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The map label for this gene is fabG [C]

Identifier: 222526098

GI number: 222526098

Start: 3525763

End: 3526458

Strand: Direct

Name: fabG [C]

Synonym: Chy400_2855

Alternate gene names: 222526098

Gene position: 3525763-3526458 (Clockwise)

Preceding gene: 222526097

Following gene: 222526099

Centisome position: 66.92

GC content: 58.33

Gene sequence:

>696_bases
ATGCGTACCATTCTGATTACCGGTGCTTCACGCGGTATCGGTGCAGCTACAGCACTTGCATTGGCCGGGCCTGACACTCG
TTTAACGCTGGCGGCGCGTGATCGTACTGCCCTCGAAGCGGTTGCCCGACAGGCTACTGCGGCTGGTGCCCAATGCCTTG
TCGTACCGTGTGATGTCACCGATCCAGCCCAGGTTGCCCCAACCGTTGCTCAGGCTGCTGGAGAAGGGACACTTGATGTT
GTGGTGCATAGTGTTGGTGGGGCTTTGGTAGCACCGCTGGCCGACATTGAACTTCCCGCCTGGGAAGAACACATGCGGAC
TCAGCTCACCAGTCTCTTCCTGGTTGCGAAAGCGACTACAGCCCGCATGGATCGCGGTAGCCTATTCATCAATATTGCCT
CAGTTGCCGCTCGCCAGGCATTCCCAGGCTGGTCGGCATATGTAGCCGCTAAACACGGCGCACTTGGCTTTATGGCTGCC
ATCCGTGAAGAGCTGCGCCCACGCGGTATTCGTGTCTGTTCGATCCTACCCGCCGCCACCGATACCGCGATTTGGGATGC
CATACCCGGTGACTGGTCGCGTACCAATATGCTACAACCGGGCGATGTTGCTGCGGTCATTGCCGCCCTTGTTGCACTTC
CACCATACGCGACGGTTGAGGATTTGACGATTGGTCATGTCGCAGGGCGATTGTGA

Upstream 100 bases:

>100_bases
ATAGGCGATAACAACGTTGAGTCTGCTGTTTCAGCGAAACAGTCTCTTCGCTAGCCTGAAGCGCAAGTGGCTGTCGTCTA
TTGCAACAGGACAAGAGAAT

Downstream 100 bases:

>100_bases
GGTGTGGCTGTTTTGTCGAAAAGTTGGGTGATGGTGTATGGGCCGGCATGGCCCACACACCCGATCTGATGCGCAACCAG
TGCGGAAGTTGTACTTCCGC

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 231; Mature: 231

Protein sequence:

>231_residues
MRTILITGASRGIGAATALALAGPDTRLTLAARDRTALEAVARQATAAGAQCLVVPCDVTDPAQVAPTVAQAAGEGTLDV
VVHSVGGALVAPLADIELPAWEEHMRTQLTSLFLVAKATTARMDRGSLFINIASVAARQAFPGWSAYVAAKHGALGFMAA
IREELRPRGIRVCSILPAATDTAIWDAIPGDWSRTNMLQPGDVAAVIAALVALPPYATVEDLTIGHVAGRL

Sequences:

>Translated_231_residues
MRTILITGASRGIGAATALALAGPDTRLTLAARDRTALEAVARQATAAGAQCLVVPCDVTDPAQVAPTVAQAAGEGTLDV
VVHSVGGALVAPLADIELPAWEEHMRTQLTSLFLVAKATTARMDRGSLFINIASVAARQAFPGWSAYVAAKHGALGFMAA
IREELRPRGIRVCSILPAATDTAIWDAIPGDWSRTNMLQPGDVAAVIAALVALPPYATVEDLTIGHVAGRL
>Mature_231_residues
MRTILITGASRGIGAATALALAGPDTRLTLAARDRTALEAVARQATAAGAQCLVVPCDVTDPAQVAPTVAQAAGEGTLDV
VVHSVGGALVAPLADIELPAWEEHMRTQLTSLFLVAKATTARMDRGSLFINIASVAARQAFPGWSAYVAAKHGALGFMAA
IREELRPRGIRVCSILPAATDTAIWDAIPGDWSRTNMLQPGDVAAVIAALVALPPYATVEDLTIGHVAGRL

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=200, Percent_Identity=31.5, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI20149619, Length=205, Percent_Identity=26.8292682926829, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787335, Length=190, Percent_Identity=30.5263157894737, Blast_Score=77, Evalue=7e-16,
Organism=Escherichia coli, GI1787526, Length=193, Percent_Identity=30.0518134715026, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI87082100, Length=234, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788459, Length=184, Percent_Identity=29.3478260869565, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17555706, Length=191, Percent_Identity=29.3193717277487, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71982365, Length=198, Percent_Identity=29.7979797979798, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI71994604, Length=228, Percent_Identity=26.7543859649123, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=192, Percent_Identity=26.5625, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=190, Percent_Identity=27.8947368421053, Blast_Score=67, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323882, Length=190, Percent_Identity=30.5263157894737, Blast_Score=75, Evalue=6e-15,
Organism=Drosophila melanogaster, GI21357041, Length=188, Percent_Identity=31.9148936170213, Blast_Score=85, Evalue=4e-17,
Organism=Drosophila melanogaster, GI28571526, Length=226, Percent_Identity=31.858407079646, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24644339, Length=229, Percent_Identity=29.6943231441048, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=203, Percent_Identity=31.0344827586207, Blast_Score=74, Evalue=8e-14,
Organism=Drosophila melanogaster, GI116007236, Length=235, Percent_Identity=25.531914893617, Blast_Score=70, Evalue=9e-13,
Organism=Drosophila melanogaster, GI24643142, Length=188, Percent_Identity=27.1276595744681, Blast_Score=67, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 23862; Mature: 23862

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00018 EF_HAND_1 ; PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTILITGASRGIGAATALALAGPDTRLTLAARDRTALEAVARQATAAGAQCLVVPCDVT
CEEEEEECCCCCCCHHHEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCC
DPAQVAPTVAQAAGEGTLDVVVHSVGGALVAPLADIELPAWEEHMRTQLTSLFLVAKATT
CCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ARMDRGSLFINIASVAARQAFPGWSAYVAAKHGALGFMAAIREELRPRGIRVCSILPAAT
HHCCCCCEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCC
DTAIWDAIPGDWSRTNMLQPGDVAAVIAALVALPPYATVEDLTIGHVAGRL
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHCCC
>Mature Secondary Structure
MRTILITGASRGIGAATALALAGPDTRLTLAARDRTALEAVARQATAAGAQCLVVPCDVT
CEEEEEECCCCCCCHHHEEEECCCCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEECCCC
DPAQVAPTVAQAAGEGTLDVVVHSVGGALVAPLADIELPAWEEHMRTQLTSLFLVAKATT
CCHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHH
ARMDRGSLFINIASVAARQAFPGWSAYVAAKHGALGFMAAIREELRPRGIRVCSILPAAT
HHCCCCCEEEEHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHCCCCEEEEEECCCCC
DTAIWDAIPGDWSRTNMLQPGDVAAVIAALVALPPYATVEDLTIGHVAGRL
CCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA