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The map label for this gene is serS [H]

Identifier: 222523768

GI number: 222523768

Start: 573333

End: 574604

Strand: Reverse

Name: serS [H]

Synonym: Chy400_0475

Alternate gene names: 222523768

Gene position: 574604-573333 (Counterclockwise)

Preceding gene: 222523769

Following gene: 222523767

Centisome position: 10.91

GC content: 55.35

Gene sequence:

>1272_bases
ATGCTTGACATTAAACTCATTCGTGAACAACCCGATGAAGTAAAACGCCGGCTCGCTCGTTGTGGGGTTGATGGGGCAGT
CGTCGATCAGGTGCTGGCTTTTGATGAACAACGCCGACGCCTGATTTATGAGGTGGAGACGCGCAAAGCTGAGCGTAATA
CCGTCTCGAAGCAGATTGGTGCGATGAAAGACCCGGCTGAGCGGCAGGCAAAGATAGATGCGATGCGCCAGTTGGGTGAT
GAAATCGCCGCGCTCGACCGGCAACTGGCCGAGGTGGAAGAGCAGCAGCGGGCAGTGATGCTCGAAATTCGCAATCTGCC
CCATCCTGATGTTCCCGATGGGGTTGATGATCGCGACAATGTGGTGATCTATCAGGAGGGTGAAGAGCGGCAGTTGCCCT
TCCCGGCCCGTCCGCACTGGGAATTGGGTGAAGCGTTAGGCATCATCGATTTTGAACGCGGGGTGAAGCTGGCCGGTTCC
CGTTTCTACGTGATGCGTGGGGCAGGCGCCCGCCTTCAGCGCGCTGTTATTCAGTGGTTGATCGATCTGCACCTGGAACA
GGGTTACCAGGAAGTGTACACACCCTTTGTGGTCAAAGAGTCGGTGTTGTGGGCATCAGGTCAGTTGCCGAAGTTCCGCG
ATAACCTCTACCGCGACGAAGAGTCGGGTTTATGGCTGGTGCCAACGGCAGAAGTTCCGTTGACCAGTCTCTACGCCGAT
GAAATCCTCGACGCGAGTCAGTTGCCGATCTATCACGTTGCCTATACGCCCTGTTTCCGCAAAGAGCAGCTTAGCGCCGG
GCGTGATGTGCGTGGTATCAAGCGCGGCCATCAGTTCGACAAGGTTGAGATGTATATGTTCGTGACGCCTGATCAGAGCT
ATCAGGCGCTCGAAAAACTGCGCCGCGATGCTGAAGAGTGTGCCCGCCGGTTAGGATTGCCGTTCCGCACTAAACTGCTC
TGTACCGGCGATCTCGGTTTTGGTTCAACCAAGACCTACGACATTGAAGTTTGGGCGCCGGGTGTGGGCGAATGGCTTGA
AGTCAGTTCGTGCTCGAATGTGGAAGCATTTCAGGCCCGACGCGCCAATTTGCGCTACCGACCTGAACCGGGAGCAAAGC
CTGAGTTTTTACACACGCTGAACGGTTCAGGATTGGGGTTACCGCGCACAATCATCGCGATTATGGAGAATTATCAGCAG
GAAGACGGAAGTATCCTGATACCTGAGGTGTTACGGCCATATATGGGTGGTATGGAACGGATCGGGCCATAA

Upstream 100 bases:

>100_bases
TCTCCCGGATCGGTACGGGCTAACGCATCGTGGTATAATTGCTCTCATCCTATTGTGGTGCGCTGTTGTGCGACAGCGTC
GTGGATTGCGGCAGAAACCT

Downstream 100 bases:

>100_bases
GCTGCGATCCGCATCAAGCAGGAAACGACGCCTATGCCGGTTGTGATTCAGCTCACCAGCGCAATGCACGGTGGTACCAG
TCCGAGTTGTGGTACCGGTG

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 423; Mature: 423

Protein sequence:

>423_residues
MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIGAMKDPAERQAKIDAMRQLGD
EIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDNVVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGS
RFYVMRGAGARLQRAVIQWLIDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYAD
EILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKLRRDAEECARRLGLPFRTKLL
CTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQARRANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQ
EDGSILIPEVLRPYMGGMERIGP

Sequences:

>Translated_423_residues
MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIGAMKDPAERQAKIDAMRQLGD
EIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDNVVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGS
RFYVMRGAGARLQRAVIQWLIDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYAD
EILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKLRRDAEECARRLGLPFRTKLL
CTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQARRANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQ
EDGSILIPEVLRPYMGGMERIGP
>Mature_423_residues
MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIGAMKDPAERQAKIDAMRQLGD
EIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDNVVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGS
RFYVMRGAGARLQRAVIQWLIDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYAD
EILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKLRRDAEECARRLGLPFRTKLL
CTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQARRANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQ
EDGSILIPEVLRPYMGGMERIGP

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=446, Percent_Identity=32.5112107623318, Blast_Score=212, Evalue=5e-55,
Organism=Homo sapiens, GI8923421, Length=432, Percent_Identity=32.1759259259259, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI225579074, Length=434, Percent_Identity=31.7972350230415, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI1787120, Length=434, Percent_Identity=47.926267281106, Blast_Score=385, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17539260, Length=464, Percent_Identity=28.8793103448276, Blast_Score=190, Evalue=1e-48,
Organism=Caenorhabditis elegans, GI17542084, Length=318, Percent_Identity=29.2452830188679, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6320226, Length=441, Percent_Identity=28.5714285714286, Blast_Score=191, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6321799, Length=292, Percent_Identity=33.2191780821918, Blast_Score=189, Evalue=8e-49,
Organism=Drosophila melanogaster, GI24581334, Length=465, Percent_Identity=30.752688172043, Blast_Score=201, Evalue=7e-52,
Organism=Drosophila melanogaster, GI17737985, Length=373, Percent_Identity=32.4396782841823, Blast_Score=172, Evalue=3e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 48257; Mature: 48257

Theoretical pI: Translated: 5.10; Mature: 5.10

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIG
CCCCEEHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHC
AMKDPAERQAKIDAMRQLGDEIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGSRFYVMRGAGARLQRAVIQWL
EEEEECCCCCCCCCCCCCCCCHHHHHCCEECCCCCEECCCEEEEEECCCHHHHHHHHHHH
IDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYAD
HHHHHHHCHHHHHCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHH
EILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKL
HHCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHCCCCCCEEEEEEEECCCHHHHHHHHH
RRDAEECARRLGLPFRTKLLCTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQAR
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCHHCCCCCCCHHHHHHH
RANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQEDGSILIPEVLRPYMGGMER
HCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCHHH
IGP
CCC
>Mature Secondary Structure
MLDIKLIREQPDEVKRRLARCGVDGAVVDQVLAFDEQRRRLIYEVETRKAERNTVSKQIG
CCCCEEHHCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHHHHC
AMKDPAERQAKIDAMRQLGDEIAALDRQLAEVEEQQRAVMLEIRNLPHPDVPDGVDDRDN
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VVIYQEGEERQLPFPARPHWELGEALGIIDFERGVKLAGSRFYVMRGAGARLQRAVIQWL
EEEEECCCCCCCCCCCCCCCCHHHHHCCEECCCCCEECCCEEEEEECCCHHHHHHHHHHH
IDLHLEQGYQEVYTPFVVKESVLWASGQLPKFRDNLYRDEESGLWLVPTAEVPLTSLYAD
HHHHHHHCHHHHHCCHHHHHHHHCCCCCCCHHHHHHCCCCCCCEEEEECCCCCHHHHHHH
EILDASQLPIYHVAYTPCFRKEQLSAGRDVRGIKRGHQFDKVEMYMFVTPDQSYQALEKL
HHCCCCCCCEEEEEECCCHHHHHHCCCCCHHHHHCCCCCCEEEEEEEECCCHHHHHHHHH
RRDAEECARRLGLPFRTKLLCTGDLGFGSTKTYDIEVWAPGVGEWLEVSSCSNVEAFQAR
HHHHHHHHHHCCCCCEEEEEEEECCCCCCCEEEEEEEECCCCCCHHCCCCCCCHHHHHHH
RANLRYRPEPGAKPEFLHTLNGSGLGLPRTIIAIMENYQQEDGSILIPEVLRPYMGGMER
HCCCCCCCCCCCCCHHHEECCCCCCCHHHHHHHHHHHHHHCCCCEECHHHHHHHHCCHHH
IGP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA