Click here to switch to the map view.

The map label for this gene is bfmBAB [H]

Identifier: 222526602

GI number: 222526602

Start: 4199211

End: 4200242

Strand: Direct

Name: bfmBAB [H]

Synonym: Chy400_3370

Alternate gene names: 222526602

Gene position: 4199211-4200242 (Clockwise)

Preceding gene: 222526601

Following gene: 222526603

Centisome position: 79.7

GC content: 56.88

Gene sequence:

>1032_bases
ATGACGTGGGATCAAGGTTTACATAAATCGACAACCGTCCTGAGTGACGATCAGGGGACACGCGAGTTGACCTATCTGGA
GGCAATCCGGGCCGCACTGCGTTACGAGATGCAGCGTGATCCGCGTGTGCTGGTGATGGGTGAAGATATTGGTGTGTATG
GTGGCGCATTCAAGGTAACCCAGGGATTGATTGATGAATTCGGTGAGGATCGGGTGATCGACACCCCCATGACCGAACTG
GCCATGCTCTACGCAGCGATTGGCATGTCGTTCGAGGGCTTCTTGCCGGTGGTCGAAATGCAATTCGCCGACTTCATCTC
AACCGGTTTTGATGCTCTGGTGCAGTTTGCGGCGACCAACCATTTTCGCTGGCGTCAACCGGTGCCGATTACGGTACGTG
CTCCCGGTGGCGGCGGCTTGCGGGCCGGCCCCTTCCATTCGCAATCGAACGAAGCCTGGTTTATCCATACTCCCGGTCTG
AAGGTGGTTGCCCCGGCGACTCCCGCCGACGCCTACGGTCTGCTGCTCAGCGCCATTCGTGACCCCAATCCGGTGATCTA
CTACGAGACAAAGTACCTCTACCGTTCGCTCAAAGGGATGGTGCCGGAAGGCGATGCGCCAGTACCAATCGGGCAGGCAG
CACTGCGACGTACCGGTGAGGAGGTGAGCATTATTACTTACGGAGCGATGGTGCAAGAAGCGCTAAGTGCAGCCCAGACC
CTTGAACAGGAAGGGCATAGCGTCGAAGTGCTTGATCTGCGTACCCTCAAACCACTCGACGAAGATGCTATTCTGACGAC
GGCGCGTAAAACCGGCAAGGTTTTGATTGTTCACGAAGCGAATCGTACTTGCGGCGTAGGTGGTGAGGTGGCTGCAATCA
TTGCTGAACGCGCCTTTGAGTATCTTGATGGGCCGATTATCCGTCTGGCCGCACCTGATACGCCGGTGCCGTACAGTCCA
CCTCTGGAAGATGCCTACCGGCCCAACGCAACCAAAATTCTGGCCGCAGCCCGTGATCTGCTGGCGTATTGA

Upstream 100 bases:

>100_bases
GCTTGATGAGGCACAGGCGTTCGCTGAAGCTTCACCGTATCCCGATCCGGCAACGCTGACCGATGGCGTCTATGCGTGAA
CCACGAGCAGGAGGCAGGCA

Downstream 100 bases:

>100_bases
GGCGGGTGGGGTAACTACTGCACACACCGCGGCAGATACGGTTTCCTGCTTGGATTATCTGTGGCGCATGGTCTGGCGTA
CAGAACGGAAACGCCAGTTT

Product: transketolase central subunit

Products: NA

Alternate protein names: Branched-chain alpha-keto acid dehydrogenase E1 component beta chain; BCKDH E1-beta [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTWDQGLHKSTTVLSDDQGTRELTYLEAIRAALRYEMQRDPRVLVMGEDIGVYGGAFKVTQGLIDEFGEDRVIDTPMTEL
AMLYAAIGMSFEGFLPVVEMQFADFISTGFDALVQFAATNHFRWRQPVPITVRAPGGGGLRAGPFHSQSNEAWFIHTPGL
KVVAPATPADAYGLLLSAIRDPNPVIYYETKYLYRSLKGMVPEGDAPVPIGQAALRRTGEEVSIITYGAMVQEALSAAQT
LEQEGHSVEVLDLRTLKPLDEDAILTTARKTGKVLIVHEANRTCGVGGEVAAIIAERAFEYLDGPIIRLAAPDTPVPYSP
PLEDAYRPNATKILAAARDLLAY

Sequences:

>Translated_343_residues
MTWDQGLHKSTTVLSDDQGTRELTYLEAIRAALRYEMQRDPRVLVMGEDIGVYGGAFKVTQGLIDEFGEDRVIDTPMTEL
AMLYAAIGMSFEGFLPVVEMQFADFISTGFDALVQFAATNHFRWRQPVPITVRAPGGGGLRAGPFHSQSNEAWFIHTPGL
KVVAPATPADAYGLLLSAIRDPNPVIYYETKYLYRSLKGMVPEGDAPVPIGQAALRRTGEEVSIITYGAMVQEALSAAQT
LEQEGHSVEVLDLRTLKPLDEDAILTTARKTGKVLIVHEANRTCGVGGEVAAIIAERAFEYLDGPIIRLAAPDTPVPYSP
PLEDAYRPNATKILAAARDLLAY
>Mature_342_residues
TWDQGLHKSTTVLSDDQGTRELTYLEAIRAALRYEMQRDPRVLVMGEDIGVYGGAFKVTQGLIDEFGEDRVIDTPMTELA
MLYAAIGMSFEGFLPVVEMQFADFISTGFDALVQFAATNHFRWRQPVPITVRAPGGGGLRAGPFHSQSNEAWFIHTPGLK
VVAPATPADAYGLLLSAIRDPNPVIYYETKYLYRSLKGMVPEGDAPVPIGQAALRRTGEEVSIITYGAMVQEALSAAQTL
EQEGHSVEVLDLRTLKPLDEDAILTTARKTGKVLIVHEANRTCGVGGEVAAIIAERAFEYLDGPIIRLAAPDTPVPYSPP
LEDAYRPNATKILAAARDLLAY

Specific function: The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components:branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltran

COG id: COG0022

COG function: function code C; Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557353, Length=330, Percent_Identity=37.8787878787879, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI34101272, Length=330, Percent_Identity=37.8787878787879, Blast_Score=225, Evalue=5e-59,
Organism=Homo sapiens, GI156564403, Length=326, Percent_Identity=35.8895705521472, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI291084858, Length=324, Percent_Identity=34.2592592592593, Blast_Score=201, Evalue=9e-52,
Organism=Caenorhabditis elegans, GI17538422, Length=325, Percent_Identity=38.1538461538462, Blast_Score=231, Evalue=3e-61,
Organism=Caenorhabditis elegans, GI17506935, Length=328, Percent_Identity=38.4146341463415, Blast_Score=224, Evalue=4e-59,
Organism=Saccharomyces cerevisiae, GI6319698, Length=334, Percent_Identity=38.622754491018, Blast_Score=236, Evalue=3e-63,
Organism=Drosophila melanogaster, GI21358145, Length=327, Percent_Identity=36.085626911315, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI24650940, Length=327, Percent_Identity=36.085626911315, Blast_Score=218, Evalue=5e-57,
Organism=Drosophila melanogaster, GI160714828, Length=329, Percent_Identity=37.3860182370821, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI160714832, Length=329, Percent_Identity=37.3860182370821, Blast_Score=217, Evalue=8e-57,
Organism=Drosophila melanogaster, GI24650943, Length=93, Percent_Identity=37.6344086021505, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24650945, Length=93, Percent_Identity=37.6344086021505, Blast_Score=78, Evalue=7e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =1.2.4.4 [H]

Molecular weight: Translated: 37426; Mature: 37295

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTWDQGLHKSTTVLSDDQGTRELTYLEAIRAALRYEMQRDPRVLVMGEDIGVYGGAFKVT
CCCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
QGLIDEFGEDRVIDTPMTELAMLYAAIGMSFEGFLPVVEMQFADFISTGFDALVQFAATN
HHHHHHCCCCCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HFRWRQPVPITVRAPGGGGLRAGPFHSQSNEAWFIHTPGLKVVAPATPADAYGLLLSAIR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHC
DPNPVIYYETKYLYRSLKGMVPEGDAPVPIGQAALRRTGEEVSIITYGAMVQEALSAAQT
CCCCEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
LEQEGHSVEVLDLRTLKPLDEDAILTTARKTGKVLIVHEANRTCGVGGEVAAIIAERAFE
HHHCCCEEEEEEEECCCCCCCCHHEEEHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
YLDGPIIRLAAPDTPVPYSPPLEDAYRPNATKILAAARDLLAY
HHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TWDQGLHKSTTVLSDDQGTRELTYLEAIRAALRYEMQRDPRVLVMGEDIGVYGGAFKVT
CCCCCCCCCCEEECCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCHHHHH
QGLIDEFGEDRVIDTPMTELAMLYAAIGMSFEGFLPVVEMQFADFISTGFDALVQFAATN
HHHHHHCCCCCEECCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCC
HFRWRQPVPITVRAPGGGGLRAGPFHSQSNEAWFIHTPGLKVVAPATPADAYGLLLSAIR
CCCCCCCCCEEEECCCCCCCCCCCCCCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHC
DPNPVIYYETKYLYRSLKGMVPEGDAPVPIGQAALRRTGEEVSIITYGAMVQEALSAAQT
CCCCEEEECHHHHHHHHHCCCCCCCCCCCCCHHHHHCCCCEEEEEEHHHHHHHHHHHHHH
LEQEGHSVEVLDLRTLKPLDEDAILTTARKTGKVLIVHEANRTCGVGGEVAAIIAERAFE
HHHCCCEEEEEEEECCCCCCCCHHEEEHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
YLDGPIIRLAAPDTPVPYSPPLEDAYRPNATKILAAARDLLAY
HHCCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8504804; 8969508; 9384377 [H]