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The map label for this gene is nuoD2

Identifier: 222526371

GI number: 222526371

Start: 3879799

End: 3881034

Strand: Direct

Name: nuoD2

Synonym: Chy400_3137

Alternate gene names: 222526371

Gene position: 3879799-3881034 (Clockwise)

Preceding gene: 222526370

Following gene: 222526372

Centisome position: 73.64

GC content: 56.55

Gene sequence:

>1236_bases
ATGACCGAACCGATCACTGTACCCACACCGCAGCAGATCATTGAGCCGGCTGTGGCTGGACGCACCGAGACGATGGTGCT
GAATATGGGGCCGCATCATCCCAGTACCCACGGTGTGCTGCGGCTTGTGCTGGAACTTGACGGTGAGGTGGTGGTGAATG
TCGCGCCTGACGTTGGCTACCTCCATACCGGCATTGAAAAGACGATGGAGAGCAAGACCTACCAGAAGGCGGTTGTGTTG
ACCGACCGGATGGACTATCTGGCTCCGCTTTCCAATAATCTGTGTTATGCTCTGGCAGTTGAAAAGCTGCTCGATGTTGA
GATTCCAGAGCGTGCTCAGATTGCACGGGTCTTGCTCACCGAGTTGCAACGTATTTCATCGCACCTGGTCTGGCTCGGCA
CTCACGCCCTCGATCTGGCGGCGATGAGTGTCTTCCTTTACGCTTTCCGCGAGCGCGAGCAGATTCTCGATATTTTTGAG
CTGGTCTCTGGGGCGCGCATGATGACCAGCTATTTTCGGATCGGTGGCCTGGCCTACGATCTGCCATCCGATTTTATCCC
GACGGTCGAGCAGTTCCTCGCTGTTATGCCATCACGGATTGATGAGTACGAGGATTTGCTCACTGCCAACCCGCTCTGGC
TCGAACGAACCGTTGGTGTTGGTGTCATTGATGCGCAATCGGCGATTGCGCTGGGCCTGACCGGTGCCAATCTACGGGCT
ACCGGCGTTGCGTATGATGTGCGCAAGGCGATGCCCTACAGCGGCTATGAGACCTACTCGTTTGAGATACCGGTTGGCAA
GAATGGCGATATTTACGACCGCTATCGAGTGCGTATCGCCGAGATGCGCCAGAGTGTGAAGATTGTGCAGCAGGCGACCG
AGCGTTTGCGTGAGTTGGGGCCTGGCCCGGTTGTGACCTCGAATCGAAAGGTTGCCCCACCGCCAAAGCGCGAGATTACC
GAGAGCATGGAGTCGCTTATCCATCACTTCAAGTTGTGGACAGAAGGTTTCAAGCCGCCACGGGGTGATGCCTACGTGAG
CATCGAGTCGCCGCGTGGTATTCTGGGCTGTTATGTGGTGAGTGATGGTAGCCCGAAACCGTGGCGTGTTCACTTCCGGG
CGCCGTCGTTTATCAATTTGCAGAGTCTGGCTCATATGGCGAAGGGCCGGATGGTTGCCGATCTGGTCGCGTTAATTGCC
AGCCTCGATCCGGTGTTGGGCGAGGTTGATCGCTAA

Upstream 100 bases:

>100_bases
GCTCCGCAAGGATCATCCGCTTGGCGATGAAGAGATTGCGTTTACGTTCAATCAGGAACGTATTTACGCTCGTAAGCCGT
TCGTGAGGGAGTAGCCGCGT

Downstream 100 bases:

>100_bases
CCGACTATCATACTGCGGAGGAAAACGTGACTCTGCTCGAAACACATCAGGCTGAGATTGAGGCAATCGTGGCGCGCTAC
GCCAGTAAGCGTAGTGCAGT

Product: NADH dehydrogenase I subunit D

Products: NA

Alternate protein names: NADH dehydrogenase I subunit D 2; NDH-1 subunit D 2

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MTEPITVPTPQQIIEPAVAGRTETMVLNMGPHHPSTHGVLRLVLELDGEVVVNVAPDVGYLHTGIEKTMESKTYQKAVVL
TDRMDYLAPLSNNLCYALAVEKLLDVEIPERAQIARVLLTELQRISSHLVWLGTHALDLAAMSVFLYAFREREQILDIFE
LVSGARMMTSYFRIGGLAYDLPSDFIPTVEQFLAVMPSRIDEYEDLLTANPLWLERTVGVGVIDAQSAIALGLTGANLRA
TGVAYDVRKAMPYSGYETYSFEIPVGKNGDIYDRYRVRIAEMRQSVKIVQQATERLRELGPGPVVTSNRKVAPPPKREIT
ESMESLIHHFKLWTEGFKPPRGDAYVSIESPRGILGCYVVSDGSPKPWRVHFRAPSFINLQSLAHMAKGRMVADLVALIA
SLDPVLGEVDR

Sequences:

>Translated_411_residues
MTEPITVPTPQQIIEPAVAGRTETMVLNMGPHHPSTHGVLRLVLELDGEVVVNVAPDVGYLHTGIEKTMESKTYQKAVVL
TDRMDYLAPLSNNLCYALAVEKLLDVEIPERAQIARVLLTELQRISSHLVWLGTHALDLAAMSVFLYAFREREQILDIFE
LVSGARMMTSYFRIGGLAYDLPSDFIPTVEQFLAVMPSRIDEYEDLLTANPLWLERTVGVGVIDAQSAIALGLTGANLRA
TGVAYDVRKAMPYSGYETYSFEIPVGKNGDIYDRYRVRIAEMRQSVKIVQQATERLRELGPGPVVTSNRKVAPPPKREIT
ESMESLIHHFKLWTEGFKPPRGDAYVSIESPRGILGCYVVSDGSPKPWRVHFRAPSFINLQSLAHMAKGRMVADLVALIA
SLDPVLGEVDR
>Mature_410_residues
TEPITVPTPQQIIEPAVAGRTETMVLNMGPHHPSTHGVLRLVLELDGEVVVNVAPDVGYLHTGIEKTMESKTYQKAVVLT
DRMDYLAPLSNNLCYALAVEKLLDVEIPERAQIARVLLTELQRISSHLVWLGTHALDLAAMSVFLYAFREREQILDIFEL
VSGARMMTSYFRIGGLAYDLPSDFIPTVEQFLAVMPSRIDEYEDLLTANPLWLERTVGVGVIDAQSAIALGLTGANLRAT
GVAYDVRKAMPYSGYETYSFEIPVGKNGDIYDRYRVRIAEMRQSVKIVQQATERLRELGPGPVVTSNRKVAPPPKREITE
SMESLIHHFKLWTEGFKPPRGDAYVSIESPRGILGCYVVSDGSPKPWRVHFRAPSFINLQSLAHMAKGRMVADLVALIAS
LDPVLGEVDR

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG0649

COG function: function code C; NADH:ubiquinone oxidoreductase 49 kD subunit 7

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein; Cytoplasmic side

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 49 kDa subunit family

Homologues:

Organism=Homo sapiens, GI4758786, Length=404, Percent_Identity=46.5346534653465, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI260898743, Length=394, Percent_Identity=45.9390862944162, Blast_Score=364, Evalue=1e-101,
Organism=Escherichia coli, GI145693162, Length=388, Percent_Identity=41.7525773195876, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI1789076, Length=393, Percent_Identity=28.7531806615776, Blast_Score=162, Evalue=4e-41,
Organism=Escherichia coli, GI1788832, Length=393, Percent_Identity=26.4631043256997, Blast_Score=136, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17555284, Length=389, Percent_Identity=46.0154241645244, Blast_Score=387, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17568379, Length=389, Percent_Identity=46.5295629820051, Blast_Score=387, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24638644, Length=406, Percent_Identity=45.0738916256158, Blast_Score=400, Evalue=1e-112,
Organism=Drosophila melanogaster, GI221459469, Length=396, Percent_Identity=44.4444444444444, Blast_Score=379, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NUOD2_CHLAA (A9WFB4)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001636487.1
- ProteinModelPortal:   A9WFB4
- SMR:   A9WFB4
- GeneID:   5827371
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_2899
- HOGENOM:   HBG459705
- OMA:   MFANEGY
- ProtClustDB:   CLSK974896
- GO:   GO:0006810
- HAMAP:   MF_01358
- InterPro:   IPR010219
- InterPro:   IPR001135
- InterPro:   IPR014029
- InterPro:   IPR022885
- TIGRFAMs:   TIGR01962

Pfam domain/function: PF00346 Complex1_49kDa

EC number: =1.6.99.5

Molecular weight: Translated: 45712; Mature: 45581

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS00535 COMPLEX1_49K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEPITVPTPQQIIEPAVAGRTETMVLNMGPHHPSTHGVLRLVLELDGEVVVNVAPDVGY
CCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHEEECCCCEEEEECCCCCH
LHTGIEKTMESKTYQKAVVLTDRMDYLAPLSNNLCYALAVEKLLDVEIPERAQIARVLLT
HHHHHHHHHHHHHHHHHEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
ELQRISSHLVWLGTHALDLAAMSVFLYAFREREQILDIFELVSGARMMTSYFRIGGLAYD
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
LPSDFIPTVEQFLAVMPSRIDEYEDLLTANPLWLERTVGVGVIDAQSAIALGLTGANLRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCEEEECCCEEEEEECCCCCEE
TGVAYDVRKAMPYSGYETYSFEIPVGKNGDIYDRYRVRIAEMRQSVKIVQQATERLRELG
CCHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGPVVTSNRKVAPPPKREITESMESLIHHFKLWTEGFKPPRGDAYVSIESPRGILGCYVV
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEE
SDGSPKPWRVHFRAPSFINLQSLAHMAKGRMVADLVALIASLDPVLGEVDR
ECCCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCHHHHCCCC
>Mature Secondary Structure 
TEPITVPTPQQIIEPAVAGRTETMVLNMGPHHPSTHGVLRLVLELDGEVVVNVAPDVGY
CCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHHHEEECCCCEEEEECCCCCH
LHTGIEKTMESKTYQKAVVLTDRMDYLAPLSNNLCYALAVEKLLDVEIPERAQIARVLLT
HHHHHHHHHHHHHHHHHEEEEHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
ELQRISSHLVWLGTHALDLAAMSVFLYAFREREQILDIFELVSGARMMTSYFRIGGLAYD
HHHHHHHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
LPSDFIPTVEQFLAVMPSRIDEYEDLLTANPLWLERTVGVGVIDAQSAIALGLTGANLRA
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHCCCCEEEECCCEEEEEECCCCCEE
TGVAYDVRKAMPYSGYETYSFEIPVGKNGDIYDRYRVRIAEMRQSVKIVQQATERLRELG
CCHHHHHHHCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PGPVVTSNRKVAPPPKREITESMESLIHHFKLWTEGFKPPRGDAYVSIESPRGILGCYVV
CCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCEEEEEEE
SDGSPKPWRVHFRAPSFINLQSLAHMAKGRMVADLVALIASLDPVLGEVDR
ECCCCCCEEEEECCCCCCCHHHHHHHHHCHHHHHHHHHHHHHCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA