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The map label for this gene is mprA [H]

Identifier: 222525947

GI number: 222525947

Start: 3335099

End: 3335776

Strand: Direct

Name: mprA [H]

Synonym: Chy400_2703

Alternate gene names: 222525947

Gene position: 3335099-3335776 (Clockwise)

Preceding gene: 222525946

Following gene: 222525951

Centisome position: 63.3

GC content: 56.64

Gene sequence:

>678_bases
ATGACACGTATCTTGGTGATTGAAGACGAAACTGAAATAGCCTCGTTTCTACGCCGTGGTCTGAGCCTGGAAGGCTATCA
GGTTGATGTGGCCTTCGATGGGACACGCGGGCTTGAGCTGGCATCGACGGGCACGTATGATCTGATTGTCCTTGACCTCA
TGTTGCCGGGGATCGATGGTCTCGAAGTCGCTCGTCGTCTCCGTGCCGACTCGAACGTACCGATCATTATGCTCACGGCG
CGTGATGCCGTGCGTGATCGGGTGGCCGGTCTGGAAGCCGGCGCCGATGATTATCTGGTGAAGCCGTTTGCCTTTGAAGA
GCTGCTCGCCCGCATTCGGGCACAGTTGCGGCGTCGGCAGTCCGGGCAGGCGCAGGATGTGCTGCGTTTCGCCAATTTAA
CTCTCGATACGCGCTCGCGTGAGTTGCGGGTAGGAGACCGGCGTGTCGAGCTGACGGCGAAAGAGTACGATCTGCTCGAA
CTCTTTATGCGTCATCCCAATCAGGTGCTGACTCGCGATATTATTTACGACCGGGTCTGGAATTACGACTTCGGCGGCGA
GAGTAATATTCTGGAAGTGTACGTGCGCTATTTGCGGCAGAAGCTTGAGGCGAATGGTGAGCCGCGCCTGATCCATACTG
TTCGCAGTGTGGGGTACATTCTCCGCGAAGATACCTGA

Upstream 100 bases:

>100_bases
CTCAAGGTTGCGATGTTGTATTTCACGACGACTATACCAGATATGATATGAGCCAGTATGCAAAATTGACGGTTGCGCTT
CCTGTTCGTATACTAAAGGC

Downstream 100 bases:

>100_bases
TCGTTTAGGAGACGCGAAGGGCCATTCGCCCTTCGCGTCTCTGTTACGGTGTTGGTTGGGGTTGGGTTTCGCCAAGTGCC
GCGAAGAGCTGCTGAACGGC

Product: winged helix family two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 225; Mature: 224

Protein sequence:

>225_residues
MTRILVIEDETEIASFLRRGLSLEGYQVDVAFDGTRGLELASTGTYDLIVLDLMLPGIDGLEVARRLRADSNVPIIMLTA
RDAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRRQSGQAQDVLRFANLTLDTRSRELRVGDRRVELTAKEYDLLE
LFMRHPNQVLTRDIIYDRVWNYDFGGESNILEVYVRYLRQKLEANGEPRLIHTVRSVGYILREDT

Sequences:

>Translated_225_residues
MTRILVIEDETEIASFLRRGLSLEGYQVDVAFDGTRGLELASTGTYDLIVLDLMLPGIDGLEVARRLRADSNVPIIMLTA
RDAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRRQSGQAQDVLRFANLTLDTRSRELRVGDRRVELTAKEYDLLE
LFMRHPNQVLTRDIIYDRVWNYDFGGESNILEVYVRYLRQKLEANGEPRLIHTVRSVGYILREDT
>Mature_224_residues
TRILVIEDETEIASFLRRGLSLEGYQVDVAFDGTRGLELASTGTYDLIVLDLMLPGIDGLEVARRLRADSNVPIIMLTAR
DAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRRQSGQAQDVLRFANLTLDTRSRELRVGDRRVELTAKEYDLLEL
FMRHPNQVLTRDIIYDRVWNYDFGGESNILEVYVRYLRQKLEANGEPRLIHTVRSVGYILREDT

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=220, Percent_Identity=46.3636363636364, Blast_Score=204, Evalue=4e-54,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=41.4746543778802, Blast_Score=175, Evalue=3e-45,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=42.7927927927928, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=38.6363636363636, Blast_Score=159, Evalue=2e-40,
Organism=Escherichia coli, GI1786911, Length=221, Percent_Identity=42.5339366515837, Blast_Score=156, Evalue=1e-39,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=42.2727272727273, Blast_Score=154, Evalue=3e-39,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=37.8260869565217, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1787375, Length=220, Percent_Identity=36.8181818181818, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790860, Length=222, Percent_Identity=35.1351351351351, Blast_Score=120, Evalue=6e-29,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=36.9565217391304, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788394, Length=221, Percent_Identity=33.4841628959276, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=33.9055793991416, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.9734513274336, Blast_Score=107, Evalue=9e-25,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=30.9012875536481, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=31.1926605504587, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790437, Length=123, Percent_Identity=30.8943089430894, Blast_Score=67, Evalue=9e-13,
Organism=Escherichia coli, GI48994928, Length=114, Percent_Identity=35.9649122807018, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1788191, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1788713, Length=85, Percent_Identity=40, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790299, Length=134, Percent_Identity=27.6119402985075, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25845; Mature: 25714

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRILVIEDETEIASFLRRGLSLEGYQVDVAFDGTRGLELASTGTYDLIVLDLMLPGIDG
CCEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCHHHHHEEHHHCCCCH
LEVARRLRADSNVPIIMLTARDAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRRQ
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHC
SGQAQDVLRFANLTLDTRSRELRVGDRRVELTAKEYDLLELFMRHPNQVLTRDIIYDRVW
CCCHHHHHHHHHCEECCCCCEEECCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHC
NYDFGGESNILEVYVRYLRQKLEANGEPRLIHTVRSVGYILREDT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TRILVIEDETEIASFLRRGLSLEGYQVDVAFDGTRGLELASTGTYDLIVLDLMLPGIDG
CEEEEEECCHHHHHHHHHCCCCCCEEEEEEECCCCCCEEECCCCHHHHHEEHHHCCCCH
LEVARRLRADSNVPIIMLTARDAVRDRVAGLEAGADDYLVKPFAFEELLARIRAQLRRRQ
HHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCCCCCCCEECCHHHHHHHHHHHHHHHHHC
SGQAQDVLRFANLTLDTRSRELRVGDRRVELTAKEYDLLELFMRHPNQVLTRDIIYDRVW
CCCHHHHHHHHHCEECCCCCEEECCCEEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHC
NYDFGGESNILEVYVRYLRQKLEANGEPRLIHTVRSVGYILREDT
CCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA