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The map label for this gene is acdA [H]

Identifier: 222526646

GI number: 222526646

Start: 4255386

End: 4256525

Strand: Reverse

Name: acdA [H]

Synonym: Chy400_3415

Alternate gene names: 222526646

Gene position: 4256525-4255386 (Counterclockwise)

Preceding gene: 222526647

Following gene: 222526645

Centisome position: 80.79

GC content: 57.54

Gene sequence:

>1140_bases
ATGGAGTTCCAGCTTACCGAAGATCAGCAGATGCTCCGCGACATGGTGCGCCAGTTTGCCGAGAAAGAGGCCAAACCAAC
TGTCGCTGAACGTGATGAACATGCCCGCTGGCCTGCCGAATTGGTGCGCAAAATGGGTGAACTCGGTCTGATGGGTGTCG
CCGTTAGCGAAGAGTACGGTGGCGCCGGAATGGATTATGTCTCGTATGCGATAGTGATTGAAGAACTCTCGCGGGTTGAT
CCGTCACTGGGTGTGATCGCCTCGGTGAATAACTCGCTGGTGTGCTACGGGATCGAGAAGTTTGGCACCGAAGAGCAGAA
GCGTGAGCTGCTGGTACCGCTGGCAAGTGGGCGGATGCTTGGGGCATTCTCGCTCAGTGAACCGGGCGCCGGTTCGGACG
CCGCAGCCCAACGAACAACTGCTGTGCGCGATGGCGACTATTACGTTATCAACGGCGTCAAGAACTGGGTTACTAACGGT
GATCACGCCGACACCATTATCTTGATGGCGATGACCGACCCCAGCAAGGGTACGAAAGGCATCACCGCATTTCTGGTTGA
CACCCACGCGCCAGGTTGTCGGGTGGTCAAAGTCGAGAACAAGCTCGGCATTCGCAGTGCACATAGCTGCCAGATGGCGT
ATGACGACTACCGCATACCGGCGTGGCGGCGGCTCGGCGAAGAGGGTCAGGGTTTCAAGATTGCGATGACGATTCTCAAC
GCCGGTCGCATCGGGATTGCGGCACAGGCGGTCGGGATTGCGCAAGGCGCGTTCGAGGCGGCACTGGAGTACAGCAAAGT
TCGTGAACAATTCGGCAAACCGATCCACGAATTCCAGGCCGTCGGCTTTACGCTGGCCGATATGGCAACCCGTATCAAAG
CGGCCCGTCTGCTCACCTACGAAGCCGCCTGGCGCAAAGATCAGGGGCTTGATTTCATCAAAGACGCCTCGATGGCGAAG
CTCTTTGCTTCCGAGACGGCGATGTGGGTGGCGACGAAGGCGGTGCAACTGCACGGTTCAAACGGCTACTCGAAAGAGTA
TCCGGTGGAACGGTTCTTCCGTGACGCGAAGATTACCGAGATTTACGAAGGGACAAGTGAGATTCAGCGCCTCGTGATCA
GCCGCGAACTGGTACGCTGA

Upstream 100 bases:

>100_bases
GCTGCGTGAATGGCTGACAACGCTTGCTTGAGGTGAACAGCTCGCGTAGAATGGGATATAGCGGTCAGCGCAAGCGCAAA
TACGAATGAAGGAGGCGATC

Downstream 100 bases:

>100_bases
TCAGAGTAGACGGCGGCGCTGCGTCGCCCAACAGGAGTTATGCGTCTCATTCTTGTGCGACACGGCGAGACGCCGTGGAA
TCAAACGTTACAGTACCAGG

Product: acyl-CoA dehydrogenase domain-containing protein

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MEFQLTEDQQMLRDMVRQFAEKEAKPTVAERDEHARWPAELVRKMGELGLMGVAVSEEYGGAGMDYVSYAIVIEELSRVD
PSLGVIASVNNSLVCYGIEKFGTEEQKRELLVPLASGRMLGAFSLSEPGAGSDAAAQRTTAVRDGDYYVINGVKNWVTNG
DHADTIILMAMTDPSKGTKGITAFLVDTHAPGCRVVKVENKLGIRSAHSCQMAYDDYRIPAWRRLGEEGQGFKIAMTILN
AGRIGIAAQAVGIAQGAFEAALEYSKVREQFGKPIHEFQAVGFTLADMATRIKAARLLTYEAAWRKDQGLDFIKDASMAK
LFASETAMWVATKAVQLHGSNGYSKEYPVERFFRDAKITEIYEGTSEIQRLVISRELVR

Sequences:

>Translated_379_residues
MEFQLTEDQQMLRDMVRQFAEKEAKPTVAERDEHARWPAELVRKMGELGLMGVAVSEEYGGAGMDYVSYAIVIEELSRVD
PSLGVIASVNNSLVCYGIEKFGTEEQKRELLVPLASGRMLGAFSLSEPGAGSDAAAQRTTAVRDGDYYVINGVKNWVTNG
DHADTIILMAMTDPSKGTKGITAFLVDTHAPGCRVVKVENKLGIRSAHSCQMAYDDYRIPAWRRLGEEGQGFKIAMTILN
AGRIGIAAQAVGIAQGAFEAALEYSKVREQFGKPIHEFQAVGFTLADMATRIKAARLLTYEAAWRKDQGLDFIKDASMAK
LFASETAMWVATKAVQLHGSNGYSKEYPVERFFRDAKITEIYEGTSEIQRLVISRELVR
>Mature_379_residues
MEFQLTEDQQMLRDMVRQFAEKEAKPTVAERDEHARWPAELVRKMGELGLMGVAVSEEYGGAGMDYVSYAIVIEELSRVD
PSLGVIASVNNSLVCYGIEKFGTEEQKRELLVPLASGRMLGAFSLSEPGAGSDAAAQRTTAVRDGDYYVINGVKNWVTNG
DHADTIILMAMTDPSKGTKGITAFLVDTHAPGCRVVKVENKLGIRSAHSCQMAYDDYRIPAWRRLGEEGQGFKIAMTILN
AGRIGIAAQAVGIAQGAFEAALEYSKVREQFGKPIHEFQAVGFTLADMATRIKAARLLTYEAAWRKDQGLDFIKDASMAK
LFASETAMWVATKAVQLHGSNGYSKEYPVERFFRDAKITEIYEGTSEIQRLVISRELVR

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=51.8617021276596, Blast_Score=372, Evalue=1e-103,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=44.7721179624665, Blast_Score=342, Evalue=4e-94,
Organism=Homo sapiens, GI187960098, Length=380, Percent_Identity=39.2105263157895, Blast_Score=268, Evalue=6e-72,
Organism=Homo sapiens, GI4557231, Length=380, Percent_Identity=39.2105263157895, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=36.5333333333333, Blast_Score=265, Evalue=4e-71,
Organism=Homo sapiens, GI7656849, Length=376, Percent_Identity=35.9042553191489, Blast_Score=262, Evalue=4e-70,
Organism=Homo sapiens, GI226958414, Length=338, Percent_Identity=37.8698224852071, Blast_Score=253, Evalue=2e-67,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=37.7308707124011, Blast_Score=232, Evalue=4e-61,
Organism=Homo sapiens, GI76496475, Length=385, Percent_Identity=37.6623376623377, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI4557235, Length=385, Percent_Identity=37.6623376623377, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI4501857, Length=382, Percent_Identity=34.8167539267016, Blast_Score=211, Evalue=9e-55,
Organism=Homo sapiens, GI4503943, Length=381, Percent_Identity=30.7086614173228, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI7669494, Length=366, Percent_Identity=30.6010928961749, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI48976061, Length=401, Percent_Identity=28.927680798005, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI211971008, Length=400, Percent_Identity=28.75, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI38505218, Length=364, Percent_Identity=26.3736263736264, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=29.7368421052632, Blast_Score=190, Evalue=1e-49,
Organism=Escherichia coli, GI87081958, Length=386, Percent_Identity=31.8652849740933, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI87082384, Length=281, Percent_Identity=25.9786476868327, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87081702, Length=291, Percent_Identity=27.8350515463918, Blast_Score=72, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=45.6989247311828, Blast_Score=330, Evalue=7e-91,
Organism=Caenorhabditis elegans, GI17506239, Length=371, Percent_Identity=45.0134770889488, Blast_Score=327, Evalue=5e-90,
Organism=Caenorhabditis elegans, GI17569725, Length=383, Percent_Identity=40.4699738903394, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=39.7905759162304, Blast_Score=273, Evalue=1e-73,
Organism=Caenorhabditis elegans, GI17538396, Length=379, Percent_Identity=37.7308707124011, Blast_Score=270, Evalue=9e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=38.3202099737533, Blast_Score=266, Evalue=2e-71,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=46.4163822525597, Blast_Score=264, Evalue=5e-71,
Organism=Caenorhabditis elegans, GI17533517, Length=376, Percent_Identity=35.6382978723404, Blast_Score=253, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI71985184, Length=382, Percent_Identity=34.5549738219895, Blast_Score=219, Evalue=2e-57,
Organism=Caenorhabditis elegans, GI32563615, Length=253, Percent_Identity=44.2687747035573, Blast_Score=214, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=38.9090909090909, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=31.5649867374005, Blast_Score=192, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI71985192, Length=339, Percent_Identity=32.7433628318584, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17551932, Length=367, Percent_Identity=30.7901907356948, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=361, Percent_Identity=30.4709141274238, Blast_Score=171, Evalue=6e-43,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=34.453781512605, Blast_Score=147, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17562446, Length=364, Percent_Identity=26.6483516483516, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI17531913, Length=177, Percent_Identity=33.8983050847458, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI86563381, Length=309, Percent_Identity=26.8608414239482, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI86563383, Length=309, Percent_Identity=26.8608414239482, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=48.5333333333333, Blast_Score=366, Evalue=1e-101,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=48, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24666513, Length=371, Percent_Identity=43.1266846361186, Blast_Score=328, Evalue=5e-90,
Organism=Drosophila melanogaster, GI21355753, Length=379, Percent_Identity=39.0501319261214, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24660351, Length=379, Percent_Identity=39.3139841688654, Blast_Score=260, Evalue=1e-69,
Organism=Drosophila melanogaster, GI281363737, Length=367, Percent_Identity=34.0599455040872, Blast_Score=210, Evalue=2e-54,
Organism=Drosophila melanogaster, GI19920834, Length=382, Percent_Identity=32.1989528795811, Blast_Score=191, Evalue=6e-49,
Organism=Drosophila melanogaster, GI281365206, Length=336, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585193, Length=336, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585195, Length=336, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24585191, Length=336, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 41828; Mature: 41828

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEFQLTEDQQMLRDMVRQFAEKEAKPTVAERDEHARWPAELVRKMGELGLMGVAVSEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GAGMDYVSYAIVIEELSRVDPSLGVIASVNNSLVCYGIEKFGTEEQKRELLVPLASGRML
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHCCCHHHHHEEEEECCCCEE
GAFSLSEPGAGSDAAAQRTTAVRDGDYYVINGVKNWVTNGDHADTIILMAMTDPSKGTKG
EEEECCCCCCCCCHHHHHHHEEECCCEEEECCHHHHCCCCCCCCEEEEEEEECCCCCCCC
ITAFLVDTHAPGCRVVKVENKLGIRSAHSCQMAYDDYRIPAWRRLGEEGQGFKIAMTILN
EEEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCCEEEEEEEEC
AGRIGIAAQAVGIAQGAFEAALEYSKVREQFGKPIHEFQAVGFTLADMATRIKAARLLTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHH
EAAWRKDQGLDFIKDASMAKLFASETAMWVATKAVQLHGSNGYSKEYPVERFFRDAKITE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCHHHHHCCCHHHH
IYEGTSEIQRLVISRELVR
HHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MEFQLTEDQQMLRDMVRQFAEKEAKPTVAERDEHARWPAELVRKMGELGLMGVAVSEEYG
CCCCCCCHHHHHHHHHHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHCCCEEEEEEECCCC
GAGMDYVSYAIVIEELSRVDPSLGVIASVNNSLVCYGIEKFGTEEQKRELLVPLASGRML
CCCHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEHHHHCCCHHHHHEEEEECCCCEE
GAFSLSEPGAGSDAAAQRTTAVRDGDYYVINGVKNWVTNGDHADTIILMAMTDPSKGTKG
EEEECCCCCCCCCHHHHHHHEEECCCEEEECCHHHHCCCCCCCCEEEEEEEECCCCCCCC
ITAFLVDTHAPGCRVVKVENKLGIRSAHSCQMAYDDYRIPAWRRLGEEGQGFKIAMTILN
EEEEEEECCCCCEEEEEECCCCCCCCCCCCEECCCCCCCHHHHHCCCCCCCEEEEEEEEC
AGRIGIAAQAVGIAQGAFEAALEYSKVREQFGKPIHEFQAVGFTLADMATRIKAARLLTY
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHHHH
EAAWRKDQGLDFIKDASMAKLFASETAMWVATKAVQLHGSNGYSKEYPVERFFRDAKITE
HHHHCCCCCCCHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCCCCCHHHHHCCCHHHH
IYEGTSEIQRLVISRELVR
HHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]