Click here to switch to the map view.

The map label for this gene is 222526884

Identifier: 222526884

GI number: 222526884

Start: 4563934

End: 4565733

Strand: Reverse

Name: 222526884

Synonym: Chy400_3661

Alternate gene names: NA

Gene position: 4565733-4563934 (Counterclockwise)

Preceding gene: 222526885

Following gene: 222526883

Centisome position: 86.65

GC content: 59.61

Gene sequence:

>1800_bases
ATGCCTGCTCGTTCTGGATTATTGCTGCTGATCATCTTCGTCGTTGTGGCAGGATTACCACCGGTTACCCCAGTTCAGGC
GGCTCATCCTACCGATCTGATCGTGAAGTTTGCCGTTCCCCAGGATACAACCGACGTTGTGCGTGCGCTGAAGGCGTTGA
AGGTGGAACCGCTCGGTGAGCAGACGTATCTGGTGCGCTTGCCGGCTGGTATGTCGGTTGAATGGGCGGGCAACCGCATT
CGTCAGCACAAGAACGTTGTCTATGCGGTGCCAGACTACGAGCGTACTATAACCCGTACCCCGAATGATCCGCTGCGCGA
ACGGCAGTGGGCATTAGGGACGATTGCGGCCTACGATGCCTGGGACATCACCACCGGCGGGCCGATTGTGGTGGCGGTTA
TTGACACCGGCATTGATGCGAGTCATCCCGAACTGGAGGGTCGGGTGTTGGGGGGCTTCAACGCGATTACCGGTAGTACC
GATGTCAGCGACGATAACGGTCACGGGACGGCGGTGGCCGGTCTGATTGCGGCCAGCGGCGATAATGGCGTCGGTATTGC
CGGCATGTGTTGGGGATGTGTCATTCTGCCGATTAAGGCGTGTCTGAGTAGTGGCCGTTGTCGGGATTCGAGTGTGATTA
GCGCCATTCGCTGGGCAACCGACAACGGAGCACGGATTATTAATCTCAGTCTGGGTGGCACACTGGCTTCGCCCGCGCTG
CACGAAGCCGTTCGCTATGCGACCGAGCGGGGGGTGTTGGTGGTGGCAGCCAGTGGCAACGAGCGGGCGGAAGGGAATGC
GCCGAATTATCCGGCGGCCTACCCGGAAACGGTAGCTATCGGCGCGAGCGGTTATAGCGATGAGGTCACCGGATTTTCAA
ATACGGGTGAGTTTATCGATCTGGTGGCACCAGGGGTTGATATTGTCACCACCACGCCGGGAAATAGCTATGCGCTGGCA
ACCGGTACCTCGTTCGCCAGTCCTTTTGCGAGTGGAGCGGCAGCACTGGTGATGACGATACGCCCTGATTTGAGCAGTGC
TGATGTGCGCTGTATTCTGTCTGTGGCAGCCGATGATCGGGGTGCGCCGGGCCGTGACGGCGAGTATGGCTATGGGCGCC
TGAATGTGCTGGCCGCCATCCAAACGGCTACGACGTATGGCGGGTGTCCGCTGGGCACGCCCGCAGTGGGTGGTAACCCT
GGGTTCGATCCCTTTGCCCGGGTGGAACCACCGGCTGATGACCGCCTCTACTTCCCCGAAACCGGTCATACGCTGGGTGG
TGGATTTCGGACTTACTGGGAGCAGAACGGTGGTTTACCGATCTTCGGCTTTCCGGTCAGCGAGGAGTTTACCGAGATCG
GGAGCGATGGCAGGCCGGTGACCGTTCAGTATTTCGAGCGTCACCGTTTTGAATGGCGACCGGAGAACCAGCCGCCGTAC
CATGTTTTGCTGTCGCGCATCGGTGATACGATCTTGCAGCGGCAGGGGCGCGACTGGACAACGTTTGAGCGCAGTGGGCC
GCTCGCCGGTTGTCTCTACTTCGCTGAAACCAATCAGTCATTGTGTGAACCGTTCCTGAGCTACTGGCAGCGCAATGGGT
TGGAGTTTGATGGCCGACCCGGCAAGAGCTATGCCGAGAGTCTGGCCTTGTTTGGCTTACCCCTGTCGGCGCCGCGAGTC
GAAGAGACGCGACCGGGCACGGTGGTGATCGTGCAGTGGTTTGAACGGGCACGTTTTGAGTTGCATCCCGACGGTCAGGT
GCTGCTGGGGCTGTTGGGGAATGAGTTGTTGGGGCGGTAG

Upstream 100 bases:

>100_bases
CCCGCCTGTTGCCTGACAATCGGTAGCAGCGGGGAGCAAAACCGGTGCTGATCGGGTACAATACGATCAGGTATGTATCG
TTGAACACAAGGGACTCTCC

Downstream 100 bases:

>100_bases
GTTGGGGCGAAACATATCCGGCTGGTTTGACCGTCCGGTGGGGCAGGCTGCCCGCCCATGTTCATGCATTCCAGTCACGC
GGGTTACGTGCCGGTACGGG

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 599; Mature: 598

Protein sequence:

>599_residues
MPARSGLLLLIIFVVVAGLPPVTPVQAAHPTDLIVKFAVPQDTTDVVRALKALKVEPLGEQTYLVRLPAGMSVEWAGNRI
RQHKNVVYAVPDYERTITRTPNDPLRERQWALGTIAAYDAWDITTGGPIVVAVIDTGIDASHPELEGRVLGGFNAITGST
DVSDDNGHGTAVAGLIAASGDNGVGIAGMCWGCVILPIKACLSSGRCRDSSVISAIRWATDNGARIINLSLGGTLASPAL
HEAVRYATERGVLVVAASGNERAEGNAPNYPAAYPETVAIGASGYSDEVTGFSNTGEFIDLVAPGVDIVTTTPGNSYALA
TGTSFASPFASGAAALVMTIRPDLSSADVRCILSVAADDRGAPGRDGEYGYGRLNVLAAIQTATTYGGCPLGTPAVGGNP
GFDPFARVEPPADDRLYFPETGHTLGGGFRTYWEQNGGLPIFGFPVSEEFTEIGSDGRPVTVQYFERHRFEWRPENQPPY
HVLLSRIGDTILQRQGRDWTTFERSGPLAGCLYFAETNQSLCEPFLSYWQRNGLEFDGRPGKSYAESLALFGLPLSAPRV
EETRPGTVVIVQWFERARFELHPDGQVLLGLLGNELLGR

Sequences:

>Translated_599_residues
MPARSGLLLLIIFVVVAGLPPVTPVQAAHPTDLIVKFAVPQDTTDVVRALKALKVEPLGEQTYLVRLPAGMSVEWAGNRI
RQHKNVVYAVPDYERTITRTPNDPLRERQWALGTIAAYDAWDITTGGPIVVAVIDTGIDASHPELEGRVLGGFNAITGST
DVSDDNGHGTAVAGLIAASGDNGVGIAGMCWGCVILPIKACLSSGRCRDSSVISAIRWATDNGARIINLSLGGTLASPAL
HEAVRYATERGVLVVAASGNERAEGNAPNYPAAYPETVAIGASGYSDEVTGFSNTGEFIDLVAPGVDIVTTTPGNSYALA
TGTSFASPFASGAAALVMTIRPDLSSADVRCILSVAADDRGAPGRDGEYGYGRLNVLAAIQTATTYGGCPLGTPAVGGNP
GFDPFARVEPPADDRLYFPETGHTLGGGFRTYWEQNGGLPIFGFPVSEEFTEIGSDGRPVTVQYFERHRFEWRPENQPPY
HVLLSRIGDTILQRQGRDWTTFERSGPLAGCLYFAETNQSLCEPFLSYWQRNGLEFDGRPGKSYAESLALFGLPLSAPRV
EETRPGTVVIVQWFERARFELHPDGQVLLGLLGNELLGR
>Mature_598_residues
PARSGLLLLIIFVVVAGLPPVTPVQAAHPTDLIVKFAVPQDTTDVVRALKALKVEPLGEQTYLVRLPAGMSVEWAGNRIR
QHKNVVYAVPDYERTITRTPNDPLRERQWALGTIAAYDAWDITTGGPIVVAVIDTGIDASHPELEGRVLGGFNAITGSTD
VSDDNGHGTAVAGLIAASGDNGVGIAGMCWGCVILPIKACLSSGRCRDSSVISAIRWATDNGARIINLSLGGTLASPALH
EAVRYATERGVLVVAASGNERAEGNAPNYPAAYPETVAIGASGYSDEVTGFSNTGEFIDLVAPGVDIVTTTPGNSYALAT
GTSFASPFASGAAALVMTIRPDLSSADVRCILSVAADDRGAPGRDGEYGYGRLNVLAAIQTATTYGGCPLGTPAVGGNPG
FDPFARVEPPADDRLYFPETGHTLGGGFRTYWEQNGGLPIFGFPVSEEFTEIGSDGRPVTVQYFERHRFEWRPENQPPYH
VLLSRIGDTILQRQGRDWTTFERSGPLAGCLYFAETNQSLCEPFLSYWQRNGLEFDGRPGKSYAESLALFGLPLSAPRVE
ETRPGTVVIVQWFERARFELHPDGQVLLGLLGNELLGR

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4506775, Length=293, Percent_Identity=27.6450511945392, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI31317307, Length=257, Percent_Identity=27.2373540856031, Blast_Score=66, Evalue=8e-11,
Organism=Caenorhabditis elegans, GI71988301, Length=341, Percent_Identity=25.8064516129032, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71988321, Length=341, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71983555, Length=403, Percent_Identity=23.0769230769231, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988315, Length=341, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI71988297, Length=341, Percent_Identity=25.8064516129032, Blast_Score=67, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI25141268, Length=357, Percent_Identity=23.249299719888, Blast_Score=66, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI71988308, Length=341, Percent_Identity=25.8064516129032, Blast_Score=65, Evalue=8e-11,
Organism=Saccharomyces cerevisiae, GI6320775, Length=251, Percent_Identity=32.6693227091633, Blast_Score=106, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6324576, Length=274, Percent_Identity=31.021897810219, Blast_Score=105, Evalue=3e-23,
Organism=Saccharomyces cerevisiae, GI6319893, Length=316, Percent_Identity=27.5316455696203, Blast_Score=100, Evalue=5e-22,
Organism=Drosophila melanogaster, GI45550681, Length=308, Percent_Identity=26.2987012987013, Blast_Score=80, Evalue=5e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 63919; Mature: 63787

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPARSGLLLLIIFVVVAGLPPVTPVQAAHPTDLIVKFAVPQDTTDVVRALKALKVEPLGE
CCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
QTYLVRLPAGMSVEWAGNRIRQHKNVVYAVPDYERTITRTPNDPLRERQWALGTIAAYDA
CEEEEECCCCCEEECCCHHHHHCCCEEEECCCCCHHEECCCCCHHHHHHHHHEEEEEECC
WDITTGGPIVVAVIDTGIDASHPELEGRVLGGFNAITGSTDVSDDNGHGTAVAGLIAASG
EEECCCCCEEEEEEECCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCEEEEEEEEECC
DNGVGIAGMCWGCVILPIKACLSSGRCRDSSVISAIRWATDNGARIINLSLGGTLASPAL
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCCCCEEEEEECCCCCCCHHH
HEAVRYATERGVLVVAASGNERAEGNAPNYPAAYPETVAIGASGYSDEVTGFSNTGEFID
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
LVAPGVDIVTTTPGNSYALATGTSFASPFASGAAALVMTIRPDLSSADVRCILSVAADDR
EECCCCEEEEECCCCCEEEECCCCCCCHHHCCCEEEEEEECCCCCCCCEEEEEEEECCCC
GAPGRDGEYGYGRLNVLAAIQTATTYGGCPLGTPAVGGNPGFDPFARVEPPADDRLYFPE
CCCCCCCCCCCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
TGHTLGGGFRTYWEQNGGLPIFGFPVSEEFTEIGSDGRPVTVQYFERHRFEWRPENQPPY
CCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHH
HVLLSRIGDTILQRQGRDWTTFERSGPLAGCLYFAETNQSLCEPFLSYWQRNGLEFDGRP
HHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCC
GKSYAESLALFGLPLSAPRVEETRPGTVVIVQWFERARFELHPDGQVLLGLLGNELLGR
CHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PARSGLLLLIIFVVVAGLPPVTPVQAAHPTDLIVKFAVPQDTTDVVRALKALKVEPLGE
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHCCCCCCC
QTYLVRLPAGMSVEWAGNRIRQHKNVVYAVPDYERTITRTPNDPLRERQWALGTIAAYDA
CEEEEECCCCCEEECCCHHHHHCCCEEEECCCCCHHEECCCCCHHHHHHHHHEEEEEECC
WDITTGGPIVVAVIDTGIDASHPELEGRVLGGFNAITGSTDVSDDNGHGTAVAGLIAASG
EEECCCCCEEEEEEECCCCCCCCCCCCEEEECCEEECCCCCCCCCCCCCEEEEEEEEECC
DNGVGIAGMCWGCVILPIKACLSSGRCRDSSVISAIRWATDNGARIINLSLGGTLASPAL
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHEEECCCCCEEEEEECCCCCCCHHH
HEAVRYATERGVLVVAASGNERAEGNAPNYPAAYPETVAIGASGYSDEVTGFSNTGEFID
HHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEE
LVAPGVDIVTTTPGNSYALATGTSFASPFASGAAALVMTIRPDLSSADVRCILSVAADDR
EECCCCEEEEECCCCCEEEECCCCCCCHHHCCCEEEEEEECCCCCCCCEEEEEEEECCCC
GAPGRDGEYGYGRLNVLAAIQTATTYGGCPLGTPAVGGNPGFDPFARVEPPADDRLYFPE
CCCCCCCCCCCCCEEEEEEEEHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCC
TGHTLGGGFRTYWEQNGGLPIFGFPVSEEFTEIGSDGRPVTVQYFERHRFEWRPENQPPY
CCCCCCCCHHHHHHCCCCEEEEECCCCHHHHHHCCCCCEEEEEEHHCCCCCCCCCCCCHH
HVLLSRIGDTILQRQGRDWTTFERSGPLAGCLYFAETNQSLCEPFLSYWQRNGLEFDGRP
HHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCCC
GKSYAESLALFGLPLSAPRVEETRPGTVVIVQWFERARFELHPDGQVLLGLLGNELLGR
CHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEHHCCCEEECCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]