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The map label for this gene is garR [H]

Identifier: 222526832

GI number: 222526832

Start: 4490128

End: 4491027

Strand: Direct

Name: garR [H]

Synonym: Chy400_3607

Alternate gene names: 222526832

Gene position: 4490128-4491027 (Clockwise)

Preceding gene: 222526830

Following gene: 222526840

Centisome position: 85.22

GC content: 61.22

Gene sequence:

>900_bases
ATGAGTGAACGAATTGGCTTCATTGGGCTGGGGATCATGGGGCGTGGCATGGCGGCCAACATTCTGCGAGCCGGGTTCCC
GTTGACGGTGTGGAACCGCACGCCGGGGCGGGCCGATGAACTGGTTGCTGCCGGCGCTCAGTTAGCAACCTCACCGGCCG
ATCTGGCTGCCCGCAGTGATATTGTGATCAGTTGTGTGAGTGATACCCCCGATGTAGAAGCCGTTCTGTTTGGACCGCAA
GGGGTGATCGAAGGTGCACGGGCCGGAATGTTGGTCATTGATATGAGTACCATCAGCCCGCAAGGCGCACAGCAGTTTGC
CGCTCGCCTGCACGATCACGGGATTGGCTTTCTCGATGCGCCGGTGAGCGGTGGCAGTGAAGGAGCCGCACGCGGAACGC
TCAGCATTATGGTTGGTGGACCGGCCCCGCTGGTGGAACGGGCGATGCCGGTCTTTCAGGCGATGGGCAAAACGATCACA
CACGTCGGCGATCACGGTGCCGGCCAGACGGTCAAGCTGGTGAATCAAATTCTGGTGGTGGGGACGATGCTGGCTATCAG
CGAAGCACTGGTCTTCGCCCAGGCCAGCGGCGTCGATTTAGAGAAGACGCTGGCAGCGGTGAGTGGTGGTGCCGCCGGAA
GCTGGATGCTCTCGAACCGTGGGCCGCAGGTCATTCGCCGCGACTGGCGGCCCGGCTTTACCATCGACCTCCAGCAAAAA
GATTTACGATTGGTGCTGGCCGCTGCCGATGCGGTCGGCGCGCCAATGCTGACCACTTCGACCGTGTTTCATCTCTACCG
CACCCTGCAACAGGCCGGATTAGGTCACGAGGGGAATCATGCCCTGATCAAAGCGATAGAGCGCCTGGCAGGGATTGAGG
TGGGGCAGCGGAGTGAGTGA

Upstream 100 bases:

>100_bases
CGGTACAGCGAGTATGTCATTGCGTTGTGATTGCAATGCCGGCAGGTATGATACCATCCTTTGTATCAGCGTTGTTCTCA
GCAAAATTGAGGAGTGAGGT

Downstream 100 bases:

>100_bases
GGATGGTGATTGGATAACATTTGCAATAGCACGGCTCGTCATCACAGGTGCGGGTTATTGATGGGCGGACTGTCGATCCG
CCCATCACCCTGCTCGTCTA

Product: NAD-binding 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 299; Mature: 298

Protein sequence:

>299_residues
MSERIGFIGLGIMGRGMAANILRAGFPLTVWNRTPGRADELVAAGAQLATSPADLAARSDIVISCVSDTPDVEAVLFGPQ
GVIEGARAGMLVIDMSTISPQGAQQFAARLHDHGIGFLDAPVSGGSEGAARGTLSIMVGGPAPLVERAMPVFQAMGKTIT
HVGDHGAGQTVKLVNQILVVGTMLAISEALVFAQASGVDLEKTLAAVSGGAAGSWMLSNRGPQVIRRDWRPGFTIDLQQK
DLRLVLAAADAVGAPMLTTSTVFHLYRTLQQAGLGHEGNHALIKAIERLAGIEVGQRSE

Sequences:

>Translated_299_residues
MSERIGFIGLGIMGRGMAANILRAGFPLTVWNRTPGRADELVAAGAQLATSPADLAARSDIVISCVSDTPDVEAVLFGPQ
GVIEGARAGMLVIDMSTISPQGAQQFAARLHDHGIGFLDAPVSGGSEGAARGTLSIMVGGPAPLVERAMPVFQAMGKTIT
HVGDHGAGQTVKLVNQILVVGTMLAISEALVFAQASGVDLEKTLAAVSGGAAGSWMLSNRGPQVIRRDWRPGFTIDLQQK
DLRLVLAAADAVGAPMLTTSTVFHLYRTLQQAGLGHEGNHALIKAIERLAGIEVGQRSE
>Mature_298_residues
SERIGFIGLGIMGRGMAANILRAGFPLTVWNRTPGRADELVAAGAQLATSPADLAARSDIVISCVSDTPDVEAVLFGPQG
VIEGARAGMLVIDMSTISPQGAQQFAARLHDHGIGFLDAPVSGGSEGAARGTLSIMVGGPAPLVERAMPVFQAMGKTITH
VGDHGAGQTVKLVNQILVVGTMLAISEALVFAQASGVDLEKTLAAVSGGAAGSWMLSNRGPQVIRRDWRPGFTIDLQQKD
LRLVLAAADAVGAPMLTTSTVFHLYRTLQQAGLGHEGNHALIKAIERLAGIEVGQRSE

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40556376, Length=265, Percent_Identity=34.3396226415094, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI23308751, Length=281, Percent_Identity=32.3843416370107, Blast_Score=145, Evalue=3e-35,
Organism=Escherichia coli, GI145693186, Length=291, Percent_Identity=40.5498281786942, Blast_Score=229, Evalue=2e-61,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=44.0972222222222, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1790315, Length=289, Percent_Identity=34.9480968858132, Blast_Score=154, Evalue=9e-39,
Organism=Escherichia coli, GI1789092, Length=285, Percent_Identity=34.0350877192982, Blast_Score=134, Evalue=6e-33,
Organism=Escherichia coli, GI1788341, Length=293, Percent_Identity=23.5494880546075, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17557316, Length=273, Percent_Identity=34.4322344322344, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24655230, Length=283, Percent_Identity=33.9222614840989, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI19922568, Length=283, Percent_Identity=33.9222614840989, Blast_Score=154, Evalue=8e-38,
Organism=Drosophila melanogaster, GI28574115, Length=282, Percent_Identity=26.241134751773, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31029; Mature: 30898

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERIGFIGLGIMGRGMAANILRAGFPLTVWNRTPGRADELVAAGAQLATSPADLAARSD
CCCCCEEEEECHHCCCHHHHHHHCCCCEEEECCCCCCHHHHHHCCHHHCCCCHHHHCCCC
IVISCVSDTPDVEAVLFGPQGVIEGARAGMLVIDMSTISPQGAQQFAARLHDHGIGFLDA
EEEEEECCCCCCEEEEECCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEC
PVSGGSEGAARGTLSIMVGGPAPLVERAMPVFQAMGKTITHVGDHGAGQTVKLVNQILVV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
GTMLAISEALVFAQASGVDLEKTLAAVSGGAAGSWMLSNRGPQVIRRDWRPGFTIDLQQK
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCEEEECCC
DLRLVLAAADAVGAPMLTTSTVFHLYRTLQQAGLGHEGNHALIKAIERLAGIEVGQRSE
CEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SERIGFIGLGIMGRGMAANILRAGFPLTVWNRTPGRADELVAAGAQLATSPADLAARSD
CCCCEEEEECHHCCCHHHHHHHCCCCEEEECCCCCCHHHHHHCCHHHCCCCHHHHCCCC
IVISCVSDTPDVEAVLFGPQGVIEGARAGMLVIDMSTISPQGAQQFAARLHDHGIGFLDA
EEEEEECCCCCCEEEEECCHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCEEEC
PVSGGSEGAARGTLSIMVGGPAPLVERAMPVFQAMGKTITHVGDHGAGQTVKLVNQILVV
CCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHH
GTMLAISEALVFAQASGVDLEKTLAAVSGGAAGSWMLSNRGPQVIRRDWRPGFTIDLQQK
HHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCEEECCCCHHHHHHCCCCCCEEEECCC
DLRLVLAAADAVGAPMLTTSTVFHLYRTLQQAGLGHEGNHALIKAIERLAGIEVGQRSE
CEEEEEEEHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]