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The map label for this gene is menA [H]

Identifier: 222523399

GI number: 222523399

Start: 124173

End: 125078

Strand: Direct

Name: menA [H]

Synonym: Chy400_0101

Alternate gene names: 222523399

Gene position: 124173-125078 (Clockwise)

Preceding gene: 222523398

Following gene: 222523400

Centisome position: 2.36

GC content: 61.7

Gene sequence:

>906_bases
ATGACAACCAAAGCAACATCAGTACCACCATCACACCTCAAAATCTGGCTAATGGCGAGCCGCCCGGCAACACTCCCGGC
AGCCGTCGTACCGGTACTGGTCGGCTCAGCCCTGGCCTACAGCAGTGACGCATTTCAACCACTGGTGATGCTGGCTGCAC
TACTCGGTGCACTCTTCATTCAAATCGGCACCAATCTCGCCAACGACTACTTCGATGCCCAAAAAGGCGCCGACACCAGC
GAACGCCTCGGCCCGGTACGGGTCACCCAGAGCGGCCTGCTCCCCGCACGCACAGTACTCACAGCAGCCCTGGTGAGCTT
TGGCCTGGCGGCCCTGGCCGGCATCTACCTGATCACCGTTGCCGGCTGGCCCATCCTGGTCATCGGCTTACTCTCAATCG
CCGCCGGCATCCTCTACACCGCCGGCCCCTTCCCCCTCGGCTACCACGGCCTCGGCGACCTGTTCACCTTCGTCTTCTTC
GGATTGGTAGCCGTTATCGGCACCGACTTCGCCCACACCGGCCAGTTCCGCTGGATTGCCCTATGGGCAGCGTTACCGAT
AGCCATGCTGGTCACCGCGATCCTCGTCGTCAACAACCTGCGCGACGCACCCACCGACCGCAAAGCCGGCAAACGCACCC
TGGCCGTCATCTTCGGCGAACGGTTCGCCCGCAGCGAATTTGCCATCCTGGTCATCGGAGCATTCGTATCACTGCCCCTG
GCCTGGATGTGGGGCGGAGCCTCACCATTCACCCTGCTGGCCTGGCTAACCGCACCAATGGCACTCAACCTGATCGACTT
CGTCAACCGCGAACGCGGTCGGGCCCTCAACAAAGCCCTGGTCGGCGCTGGCCGATTACATCTGGCGTTCGGCGTACTCT
TCGCAATTGGGTTGTTATTTGGCTAA

Upstream 100 bases:

>100_bases
CATCTCCCCTCCCCTAACTCCTCCCCCCAGCGGGGGGAGGCTGGGAGGGGGGCGAGGGGTGAAGTGAGCGCCACCACTCA
CGTGACAGAAAGAGCACACT

Downstream 100 bases:

>100_bases
TCCAGACACCAGACCGACCGGCACCCCAGGCCGCGCATCCACACTGTCCGGCCCTGCCAACTGGCGAGAGTACCTTGCCG
TACAATGTCGTGGCTGCTCA

Product: 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Products: NA

Alternate protein names: DHNA-octaprenyltransferase [H]

Number of amino acids: Translated: 301; Mature: 300

Protein sequence:

>301_residues
MTTKATSVPPSHLKIWLMASRPATLPAAVVPVLVGSALAYSSDAFQPLVMLAALLGALFIQIGTNLANDYFDAQKGADTS
ERLGPVRVTQSGLLPARTVLTAALVSFGLAALAGIYLITVAGWPILVIGLLSIAAGILYTAGPFPLGYHGLGDLFTFVFF
GLVAVIGTDFAHTGQFRWIALWAALPIAMLVTAILVVNNLRDAPTDRKAGKRTLAVIFGERFARSEFAILVIGAFVSLPL
AWMWGGASPFTLLAWLTAPMALNLIDFVNRERGRALNKALVGAGRLHLAFGVLFAIGLLFG

Sequences:

>Translated_301_residues
MTTKATSVPPSHLKIWLMASRPATLPAAVVPVLVGSALAYSSDAFQPLVMLAALLGALFIQIGTNLANDYFDAQKGADTS
ERLGPVRVTQSGLLPARTVLTAALVSFGLAALAGIYLITVAGWPILVIGLLSIAAGILYTAGPFPLGYHGLGDLFTFVFF
GLVAVIGTDFAHTGQFRWIALWAALPIAMLVTAILVVNNLRDAPTDRKAGKRTLAVIFGERFARSEFAILVIGAFVSLPL
AWMWGGASPFTLLAWLTAPMALNLIDFVNRERGRALNKALVGAGRLHLAFGVLFAIGLLFG
>Mature_300_residues
TTKATSVPPSHLKIWLMASRPATLPAAVVPVLVGSALAYSSDAFQPLVMLAALLGALFIQIGTNLANDYFDAQKGADTSE
RLGPVRVTQSGLLPARTVLTAALVSFGLAALAGIYLITVAGWPILVIGLLSIAAGILYTAGPFPLGYHGLGDLFTFVFFG
LVAVIGTDFAHTGQFRWIALWAALPIAMLVTAILVVNNLRDAPTDRKAGKRTLAVIFGERFARSEFAILVIGAFVSLPLA
WMWGGASPFTLLAWLTAPMALNLIDFVNRERGRALNKALVGAGRLHLAFGVLFAIGLLFG

Specific function: Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to dimethylmenaquinone (DMK). Attaches octaprenylpyrophosphate, a membrane-bound 40-carbon side chain to DHNA. The conversion of DHNA to DMK proceeds in three stages:the removal of the carboxyl group of DHNA

COG id: COG1575

COG function: function code H; 1,4-dihydroxy-2-naphthoate octaprenyltransferase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the menA family [H]

Homologues:

Organism=Homo sapiens, GI7019551, Length=289, Percent_Identity=28.0276816608997, Blast_Score=91, Evalue=1e-18,
Organism=Escherichia coli, GI1790365, Length=272, Percent_Identity=39.3382352941176, Blast_Score=168, Evalue=4e-43,
Organism=Drosophila melanogaster, GI17737429, Length=292, Percent_Identity=29.4520547945205, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004657
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: =2.5.1.74 [H]

Molecular weight: Translated: 31814; Mature: 31683

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKATSVPPSHLKIWLMASRPATLPAAVVPVLVGSALAYSSDAFQPLVMLAALLGALFI
CCCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QIGTNLANDYFDAQKGADTSERLGPVRVTQSGLLPARTVLTAALVSFGLAALAGIYLITV
HHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPILVIGLLSIAAGILYTAGPFPLGYHGLGDLFTFVFFGLVAVIGTDFAHTGQFRWIA
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHH
LWAALPIAMLVTAILVVNNLRDAPTDRKAGKRTLAVIFGERFARSEFAILVIGAFVSLPL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AWMWGGASPFTLLAWLTAPMALNLIDFVNRERGRALNKALVGAGRLHLAFGVLFAIGLLF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
G
C
>Mature Secondary Structure 
TTKATSVPPSHLKIWLMASRPATLPAAVVPVLVGSALAYSSDAFQPLVMLAALLGALFI
CCCCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
QIGTNLANDYFDAQKGADTSERLGPVRVTQSGLLPARTVLTAALVSFGLAALAGIYLITV
HHHHHHHHHHHHHHCCCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AGWPILVIGLLSIAAGILYTAGPFPLGYHGLGDLFTFVFFGLVAVIGTDFAHTGQFRWIA
CCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHCCCCHHHHH
LWAALPIAMLVTAILVVNNLRDAPTDRKAGKRTLAVIFGERFARSEFAILVIGAFVSLPL
HHHHHHHHHHHHHHHHHHHCCCCCCCHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
AWMWGGASPFTLLAWLTAPMALNLIDFVNRERGRALNKALVGAGRLHLAFGVLFAIGLLF
HHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9573170; 8346018; 9278503 [H]