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The map label for this gene is panE [C]

Identifier: 222526842

GI number: 222526842

Start: 4501620

End: 4502582

Strand: Reverse

Name: panE [C]

Synonym: Chy400_3618

Alternate gene names: 222526842

Gene position: 4502582-4501620 (Counterclockwise)

Preceding gene: 222526843

Following gene: 222526841

Centisome position: 85.46

GC content: 60.85

Gene sequence:

>963_bases
ATGAGTGTCGAAAACCCAATGCGGATAGCGATTGTTGGTGTTGGTGGTGTCGGCGGCTACTTCGGTGGTCGTCTGGCCCA
GGCCGGTCACGACGTTTTCTTTATTGCCCGGGGCGATCATCTGGCAGCTATGCGAAGCCATGGCCTGCGCGTGCAGAGCA
TTGCCGGCGATTTCTGGTTACCGGACGTGAAGGCAACCGATCAACCCGCCGAGGTAGGCCCGGTTGATCTGGTGATTGTG
GGTGTGAAAGGCTGGCAGGTGCGTGAAGCGGCATACGCGATGCAACCGCTGATCGGCCCAGAGACGGCTGTGCTTCCGCT
GCTCAATGGGGTCGATGCGCCGACCGAACTGGCAGAGGTACTCGGCGCCGAACATGTGTTGGCCGGCTTGTGCCGCATCA
TTGCCTATCGGGCTGCACCGGGTGTGATTGTTCATGCCGGAGTCAATCCGCCCTCTATCGATTTCGGTGAACTCGACAAT
CGCCATACCCCTCGCCTGGCGCGGATTCAGGCCGCACTGGAGGGGGCCGGTATTCGCGCCTTTATCCCCGAAAACATCCA
CGTTGCGCTCTGGCAGAAGTTCATGCTGATTTGCGCCTGGAGTGGGTTTGGCGCTGCTACCCGCGCCCCGATTGGGGTCT
GGCGTTCCCTGCCTGAAACCCGCCCCCTGGTCGAACGTTGTTTGCAAGAGGTGGTTGATGTGGCCGCCGCTCGCGGTGTG
ATGCTGCCGGACAATGCGGTGAGCACAATGATGGCGTTTATCGATAGCATGCCTTACGAAGGGACAGCCTCGCTGCAGCG
CGATATTATGAGCGGCCAGCCTTCAGAACTGGCCAGCCAGAATGGAGCGCTGGTACGCCTGGCGCGTGCCGCCGGTGTTC
CGGTGCCGGTCAACGAGATGCTGTACGCTATCTTGCTGCCGCAAGAATTAGCCGCCCGCGGCCAACTACCGACCCAACGT
TGA

Upstream 100 bases:

>100_bases
CAGCAAGATACCACCCCGTCAGCCGCAGCCGATCCAGCACGGTGATGAGTTGCGGCTGGGAGCGCTAAAGCTTATCGTTG
AATTGTCGTAAGAGTGCTGT

Downstream 100 bases:

>100_bases
ATGCGCTAGAGAGGAGCGCCGCATGTCTGCACGTCTGTCCCGCCTGGTAGAGCGTCTGGTTGCCGCAGATTACGCCGGTG
CCGCCTTGATGCCGGCTACC

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 320; Mature: 319

Protein sequence:

>320_residues
MSVENPMRIAIVGVGGVGGYFGGRLAQAGHDVFFIARGDHLAAMRSHGLRVQSIAGDFWLPDVKATDQPAEVGPVDLVIV
GVKGWQVREAAYAMQPLIGPETAVLPLLNGVDAPTELAEVLGAEHVLAGLCRIIAYRAAPGVIVHAGVNPPSIDFGELDN
RHTPRLARIQAALEGAGIRAFIPENIHVALWQKFMLICAWSGFGAATRAPIGVWRSLPETRPLVERCLQEVVDVAAARGV
MLPDNAVSTMMAFIDSMPYEGTASLQRDIMSGQPSELASQNGALVRLARAAGVPVPVNEMLYAILLPQELAARGQLPTQR

Sequences:

>Translated_320_residues
MSVENPMRIAIVGVGGVGGYFGGRLAQAGHDVFFIARGDHLAAMRSHGLRVQSIAGDFWLPDVKATDQPAEVGPVDLVIV
GVKGWQVREAAYAMQPLIGPETAVLPLLNGVDAPTELAEVLGAEHVLAGLCRIIAYRAAPGVIVHAGVNPPSIDFGELDN
RHTPRLARIQAALEGAGIRAFIPENIHVALWQKFMLICAWSGFGAATRAPIGVWRSLPETRPLVERCLQEVVDVAAARGV
MLPDNAVSTMMAFIDSMPYEGTASLQRDIMSGQPSELASQNGALVRLARAAGVPVPVNEMLYAILLPQELAARGQLPTQR
>Mature_319_residues
SVENPMRIAIVGVGGVGGYFGGRLAQAGHDVFFIARGDHLAAMRSHGLRVQSIAGDFWLPDVKATDQPAEVGPVDLVIVG
VKGWQVREAAYAMQPLIGPETAVLPLLNGVDAPTELAEVLGAEHVLAGLCRIIAYRAAPGVIVHAGVNPPSIDFGELDNR
HTPRLARIQAALEGAGIRAFIPENIHVALWQKFMLICAWSGFGAATRAPIGVWRSLPETRPLVERCLQEVVDVAAARGVM
LPDNAVSTMMAFIDSMPYEGTASLQRDIMSGQPSELASQNGALVRLARAAGVPVPVNEMLYAILLPQELAARGQLPTQR

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786627, Length=309, Percent_Identity=24.9190938511327, Blast_Score=69, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 34064; Mature: 33933

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVENPMRIAIVGVGGVGGYFGGRLAQAGHDVFFIARGDHLAAMRSHGLRVQSIAGDFWL
CCCCCCEEEEEEEECCCCHHHCCHHHHCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCC
PDVKATDQPAEVGPVDLVIVGVKGWQVREAAYAMQPLIGPETAVLPLLNGVDAPTELAEV
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHH
LGAEHVLAGLCRIIAYRAAPGVIVHAGVNPPSIDFGELDNRHTPRLARIQAALEGAGIRA
HCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
FIPENIHVALWQKFMLICAWSGFGAATRAPIGVWRSLPETRPLVERCLQEVVDVAAARGV
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
MLPDNAVSTMMAFIDSMPYEGTASLQRDIMSGQPSELASQNGALVRLARAAGVPVPVNEM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEHHHCCCCCCHHHH
LYAILLPQELAARGQLPTQR
HHHHHCCHHHHHCCCCCCCC
>Mature Secondary Structure 
SVENPMRIAIVGVGGVGGYFGGRLAQAGHDVFFIARGDHLAAMRSHGLRVQSIAGDFWL
CCCCCEEEEEEEECCCCHHHCCHHHHCCCCEEEEECCCHHHHHHHCCCEEEEECCCCCC
PDVKATDQPAEVGPVDLVIVGVKGWQVREAAYAMQPLIGPETAVLPLLNGVDAPTELAEV
CCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHH
LGAEHVLAGLCRIIAYRAAPGVIVHAGVNPPSIDFGELDNRHTPRLARIQAALEGAGIRA
HCHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCEEE
FIPENIHVALWQKFMLICAWSGFGAATRAPIGVWRSLPETRPLVERCLQEVVDVAAARGV
ECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCC
MLPDNAVSTMMAFIDSMPYEGTASLQRDIMSGQPSELASQNGALVRLARAAGVPVPVNEM
CCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHCCCCEEEEHHHCCCCCCHHHH
LYAILLPQELAARGQLPTQR
HHHHHCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11759840 [H]