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The map label for this gene is psaA [H]

Identifier: 222525403

GI number: 222525403

Start: 2724500

End: 2725591

Strand: Direct

Name: psaA [H]

Synonym: Chy400_2148

Alternate gene names: 222525403

Gene position: 2724500-2725591 (Clockwise)

Preceding gene: 222525385

Following gene: 222525404

Centisome position: 51.71

GC content: 56.96

Gene sequence:

>1092_bases
ATGCGTTTCATACAACAGATAACCGTTTTGCTCGCAGGTATGCTGCTGATGGCAGCATGTGGGCAAGCACCGGCGAGTCA
GCCCACCGCAGTACCGGCGACGGACAACACCTCAGCGCAACCAATGCTGGTTATGGCCAGTACCAGTATCGTGGCCGATG
TTGTGCGTCAGGTCGGTGGTGATCGGGTTCAGGTCGAGACGATTGTGCCGATTGGGGCCGACACCCACGGCTTTGAGCCG
ACACCTCAAGACCTGGCACGAGTGAGTGAAGCCAGGGTCATCTTCACGGTTGGTGCCGGCTATGAAGAGTTTATTGATCG
TCTGATCGCGAGTTCAGGGACGCAAGCTGAAGTCGTCGATCTGTCGGCGAACCTTGCCCTGCGTGCATTGACGGAAGCGG
AAGCTACCGGTCATGCCCACGAGGAAGAGCACACCGACGAACACGGAACAGAGGCAGCCGGTGCTGCCGGTGATACCCAC
GCCGACGATCACAGCAACACGCAGGCTGACGCCCACGGTGATGAGCATGGTGATGAACATGCCGACGAGCACGGGGCAGG
GTCGGTTGACCCCCATACCTGGACGGATCCGGCTAACGTGAAAATCTGGACTGATCTGATCTATACCACGCTGAGCCGTC
TCGATCCAGATCACGCTGAAGCATACGCTACCCGGGCAACCGATTACAAGCGTCAGCTCGATGATCTTGATCGCTGGATT
GCCGATCAATTTGCCTCTATCCCGGCAGAACGGCGCTTACTCGTCTCTGACCACATTATCTTTGGCTATATGGCCGATAA
GTACGGGTTACGCCAGTTGGGGGCAATTATTCCTGGGGTAAGTTCGAGTGCCGCCCCCTCGGCTCAGGAATTGGCAGCGT
TGCAAGACCTGATTGCCGACTATGGCGTGACGGCCATCTTTGTTGGTAATGTTGCGAATCAGCAGATCGCCGAGCAGATC
GCTCGCGATACCGGCGTGCGCATTATCACCGTGTTAACCGAGTCGCTGACCGATGCGAACGGGCCAGGCGCGACGTACCT
CGACTACATGCGCTTTAATGTCCAGGCAATTGTTGATGGGTTGCGTAGTTAA

Upstream 100 bases:

>100_bases
CCGATTGCATTACCCGCCCCGATTCGCCGGCATTTGACAACAGGTGCTCTTTGGCACATAATCTCTTTTGAAACAATGTT
TCATTAAGGAGGATCAAACG

Downstream 100 bases:

>100_bases
TCTACGTTCTCGCGTACAATAGAGCAGCATCAGTGATGCTGTCACCATCACTGATGCTGCACCGGTTTTTATGCCTGAAG
GAAGGCGATTATGACAGCTT

Product: periplasmic solute binding protein

Products: Zn (II) [Cytoplasm]; ADP; phosphate [C]

Alternate protein names: Pneumococcal surface adhesin A [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MRFIQQITVLLAGMLLMAACGQAPASQPTAVPATDNTSAQPMLVMASTSIVADVVRQVGGDRVQVETIVPIGADTHGFEP
TPQDLARVSEARVIFTVGAGYEEFIDRLIASSGTQAEVVDLSANLALRALTEAEATGHAHEEEHTDEHGTEAAGAAGDTH
ADDHSNTQADAHGDEHGDEHADEHGAGSVDPHTWTDPANVKIWTDLIYTTLSRLDPDHAEAYATRATDYKRQLDDLDRWI
ADQFASIPAERRLLVSDHIIFGYMADKYGLRQLGAIIPGVSSSAAPSAQELAALQDLIADYGVTAIFVGNVANQQIAEQI
ARDTGVRIITVLTESLTDANGPGATYLDYMRFNVQAIVDGLRS

Sequences:

>Translated_363_residues
MRFIQQITVLLAGMLLMAACGQAPASQPTAVPATDNTSAQPMLVMASTSIVADVVRQVGGDRVQVETIVPIGADTHGFEP
TPQDLARVSEARVIFTVGAGYEEFIDRLIASSGTQAEVVDLSANLALRALTEAEATGHAHEEEHTDEHGTEAAGAAGDTH
ADDHSNTQADAHGDEHGDEHADEHGAGSVDPHTWTDPANVKIWTDLIYTTLSRLDPDHAEAYATRATDYKRQLDDLDRWI
ADQFASIPAERRLLVSDHIIFGYMADKYGLRQLGAIIPGVSSSAAPSAQELAALQDLIADYGVTAIFVGNVANQQIAEQI
ARDTGVRIITVLTESLTDANGPGATYLDYMRFNVQAIVDGLRS
>Mature_363_residues
MRFIQQITVLLAGMLLMAACGQAPASQPTAVPATDNTSAQPMLVMASTSIVADVVRQVGGDRVQVETIVPIGADTHGFEP
TPQDLARVSEARVIFTVGAGYEEFIDRLIASSGTQAEVVDLSANLALRALTEAEATGHAHEEEHTDEHGTEAAGAAGDTH
ADDHSNTQADAHGDEHGDEHADEHGAGSVDPHTWTDPANVKIWTDLIYTTLSRLDPDHAEAYATRATDYKRQLDDLDRWI
ADQFASIPAERRLLVSDHIIFGYMADKYGLRQLGAIIPGVSSSAAPSAQELAALQDLIADYGVTAIFVGNVANQQIAEQI
ARDTGVRIITVLTESLTDANGPGATYLDYMRFNVQAIVDGLRS

Specific function: Part of an ATP-driven transport system for manganese. Also act as an adhesin which is involved on adherence to extracellular matrix. It is an important factor in pathogenesis and infection [H]

COG id: COG0803

COG function: function code P; ABC-type metal ion transport system, periplasmic component/surface adhesin

Gene ontology:

Cell location: Cell membrane; Lipid-anchor [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 9 family. Lipoprotein receptor antigen (Lrai) subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006127
- InterPro:   IPR006129
- InterPro:   IPR006128 [H]

Pfam domain/function: PF01297 SBP_bac_9 [H]

EC number: NA

Molecular weight: Translated: 38777; Mature: 38777

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFIQQITVLLAGMLLMAACGQAPASQPTAVPATDNTSAQPMLVMASTSIVADVVRQVGG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCC
DRVQVETIVPIGADTHGFEPTPQDLARVSEARVIFTVGAGYEEFIDRLIASSGTQAEVVD
CEEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCEEEEE
LSANLALRALTEAEATGHAHEEEHTDEHGTEAAGAAGDTHADDHSNTQADAHGDEHGDEH
ECCCHHHHHHHHHHHCCCCCCHHCCHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ADEHGAGSVDPHTWTDPANVKIWTDLIYTTLSRLDPDHAEAYATRATDYKRQLDDLDRWI
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ADQFASIPAERRLLVSDHIIFGYMADKYGLRQLGAIIPGVSSSAAPSAQELAALQDLIAD
HHHHHHCCHHHEEEHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YGVTAIFVGNVANQQIAEQIARDTGVRIITVLTESLTDANGPGATYLDYMRFNVQAIVDG
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LRS
HCC
>Mature Secondary Structure
MRFIQQITVLLAGMLLMAACGQAPASQPTAVPATDNTSAQPMLVMASTSIVADVVRQVGG
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEHHHHHHHHHHHHCC
DRVQVETIVPIGADTHGFEPTPQDLARVSEARVIFTVGAGYEEFIDRLIASSGTQAEVVD
CEEEEEEEEEECCCCCCCCCCHHHHHHHHCCEEEEEECCCHHHHHHHHHHCCCCCEEEEE
LSANLALRALTEAEATGHAHEEEHTDEHGTEAAGAAGDTHADDHSNTQADAHGDEHGDEH
ECCCHHHHHHHHHHHCCCCCCHHCCHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCHH
ADEHGAGSVDPHTWTDPANVKIWTDLIYTTLSRLDPDHAEAYATRATDYKRQLDDLDRWI
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
ADQFASIPAERRLLVSDHIIFGYMADKYGLRQLGAIIPGVSSSAAPSAQELAALQDLIAD
HHHHHHCCHHHEEEHCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
YGVTAIFVGNVANQQIAEQIARDTGVRIITVLTESLTDANGPGATYLDYMRFNVQAIVDG
CCCEEEEECCHHHHHHHHHHHHHCCCEEEEHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
LRS
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Zn (II) [Periplasm]; H2O; ATP [C]

Specific reaction: Zn (II) [Periplasm] + H2O + ATP = Zn (II) [Cytoplasm] + ADP + phosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8945574; 9767595; 11463916; 9379902 [H]