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The map label for this gene is moaA [H]

Identifier: 222524567

GI number: 222524567

Start: 1653583

End: 1654644

Strand: Direct

Name: moaA [H]

Synonym: Chy400_1291

Alternate gene names: 222524567

Gene position: 1653583-1654644 (Clockwise)

Preceding gene: 222524566

Following gene: 222524568

Centisome position: 31.38

GC content: 61.39

Gene sequence:

>1062_bases
ATGGCCGCCAACCAGCTCTCTGGCACGACCCCGATCATCTTCTACGACCCCGCCCGCCATCCCCGCTATGCCACCGATAC
GCCGGCACTCGATCAGTATGGCCGCCGTATCGACTATCTGCGCGTCTCACTGACCGACCGCTGCAATATGCGTTGTGTCT
ACTGCATGCCTGCCGTTGGTGTGCAATTCGCCCCTCGTCCTGAACTGCTGACCAATGAAGAGCTGCTGCTGGTGATCACT
GCCGCTGCCCGTGCCGGCTTCCGCAAGTTGCGCCTGACCGGCGGCGAACCGACGCTGCGCCATGATCTGGTCAATCTGGT
GCGTGAACTGAAACGCATTCCCGGCATTGAACATATTGCGATGACAACCAACGCGCTTCGTTTGCGCAAACTGGCCCAAC
CGCTGCGCGAAGCTGGTCTGGATCGGGTCAATATCAGTATCGACACCCTCGATCCGCTGAAGTTTCGGATGATTACCCGT
GGCGGTAATCTCGAAGAGGTTTGGGCCGGTATTGAAGCTGCTGACGCGGCTGGCCTGCATCCCATCAAACTGAATGCGGT
GGTCGTGCGAGGGATGAATGATGATGAAGTGGTGCGGCTGGCGGGGTTGACGCTGGAGCGACCCTGGGAATTCCGCTTCA
TCGAGGTGATGCCCCTCACCGGGGTGGCCGGCCTCGCTGAAGAGGGTATCGTGGCCAGCGCCGAGCTGATTGCGCGGCTC
GAACAACACTATGGCCCGCTTGAGGAGATCGGCCACGCGCCGAGTGATCCGGCGCGCACGTATCGCCTACCCGGTGCGAA
GGGGGTGATCGGATTTATTTCCAGCGTCAGCGACCCCTTCTGCGCCACCTGTAACCGGATGCGGCTCACCGCTGATGGTC
GCCTGCACCTCTGTCTGCTCCGTGATGACGAAGTTGATCTGCGGGCCGCAGTCCGGGGCGGGGCCAGCGTCGCCGATCTT
GAACAAATCATTCGCCACGCCGTCTATATCAAACCATGGGGGCACGGCCTCCCTGCCGGCGTGAAGCCAACCCTGCGCGG
GATGTCAGAGTTAGGTGGCTGA

Upstream 100 bases:

>100_bases
GGTGTAGCCGATTCGGTACCGGTGGGCCAATTCAGCCCACCGGTACGTGTTTCACATCGGTTGTTCGTTCGCCGTCTGTT
TGTCACAATGAGGTGAGGCT

Downstream 100 bases:

>100_bases
TCCGCAGGGTCATTTTCCAACAACTCTCTAACGATCAACTGCCGGCTGAGTGATTACAATGCATGATGGTGCTAATATCG
CAATCCGCCGCTGCGTCAGG

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MAANQLSGTTPIIFYDPARHPRYATDTPALDQYGRRIDYLRVSLTDRCNMRCVYCMPAVGVQFAPRPELLTNEELLLVIT
AAARAGFRKLRLTGGEPTLRHDLVNLVRELKRIPGIEHIAMTTNALRLRKLAQPLREAGLDRVNISIDTLDPLKFRMITR
GGNLEEVWAGIEAADAAGLHPIKLNAVVVRGMNDDEVVRLAGLTLERPWEFRFIEVMPLTGVAGLAEEGIVASAELIARL
EQHYGPLEEIGHAPSDPARTYRLPGAKGVIGFISSVSDPFCATCNRMRLTADGRLHLCLLRDDEVDLRAAVRGGASVADL
EQIIRHAVYIKPWGHGLPAGVKPTLRGMSELGG

Sequences:

>Translated_353_residues
MAANQLSGTTPIIFYDPARHPRYATDTPALDQYGRRIDYLRVSLTDRCNMRCVYCMPAVGVQFAPRPELLTNEELLLVIT
AAARAGFRKLRLTGGEPTLRHDLVNLVRELKRIPGIEHIAMTTNALRLRKLAQPLREAGLDRVNISIDTLDPLKFRMITR
GGNLEEVWAGIEAADAAGLHPIKLNAVVVRGMNDDEVVRLAGLTLERPWEFRFIEVMPLTGVAGLAEEGIVASAELIARL
EQHYGPLEEIGHAPSDPARTYRLPGAKGVIGFISSVSDPFCATCNRMRLTADGRLHLCLLRDDEVDLRAAVRGGASVADL
EQIIRHAVYIKPWGHGLPAGVKPTLRGMSELGG
>Mature_352_residues
AANQLSGTTPIIFYDPARHPRYATDTPALDQYGRRIDYLRVSLTDRCNMRCVYCMPAVGVQFAPRPELLTNEELLLVITA
AARAGFRKLRLTGGEPTLRHDLVNLVRELKRIPGIEHIAMTTNALRLRKLAQPLREAGLDRVNISIDTLDPLKFRMITRG
GNLEEVWAGIEAADAAGLHPIKLNAVVVRGMNDDEVVRLAGLTLERPWEFRFIEVMPLTGVAGLAEEGIVASAELIARLE
QHYGPLEEIGHAPSDPARTYRLPGAKGVIGFISSVSDPFCATCNRMRLTADGRLHLCLLRDDEVDLRAAVRGGASVADLE
QIIRHAVYIKPWGHGLPAGVKPTLRGMSELGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=306, Percent_Identity=43.4640522875817, Blast_Score=264, Evalue=1e-70,
Organism=Homo sapiens, GI22027536, Length=305, Percent_Identity=43.6065573770492, Blast_Score=263, Evalue=1e-70,
Organism=Escherichia coli, GI1786999, Length=328, Percent_Identity=35.0609756097561, Blast_Score=193, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI32566331, Length=312, Percent_Identity=41.9871794871795, Blast_Score=262, Evalue=2e-70,
Organism=Caenorhabditis elegans, GI32566329, Length=329, Percent_Identity=41.6413373860182, Blast_Score=259, Evalue=1e-69,
Organism=Caenorhabditis elegans, GI17561210, Length=329, Percent_Identity=41.3373860182371, Blast_Score=254, Evalue=5e-68,
Organism=Drosophila melanogaster, GI28574490, Length=312, Percent_Identity=42.9487179487179, Blast_Score=248, Evalue=5e-66,
Organism=Drosophila melanogaster, GI28574488, Length=312, Percent_Identity=42.9487179487179, Blast_Score=247, Evalue=8e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38785; Mature: 38653

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAANQLSGTTPIIFYDPARHPRYATDTPALDQYGRRIDYLRVSLTDRCNMRCVYCMPAVG
CCCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHCCEEEEEEEEECCCCCCEEEEEECCCC
VQFAPRPELLTNEELLLVITAAARAGFRKLRLTGGEPTLRHDLVNLVRELKRIPGIEHIA
CCCCCCCCCCCCCCEEEEEEEHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEE
MTTNALRLRKLAQPLREAGLDRVNISIDTLDPLKFRMITRGGNLEEVWAGIEAADAAGLH
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCHHHHHCCCHHHCCCCCC
PIKLNAVVVRGMNDDEVVRLAGLTLERPWEFRFIEVMPLTGVAGLAEEGIVASAELIARL
EEEEEEEEEECCCCCCEEEEECCEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHH
EQHYGPLEEIGHAPSDPARTYRLPGAKGVIGFISSVSDPFCATCNRMRLTADGRLHLCLL
HHHCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHCCCCEEEEECCCEEEEEE
RDDEVDLRAAVRGGASVADLEQIIRHAVYIKPWGHGLPAGVKPTLRGMSELGG
ECCCCCHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
AANQLSGTTPIIFYDPARHPRYATDTPALDQYGRRIDYLRVSLTDRCNMRCVYCMPAVG
CCCCCCCCCCEEEECCCCCCCCCCCCCCHHHHCCEEEEEEEEECCCCCCEEEEEECCCC
VQFAPRPELLTNEELLLVITAAARAGFRKLRLTGGEPTLRHDLVNLVRELKRIPGIEHIA
CCCCCCCCCCCCCCEEEEEEEHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEE
MTTNALRLRKLAQPLREAGLDRVNISIDTLDPLKFRMITRGGNLEEVWAGIEAADAAGLH
HHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEEECCCCHHHHHCCCHHHCCCCCC
PIKLNAVVVRGMNDDEVVRLAGLTLERPWEFRFIEVMPLTGVAGLAEEGIVASAELIARL
EEEEEEEEEECCCCCCEEEEECCEECCCCCEEEEEEEECCCCCCHHHCCCHHHHHHHHHH
EQHYGPLEEIGHAPSDPARTYRLPGAKGVIGFISSVSDPFCATCNRMRLTADGRLHLCLL
HHHCCCHHHHCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHCCCCEEEEECCCEEEEEE
RDDEVDLRAAVRGGASVADLEQIIRHAVYIKPWGHGLPAGVKPTLRGMSELGG
ECCCCCHHHHHCCCCCHHHHHHHHHHHEEECCCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA