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The map label for this gene is mutS2 [H]

Identifier: 222524571

GI number: 222524571

Start: 1658967

End: 1661426

Strand: Direct

Name: mutS2 [H]

Synonym: Chy400_1295

Alternate gene names: 222524571

Gene position: 1658967-1661426 (Clockwise)

Preceding gene: 222524570

Following gene: 222524572

Centisome position: 31.49

GC content: 59.35

Gene sequence:

>2460_bases
ATGTCGATCCCGGAATCTTCGCTGATTACACTTGAATTCGACGTCATTCGTGACCGTCTGGCTCAATATACTGCTTTTTC
AGCCTCGCGTGAACTGGCCTTAAGTCTGACTCCGGCCACCGATCTGGCTGAAGTCCGGCGACGGCAGGCTTTAACTGCCG
AAGCCCGGCTGCTGCTGGAAGAATGGCCGGAGGTGAGTATCGGTGGGGCGCGTGATGTGCGTCGCGCCGTGCAGCACGCT
GCCCGTGGCGGTATTCTTGATGGCACAACCCTGCGCGAGATTGCGGCCACCTTGCAGAGTGCGGCGCTACTCCGTCAGCG
ACTGAGCCGCCTCGACGAACGTTTTCCGTTGCTGATTGACCTGGCCAATACGCTGCCCGTCATTCCATCGTTAAGCGAGG
CAATTGATCGGGCAATCGGTGATGATGGTCAGGTGTTGGATAGCGCCAGCCCTACACTTGCCCGCTTACGTCACGAAGTG
CGGGTGGCATTTAACCGTCTGCAAGAGCGCCTCCAGAGCATGATCCATTCCAGCGCACTGGCCGGTGCGCTTCAGGAGCC
GATTATCACCGTGCGGAATGGCCGGTATGTCATTCCGGTGAAGGCCAGCCACCGCCGGGAAGTTCGCGGTCTGGTGCATG
ATCAGTCGGGATCGGGGGCAACTCTCTACATTGAGCCAATGGCAATTGTCGAGTTGAACAACCGCTGGCGCGAGCTGCAA
TCTGCCGAGGCGGAAGAAGTGCAGCGCATTCTCAGCACGTTATCCGACCAGGTCGGTGCAGCAGCCAATCTGATCACCAG
TACCGTCAATACGCTGGCTACCCTCGACCTGGCATTTGCGCTGGCCCGCTACGCCATTGCTACCCGCAGCACGGCACCGG
AGATTGTCGATTGGCGACCCGACGATCCGCCGTCGCCTGAACCACCGCTACGCCTGACACGGGCACGCCATCCGTTGCTC
CCTGCTGAGACCGTAGTCCCGATTGATCTTTGGCTTGGCGGCGAGTTTTCGCTGTTGTTGATCACCGGCCCCAATACCGG
TGGCAAGACGGTAGCCCTCAAAACCACCGGCTTGCTGGCCCTGATGGCACAGGCCGGCATGCAAATTCCAGCCGATCAAC
CGTCGCGTTTGCCGGTGTTTCAGTACATCTTTGCCGACATCGGTGATGAGCAGAGCATCGAACAGAGCCTCAGTACCTTC
TCGTCGCACATGGCGAATATTATCCGCGTGCTACAAACGTTGACGGCTGCACAACAAATGCCATCGGAGAGCGACGCATA
CGCCCTGTTCGATGACCGCCGACCGGCAGCGCTGGTTCTGTTCGACGAATTAGGTGCCGGTACCGATCCGGTAGAAGGCG
CAGCCCTGGCACGAGCGATTATTGGCCGCCTGCTTGAGCTGGGAGTACTGGGTATTGCTACCACCCATTATGCCGAGCTG
AAGGCATTTGCGTACACGACTCCAGGGGTGCAGAATGCCTCAGTTGAGTTTGATATCGAGACCCTGGCGCCAACCTACCG
GTTAAGTATCGGTATCCCCGGTCGTTCAAATGCCCTGGCGATTGCCGCCCGTCTGGGCTTAGACCCGACACTGATCGAAC
AGGCGCGCTCTTTTATCGACCGCAAAGAGGCGCAGGTTGAAGACTTGCTGGCCGGCATTCAGCGTGAACGTGATGCCGCT
GCCGCCGCATTACAGCGTGCCGAGGAATTGCGGCTTGACGCCGAACGCTACCGTGACCGGCTGGCGGCTGAACAACAGGC
CTTTGCCGCCGAACGGGCCGCAGCACTTGAAGCCGCCCGTGCCGAGATCGAAGCAGAACTGCGGGAAGTCCGTCAGCAAC
TACGCCGGTTACGTGAAGAGTTTCGCACCGTCAATATATCACGCCAGTGGCTTGAAGAAGCCGAGAAACGACTGGCGACG
ACTGCCGAGCAGTCACAACAGGCCGTTGCCCGTCTAAACGTGCAGACCCAACCTGCGCCACCACCCCCAGCCGAAAAGCC
GTTACAGGTTGGCGATCAGGTACAGGTTACTTCCATCGGCCTGAACGGCGAAATTGTCGCCATTGATGAAGAGGATCAAA
CTGCCACGGTACAGGTTGGCGGCTTCCGCATGACAGTCAGCTTCAACGATCTGAAGCGGGCAAAGGGCAAAAGTGATGAC
GGCCAGCGCTTTACCCCTCCGGCACGAACCGTTCATCTTCCCCCAACACCCGATGTCTCGATGACCTTCGACATGCGGGG
CTGGCGAGCGGCTGAGGTGAGTGATCGTCTGGATCGCTATCTAAACGATGCGTATCTCGCCGGCCTGCACCAGGTACGCC
TGATCCACGGCAAAGGCACCGGTGCGCTGCGCCAGGTGGTGCGAGAACTTCTGGCCGGTCACCCACTGGTAGCCTCGTTC
AGCAGTGGTGGCCGCGATGGTGGTGATGGTGTCACGATTGCGACGCTTGTCGACCGGTGA

Upstream 100 bases:

>100_bases
AATTATCTTTCAGGTCCAATAATCAACCCCTGGGCCGATGGCATGATTGACGGTTAGTTATAACCTGAACGCAAGAAATC
TTGCGTTAATGAGTGCTGGT

Downstream 100 bases:

>100_bases
TGACATCTTGCCTGCTCGCGGGAGTCATGTTTGTATGATAAACGATGCAACCGTCTCGGCTCCCGCACCTCACCCCCTGA
CCCTCGCTCCGCTTCCATCG

Product: MutS2 family protein

Products: ADP; phosphate; H+

Alternate protein names: NA

Number of amino acids: Translated: 819; Mature: 818

Protein sequence:

>819_residues
MSIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLEEWPEVSIGGARDVRRAVQHA
ARGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLIDLANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEV
RVAFNRLQERLQSMIHSSALAGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQ
SAEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRPDDPPSPEPPLRLTRARHPLL
PAETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLALMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTF
SSHMANIIRVLQTLTAAQQMPSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAEL
KAFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFIDRKEAQVEDLLAGIQRERDAA
AAALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAARAEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLAT
TAEQSQQAVARLNVQTQPAPPPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDD
GQRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGTGALRQVVRELLAGHPLVASF
SSGGRDGGDGVTIATLVDR

Sequences:

>Translated_819_residues
MSIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLEEWPEVSIGGARDVRRAVQHA
ARGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLIDLANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEV
RVAFNRLQERLQSMIHSSALAGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQ
SAEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRPDDPPSPEPPLRLTRARHPLL
PAETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLALMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTF
SSHMANIIRVLQTLTAAQQMPSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAEL
KAFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFIDRKEAQVEDLLAGIQRERDAA
AAALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAARAEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLAT
TAEQSQQAVARLNVQTQPAPPPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDD
GQRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGTGALRQVVRELLAGHPLVASF
SSGGRDGGDGVTIATLVDR
>Mature_818_residues
SIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLEEWPEVSIGGARDVRRAVQHAA
RGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLIDLANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEVR
VAFNRLQERLQSMIHSSALAGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQS
AEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRPDDPPSPEPPLRLTRARHPLLP
AETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLALMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTFS
SHMANIIRVLQTLTAAQQMPSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAELK
AFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFIDRKEAQVEDLLAGIQRERDAAA
AALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAARAEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLATT
AEQSQQAVARLNVQTQPAPPPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDDG
QRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGTGALRQVVRELLAGHPLVASFS
SGGRDGGDGVTIATLVDR

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=382, Percent_Identity=25.3926701570681, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI4504191, Length=331, Percent_Identity=26.8882175226586, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI26638666, Length=346, Percent_Identity=27.1676300578035, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI4505253, Length=346, Percent_Identity=27.1676300578035, Blast_Score=85, Evalue=3e-16,
Organism=Homo sapiens, GI4557761, Length=408, Percent_Identity=24.0196078431373, Blast_Score=84, Evalue=5e-16,
Organism=Homo sapiens, GI26638664, Length=346, Percent_Identity=27.4566473988439, Blast_Score=82, Evalue=3e-15,
Organism=Homo sapiens, GI284813531, Length=285, Percent_Identity=25.6140350877193, Blast_Score=77, Evalue=9e-14,
Organism=Homo sapiens, GI262231786, Length=245, Percent_Identity=28.9795918367347, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1789089, Length=280, Percent_Identity=29.6428571428571, Blast_Score=99, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI17534743, Length=227, Percent_Identity=29.9559471365639, Blast_Score=101, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=358, Percent_Identity=25.1396648044693, Blast_Score=100, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI17508447, Length=299, Percent_Identity=25.0836120401338, Blast_Score=74, Evalue=2e-13,
Organism=Saccharomyces cerevisiae, GI6324482, Length=323, Percent_Identity=26.9349845201238, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6319935, Length=280, Percent_Identity=28.9285714285714, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320302, Length=345, Percent_Identity=25.7971014492754, Blast_Score=79, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321109, Length=273, Percent_Identity=26.007326007326, Blast_Score=71, Evalue=9e-13,
Organism=Saccharomyces cerevisiae, GI6321912, Length=214, Percent_Identity=23.3644859813084, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24664545, Length=290, Percent_Identity=29.3103448275862, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24584320, Length=334, Percent_Identity=26.9461077844311, Blast_Score=87, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: 3.6.3.14

Molecular weight: Translated: 89388; Mature: 89256

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLE
CCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
EWPEVSIGGARDVRRAVQHAARGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLID
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
LANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEVRVAFNRLQERLQSMIHSSAL
HHHHCCCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQ
HHHHHCCEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCEEEECCEEEEEHHHHHHHHH
SAEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDPPSPEPPLRLTRARHPLLPAETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLA
CCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEEHHHHHH
LMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTFSSHMANIIRVLQTLTAAQQM
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAEL
CCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFID
HHEEEECCCCCCCEEEEEHHHCCCEEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHH
RKEAQVEDLLAGIQRERDAAAAALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLATTAEQSQQAVARLNVQTQPAP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDD
CCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCEEEEEEHHHHHHHCCCCCC
GQRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGT
CCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
GALRQVVRELLAGHPLVASFSSGGRDGGDGVTIATLVDR
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure 
SIPESSLITLEFDVIRDRLAQYTAFSASRELALSLTPATDLAEVRRRQALTAEARLLLE
CCCCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHH
EWPEVSIGGARDVRRAVQHAARGGILDGTTLREIAATLQSAALLRQRLSRLDERFPLLID
HCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
LANTLPVIPSLSEAIDRAIGDDGQVLDSASPTLARLRHEVRVAFNRLQERLQSMIHSSAL
HHHHCCCCCCHHHHHHHHCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGALQEPIITVRNGRYVIPVKASHRREVRGLVHDQSGSGATLYIEPMAIVELNNRWRELQ
HHHHHCCEEEEECCCEEEEECCCHHHHHHHHHCCCCCCCCEEEECCEEEEEHHHHHHHHH
SAEAEEVQRILSTLSDQVGAAANLITSTVNTLATLDLAFALARYAIATRSTAPEIVDWRP
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DDPPSPEPPLRLTRARHPLLPAETVVPIDLWLGGEFSLLLITGPNTGGKTVALKTTGLLA
CCCCCCCCCCHHHHCCCCCCCCCCEEEEEEEECCCEEEEEEECCCCCCCEEEEEHHHHHH
LMAQAGMQIPADQPSRLPVFQYIFADIGDEQSIEQSLSTFSSHMANIIRVLQTLTAAQQM
HHHHCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
PSESDAYALFDDRRPAALVLFDELGAGTDPVEGAALARAIIGRLLELGVLGIATTHYAEL
CCCCCCEEEECCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAFAYTTPGVQNASVEFDIETLAPTYRLSIGIPGRSNALAIAARLGLDPTLIEQARSFID
HHEEEECCCCCCCEEEEEHHHCCCEEEEEEECCCCCCCEEEEEHHCCCHHHHHHHHHHHH
RKEAQVEDLLAGIQRERDAAAAALQRAEELRLDAERYRDRLAAEQQAFAAERAAALEAAR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEIEAELREVRQQLRRLREEFRTVNISRQWLEEAEKRLATTAEQSQQAVARLNVQTQPAP
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PPPAEKPLQVGDQVQVTSIGLNGEIVAIDEEDQTATVQVGGFRMTVSFNDLKRAKGKSDD
CCCCCCCCCCCCEEEEEEECCCCEEEEECCCCCEEEEEECCEEEEEEHHHHHHHCCCCCC
GQRFTPPARTVHLPPTPDVSMTFDMRGWRAAEVSDRLDRYLNDAYLAGLHQVRLIHGKGT
CCCCCCCCCEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCC
GALRQVVRELLAGHPLVASFSSGGRDGGDGVTIATLVDR
HHHHHHHHHHHCCCCEEEECCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA