue=7e-70,
Organism=Homo sapiens, GI38679977, Length=512, Percent_Identity=32.421875, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI38679967, Length=512, Percent_Identity=32.421875, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI38679971, Length=512, Percent_Identity=32.421875, Blast_Score=261, Evalue=8e-70,
Organism=Homo sapiens, GI38679974, Length=512, Percent_Identity=32.421875, Blast_Score=261, Evalue=9e-70,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=31.9688109161793, Blast_Score=249, Evalue=3e-66,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=55.6053811659193, Blast_Score=482, Evalue=1e-137,
Organism=Escherichia coli, GI1786216, Length=236, Percent_Identity=25.8474576271186, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71987519, Length=441, Percent_Identity=48.0725623582766, Blast_Score=422, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=45.823927765237, Blast_Score=399, Evalue=1e-111,
Organism=Caenorhabditis elegans, GI17562816, Length=460, Percent_Identity=45.8695652173913, Blast_Score=386, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI133931226, Length=488, Percent_Identity=29.9180327868852, Blast_Score=212, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=505, Percent_Identity=29.7029702970297, Blast_Score=202, Evalue=2e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=29.8418972332016, Blast_Score=202, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=46.4125560538117, Blast_Score=368, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6321376, Length=448, Percent_Identity=46.6517857142857, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6319685, Length=441, Percent_Identity=40.3628117913832, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6323863, Length=464, Percent_Identity=32.7586206896552, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6324343, Length=524, Percent_Identity=32.6335877862595, Blast_Score=234, Evalue=3e-62,
Organism=Drosophila melanogaster, GI24651757, Length=444, Percent_Identity=46.3963963963964, Blast_Score=412, Evalue=1e-115,
Organism=Drosophila melanogaster, GI281363050, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652224, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652222, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652220, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652218, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652212, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652210, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652214, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI19921944, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24652216, Length=459, Percent_Identity=47.276688453159, Blast_Score=399, Evalue=1e-111,
Organism=Drosophila melanogaster, GI24651759, Length=406, Percent_Identity=45.8128078817734, Blast_Score=370, Evalue=1e-102,
Organism=Drosophila melanogaster, GI161076407, Length=516, Percent_Identity=31.9767441860465, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586460, Length=516, Percent_Identity=31.9767441860465, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI24586458, Length=516, Percent_Identity=31.9767441860465, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI161076409, Length=516, Percent_Identity=31.9767441860465, Blast_Score=244, Evalue=1e-64,
Organism=Drosophila melanogaster, GI45555749, Length=330, Percent_Identity=23.6363636363636, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49972; Mature: 49972

Theoretical pI: Translated: 5.71; Mature: 5.71

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCIGPPPAAKSY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCHHHHHH
LNAPALISAALVSGCDAIHPGYGFLSENPYFAEMCADCKLTFIGPPPEPIRLMGDKAIGR
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEECCCHHHCH
ETMRKAGVPTVPGSDGEVRSLEEAIDVARQIGYPVLLKPSGGGGGRGMRVAYDEADLQRA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHHH
FPTARAEAEAAFGNGALLLEKYLTRVRHVEIQVLADQYGHAIHLGERDCSAQRRHQKIVE
CCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPAVTPELRERMGADAVRGIKSIGYVNAGTLEFLLDQDGNYYFIEMNTRIQVEHPVT
HCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EQVTGIDLVRWQLLIASGERLTLRQEDIKITRHAIECRINAEDPERDFLPASGEVEFYLP
HHHCCHHHHEEEEEEECCCEEEEEHHHHHEEEEEEEEEECCCCCCCCCCCCCCCEEEEEC
PGGPGVRVDSHLYSGYTPPGTYDSLLAKIITFGDTRDEALNRMRRALNECVITGIKTTIP
CCCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
FQLALIDDPEFRAGRIHTGYVAELLRQWKETLNPV
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIRKVLVANRGEIAVRIIRACQELGIRTVVAYSTADRDSLAVRLADEAVCIGPPPAAKSY
CCCEEEECCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEEECCEEEECCCHHHHHH
LNAPALISAALVSGCDAIHPGYGFLSENPYFAEMCADCKLTFIGPPPEPIRLMGDKAIGR
CCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCEEEEECCCCCCCEECCCHHHCH
ETMRKAGVPTVPGSDGEVRSLEEAIDVARQIGYPVLLKPSGGGGGRGMRVAYDEADLQRA
HHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCEEEECHHHHHHH
FPTARAEAEAAFGNGALLLEKYLTRVRHVEIQVLADQYGHAIHLGERDCSAQRRHQKIVE
CCCHHHHHHHHCCCCHHHHHHHHHHHHHEEEEEEECCCCCEEEECCCCHHHHHHHHHHHH
EAPSPAVTPELRERMGADAVRGIKSIGYVNAGTLEFLLDQDGNYYFIEMNTRIQVEHPVT
HCCCCCCCHHHHHHCCCHHHHHHHHCCCCCCCEEEEEEECCCCEEEEEECCEEEECCCCH
EQVTGIDLVRWQLLIASGERLTLRQEDIKITRHAIECRINAEDPERDFLPASGEVEFYLP
HHHCCHHHHEEEEEEECCCEEEEEHHHHHEEEEEEEEEECCCCCCCCCCCCCCCEEEEEC
PGGPGVRVDSHLYSGYTPPGTYDSLLAKIITFGDTRDEALNRMRRALNECVITGIKTTIP
CCCCCCEECCHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCC
FQLALIDDPEFRAGRIHTGYVAELLRQWKETLNPV
EEEEEECCCCCCCCCEEHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]