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The map label for this gene is mutX [H]

Identifier: 222523769

GI number: 222523769

Start: 574682

End: 575179

Strand: Reverse

Name: mutX [H]

Synonym: Chy400_0476

Alternate gene names: 222523769

Gene position: 575179-574682 (Counterclockwise)

Preceding gene: 222523770

Following gene: 222523768

Centisome position: 10.92

GC content: 54.02

Gene sequence:

>498_bases
ATGCCCTACACACCAATTCTGGCCACACTTGGTTATGTGCTATCGCCCGACCGGCAATCGGTCTTGATGGTTCATCGCAA
TGCCCGTCCCGGTGATCAACATTTAGGTAAGTATAACGGCCTGGGTGGTAAGCTCGAACGCGATGAAGAGATTGTTGCCG
GTATCCAGCGCGAATTGTTTGAAGAAGCCGGCATTACTGCGCTCGAATTGACATTGCGAGGTACAGTAAGCTGGCCGGGG
TTCGGCAAACATGGTGAAGACTGGTTTGCGTTTATCTTCTTAATCACTCGTTTCGCCGGCGAGCCGCCACCATCTAATGA
AGAAGGCACTCTTGAATGGGTACCGCTCCAGCGTGTCATGCACCTTCCCCTGTGGCCGGGTGATCGATTTTTTCTCCCGC
TGGTCTTCGATGACGATCCGCGTCCATTCCATGGCGTGATGCCTTATGCGAACGGTCAACCGGTGGCCTGGAACTTCTCC
CGGATCGGTACGGGCTAA

Upstream 100 bases:

>100_bases
TGCCCGCAGGCGTGGAAGCCGGTAGTGCGCGGCGGATTGCCGAGGCGCGGCGTGGCGAACGTGGAATCTTTGCATCCTGG
TAGTTGTTGTTGAGGTGGTT

Downstream 100 bases:

>100_bases
CGCATCGTGGTATAATTGCTCTCATCCTATTGTGGTGCGCTGTTGTGCGACAGCGTCGTGGATTGCGGCAGAAACCTATG
CTTGACATTAAACTCATTCG

Product: NUDIX hydrolase

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MPYTPILATLGYVLSPDRQSVLMVHRNARPGDQHLGKYNGLGGKLERDEEIVAGIQRELFEEAGITALELTLRGTVSWPG
FGKHGEDWFAFIFLITRFAGEPPPSNEEGTLEWVPLQRVMHLPLWPGDRFFLPLVFDDDPRPFHGVMPYANGQPVAWNFS
RIGTG

Sequences:

>Translated_165_residues
MPYTPILATLGYVLSPDRQSVLMVHRNARPGDQHLGKYNGLGGKLERDEEIVAGIQRELFEEAGITALELTLRGTVSWPG
FGKHGEDWFAFIFLITRFAGEPPPSNEEGTLEWVPLQRVMHLPLWPGDRFFLPLVFDDDPRPFHGVMPYANGQPVAWNFS
RIGTG
>Mature_164_residues
PYTPILATLGYVLSPDRQSVLMVHRNARPGDQHLGKYNGLGGKLERDEEIVAGIQRELFEEAGITALELTLRGTVSWPGF
GKHGEDWFAFIFLITRFAGEPPPSNEEGTLEWVPLQRVMHLPLWPGDRFFLPLVFDDDPRPFHGVMPYANGQPVAWNFSR
IGTG

Specific function: Involved in the DNA repair system to avoid A.T to G.C transversions. Degrades 8-oxo-dGTP to the monophosphate, but is also active on all of the nucleoside triphosphates [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003562
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: NA

Molecular weight: Translated: 18557; Mature: 18426

Theoretical pI: Translated: 5.21; Mature: 5.21

Prosite motif: PS00893 NUDIX ; PS00159 ALDOLASE_KDPG_KHG_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYTPILATLGYVLSPDRQSVLMVHRNARPGDQHLGKYNGLGGKLERDEEIVAGIQRELF
CCCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
EEAGITALELTLRGTVSWPGFGKHGEDWFAFIFLITRFAGEPPPSNEEGTLEWVPLQRVM
HHCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHH
HLPLWPGDRFFLPLVFDDDPRPFHGVMPYANGQPVAWNFSRIGTG
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEHHCCCCC
>Mature Secondary Structure 
PYTPILATLGYVLSPDRQSVLMVHRNARPGDQHLGKYNGLGGKLERDEEIVAGIQRELF
CCCHHHHHHHHHCCCCCCEEEEEECCCCCCHHHCCCCCCCCCCCCCHHHHHHHHHHHHH
EEAGITALELTLRGTVSWPGFGKHGEDWFAFIFLITRFAGEPPPSNEEGTLEWVPLQRVM
HHCCCEEEEEEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEHHHHH
HLPLWPGDRFFLPLVFDDDPRPFHGVMPYANGQPVAWNFSRIGTG
CCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8170394; 11463916; 8163538 [H]