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The map label for this gene is apt

Identifier: 222523585

GI number: 222523585

Start: 352807

End: 353328

Strand: Direct

Name: apt

Synonym: Chy400_0291

Alternate gene names: 222523585

Gene position: 352807-353328 (Clockwise)

Preceding gene: 222523578

Following gene: 222523586

Centisome position: 6.7

GC content: 54.02

Gene sequence:

>522_bases
ATGACGCGGCAAGATCTGGCCAGTCTGATCCGGAACATTCCCGACTTTCCAATACCCGGTATTCAGTTTAAAGATATTAC
CACGTTGATCGGCAACGGTCAGGCATTCAGTGAGGTTATTGATCGTCTGCACGAACGCTACCAGAATCAGCAGATTGATG
CGGTAGTCGGGATCGAGTCACGGGGGTTCATCTTTAGTGCGCCACTGGCCTACCGGCTGGGGGTAGGGTTGGTGCCGATT
CGCAAACCGGGTAAACTACCGGCTGCCACGTATCAGATCGAGTATCAGCTTGAATATGGCACAAACCGGCTAGAGATTCA
CCGCGACGCCTTCCAGCCCGGTGCACGTGTGCTGGTGATTGATGATCTGCTGGCGACCGGCGGCACGATTGCCGCAGCCT
GTGATCTAATTGAAATGGCAGGTGGACAGGTTGCCGAGCTGGCATTTGTGATTGAGCTGACATTTCTCAATGGTCGTGAA
CGGCTGCGTGAACGACCGGTCTTCTCGCTGATCCAGTTTTAG

Upstream 100 bases:

>100_bases
ACTTGACTTGTGATCGAATACACATACTACCGTACACAGGCAAGAGCAGATTCTCTATAATAGCGAGTGTACTGACTATT
TGCGTAACAATGGAGGGCGT

Downstream 100 bases:

>100_bases
AAGGTAGCTCATCTGACAGACAACATGCGAGAGCACACAGCATCCCCGTGACCAGCAGGGTGAACGGTGTGACACGCGCA
TGGCCGCAAGCACGGCTGGT

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 173; Mature: 172

Protein sequence:

>173_residues
MTRQDLASLIRNIPDFPIPGIQFKDITTLIGNGQAFSEVIDRLHERYQNQQIDAVVGIESRGFIFSAPLAYRLGVGLVPI
RKPGKLPAATYQIEYQLEYGTNRLEIHRDAFQPGARVLVIDDLLATGGTIAAACDLIEMAGGQVAELAFVIELTFLNGRE
RLRERPVFSLIQF

Sequences:

>Translated_173_residues
MTRQDLASLIRNIPDFPIPGIQFKDITTLIGNGQAFSEVIDRLHERYQNQQIDAVVGIESRGFIFSAPLAYRLGVGLVPI
RKPGKLPAATYQIEYQLEYGTNRLEIHRDAFQPGARVLVIDDLLATGGTIAAACDLIEMAGGQVAELAFVIELTFLNGRE
RLRERPVFSLIQF
>Mature_172_residues
TRQDLASLIRNIPDFPIPGIQFKDITTLIGNGQAFSEVIDRLHERYQNQQIDAVVGIESRGFIFSAPLAYRLGVGLVPIR
KPGKLPAATYQIEYQLEYGTNRLEIHRDAFQPGARVLVIDDLLATGGTIAAACDLIEMAGGQVAELAFVIELTFLNGRER
LRERPVFSLIQF

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=167, Percent_Identity=47.3053892215569, Blast_Score=155, Evalue=2e-38,
Organism=Homo sapiens, GI71773201, Length=121, Percent_Identity=47.9338842975207, Blast_Score=115, Evalue=2e-26,
Organism=Escherichia coli, GI1786675, Length=170, Percent_Identity=53.5294117647059, Blast_Score=179, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=173, Percent_Identity=46.242774566474, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6323619, Length=173, Percent_Identity=42.1965317919075, Blast_Score=127, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6320649, Length=173, Percent_Identity=38.728323699422, Blast_Score=108, Evalue=6e-25,
Organism=Drosophila melanogaster, GI17136334, Length=170, Percent_Identity=42.9411764705882, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_CHLAA (A9WCV7)

Other databases:

- EMBL:   CP000909
- RefSeq:   YP_001633915.1
- ProteinModelPortal:   A9WCV7
- SMR:   A9WCV7
- GeneID:   5828030
- GenomeReviews:   CP000909_GR
- KEGG:   cau:Caur_0273
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 19242; Mature: 19111

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER; PS00144 ASN_GLN_ASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRQDLASLIRNIPDFPIPGIQFKDITTLIGNGQAFSEVIDRLHERYQNQQIDAVVGIES
CCHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
RGFIFSAPLAYRLGVGLVPIRKPGKLPAATYQIEYQLEYGTNRLEIHRDAFQPGARVLVI
CCEEEECCHHHHHCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEEEHHHCCCCCEEEEE
DDLLATGGTIAAACDLIEMAGGQVAELAFVIELTFLNGRERLRERPVFSLIQF
ECHHHCCCHHHHHHHHHHHCCCCHHEEEEEEEEEECCCHHHHHHCCHHHHHCC
>Mature Secondary Structure 
TRQDLASLIRNIPDFPIPGIQFKDITTLIGNGQAFSEVIDRLHERYQNQQIDAVVGIES
CHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECC
RGFIFSAPLAYRLGVGLVPIRKPGKLPAATYQIEYQLEYGTNRLEIHRDAFQPGARVLVI
CCEEEECCHHHHHCCCEEECCCCCCCCCEEEEEEEEEECCCCEEEEEHHHCCCCCEEEEE
DDLLATGGTIAAACDLIEMAGGQVAELAFVIELTFLNGRERLRERPVFSLIQF
ECHHHCCCHHHHHHHHHHHCCCCHHEEEEEEEEEECCCHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA