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The map label for this gene is gluP [H]

Identifier: 222524105

GI number: 222524105

Start: 1033329

End: 1034144

Strand: Reverse

Name: gluP [H]

Synonym: Chy400_0821

Alternate gene names: 222524105

Gene position: 1034144-1033329 (Counterclockwise)

Preceding gene: 222524106

Following gene: 222524104

Centisome position: 19.63

GC content: 55.88

Gene sequence:

>816_bases
ATGACCCGTCCACCTGATGAATCCGACGATATTGAAGCATTTCTGCGTCGAGCCGAGCGCGAGTTTGGCCTTCGTCCCGA
TCTGCCGGAAGAACCTCCTCCACCTCCACCCCGCCCCGCTCCACCTCGTCCGTTTGTGACACAGAGTTTGCTCTGGGCGA
TAGGGATTGTCTACGTTCTGAGTTGTGTGCTCAGTGGATCGTTCTTTCAACCGGCATTTCCGGTACTGGCAGTCCTGGGG
GCGAAGATCAACGAGCGGATTGCCGATGGTGAACTATGGCGGCTGTTGACCGCTGTGTTCCTGCACGCAAACCTGATCCA
TATCTTCTTCAACGGGTATGCGCTCTCGGTACTGGGGCCAGAGACCGAACGTTTTTATGGCCATGGCCGTTTTCTCGCCC
TCTATCTGATCAGTGGACTCGGTGGCAGTATCGCGTCATACGCTCTCTCTCCGGCACCGGCAGTGGGAGCGAGCGGGGCA
ATCTTCGGTCTGATTGGTGGGCTGGGTGTGTTCTACTATCTCAACCGCCGGGTATTGGGTGAGTTTGGTCAAAATCAGGT
GCGTGGCATTGTGGCAATTGCCTTGATTAATCTGTTGATTGGTTTTGCAGCCCAGGGCGTCATCGATAACTGGGGGCATC
TCGGTGGATTGCTGAGTGGGATTGTGATCGGCGTTGCCCTCGCCCCTCGACTGACTGTCGATCTACGCTTTTTTCCACCG
TTGTTCATTCGCCGTTTCCCGATGCAGGGCTGGTTGTGGGTGTTTGCCATTGCACTGGTGATGATTGTCCTGGTACGCCT
GGTAACGCCGGCATAA

Upstream 100 bases:

>100_bases
TGTGCCAGTTTTGGCATGTTTCGGAATGAGTTTCACCGCGGTGAGGCGTTTCGCCAGATCGTGCGCGAGTTGGCTGGCGG
TCGCGCCGGGGAGCAGAAGT

Downstream 100 bases:

>100_bases
CGTGGTTGATTGGGAAGTCGGGATTTTGTGAAGGAAAGAAGAGGAGTATGGTCAAGAGTGATGGATCGCGTCCAACACAT
TTGCTCTTTGACCGCACACA

Product: Rhomboid family protein

Products: NA

Alternate protein names: Intramembrane serine protease [H]

Number of amino acids: Translated: 271; Mature: 270

Protein sequence:

>271_residues
MTRPPDESDDIEAFLRRAEREFGLRPDLPEEPPPPPPRPAPPRPFVTQSLLWAIGIVYVLSCVLSGSFFQPAFPVLAVLG
AKINERIADGELWRLLTAVFLHANLIHIFFNGYALSVLGPETERFYGHGRFLALYLISGLGGSIASYALSPAPAVGASGA
IFGLIGGLGVFYYLNRRVLGEFGQNQVRGIVAIALINLLIGFAAQGVIDNWGHLGGLLSGIVIGVALAPRLTVDLRFFPP
LFIRRFPMQGWLWVFAIALVMIVLVRLVTPA

Sequences:

>Translated_271_residues
MTRPPDESDDIEAFLRRAEREFGLRPDLPEEPPPPPPRPAPPRPFVTQSLLWAIGIVYVLSCVLSGSFFQPAFPVLAVLG
AKINERIADGELWRLLTAVFLHANLIHIFFNGYALSVLGPETERFYGHGRFLALYLISGLGGSIASYALSPAPAVGASGA
IFGLIGGLGVFYYLNRRVLGEFGQNQVRGIVAIALINLLIGFAAQGVIDNWGHLGGLLSGIVIGVALAPRLTVDLRFFPP
LFIRRFPMQGWLWVFAIALVMIVLVRLVTPA
>Mature_270_residues
TRPPDESDDIEAFLRRAEREFGLRPDLPEEPPPPPPRPAPPRPFVTQSLLWAIGIVYVLSCVLSGSFFQPAFPVLAVLGA
KINERIADGELWRLLTAVFLHANLIHIFFNGYALSVLGPETERFYGHGRFLALYLISGLGGSIASYALSPAPAVGASGAI
FGLIGGLGVFYYLNRRVLGEFGQNQVRGIVAIALINLLIGFAAQGVIDNWGHLGGLLSGIVIGVALAPRLTVDLRFFPPL
FIRRFPMQGWLWVFAIALVMIVLVRLVTPA

Specific function: Rhomboid-type serine protease that catalyzes intramembrane proteolysis. Important for normal cell division and sporulation. May act as a glucose exporter [H]

COG id: COG0705

COG function: function code R; Uncharacterized membrane protein (homolog of Drosophila rhomboid)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 TPR repeats [H]

Homologues:

Organism=Caenorhabditis elegans, GI133901888, Length=142, Percent_Identity=33.0985915492958, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI115532986, Length=147, Percent_Identity=34.0136054421769, Blast_Score=74, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI115534507, Length=154, Percent_Identity=29.2207792207792, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002610
- InterPro:   IPR022764
- InterPro:   IPR001440
- InterPro:   IPR013026
- InterPro:   IPR011990
- InterPro:   IPR019734 [H]

Pfam domain/function: PF01694 Rhomboid; PF00515 TPR_1 [H]

EC number: =3.4.21.105 [H]

Molecular weight: Translated: 29496; Mature: 29365

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRPPDESDDIEAFLRRAEREFGLRPDLPEEPPPPPPRPAPPRPFVTQSLLWAIGIVYVL
CCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SCVLSGSFFQPAFPVLAVLGAKINERIADGELWRLLTAVFLHANLIHIFFNGYALSVLGP
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ETERFYGHGRFLALYLISGLGGSIASYALSPAPAVGASGAIFGLIGGLGVFYYLNRRVLG
CHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFGQNQVRGIVAIALINLLIGFAAQGVIDNWGHLGGLLSGIVIGVALAPRLTVDLRFFPP
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCH
LFIRRFPMQGWLWVFAIALVMIVLVRLVTPA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TRPPDESDDIEAFLRRAEREFGLRPDLPEEPPPPPPRPAPPRPFVTQSLLWAIGIVYVL
CCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
SCVLSGSFFQPAFPVLAVLGAKINERIADGELWRLLTAVFLHANLIHIFFNGYALSVLGP
HHHHCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECC
ETERFYGHGRFLALYLISGLGGSIASYALSPAPAVGASGAIFGLIGGLGVFYYLNRRVLG
CHHHHHCCHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EFGQNQVRGIVAIALINLLIGFAAQGVIDNWGHLGGLLSGIVIGVALAPRLTVDLRFFPP
HHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEEEECCCH
LFIRRFPMQGWLWVFAIALVMIVLVRLVTPA
HHHHHCCCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]